• Tuberculosis and Respiratory Diseases
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• 제58권1호
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• pp.78-82
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• 2005

그레이브스병으로 진단받고 2년간 PTU 복용 중 폐포 출혈과 ANCA 양성 소견 보여 PTU에 의해 유발 된 ANCA 관련 혈관염으로 진단된 후 PTU 중단과 고용량 스테로이드와 면역 억제제 사용 후 증상 및 방사선학적으로 호전된 증례를 경험하여 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제51권2호
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• pp.166-172
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• 2001

저자들은 외음부에 불법적인 실리콘액 피하주사 후 미만성 폐출혈을 동반한 임상적으로 진단한 급성호흡곤란 증후군 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제28권5호
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• pp.495-498
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• 1995

Pulmonary arteriovenous fistula can be either congenital or acquired. The vast majority are congenital, and about 60% have been associated with hereditary hemorrhagic telangiectasia [Rendu-Osler-Weber disease . Secondary or acquired pulmonary arteriovenous fistula occurs with trauma, schistosomiasis, long-standing hepatic cirrhosis, metastatic carcinoma, and actinomycosis. Pulmonary hemorrhage secondary to acquired pulmonary arteriovenous fistula is a rare event associated with mortality. We have experienced 64 year-old female patient with the hemoptysis secondary to acquired pulmonary arteriovenous fistula due to the infection of pulmonary parasite. The chest PA and CT scan was showed calcified nodule to the distal portion of lateral segmental bronchus of RML. The bronchial angiogram was demonstrated slightly hypertrophied bronchial artery supplying RML bronchus and the presence of hypervascularization around the calcified nodule, rapid A-V shunting is noted by fluoroscopy. The patient was successfully treated by the right middle lobectomy.

• Tuberculosis and Respiratory Diseases
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• 제59권1호
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• pp.86-92
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• 2005

Goodpasture's syndrome is a disease that is characterized by hemoptysis, anemia, and glomerulonephritis with renal failure. Goodpasture reported a case of a young man who expired as a result of a pulmonary hemorrhage and glomerulonephritis at the recovery phase after an influenza infection in 1919. In 1958, Stanton et al. described a combined case of these two diseases as Goodpasture's syndrome. Since then, antiglomerular basement membrane antibody(anti-GBM Ab) has been confirmed to play an important role in the mechanism of this syndrome, and it was reported that this syndrome was an autoimmune disease. The triad of alveolar hemorrhage, glomerulonephritis and circulating anti-GBM Ab forms the basis of a diagnosis of Goodpasture's syndrome. When patients are affected by disease, the relief of symptoms can be accomplished by eliminating the anti-GBM Ab from the circulatory system through hemodialysis, plasmapheresis and immunoabsorption. However, the patients usually die from a massive pulmonary hemorrhage when the diagnosis or treatment is delayed. The incidence of Goodpasture's syndrome is common in the western world, but it is extremely rare in Korea with only five cases being reported. In three of these cases, pulmonary hemorrhage and renal failure was the initial manifestation. Therefore, hemodialysis or plasmapheresis were absolutely essential treatments. We report a case of Goodpasture's syndrome in Korea with a normal renal function.

• Tuberculosis and Respiratory Diseases
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• 제51권6호
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• pp.503-516
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• 2001

연구배경 : 급성 출혈성 쇼크에서 발생하는 급성폐손상의 병인론을 호중구의 산소기 생성과 연관하여 규명하고자 본 연구를 시행하였다. 급성출혈성쇼크에서 폐장내 산소기 생성의 주된 원인이 호중구의 침윤에 의한 것이며 이 때 PLA2의 활성화가호중구의 respiratory burst의 직접적인 원인임올 밝히고지 하였다. 방 법 : 체중 300-350 g 정도의 흰쥐에서 체중/kg 당 20ml정도의 혈액을 5분 동안 뽑아내어 급성 출혈성 쇼크를 유발하고 이 출혈성 쇼크 상태를 1시간 동안 유지하였다. 그 후 급성 폐손상의 지표들을 측정하였다. 동시에 폐장의 미세구조의 변화 및 세포화학적인 검사를 통하여 폐장조직내의 산소기의 형성을 확인하였다. 또한 PLA2 억제제인 mepacrine을 출혈직전에 투여하여 PLA2의 억제에 따른 변화도 검사, 비교하였다. 결 과 : 급성 출혈성 쇼크에 의해 유도된 급성 폐손상에서 호중구의 폐장내 침윤이 확인되었고 이 때 폐부종 및 조직내 산소기 형성의 증가가 관찰되었으며, 폐장내 PLA2의 활성도도 증가하였다. 그러나 mepacrine을 이용하여 PLA2를 억제한 결과, 폐부종의 감소, 산소기 형성의 감소가 확인되었다. 결 론 : 급성 출혈성 쇼크에 의한 급성폐손상은 호중구에 의한 산화성스트레스가 그 원인으로 생각되고 이 때 호중구에 의한 산화성스트레스의 발생에는 PLA2가 주된 역할을 한다고 사료된다.

• Clinical and Experimental Pediatrics
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• 제46권9호
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• pp.930-933
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• 2003

저자들은 신나 흡인 후 발생한 구토와 보챔을 주소로 내원한 환아에서 발생한 폐출혈을 동반한 화학성 폐렴 1례를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다.

• 한국임상수의학회지
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• 제15권2호
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• pp.427-431
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• 1998

This study was undertaken to investigate the effect of exercise induced pulmonary hemorrhage(EIPH) on the finishing position of racehorses, 400 bleeders(305: 1 time, 76: 2 times, 19: 3 times, total: 514 cases) which had bled(EIPH) from their nostrils after their races at the Seoul racecourse during the 5 years period('93-'97) were analyzed for this study. The ratio of bleeders to total racehorses in finishing position 1-3,4-6, 7-9 or above 10 was 0.55, 0.84, 0.90 or 1.13%, respectively. There is tendency to higher incidence of bleeding in the later positioned racehorses group. To analyze the correlation between EIPH and finishing position, finishing potion of each EIPHed horses' was checked at 7 successive races(3 races each before/after EIPH. The average final position at the -3rd race, -2nd racer -lst racer EIPHed race, 1st race,2nd race and 3rd race of each bleeder was 5.85. 5.94, 6.21, 7.32, 7.20, 6.51 and 6.53, respectively. Raring times were adjusted to 1,000 m equivalent. Average racing times of the -3rd race,-2nd racer -lst raced EIPHed race, 1st race, 2nd race and 3rd race of each bleeder was 67.1, 67.1, 67.2, 67.6, 67.5, 67.4 and 67.3 second, respectively. Bleeders which finished the race within 1 second following the winners were 25. 3% of total bleeders. The rest 74.7% reached at the finish line 1 second later than the winners. Particularly 46.3% of bleeders were above 2 second later. Therefore this study suggested that bleeding has effect on performance of the racehorse, consequently it make bleeders be placed later positions.

• Journal of Chest Surgery
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• 제26권5호
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• pp.380-383
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• 1993

Aspergillosis is not only the problem increasing the freguency for recent decades but also a serious one. Coexistent pulmonary diseases are frequent and the most common antecedent disease is Tuberculosis with healed cavitary lesion. Interest of the surgeons is aroused because of it`s predilection to sudden life-threatening, exsanguinating pulmonary hemorrhage. 11 patients with pulmonary aspergillosis evaluated at this hospital in a 7-year period, and the results were as follows: 1.male to female ratio was 1:1.75. 2.The most common symptom was gross or microscopic hemoptysis[72.7%]and other symptoms were chest pain[9.1%] and chronic productive coughing[9.1%]. 3.The right upper lobe was most common involving site[81.8%] 4.Surgical interventions were 8 cases of lobectomy, 1 case of lobectomy with wedge resection, 2 cases of wedge resection. 5.Post-operative complications developed in 5 patients and were 4 cases of wound infections, 2 cases of empyemas, 1 case of bleeding, 1 case of atelectasis.

• Tuberculosis and Respiratory Diseases
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• 제70권3호
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• pp.242-246
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• 2011

Pulmonary capillary hemangiomatosis (PCH) is a rare disease of unknown etiology that is characterized by nodules composed of infiltrating capillary blood vessels. Herein, we describe a case of a PCH-like lesion that was detected by chest computed tomography. Transthoracic needle aspiration resulted in life-threatening hemorrhage. The patient was followed for seven years. He remained in good health and a follow up image showed little interval change.

• 대한한의학방제학회지
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• 제8권1호
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• pp.225-239
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• 2000

Pulmonary edema is a disease involving the principal symptoms: dyspnea, bloody phlegm, asthma, cough, etc. According to oriental medical references, Jeomglyukdaejosapaetang (J.D.T) was efficacious for dropsy, cough, dysnea, etc, so it was thought to be used for remedy of pulmonary edema. Therefore experimental study was performed to investigate the effects of J.C.T on pulmonary edema of the rats induced by the herbicide, paraquat.Thus the survival rats, respiratory rats, lung weights and histopathological view of the lungs of rats were studied. The results are as follows. 1. The survival rates at 72hours of the rats injected with paraquat and treated with J.D.T increased in B group(J.D.T + Cortex Lycii Radicis + Cortex mori). The others were not different with the control. 2. The respiratory rates of the rats which survived 72hours later significantly decreased in B group(J.D.T + Cortex Lycii Radicis + Cortex mori). 3. The lung weights of the rats which survived for 72hours later significantly decreased in B group(J.B.T + Cortex Lycii Radicis + Cortex mori). 4. The histopathological views of the lungs of rats induced by paraquat were seen severe hemorrhage, edema and some broken alveoli in control group. But B group(J.D.T + Cortex Lycii Radicis + Cortex mori) were seen little hemorrhage and interstitial hyperplasia. According to the above results, J.D.T + Cortex Lycii Radicis + Cortex mort is effective on the remedy for pulmonary edema of rats induced by paraquat.