• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• Journal of Ecology and Environment
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• 제41권3호
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• pp.78-84
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• 2017

Recently, great demands are rising around the globe for monitoring and studying of long-term ecological changes. To go with the stream, many researchers in South Korea have attempted to share and integrate ecological data for practical use. Although some achievements were made in the meantime, we still have to overcome a big obstacle that existing ecological data in South Korea are mostly spread all over the country in various formats of computer files. In this study, we aim to handle the situation by developing a semi-automatic data conversion tool for Korean ecological data standardization, based on some predefined protocols for ecological data collection and management. The current implementation of this tool works on only five species (libythea celtis, spittle bugs, mosquitoes, pinus, and quercus mongolica), helping data managers to quickly and efficiently obtain a standardized format of ecological data from raw collection data. With this tool, the procedure of data conversion is divided into four steps: data file and protocol selection step, species selection step, attribute mapping step, and data standardization step. To find the usability of this tool, we utilized it to conduct the standardization of raw five species data collected from six different observatory sites of Korean National Parks. As a result, we could obtain a common form of standardized data in a relatively short time. With the help of this tool, various ecological data could be easily integrated into the nationwide common platform, providing broad applicability towards solving many issues in ecological and environmental system.

• 한국항행학회논문지
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• 제12권2호
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• pp.91-99
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• 2008

본 논문에서는 글로벌스타 위성 모뎀을 이용한 무선 원격제어 및 감시 시스템을 구축하였다. 시스템은 C8051F023 마이크로컨트롤러를 이용한 글로벌스타 위성 시스템 단말장비와 WGIS(Web-based GIS)를 이용한 사용자 프로그램으로 구성된다. 이를 통해서 단말장비와 사용자 프로그램 사이의 무선 원격제어 및 감시를 실험하였다. 사용자는 WGIS 프로그램를 사용한 Main 및 Control 다이얼로그를 통하여 용이하게 단말장비를 제어 및 감시 할 수 있으며 또한 위치정보를 확인 할 수 있었다. 단말장비 및 사용자 프로그램의 데이터 통신을 위해서 글로벌스타 위성 모뎀을 위한 PPP 및 TCP/IP 프로토콜을 구현하여 데이터 통신을 원활하게 수행할 수 있도록 하였다. GIS(Geographic Information System) 도구는 ESRI사의 ArcView와 MapObject로 구성되며 GIS를 통하여 사용자에게 시각적으로 다양한 정보를 제공할 수 있었다.

• 지역사회간호학회지
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• 제31권2호
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• pp.166-178
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• 2020

Purpose: This study was conducted to examine the effects of the oral care program for improving swallowing function of the elderly using welfare centers on depression, self efficacy, subjective oral health status and swallowing related quality of life. Methods: The intervention in this study was systematically developed through the six stages of Intervention Mapping Protocol (IMP) and was based on Mead's symbolic interaction theory and Bandura's self efficacy theory. A non equivalent control group pre and post-test design was conducted on a total of 37 elderly people (experimental group: 19, control group: 18) from D city. The oral care program was administered to the experimental group once a week for five weeks, totaling five times, and the exact program ran for 50 minutes. The collected data were analyzed using the SPSS/WIN 25.0 program. Results: Following the intervention, subjective oral health score, and swallowing related quality of life were significantly improved in the experimental group. Conclusion: The oral care program presented in this study was found to be effective in increasing subjective oral health status, and swallowing related quality of life for the elderly using welfare centers.

• Journal of Microbiology and Biotechnology
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• 제11권5호
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• pp.819-824
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• 2001

The principal DNA modification systems of the amino-acid-producing bacteria Corynebacterium glutamicum AS019, Brevibacterium flavum BF4, and B. lactofermentum BL1 was investigated using two approaches; digestion of plasmid DNA isolated from these species TseI and Fnu4HI, and sequence analysis of the putative methyltransferase target sites following the derivatization of DNA using metabisulfite treatment. The C. glutamicum and B. flavum strains showed similar digestion patterns to the two enzymes, indicating that the target for cytidine methyltransferase recognizes 5'-GCSGC-3'(where S is either G or C). Mapping the methylated cytidine sites by bisulfite derivatization, followed by PCR amplification and sequencing, was only possible when the protocol included an additional step eliminating any underivatized DNA after PCR amplification, thereby indicating that the derivatization was not $100\%$ efficient. This may have been due to the high G0C content of this genus. It was confirmed that C. glutamicum AS019 and B. flavum BF4 methylated the cytidine in the $Gm^5CCGC$ sequences, yet there were no similar patterns of methylation in B. lactofermentum, which was consistent with the distinctive degradation pattern seen for the above enzymes. These findings demonstrate the successful application of a modified bisulfite derivatization method with the Corynebacterium species for determining methylation patterns, and showed that different species in the geneus contain distinctive restriction and modification systems.

• 대한간호학회지
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• 제49권4호
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• pp.472-485
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• 2019

Purpose: This study aimed to develop and evaluate the effectiveness of an adapted health literacy self-management intervention for elderly cancer patients undergoing chemotherapy. Methods: The intervention in this study was systematically developed through the six stages of Intervention Mapping Protocol and was based on Fransen et al's causal pathway model. A quasi-experimental trial was conducted on a total of 52 elderly patients (26 in an experimental group and 26 in a control group) undergoing chemotherapy in Korea. The intervention consisted of seven sessions over 5 weeks. The experimental tool for this study was an adapted health literacy self-management intervention, which was designed to promote a reduction in the symptom experience and distress of elderly cancer patients through the promotion of self-management behavior. To develop efficient educational materials, the participants' health literacy was measured. To educate participants, clear communication and the teach-back method were used. In addition, for the improvement of self-efficacy, four sources were utilized. For the promotion of self-management behavior, five self-management skills were strengthened. Data were collected before and after the intervention from June 4 to September 14, 2018. The data were analyzed with SPSS/WIN 21.0. Results: Following the intervention, self-management knowledge and behavior and, self-efficacy significantly improved in experimental group. Symptom experience and distress decreased in the experimental group compared to the control group. Conclusion: The self-management intervention presented in this study was found to be effective in increasing self-management knowledge and behavior and, self-efficacy, and ultimately in reducing symptom experience and distress for elderly patients undergoing chemotherapy.

• Asia Marketing Journal
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• 제15권3호
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• pp.1-14
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• 2013

Our research brings managerial insights for developing new digital convergence of devices and services. To explain the phenomenon of device and service convergence, we combine two different approaches from separate research fields: a perceptual mapping technique generally used for segmentation in marketing and associative network analysis mobilized to understanding network structure of core and peripheral as well as the information mediating role of nodes in network science. By combining these two approaches, we provide an in-depth analysis of the associations among devices and services by assessing the centrality of device and service nodes in an associative network. This is done by examining the connections between these services and devices as well as investigating the role of mediation in the combined device-service associative network. Our results based on bi-partite network analysis of survey responses from 250 Internet Protocol (IP) television viewers show which device and which service will play the major role in future device and service convergence as well as which characteristics and functionalities have to be incorporated into future convergence. Among the devices, the mobile handset with the betweenness centrality of 0.26 appears to be the device that would lead future device convergence. Among the services, wireless broadband with the betweenness centrality of 0.276 appears to be the service on which future service convergence needs to be developed. This result is quite unexpected, since wireless broadband has a lower penetration rate than other services, such as fixed broadband and cable TV. In addition, we indicate the possibility of converging devices, such as personal digital assistant (PDA) and mobile handset, and services, such as IPTV and mobile Internet, into wireless broadband services in the future.

• 한국지리정보학회지
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• 제27권2호
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• pp.78-95
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• 2024

기후변화와 도시 문제를 고려해 다양한 영역에 걸친 환경계획의 수립과 비교를 위해서는 일관된 기준으로 분류된 지역 규모 수준의 공간자료 구축이 중요하다. 본 연구는 World Urban Database and Access Portal Tools(WUDAPT)에서 제시한 절차를 사용하여 기후 및 환경 연구가 활발히 이루어지고 있는 창원시의 Local Climate Zone(LCZ)를 분류하였다. 또한, 동질적인 기후 특성을 가진 지역일지라도 일부 격자가 다른 기후 특성으로 분류되는 파편화 문제를 개선하기 위해 필터링 기법을 적용하고 필터링 반경에 따른 LCZ 분류 특성을 비교하였다. 위성영상과 지상참조자료, 감독분류 머신러닝 기법인 Random Forest를 활용하여 필터링하지 않은 분류지도와 필터링 반경이 1, 2, 3인 분류지도를 제작하여 정확도를 비교하였다. 또한, 도시지역의 건물 유형에 따른 LCZ 분류특성을 비교하기 위해 GIS를 활용한 분류방법론에서 사용되는 도시형태지수를 제작하여 선행 연구에서 제시한 범위와 비교하였다. 그 결과, 전체 정확도는 필터링 반경이 1일 때 가장 높은 값을 보였다. 도시형태지수를 비교하였을 때 LCZ 유형별 차이는 적었고 대부분 선행연구의 범위를 만족하는 것을 확인하였다. 그러나 연구 결과를 통해 건물의 높이 정보를 반영하지 못하는 한계를 확인하였고, 이를 보완할 수 있는 데이터를 추가하여 분류한다면 더 높은 정확도의 결과물을 획득할 수 있을 것이라 판단된다. 연구 결과는 국내 도시기후 관련 환경 연구분야의 기초 공간자료 제작하기 위한 참고자료로 활용될 수 있을 것이다.

• 한국컴퓨터그래픽스학회논문지
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• 제24권1호
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• pp.9-16
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• 2018

본 논문에서는 광 회절 단층 촬영 (Optical Diffraction Tomography, ODT) 기법을 사용해 얻어진 세포 영상을 3차원 가상 공간에 시각적으로 표현하고 기존의 세포 영상들과의 일치감을 주는 색상 매핑 기술을 포함한 가시화 프레임 워크를 소개한다. 전체 볼륨을 구성하는 내부 구조에 대한 정보가 잘 알려져 있거나 명확하게 구분 가능한 인체의 장기 또는 산업 기기와 같은 기존의 볼륨 데이터와는 달리 세포 영상 데이터는 세포소기관들 간의 경계가 모호하거나 상황에 따라 형상의 변화가 다양하다는 특징을 가지고 있어, 세포의 형상에 대한 일관적인 시각 표현이 상대적으로 어렵다는 문제가 있다. 본 논문에서는 이를 해소하기 위해 세포의 3차원 형상을 실시간으로 렌더링 할 수 있는 가시화 기법을 제안한다. 제안하는 기법에서는 우선 세포의 3차원 형상을 나타내기 위해 볼륨 데이터의 가시화에서 널리 활용되고 있는 볼륨 렌더링 기법을 ODT 영상에 맞게 적용했으며, 빈 공간 교란 기법을 통한 렌더링 결과의 개선으로 세포내 구조의 연속성을 나타낼 수 있게 했다. 또한 다중 전이 함수에 대해 레이어 기반 독립 렌더링을 적용하는 것을 통해 다수의 세포내 구조를 하나의 화면에 표현하는 복합 가시화 기법을 제안했다. ODT 영상 및 염색 영상을 동시에 촬영 가능한 현미경으로부터 얻어진 세포 영상을 가시화 하는 것을 통해 제시된 가시화 기법의 유용성을 확인했다.

• Journal of Acupuncture Research
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• 제21권6호
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• pp.177-186
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• 2004

Introduction : Recent studies Suggested that there is a strong correlation between acupuncture stimulation and its related cortical activation. Anther study showed that either positive or negative BOLD effects could be observed depending on anatomical structure in acupuncture stimulation. In ttis study, we investigated a new acupoint $KI_6$ (照海), which was known as motor-related acupoint and obtained an evidence that the stimulation of $KI_6$ resulted in either negative or positive BOLD response to stimulation. Methods & Results : 1. Subjects and paradigms : Two separate stimulation paradigms were performed on five healthy (aged 22-23 yrs) in this study. First, the paradigm of acupuncture stimulation was that the acupuncture needle was inserted in acupoints $KI_6$, which is located in lateral side of the foot and then continuously twisted(補瀉를 除外한 捻轉法) for 70 seconds for 10 cycles of activation. During rest period (70 seconds), the needle was completed removed from acupoint. Total 60 cycles were performed and 10 images were obtained per cycle. Second, nonacupoint was randomly selected and the same paradigm was performed as acupoint stimulation. The stimulation protocol comprised 10 cycles of alternating. activation and rest (10 images per cycle). Total 60 cycles were performed and each cycle take about 1.5 sec for motor task. Subjects take an at least 15 minutes break before starting anther paradigm. 2. fMRI mapping : Multi-slice functional images were obtained on a 1.5T Magnetom Vision MRI scanner (Simens Medical, Erlangen, Germany) equipped with high performance whole-body gradients. The BOLD T2 * - weighted images were acquired with acho planar imaging sequence (TR = 1.2 sec, TE = 60 msec, and flip angle = $90_{\circ}$). The other sequence parameter are : FOV = 210 mm, matrix=$64{\times}128$ or $64{\times}64$, slice number=10 and slice thickness = 5 or 8 mm. the anatomic images were obtained with Spin-echo T1-weighted images. The resulting images were then anaiyzed with STIMULATE (CMRR, U. of Minnesota) to generate functional maps using a student T-test (p < 0.005) and cluster analysis. Both positive and negative response were evaluated. Conclusions : We have observed the activation of the motor cortex by stimulating motor-related acupoint ($KI_6$). Among five subjects, negative BOLD response was shown in four and positive response in one. All subjects showed positive response to conventional finger flexion-extension task. To understand the detailed mechanisms of correlation between acupuncture stimulation and BOLD fMRI changes and two typs of response, further study strongly required.