• 한국임상수의학회지
• /
• 제38권3호
• /
• pp.127-134
• /
• 2021

Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory and pruritic skin disease presenting characteristic clinical features in dogs. Despite oclacitinib and lokivetmab being commonly used, no study has compared their efficacies in CAD. This study aimed to compare the efficacy, safety, and control of CAD-associated pruritus and skin lesions between oclacitinib and lokivetmab. It also investigated whether switching to lokivetmab from oclacitinib or prednisolone had any benefits. Twenty-five client-owned dogs, newly diagnosed with CAD, were allocated to the oclacitinib (n = 20) and lokivetmab (n = 5) groups and administered oclacitinib (0.4-0.6 mg/kg orally, twice daily for 14 days, then once daily) and lokivetmab (2 mg/kg subcutaneously, every month) for 8 weeks, respectively. The switching group included five dogs previously administered with oclacitinib (n = 4) or prednisolone (n = 1) who were switched to lokivetmab directly at the start of the study. The pruritus visual analog scale (PVAS) and Canine Atopic Dermatitis Extent and Severity Index (CADESI-04) values were surveyed at weeks 0, 4, and 8. Oclacitinib and lokivetmab significantly reduced the PVAS and CADESI-04 scores. Switching from oclacitinib or prednisolone to lokivetmab maintained the severity of pruritus (4 weeks: p = 0.068; 8 weeks: p = 0.068) and dermatitis (4 weeks: p = 0.144; 8 weeks: p = 0.068) at the levels measured at baseline. Thus, both oclacitinib and lokivetmab reduced CAD-associated pruritus by a similar degree. Switching to lokivetmab maintained the severity of pruritus and dermatitis at the same level as the previous treatment.

• 한방안이비인후피부과학회지
• /
• 제18권2호
• /
• pp.104-108
• /
• 2005

Drug eruption refers to an adverse effect which is unintentionally given rise to by dosage, injection, inhalation, suppository and ointment, etc. Maculopapular, urticarial, morbilliform, papulosquamous, pustular, and bullous morphologies may be encountered. Adverse drug reactions also can cause pruritus or dysesthesia unaccompanied by rash. We treated a patient suffered from maculopapular rash and pruritus with acupuncture, herb medication and wet dressing. After treatment we observed the improvement. Based on this study, it is considered that oriental medical treatment can be applied to the management of drug eruption.

• 대한수의학회지
• /
• 제45권3호
• /
• pp.439-444
• /
• 2005

A 7.1 kg, seven-year old, castrated male, Shih-Tzu with severe pruritus, chronic otitis externa and Malassezia infection was referred to Veterinary Medical Teaching Hospital of Chungnam National University. In local animal hospital, steroid therapy was used to treat uncontrollable pruritus, but the clinical signs were recurrent when steroid therapy was discontinued. On physical examination, generalized alopecia, erythema, papules, severe crust and diffuse lichenification were presented. Tape strip test of skin lesions revealed cocci and Malassezia infections. Based on the result of history, clinical signs and examination described above, canine atopic dermatitis with secondary superficial pyoderma and Malassezia dermatitis was diagnosed. Oral challenge with cyclosporine and antibiotics had good results in clinical signs. Clinical sign scores were evaluated by investigator with CADESI at 2weeks, 4weeks, 6weeks, 8weeks and 10weeks after cyclosporine administration. And in the result of comparing of allergen-specific IgE value, the level of allergen-specific IgE to general causative allergen after 10 weeks of cyclosporine therapy was higher than that before cyclosporine therapy.

• 대한예방한의학회지
• /
• 제8권2호
• /
• pp.55-63
• /
• 2004

Objectives : This study was designed to identify the possibility of aroma oils as the complementary medical goods specially for the effects of aromatheraphy on xerosis cutis. Materials and Methods : The participants were 23 adult patients and all participants of this study use aroma oils which is known to effect on xerosis cutis. The subjects consist of voluntary patients with xerosis cutis in Seong-So Hospital in Andong Kyoungbuk, Korea. From April 1st to April 30th, 2004 for 4 weeks, the subjects massaged aroma oils on itching parts or the whole body. Aroma oils were Lavender, Losemary, Jasmine and blended drop by drop per 10ml jojoba oil which used a carrier oil. Skin pH was measured with a skin pH meter(Model : HI98110, Se-Chang instruments, made in Portuga. After 4weeks using aroma oils, the participants answered questions about the feeling of satisfaction with aroma oils. Results : Changes in the physiological indices. The mean deviation of skin pH was $5.58{\pm}0.47$ points before using aroma oils and $5.53{\pm}0.45$ points after 2 weeks, no statistical significance was found(p=0.221). MD was $5.36{\pm}0.41$ points after 4 weeks using aroma oils, which was statistically significant decrease of 0.22 points(p=0.001) Changes on the Pruritus Score Scale. A modified scale of the Pruritus Score Scale(Duo, 1987) was used to measure the severity, location, frequency, and the inconveniences of daily life due to prurius. The maximum scale of severity was 4 points, the full marks of location was 2 points, the full marks of frequency was 3 points, the full marks of inconveniences of daily life due to pruritus was 3 points. The scores ranged from 0 to 12, with 12 indicating the most severe pruritus. There was no statistical difference in severity and frequency score at 4 weeks later(severity p=0.097, frequency p=0.633). A statistically significant difference was found in the score of location and the inconveniences of daily life due to pruritus(each p=0.003). Conclusion : Generally speaking, the patient suffering from renal itch is the higher than normal in skin pH levels. that means to show alkaline condition of skin surface. In some case in this study, skin pH levels was rather lower than normal levels when measured actually patients suffering from renal itch by skin pH meter. But in this study post-test skin pH levels decreased, showing the contribution of aromathrapy to acidic condition of skin surface in suffering from renal itch. It seems to be some help to cure a pruritus and also have no ill effects on aroma oils.

• 한국임상수의학회지
• /
• 제28권3호
• /
• pp.273-279
• /
• 2011

보툴리늄 톡신(BoNT/A)은 사람에서 안전하고 효과적인 주름치료제로 적용되고 있으며 최근에는 주름치료효과 이외의 효능에 관한 연구가 활발히 진행되고 있다. 본 연구의 목적은 개 피부에 히스타민을 피하 주입하여 소양증을 유발한 다음 보툴리늄 톡신의 항소양 효과를 평가하는 것이다. 총 5 마리의 비글을 이용하여 우측 배측 흉부 피부에 보툴리늄 톡신 0.05 ml (5unit)를 주입한 처치부위와 좌측 배측 흉부 피부에 0.05 ml의 생리식염수를 주입한 대조부위를 비교하였다. 보툴리늄 톡신 투여 전, 투여 후 1, 3, 7일에 Histamine 을 피내주입하여 소양증을 유발하였다. 소양증의 정도, 팽진의 지름과 두께, 홍반수치 및 피부표면 온도를 측정하여 보툴리늄 톡신 주입 효과를 평가하였다. 소양증의 정도는 처치부위에서 유의하게 감소하였으며(p < 0.05) 팽진의 지름과 두께도 처치부위에서 유의하게 감소했다(p < 0.05). 홍반수치는 최초 히스타민을 피내투여한 직후에 처치부위와 대조부위에서 모두 증가했으나 대조부위에 비해서 처치부위에서 적게 증가하였다. 피부표면온도는 처치부위에서 유의하게 감소하였다(p < 0.05). 본 연구결과 보툴리늄 톡신은 개 피부에서 히스타민에 의한 소양증에 대한 항소양 효과를 보였으며 임상적으로 극심한 국소 소양증을 보이는 피부질환에 대해 적용할 수 있을 것으로 사료된다.

• The Korean Journal of Pain
• /
• 제10권1호
• /
• pp.48-53
• /
• 1997

Background : Epidural morphine provides excellent postoperative analgesia but is often associated with side effects such as nausea, vomiting and pruritus. It has been reported that mixed agonist-antagonist, nalbuphine can reverse side effects of epidural morphine without compromising analgesia. This study was designed to compare the efficacy of each intravenous dose of nalbuphine for treatment of side effects following epidural morphine. Methods : All patients received continuous infusion(2 ml/hr) of epidural morphine-local anesthetics mixture(morphine 4 mg, 1% mepivacaine 50 ml and 0.25% bupivacaine 50 ml) following a loading dose (morphine 2 mg with 1% mepivacaine 7 ml). Patients requesting treatment for nausea, vomiting and pruritus randomly received intravenous nalbuphine 0.05 mg/kg(Group 1; n=20), 0.1 mg/kg(Group 2; n=20) or 0.15 mg/kg(Group 3; n=20). The severity of nausea, vomiting, pruritus, degree of pain, sedation and vital sign were assessed prior to and 30 min after each dose. Results : The severity of nausea, vomiting and pruritus decreased significantly in all groups(p<0.01). Pain and sedation scores were unchanged in all groups. One patient received nalbuphine 0.15 mg/kg, complained of dizziness, agitation and palpitation. His blood pressure who had increased to 170/100 after first dose. Conclusions : This study suggests that intravenous nalbuphine is good for treatment of side effects following epidural morphine, and the dose of Group 1, 0.05 mg/kg, may be recommended as an optimal dose.

• 한방안이비인후피부과학회지
• /
• 제33권2호
• /
• pp.186-196
• /
• 2020

Objectives : This study is to report a case of chronic allergic contact dermatitis, treated with Korean medicine, primarily focused on Oryeong-san. Methods : A 43-year-old female has suffered from dermatitis in axillary, lower abdominal, inguinal and popliteal area for more than 10 years. She was diagnosed with chronic allergic contact dermatitis accompanied by skin symptoms such as severe pruritus, erythema, skin pigmentation, papules and lichenification, and by decreased quality-of-life. She received Korean medicine treatment including herbal medicine, acupuncture and herbal external medication for 4 months. Results : The skin symptoms such as pruritus, erythema, skin pigmentation, papules and lichenification were remarkably improved. Also, the NRS of pruritus changed from 10 to under 1, and the DLQI score changed from 29 to 6. Conclusions : This case report suggests that Korean medicine, especially Oryeong-san may have a role in treating skin symptoms such as pruritus, erythema, skin pigmentation, papules and lichenification in the patients diagnosed with chronic allergic contact dermatitis. Also, the improvement of skin symptoms treated with Korean medicine may result in quality-of-life improvement in those patients.

• 한방안이비인후피부과학회지
• /
• 제34권2호
• /
• pp.91-98
• /
• 2021

Objective : The purpose of this study is to report a case of lacquer allergy improved by Korean medicine treatment. Methods : The patient visited our hospital complaining of rash, and pruritus which lasted for 10days after eating lacquer chicken. Considering that patient's symptoms occurred due to food allergen, we prescribed Injinho-tang(Yinchenhao-tang) and acupuncture at Daejang-Junggyeok for 7days. Results : On the 4th day of treatment, pruritus decreased to less than half of the initial treatment, and skin symptoms also improved to a mild level. About a week later, most of the skin symptoms disappeared (Total Objective Symptom score decreased 10 to 3), and subjective symptoms such as pruritus improved to about 30% of the time of the first visit (Total Subjective Symptom score decreased 12 to 3). Conclusions : After 7days of Korean medicine treatment, lacquer tree allergy with skin lesions and pruritus has improved considerably.

• 한방안이비인후피부과학회지
• /
• 제34권2호
• /
• pp.70-79
• /
• 2021

본 연구는 장기간 스테로이드 주사 및 연고, 항히스타민제 복용 등에도 악화된 중증 각화성 결절 양진 환자 치험례이다. 환자에게 한약 투약, 침, 증기, 습부항, 약침, 한방 외용제 치료를 시행한 결과 결절 과각화 감소 및 소양감, 열감, 통증, 수면 장애 등 제반 증상에 치료 효과가 있음을 확인할 수 있었다.

• 사상체질의학회지
• /
• 제11권2호
• /
• pp.361-376
• /
• 1999

1. 연구배경(硏究背景) 및 목적(目的) 피부질환의 가장 흔한 증상 가운데 하나인 소양증(瘙痒症)에 대한 임상적(臨床的) 연구(硏究)를 시행하여 소양증의 특성을 정확히 파악하고 치료에 도움을 주고자 하였다. 2. 연구방법(硏究方法) 1997년 11월부터 1999년 9월까지 1년 10개월간 동국대학교 분당한방병원 사상체질과에 소양증(瘙痒症)을 주소로 하여 내원한 외래환자 가운데 2회 이상 내원하여 치료경과가 확인된 59영(남자 35명, 여자 24명)을 대상으로 소양증 환자의 일반적(一般的) 특성(特性), 소양증(瘙痒症)의 양태(樣態), 치료특성(治療特性), 치료효과(治療效果)를 조사하고 분석하였다. 3. 연구결과(硏究結果) 소양증은 남자가 여자보다 많았으며 20대와 30대에서 많았다. 소양증의 이환기간(罹患其間)은 1개월에서 1년 미만인 경우가 많았고, 양방(洋方) 의료기관을 거쳐서 오는 경우가 대부분이었다. 소양증은 주야(晝夜)구분 없이 심한 경우가 많았고, 소양증 환자의 전신증상(全身症狀)은 전체적으로 대변이상(大便異常)이 많았으며, 사상체질별로는 소음인(少陰人)에서는 소화불량(消化不良)과 수면장애(睡眠障碍)가 많았고, 소양인(少陽人)에서는 대변이상(大便異常)과 설태이상(舌苔異常)이 많았으며, 태음인(太陰人)에서는 설태이상(舌苔異常)과 한출이상(汗出異常)이 많았다. 소양증에 많이 사용된 처방은 곽향정기산(藿香正氣散), 양격산화탕(凉膈散火湯), 청심연자탕(淸心蓮子湯) 등이었고, 치료효과(治療效果)의 분포는 호전(好戰)이 61.0%. 비호전(非好戰)이 39.0%로 나타났다. 치료효과는 연령이 30세 이상인 경우가 20세 이하인 경우보다 유의하게 호전되었으며. 이환기간이 1년 미만으로 짧은 경우가 1년 이상으로 긴 경우보다 유의하게 호전되었으며, 양방치료를 않거나, 지속적으로 치료 중인 경우가 간헐적으로 치료중인 경우보다 유의하게 호전되었으며, 소양증의 정도가 심한 경우가 약한 경우보다 유의하게 호전되었다.