• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.189-191
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• 1996

Computerized spirometer was developed in a form of proto type system. The system consisted of pneumotachometer, flow measurement unit, fan ventilator unit, and software program. Patient's respiratory flow signal was first converted to corresponding pressure drop signal by a screen type pneumotachometer, sensed by a differential pressure transducer, amplified and low pass filtered, and digitized at a rate of 100 Hz, then fed into a PC thru RS-232C serial port. Customized application software controls data acquisition followed by computation of test parameters. The fan ventilator unit dries and eliminates microorganism in the pneumotachometer after each test. The system performs conventional spirometic tests and manages the test results in a database for retrograde research. The proto type system was fully developed and the commercialized system is currently being built up.

• Proceedings of the Korea Society of Design Studies Conference
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• 2003.05a
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• pp.12-13
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• 2003

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.41.2-41.2
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• 2018

EL CVn-type eclipsing binaries are composed of a massive A-type main-sequence primary star and a hotter B-type secondary one. These are worthy of particular attention because the secondary stars are rare objects to be extremely low-mass white dwarf precursors (ELM proto-WD) with the mass of ${\leq}0.2M_{\odot}$, evolving to higher effective temperatures and higher surface gravities. A few of them were discovered to show multi-periodic pulsations in one or both components. We monitored one of these rare and interesting objects, J0247-25 (=1SWASP J024743.37-251549.2), at two KMTNet sites of SAAO in South Africa and SSO in Australia. The observations were performed with the KMTNet 1.6m telescopes and pre-science 4K CCD cameras during the system test run from July to November 2014. Using the photometric data obtained for a total of 23 nights, we constructed well-defined eclipsing light curves in B/V-bands and derived absolute parameters (mass and radius, etc.) of each binary component. After subtracting model eclipsing curves from the data, we detected seven frequencies with 33~53 cycles per day (c/d) and identified them to be Delta Sct-type pulsations originated from the A-type primary component. Five frequencies were turned out to be excited by rotational splitting of non-radial pressure modes, enabled us to investigate rotational properties. We could not detect any frequency higher than 100 c/d, implying that pulsation amplitudes of the proto-WD secondary decrease greatly.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.2
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• pp.255-260
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• 2018

This study is focusing on the trade-offs between the passband ripples and transition bands of the Chebyshev BPF, which is converted by using the Chebyshev LPF that is well known as a proto-type analog filter. It is also focusing on the trade-offs between the passband ripples and transition bands of the cascading Chebyshev BPF, as well as, the trade-offs between the two BPFs. The study finds the frequency responses of the proto-type analog LPF, the Chebyshev BPF and the cascading Chebyshev BPF. The study shows the results as comparative analysis tables. The study designs the 10th Chebyshev BPF in order to analyze it easily. The simulation results show that the Chebyshev BPF decreases about 55% of the transition band for the -2.5[dB] passband ripple comparing to the -0.5[dB] passband ripple. This study shows the effectiveness and economic feasibility in the restricted frequency communication environment for the decrease of the transition band as providing the passband ripple margin.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.1
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• pp.277-283
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• 1995

For the development of low NO$_{x}$ gas burners aimed for absorption chiller/heater unit, three proto type burners of different capacity (265000, 498000, and 664000 kcal/h) have been manufactured through a combustion method of step-by-step air injection. In order to characterize the overall features of the flame and the properties of the emission gas, the temperature of the flame and the concentration of NO$_{x}$ and CO were determined. The main factors in the design of burners (the area of primary air injection, the diameter of secondary air injection hole, fuel nozzle diameter) were observed to increase linearly with the scale-up of burner capacity. The flame temperature profiles of the burners were observed to be almost similar, irrespective of their capacity. However, as their capacity increased, the flame temperature slightly increased and the hot region of the flames moved to ward the flame tip along with the expansion to the direction of radius. From the proto type units, the amount of their NO$_{x}$ emission was determined to be around 25 - 30 vppm(3% )$_{2}$) and the CO emission was less than 19 vppm (3% $O_{2}$).TEX>).

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.05a
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• pp.22-25
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• 2009

Development of a curvic-coupling was presented in this paper. The research covers design, structural analysis, hot-temperature-torsion-test, curvic-coupling applied proto-type turbine disk manufacturing, and assembly test of a curvic-coupling rotor system for the turbopump application. Curvic-coupling was designed based on the Gleason-standard-tooth shape. The load capability of the designed curvic coupling was validated by the structural analysis and hot-temperature-torsion-test. A proto-type turbine disk which had adopted designed curvic-coupling was manufactured, assembled and tested to reveal that shaft-disk assembly run-outs in axial and radial directions were much smaller than the design requirements. The development will be finalized after spin test of shaft-disk assembly in near future.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.842-844
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• 2012

This paper introduces a 5GHz FIR filter low noise amplifier (LNA) based on a distributed amplifier and analyzes the its characteristics. The proposed FIR filter-LNA has the MA(moving average) filter characteristic which improves the frequency selectivity of the amplifier. Proto-type circuits with FR4 and ${\varepsilon}_r=10.2$ PCB have been realized and simulated using ADS (Advanced Design System). The simulation results verified that the designed LNA had a gain of about 10dB and the frequency characteristic of the MA FIR filter. It is expected that the proposed FIR filter LNA can be applicable to the various applications using an amplifier and a filter in RF systems.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.43.2-43.2
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• 2017

We report our discovery of a significant population of CN-enhanced red clump stars in the classical bulge component of the Milky Way. Since CN-rich stars trace a population with enhanced Helium, Nitrogen, and Sodium originated in globular clusters (GCs), this is a direct evidence that proto-GCs were the major building blocks in the formation of the classical bulges and early-type galaxies in the hierarchical merging paradigm.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.53 no.3
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• pp.142-147
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• 2004

In this study, We developed the microprocessor based controller for Auto Section Switch(ASS). This is installed at consumer's medium-high voltage(load capacity is below 4,000 kVA) switchgear. This function is cooperate with protection device of fault section and automatically dividing the section. And It is designed by Air putter type extinction structure and adopt the mechanism and breaking part module of existing Load Breaker Switch. In addition, We successfully conducted the operation test and checked main function of proto-type.