• Safety and Health at Work
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• v.13 no.4
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• pp.475-481
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• 2022

Background: This study investigated the association between fair and supportive leadership and symptoms of burnout and insomnia in police employees. Burnout and insomnia can have negative consequences for health, performance, and safety among employees in the police profession, and risk and protective factors should be thoroughly investigated. Methods: Data were collected in a police district in Norway through questionnaires administered in October 2018 and May 2019. The sample consisted of 206 police employees (52% males), with an average age of 42 years and 16 years of experience in the police occupation. Results: The results showed that a high degree of fair and supportive leadership was associated with lower levels of burnout and insomnia six months later. Fair and supportive leadership explained a greater amount of variance in burnout compared to insomnia. This finding indicates that fair and supportive leadership is a more important buffer factor against burnout than it is against insomnia. Stress was positively associated with burnout and insomnia, whereas quantitative job demands had no significant association with the concepts. Conclusion: Fair and supportive leadership can help protect employees from adverse consequences of stress and contribute to improved occupational health, whereas a low degree of support and fair treatment from leaders can both represent a stressor by itself and contribute to poorer coping of stressful events at work. The important role of leadership should be incorporated in measures aimed at preventing and reducing burnout and sleep problems.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.142-146
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• 2015

Human resources development is considered a critical issue for improving productivity of workers in construction industry. The aim of this study is to identify and rank the key motivating factors that impact skilled workers productivity according to their relative importance. A total of 27 factors were identified through a literature review, which were categorized into 2 group financial and un-financial motivators. A questionnaire instrument was adopted in this study. The study revealed that the most significant group which affected skilled workers' productivity in construction projects was financial group with the recognition of the un-financial group importance. The results emphasized that the financial group has an edge over the un-financial group which reflect the priority of need for the respondents. The results indicated that the un-financial group represents a backbone in its importance after the financial group which reflects that un-financial factors can improve productivity. The findings showed that the provision of companies to safety conditions factor such as protective safety clothing and protective equipment was ranked very low by the respondents. This is due to the dominant culture of the workers as well as the lack of their awareness regarding their own safety and lack of companies' interest in safety and health for workers. Construction companies are advised to take the key motivating factors obtained from the results of this study into serious consideration in order to improve the satisfaction of their workers and improve their productivity.

• Journal of Microbiology and Biotechnology
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• v.34 no.4
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• pp.940-948
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• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.139-145
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• 2005

This study was performed to investigate the effect of Bohyulanshin-tang on brain-derived neurotophic factor(BDNF) expression in SK-N-SH (immortalized human neuroblastoma) cell line. MTT-based cytotoxicity assay revealed that cells of 0.1 mg/ml group and 1 mg/ml group significantly increased compared with Control group. Westren blotting and RT-PCR analysis showed that Bohyulanshin-tang significantly increased BDNF mRNA expression of 0.1 mg/ml group and 1 mg/ml group compared with Control group. Another analysis revealed that Bohyulanshin-tang significantly increased BDNF expression of 0.1 mg/ml group and 1 mg/ml group compared with Control group. These results showed that cell-protective abilities and cell-proliferating effects of Bohyulanshin-tang approached that of Fluoxetine.

• BMB Reports
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• v.39 no.5
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• pp.479-491
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• 2006

Heme oxygenase (HO), the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and bilirubin, has recently received overwhelming research attention. To date three mammalian HO isozymes have been identified, and the only inducible form is HO-1 while HO-2 and HO-3 are constitutively expressed. Advances in unveiling signal transduction network indicate that a battery of redox-sensitive transcription factors, such as activator protein-1 (AP-1), nuclear factor-kappa B (NF-${\kappa}B$) and nuclear factor E2-related factor-2 (Nrf2), and their upstream kinases including mitogen-activated protein kinases play an important regulatory role in HO-1 gene induction. The products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli. In this context, it is interesting to note that induction of HO-1 expression contributes to protection against liver damage induced by several chemical compounds such as acetaminophen, carbon tetrachloride and heavy metals, suggesting HO-1 induction as an important cellular endeavor for hepatoprotection. The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect against chemically-induced liver injury as well as hepatocarcinogenesis.

• BMB Reports
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• v.44 no.12
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• pp.811-815
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• 2011

Inhalational anthrax is caused by B. anthracis, a virulent sporeforming bacterium which secretes anthrax toxins consisting of protective antigen (PA), lethal factor (LF) and edema factor (EF). LF is a Zn-dependent metalloprotease and is the main determinant in the pathogenesis of anthrax. Here we report the identification of a lead small-molecule inhibitor of anthrax lethal factor by screening an available synthetic small-molecule inhibitor library using fluorescence-based high-throughput screening (HTS) approach. Seven small molecules were found to have inhibitory effect against LF activity, among which SM157 had the highest inhibitory activity. All theses small molecule inhibitors inhibited LF in a noncompetitive inhibition mode. SM157 and SM167 are from the same family, both having an identical group complex, which is predicted to insert into S1' pocket of LF. More potent small-molecule inhibitors could be developed by modifying SM157 based on this identical group complex.

• Korean Journal of Social Welfare
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• v.55
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• pp.255-281
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• 2003

This study sought to explore factors affecting the adjustment of children living in shelters for battered women. Specifically, the impact of domestic violence on children's internal and external adjustment was examined using data from two samples: children who were exposed to marital violence and those who did not have violent experience. Likewise, this study identified the variables that distinguished the "resilient" children from the maladjusted group. The pathways by which protective factors considerably affected children's adjustment were also investigated. A total of 72 children in a women's shelter and their mothers and 76 children in nonviolent homes and their mothers were considered. ANOVA, logistic regression models, and path analysis were employed to process the data. Results revealed that children of battered women demonstrated a high frequency of aggressive and delinquent behaviors and had poor academic achievement and depressive mood compared to children coming from nonviolent homes. Likewise, children who were exposed to marital violence and were physically abused themselves were more likely show aggressive or delinquent behaviors compared to those who only witnessed marital violence. In addition, social support was found to be a protective factor in academic achievement. Predictors of delinquent behavior included the mother's education and income as well as the children's age and social support. Factors related to children's self-esteem included the social support and the mother's self-esteem. Moreover, woman battering has a direct effect on children's adjustment as well as indirect effect through children's academic achievement and self-esteem. Finally, woman battering indirectly affected children's academic achievement through the mother's depression or the child's social support. Based on these findings, practical implications of enhancing children's adjustment were discussed.

• Journal of Microbiology and Biotechnology
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• v.20 no.9
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• pp.1331-1338
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• 2010

This study was designed to investigate the potentially protective effects of Curcuma longa Linn. extract (CLE) on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity in rats. Male Sprague-Dawley rats were pretreated with 50 or 100mg/kg of CLE or 100mg/kg of butylated hydroxytoluene(BHT) for 14 days before $CCl_4$ administration. In addition, the CLE control group was pretreated with 100mg/kg CLE for only 14 days. Three hours after the final treatment, a single dose of $CCl_4$ (20mg/kg) was administrated intraperitoneally to each group. After the completion of this phase of the experiment, food and water were removed 12 h prior to the next step. The rats were then anesthetized by urethane and their blood and liver were collected. It was observed that the aspartate aminotransferase and alanine aminotransferase activities of the serum, and the hepatic malondialdehyde levels had significantly decreased in the CLE group when compared with the $CCl_4$-treated group. The antioxidant activities, such as superoxide dismutase, catalase, and glutathione peroxidase activities, in addition to glutathione content, had increased considerably in the CLE group compared with the $CCl_4$-treated group. Phase II detoxifying enzymes, such as glutathione S-transferase, were found to have significantly increased in the CLE group as opposed to the $CCl_4$-treated group. The content of Nrf2 was determined by Western blot analysis. Pretreated CLE increased the level of nuclear translocated Nrf2, and the Nrf2 then increased the activity of the antioxidant and phase II detoxifying enzymes. These results indicate that CLE has protective effects against $CCl_4$-induced hepatotoxicity in rats, via activities of antioxidant and phase II detoxifying enzymes, and through the activation of nuclear translocated Nrf2.

• BMB Reports
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• v.37 no.2
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• pp.185-191
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• 2004

Tissue transglutaminase (tTGase) regulates various biological processes, including extracellular matrix organization, cellular differentiation, and apoptosis. Here we report the protective role of tTGase in the cell death that is induced by the tumor necrosis factor $\alpha$ (TNF-$\alpha$) and ceramide, a product of the TNF-$\alpha$ signaling pathway, in human neuroblastoma SH-SY5Y cells. Treatment with retinoic acid (RA) induced the differentiation of the neuroblastoma cells with the formation of extended neurites. Immunostaining and Western blot analysis showed the tTGase expression by RA treatment. TNF-$\alpha$ or $C_2$ ceramide, a cell permeable ceramide analog, induced cell death in normal cells, but cell death was largely inhibited by the RA treatment. The inhibition of tTGase by the tTGase inhibitors, monodansylcadaverine and cystamine, eliminated the protective role of RA-treatment in the cell death that is caused by TNF-$\alpha$ or $C_2$-ceramide. In addition, the co-treatment of TNF-$\alpha$ and cycloheximide ecreased the protein level of tTGase and cell viability in the RA-treated cells, supporting the role of tTGase in the protection of cell death. DNA fragmentation was also induced by the co-treatment of TNF-$\alpha$ and cycloheximide. These results suggest that tTGase expressed by RA treatment plays an important role in the protection of cell death caused by TNF-$\alpha$ and ceramide.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.594-606
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• 2018

The purpose of this study is to examine the mediating effect of positive psychological capital as an protective factor and mental health as an risk factor on the relationship between smart phone addiction and self life management of university students. The following are the results of the analysis on the measures of smart-phone addiction, positive psychological capital, mental health and self life management among the 266 college students. First, the analysis of the correlation between relevant factors, smart-phone addiction showed a significant amulet correlation between self life management and positive psychological capital and a significant static correlation between mental health. Second, the positive psychological capital showed a mediate effect as a result of the analysis of university students' smart-phone addiction and self life management. Third, the results of a regression analysis between positive psychological capital and psychosomatic health sub-factors, optimism and resilience in the positive psychological capital and Depression and Impulsion in mental health, had a significant impact on managing self-life management Based on the results of this study, we discussed educational implications for the management of university students ' lives and suggestions for further research.