• Restorative Dentistry and Endodontics
• /
• 제6권1호
• /
• pp.27-35
• /
• 1980

This study was to evaluate the effectiveness of a few disinfectant on amputated pulps of domestic dogs. The materials employed for the purpose were zinc oxide eugenol paste, calcium hydroxide as control groups and guaiacol (1%, 5%, 10% by weight) added zinc oxide eugenol paste and formaldehyde (1%, 5%, 10% by weight) added calcium hydroxide as experimental groups. Following were the results obtained throngh histo-pathological examination. 1) In calcium hydroxide-formaldehyde groups, secondary dentin formation was observed in the 2 weeks, but the remaining pulp tissue was severely atrophied according to the concentration of formaldehyde and the time increased. 2) In zinc oxide eugenol-guaiacol groups, the first evidence of secondary dentin formation was observed in the 3 weeks. It seems that the concentration variety of guaiacol influenced very little to the potential ability of dentin formation. 3) Except 1% formaldehyde containing calcium hydroxide group, every group showed severe pulp degeneration. In all groups of zinc oxide eugenol-guaiacol cases revealed the tendency of recovery.

• Restorative Dentistry and Endodontics
• /
• 제48권4호
• /
• pp.39.1-39.23
• /
• 2023

Objectives: This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells. Materials and Methods: Electronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed. Results: Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%-38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment (n = 3). However, orally administered drugs did not reduce pulp inflammation (n = 4). Cytotoxicity (n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies. Conclusions: Few in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings.

• 한국펄프종이공학회:학술대회논문집
• /
• 한국펄프종이공학회 1999년도 Pre-symposium of the 10th ISWPC Recent Advances in Paper Science and Technology
• /
• pp.296-301
• /
• 1999

Different papers such as toilet and towel tissue, newsprint and copy paper made from reclaimed fibres were characterized using UV-VIS reflectance and fluorescence spectroscopy. The emission properties of the extracts of the papers were also evaluated. Photochemical irradiation at ambient temperatures, and thermal aging of the copy papers at 105$^{\circ}C$ and 150$^{\circ}C$ were performed. Post-colour numbers (PC) were calculated from the reflectance values measured from the corresponding UV-VIS reflectance spectra. Light absorption coefficient spectra were calculated before and after irradiation, and the changes in absorption coefficient were related to the content of chromophores in the papers. Photochemical and thermal discolouration of the copy papers, similar to that of virgin fibres, was readily observed. The influence of changes in the concentrations of fluorescent brightening agents and dyes on the spectral properties was also assessed. Photostabilization studies of the copy papers were performed with the use of polymer additives polyethylene glycol (PEG) and polytetrahydrofuran (PTHF).

• 동국한의학연구소논문집
• /
• 제2권1호
• /
• pp.177-182
• /
• 1993

This study were performed for the effects of Panax ginseng on the side effect of Cyclophosphamide to splenic tissue in the Rats. The experimental animals were divided into control group, test group by the way of the method treatment of the drug. Each group was sacrificed and stained in accordance with the schedule and observed under light microscope. The results of this study were as follows : 1. After the ginseng extract administration rat's weight and volume were similarly increased than normal and control group. 2. The decrease of the numbers of the splenic tissue after treatment of cyclophosphamide(CP) were recovered with prescription of the ginseng extract; the decrease of white pulp, red pulp, marginal zone were recovered. 3. Increased macrophage in red pulp of splenic tissue with administration of CP were disapeared after treatment of ginseng extract.

• Restorative Dentistry and Endodontics
• /
• 제24권1호
• /
• pp.180-186
• /
• 1999

Eugenol has been reported to reduce odontogenic pain and is known to have a structure similar to capsaicin, a potent stimulant of certain nociceptors. We have hypothesized that the analgesic effect of eugenol may be due, in part, to inhibition of capsaicin-sensitive nociceptors. To test this hypothesis, we evaluate whether eugenol inhibits capsaicin-sensitive release of immunoreactive calcitonin generated peptide(iCGRP) from bovine dental pulp. Freshly extracted bovine incisors were transported to the lab. on ice, Spilitted and pulp tissue was removed. The tissue was chopped into 200${\mu}m$ slices. Dental pulp was superfused(340 ${\mu}l/min$) in vitro with oxygenated Kreb's buffer. Eugenol and vehicle(0.02% 2-hydroxyl-${\beta}$-cyclodextrin) were administered prior to stimulation of pulp with capsaicin and iCGRP was measured by RIA. The results were as follows: 1. Administration of eugenol has no effect on basal release of iCGRP. 2. In the vehicle treated group, capsaicin evoked a 2.5-fold increase over basal iCGRP levels. 3. Administration of eugenol(600 ${\mu}M$) reduced capsaicin evoked release of iCGRP by more than 40%(153.4${\pm}$41.1% vs 258.9${\pm}$21.7%). 4. 2-hydroxylpropyl-${\beta}$-cyclodextrin of less than 0.02% is found to be an effective vehicle to dissolve eugenol without evoking iCGRP release from dental bovine pulp. These data indicate that eugenol inhibits pulpal capsaicin-sensitive fibers and suggest that intracanal medicament of eugenol may relieve pain, in part, by this mechanism.

• 대한소아치과학회지
• /
• 제40권2호
• /
• pp.120-126
• /
• 2013

심한 우식을 보이는 미성숙 영구치 치료에 있어서 치수생활력을 보존하는 것은 중요하다. 치수절단술을 시행 시 생체적합성이 있는 재료를 이용하여 치료함으로써 남아있는 생활력이 있는 치수를 보호하며 미성숙 영구치의 치근 성장을 도모할 수 있다. 혈소판 농축 섬유소는 환자의 혈액을 직접 채취하여 적용하기 때문에 생체적합성이 뛰어나며 다양한 성장인자를 함유하고 있어 치수생활력을 유지하고 미성숙 영구치의 치근 발육을 촉진시킬 수 있다. 본 증례에서는 심한 치아 우식증을 보이는 미성숙 영구치에서 치수절단술 시행 후 남아 있는 치수 상부에 혈소판 농축 섬유소를 적용하였다. 정기적인 검진 결과 미성숙 영구치의 치근 성장 및 정상적인 치아 주위 조직들이 관찰되었다. 향후 장기간의 임상적 관찰이 필요할 것이며 더 많은 임상 증례를 바탕으로 한 연구가 필요할 것이다.

• 한국펄프종이공학회:학술대회논문집
• /
• 한국펄프종이공학회 2006년도 춘계학술발표논문집
• /
• pp.254-259
• /
• 2006

• Restorative Dentistry and Endodontics
• /
• 제15권1호
• /
• pp.153-164
• /
• 1990

Human dental pulps obtained from normal teeth, hypersensitive teeth and teeth with inflamed pulp were studied to measure and to compare the endogenous levels of arachidonic acid metabolites in order to see the relative activities of the different pathways involved in arachidonic acid metabolism. Pulp homogenates were incubated with $^{14}C$-arachidonic acid and lipid solvent extracts were separated by thin layer chromatography (TLC) to be analyzed by autoradiography and TLC analyzer. 1. The most significant metabolite was HETEs showing $96.9{\pm}37.8$pmol/mg tissue protein/hr in normal pulp, $169.2{\pm}76.7$ in hypersensitive pulp and $385.4{\pm}113.2$ in inflamed pulp. In normal pulp $LTB_4$, 6-keto-$PGF_{1\alpha}+PGE_2$, $TXB_2$ and unidentified metabolite were formed in decreasing order. While in hypersensitive and inflamed pulp 6-keto-$PGF_{1\alpha}+PGE_2$, $LTB_4$, $TXB_2$ and unidentified metabolite were formed in decreasing order. 2. In hypersensitive pulp only HETEs were significantly increased when compared with that in normal pulp. The levels of all the converted metabolites in inflamed pulp were significantly increased compared with those in normal pulp. In inflamed pulp, the levels of $TXB_2$ and HETEs were significantly increased compared with those in hypersensitive pulp. 3. The ratio of each metabolites to the total converted metabolites showed an increased value of $TXB_2$ and 6-keto-$PGF_{1\alpha}+PGE_2$, as the degree of inflammation was increased, while that of HETEs decreased both in hypersensitive pulp and inflamed pulp more than in normal pulp. 4. The relative amounts of the total metabolites formed in lipoxygenase pathway to cyclo-oxygenase pathway were 6.8 fold in normal pulp, 4.4 fold in hypersensitive pulp and 3.8 fold in inflamed pulp.

• Restorative Dentistry and Endodontics
• /
• 제24권4호
• /
• pp.554-559
• /
• 1999

Aucubin, an iridoid glucoside isolated from Aucuba japonica, has pharmacological effects such as antimicrobial effect, liver protective function and inhibition of liver RNA and protein biosynthesis, etc. This study was performed to observe the effect of aucubin on the pulp tissue after pulpotomy. Aucubin was converted to aucubinogenin as an active form by ${\beta}$-glucosidase. In 3 Mongrel dogs, the pulps were mechanically exposed with a sterile round bur and excised with sterile excavator. After bleeding control, aucubin was applied on remaining pulp tissues and then they were sealed with IRM in experimental group. In control group, $Ca(OH)_2$ powder was applied on remaining pulp tissues and then they were sealed with IRM. After interval of 1 and 12 weeks, the dogs were sacrificed. The teeth were prepared for histologic evaluation and examined by light microscope. Aucubin 1 week group showed that mild inflammation and vascular congestion in most of the specimen. More various degree of inflammation was found in experimental group than in control group. Premature calcified mass were found in the both 1 weeks groups. Continuous well-formed dentin bridge was found in both 12 weeks groups. Collectively, this study suggests that the possibility of aucubin as a medicament after pulpotomy.

• 펄프종이기술
• /
• 제36권4호
• /
• pp.77-82
• /
• 2004

Expression-deliquoring tests using three types of paper sludges (tissue, newsprint, and paperboard) as deliquoring agent were carried out in order to investigate the effects of sludge dosage and pressure on the expression-deliquoring of slurry. The addition of deli­quoring agent causes expression-deliquoring of slurry to be faster than would be the case without the deliquoring agent. In case of the tissue sludge, the highest compression rate was achieved when $5\%$ of deliquoring agent was added, while in cases of the news­print and the paperboard sludge, $7\%$. Compression rate was increased as pressure increases. Porosity was decreased as pressure increases. The lowest porosity was observed when $5\%$ of tissue sludge was added. When compared the weight of cake where deliquoring agent was not added and the weight of cake that was fastest expression-deliquoring, there was about $17.5\%$ of the weight reduction