• Clinical and Experimental Reproductive Medicine
• /
• 제48권2호
• /
• pp.163-173
• /
• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제13권2호
• /
• pp.978-1002
• /
• 2019

With the rapid development of the Internet of Things, the problem of privacy protection has been paid great attention. Recently, Nikooghadam et al. pointed out that Kumari et al.'s protocol can neither resist off-line guessing attack nor preserve user anonymity. Moreover, the authors also proposed an authentication supportive session initial protocol, claiming to resist various vulnerability attacks. Unfortunately, this paper proves that the authentication protocols of Kumari et al. and Nikooghadam et al. have neither the ability to preserve perfect forward secrecy nor the ability to resist key-compromise impersonation attack. In order to remedy such flaws in their protocols, we design a lightweight authentication protocol using elliptic curve cryptography. By way of informal security analysis, it is shown that the proposed protocol can both resist a variety of attacks and provide more security. Afterward, it is also proved that the protocol is resistant against active and passive attacks under Dolev-Yao model by means of Burrows-Abadi-Needham logic (BAN-Logic), and fulfills mutual authentication using Automated Validation of Internet Security Protocols and Applications (AVISPA) software. Subsequently, we compare the protocol with the related scheme in terms of computational complexity and security. The comparative analytics witness that the proposed protocol is more suitable for practical application scenarios.

• 임상간호연구
• /
• 제29권1호
• /
• pp.75-84
• /
• 2023

Purpose: This study developed a protocol for nursing care after death for adult patients in hospitals. Methods: This was a methodological study to develop a care after death protocol. The preliminary protocol was developed based on a literature review, guidelines, and practice recommendations from groups of experts and clinical nurses. Content validity was evaluated by a group of experts (n=6) and nurses (n=30) in two hospitals. Results: The preliminary protocol recommendations were modified by validation and the open-question analysis results. The final protocol comprised three general recommendations and 43 recommendations in five steps that are verification and notification of a death, personal care of the body, viewing the patient, patient transfer, and documentation and self-care. Conclusion: This study result provides nurses with a consensus information on patient care after death and family support in a hospital setting. This nursing protocol is expected to improve the quality of care after death for adult patients and their families, and can be used for developing educational and emotional support for nurses to accomplish their important role.

• Clinical and Experimental Pediatrics
• /
• 제54권11호
• /
• pp.463-469
• /
• 2011

Purpose: To validate the Dinamap ProCare 200 blood pressure (BP) monitor against a mercury sphygmomanometer in children 7 to 18 years old in accordance with the 2010 International Protocol of European Society of Hypertension (ESH-IP2) and the British Hypertension Society (BHS) protocol. Methods: Forty-five children were recruited for the study. A validation procedure was performed following the protocol based on the ESH-IP2 and BHS protocols for children and adolescents. Each subject underwent 7 sequential BP measurements alternatively with a mercury sphygmomanometer and the test device by trained nurses. The results were analyzed according to the validation criteria of ESH-IP2. Results: The mean (${\pm}SD$) difference in the absolute BP values between test device and mercury sphygmomanometer readings was $1.85{\pm}1.65$ mmHg for systolic BP (SBP) and $4.41{\pm}3.53$ mmHg for diastolic BP (DBP). These results fulfilled the Association for the Advancement of Medical Instrumentation criterion of a mean${\pm}$SD below $5{\pm}8$ mmHg for both SBP and DBP. The percentages of test device-observer mercury sphygmomanometer BP differences within 5, 10, and 15 mmHg were 96%, 100%, and 100% for SBP, and 69%, 92%, and 100% for DBP, respectively, in the part 1 analysis; both SBP and DBP passed the part 1 criteria. In the part 2 analysis, SBP passed the criteria but DBP failed. Conclusion: Although the Dinamap ProCare 200 BP monitor failed an adapted ESH-IP2, SBP passed. When comparing BP readings measured by oscillometers and mercury sphygmomanometers, one has to consider the differences between them, particularly in DBP, because DBP can be underestimated.

• Wind and Structures
• /
• 제19권3호
• /
• pp.271-294
• /
• 2014

The impact of artefacts in archived wind observations on the design wind speed obtained by extreme value analysis is demonstrated using case studies. A signpost protocol for detecting candidate artefacts is described and its performance assessed by comparing results against previously validated data. The protocol targets artefacts by exploiting the serial correlation between observations. Additional "sieve" algorithms are proposed to identify types of correctable artefact from their "signature" in the data. In extreme value analysis, artefacts displace valid observations only when they are larger, hence always increase the design wind speed. Care must be taken not identify large valid values as artefacts, since their removal will tend to underestimate the design wind speed.

• 한국컴퓨터정보학회논문지
• /
• 제10권5호
• /
• pp.161-170
• /
• 2005

인증서의 유효성을 검증하기 위해 CRL(Certificate Revocation List)dmf 이용할 경우 시간차 문제 때문에 실시간으로 그 유효성을 검증할 수 없으며 OCSP(Online Certificate Status Protocol)를 이용할 경우 규모가 큰 보안시스템에서는 검증서버에 과부하를 주는 문제가 있다. 그리고 IEEE 802. 1x 무선랜 표준에서는 클라이언트가 인증서버로부터 승인받기 전에는 유선랜으로의 접근이 허용되지 않기 때문에 인증서버를 실시간으로 인증할 수 없다. 본 논문에서는 이러한 문제점들을 해결하기 위하여 무선랜에서 통신 내용을 보호하고 통신자 간의 신원을 상호 실시간으로 확인할 수 있는 보안시스템을 설계하였다. 설계된 인증서 검증 프로토콜은 검증 결과의 현재성은 물론 시스템의 높은 안전성과 효율성을 보여주었으며 인증서의 유효성 검증 속도도 시스템의 규모와 상관없이 항상 일정하며 사용자가 신뢰하고 있어야 할 기관의 수도 적고 검증서버의 과부하도 막을 수 있었다. 그리고 고속 고용량과 저속 저용량의 클라이언트에 적합한 사용자 인증 및 키 교환 프로토콜은 실시간 상호 인증은 물론 인증 사실의 공인을 가능하게 하였다.

• ETRI Journal
• /
• 제24권1호
• /
• pp.12-22
• /
• 2002

A Mobile IP allows IP hosts to move between different networks without changing their IP addresses. Mobile IP systems supporting local registration were introduced to reduce the number of times a home registration with the remotely located home agent was needed. The local registration Mobile IP scheme enhanced performance by processing registration requests of mobile nodes at a local agent. The local registration approach may affect other aspects of the Mobile IP systems such as fault tolerance. In this paper, we briefly review previous solutions for supporting fault tolerance in local registration Mobile IP systems and propose a fault tolerance protocol with a backup foreign agent in a hierarchical local registration mobile IP to enhance the efficiency of such systems against foreign agent failures. We also describe the specification of the proposed protocol using LOTOS and perform its validation using MiniLite. Finally, we analyze the performance of our proposed fault tolerance protocol through simulation.

• 한국통신학회논문지
• /
• 제26권5A호
• /
• pp.889-901
• /
• 2001

본 논문에서 Multiprotocol Label Switching 시스템을 위한 Label Distribution Protocol의 개발과 분석에 관해서 기술한다. 먼저 Gigabit Switched Router를 만들기 위해서, 상용화시 Carrier Class 제품에 적용하기 위한 LDP의 구현시 고려해야 될 사항에 대해 살피고, 상세 설계를 제안한다. IETF 표준에 의거한 LDP의 구현을 위한 상세 설계는 프로토콜 상태기계의 유도 트리와 프로세스 대수를 사용한 형식적 명세를 사용하여 제시한다. 본 논문에서는 제시된 유도트리와 프로세스 대수를 사용한 프로토콜 동작의 분석을 통해, 구현된 LDP의 상호 연동성과 완전성, 생존성, 도달성, 안전성을 검증한다. 또한 이를 사용하여 구현된 LDP가 기존 상용 제품들과의 연동성과 그 동작의 신뢰성을 확보할 것을 기대한다. 결과적으로 구현된 LDP의 프로토콜 동작들의 검증을 제공한다.

• 대한공업교육학회지
• /
• 제33권2호
• /
• pp.248-258
• /
• 2008

현재 인터넷은 응용계층에서 HTTP를 사용하고 트랜스포트 계층에서는 TCP를 사용하여 서비스를 제공하고 있다. 새롭게 제안된 전송 계층 프로토콜인 SCTP(Stream Control Transmission Protocol)는 슬로우 스타트 기간 동안에 초기 윈도우의 값 등을 제외하고는 TCP와 유사한 혼잡 제어 메커니즘을 사용한다. 본 논문에서는 이 점에 주목하여 슬로우 스타트 기간 동안에 HTTP over SCTP의 평균 전송 시간을 구하는 수학적 모델을 제시하고 이를 기존의 HTTP over TCP와 비교한다. 비교 결과는 HTTP over SCTP의 평균 전송 시간이 HTTP over TCP의 그것보다 평균 11 % 우수함을 보여준다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권7호
• /
• pp.3371-3396
• /
• 2016

Authentication protocols for multi-server architectures have gained momentum in recent times due to advancements in computing technologies and associated constraints. Lu et al. recently proposed a biometrics and smartcards-based authentication scheme for multi-server environment. The careful analysis of this paper demonstrates Lu et al.'s protocol is susceptible to user impersonation attacks and comprises insufficient data. In addition, this paper proposes an improved authentication with key-agreement protocol for multi-server architecture based on biometrics and smartcards. The formal security of the proposed protocol is verified using the widely accepted AVISPA (Automated Validation of Internet Security Protocols and Applications) tool to ensure that our protocol can withstand active and passive attacks. The formal and informal security analysis, and performance analysis sections determines that our protocol is robust and efficient compared to Lu et al.'s protocol and existing similar protocols.