• Journal of Pharmaceutical Investigation
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• 제30권3호
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• pp.191-199
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• 2000

Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.

• 지역사회간호학회지
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• 제13권3호
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• pp.541-555
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• 2002

Objectives: This study is aimed to analyze the trend of research on nutrition, pain and fatigue of cancer patients in Korea, suggest direction for future research of nutrition, pain and fatigue of cancer patients. Methods: 74 studies published from 1991 to 2001 were examined according to the year of publication, types of journal, research design, types of disease, care methods, major concepts, tool and research findings. Results: 1) The number of studies related nutrition, pain and fatigue of cancer patients had increased rapidly since the 1996's(78.4%). 2) 42 nutrition, pain and fatigue of cancer patients studies(56.1%) were done for a thesis for a degree and 32 were nondegree research studies(43.9%). 3) 70 studies(94.7%) were quantitative study, which included in 40 descriptive studies(54.1%), 22 experimental studies (29.75), 5 correlative studies(6.8%), 2 comparative studies(2.7%) and 1 case study(1.4%), and 4 studies(5.3%) were qualitative study, which included in 3 content analysis studies(3.9%) and 1 phenomenological study(1.4%). 4) Researches about cancer more than 2 were the most by 48 studies (66.1%), following leukemia researches were 8 studies(10.8%), breast cancer researches were 7 studies(9.5%), gastric cancer researches were 4 studies(5.4%), pediatric cancer researches were 3 studies(4.1%), uterine cancer researches were 2 studies(2.7%). 5) Researches about chemotherapy were the most by 39 studies(52.6%), following analgesic researches were 14 studies(18.9%), researches that do not present treatment method were 9 studies(12.2%), radiation researches were 7 studies(9.5%). 6) In 22 experimental studies, the effects of 13 types of nursing interventions were tested. Research findings were effective almost but muscle relaxation therapy to decrease nausea and vomiting was no effect. Conclusion: We need more researches about research of nutrition, pain and fatigue of cancer patients, especially need to prove the effect of intervention or program for nutrition, pain and fatigue of cancer patients by experimental research designs and need more qualitative researches to identify indepth the meaning of nutrition, pain and fatigue of cancer patients.

• 동서간호학연구지
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• 제5권1호
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• pp.102-113
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• 2000

The study attempts to analyze the trends of study related with oriental nursing. This article reviewed 81 researches on oriental nursing from 1985 to July 2000, by examining them according to the articles' characteristics, sources by publication period, research design, nursing intervention effect of experimental study and concept, and content of literature review. The findings of the analysis can be summarized as follows; 1. The number of studies related with oriental nursing has progressively increased by year from 1985, and that of articles was the highest during the period between 1995 to 1999. Since the 1990s, the number of articles including thesis and dissertation increased, and a third of subject articles were thesis among them. 2. The majority of research design were survey and correlational studies, and most of them were published in the 1990s. Literature review articles also occupied a certain portion, and most of them were published after 1995. In addition, the research design of dissertation revealed in various types. 3. Nursing intervention used in the experimental study was Dan Jeon Breathing, San-Yin-Jiao (SP-6) Pressure, Percutanous Electrical Nerve Stimulation, Guided Imagery, Diet for Sasang Constitution, Yoga Exercise, Qigong Exercise, Meridian Massage, Bed Exercise Program, Health Contract and Structured Rehabilitation Education. Among the study subjects, patients with chronic illness were at the highest rate, and the most nursing intervention effects presented physiological effect, activities of daily living and relieving pain. In most studies, the affirmative effect proved. 4. The key concept of literature review articles is energy, oriental nursing, health promotion, oriental medicine management of illness and etc. Being important concepts to understand oriental nursing, they confirm similar perspective of oriental medicine and nursing and show simultaneously the importance of nursing considered into the cultural perspective. The summary of the above results shows a tendency that the thesis and dissertation have been relatively considered with various research designs, while the others have focused on literature review. Especially, experimental study proved affirmative effect through various experimental treatment of nursing intervention related with oriental medicine. Besides in the literature review, inquiry of theories and practical perspective, which is necessary for the establishment of oriental nursing, was introduced. However, for the establishment of oriental nursing, more studies are to be required along with development of nursing intervention related with health promotion.

• 전자공학회논문지 IE
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• 제45권4호
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• pp.11-18
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• 2008

본 연구는 다족 로봇용 자세제어장치(ACS - Attitude Control System)인 관성측정 시스템(IMU) 의 H/W 설계와 자세제어 알고리즘 S/W을 설계하여 다관절용 로봇의 IMU 통합시스템을 구현 후 이 시스템의 동작성능을 검증하기 위해 Mtx와 MTx와의 성능을 비교 검증을 하고자 한다. ACS는 자이로와 가속도계 그리고 지자기 센서를 이용하여 항체의 롤, 피치각 자세를 제어하는 시스템이다. 일반적인 저가형 MEMS 관성센서로는 오차가 심하게 발생하여 항체의 정확한 위치를 계산하기 힘들다. 본 연구에서는 ACS 개발하기 위하여 상용의 MEMS 가속도계 및 자이고 센서, 추가적으로 지자기 센서를 사용하여 관성측정 시스템(IMU)을 표현한다. 구현된 IMU 시스템에 자세계산 프로그램을 내장하여 일정 성능을 보장하는 롤, 피치, 요 자세각 알고리즘을 설계하여 시스템에 포팅한다. 본 연구에서는 자이로와 가속도계 출력을 혼합하여 롤, 피치각을 보상함으로써 지속적으로 일정 수준이상의 성능을 보장하는 ACS를 구현하기위해 목표 플랫폼에 적재하여 실시간으로 구동하여 포팅하고 검증하였다.

• 한국사회복지학
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• 제59권4호
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• pp.5-34
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• 2007

본 연구는 다중수렴모델(Multiple Convergence Model)을 적용하여 나눔교육을 통한 아동의 변화를 보다 다각적이고 심층적으로 이해해 보고자 한다. 양적 연구를 통해서는 초등학교 고학년 아동을 대상으로 친사회성 행동 향상에 초점을 두고 변화를 살펴보았으며, 질적 연구를 통해서는 나눔교육 후의 아동 변화에 대해 아동, 학부모, 교사의 시각에서 다차원적으로 변화의 내용과 의미를 분석하였다. 분석결과, 나눔교육을 받은 고학년 아동들은 친사회적 행동에서 통계적으로 유의미한 긍정적 변화가 나타났으며, 아동, 학부모, 교사의 시각에서도 그러한 변화는 확인되었다. 또한 양적 결과를 질적 결과를 통해 확증하는 수렴적 방법을 활용해 종합해 본 결과, 나눔교육이 아동에게 매우 긍정적인 의미있는 변화를 유발하는 것으로 나타났다. 이러한 결과를 바탕으로 본 연구는 나눔교육의 주요 장(주체)인 가정 학교 지역사회에서 나눔교육의 효과를 극대화시키기 위한 방안들을 논의한다. 본 연구는 '나눔교육을 통한 아동의 변화'라는 현상에 대해 포괄적 심층적 이해 제고를 위해 국내 최로로 다중수렴모델을 적용하는데, 이는 사회복지연구방법의 지평을 확대하는 효과, 즉 새로운 연구방법론 활용의 기초를 마련할 것으로 기대한다.

• Perspectives in Nursing Science
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• 제8권2호
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• pp.129-138
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• 2011

Purpose: The purpose of this study was to identify the current status of evidence-based research, education, and practice, and to suggest a directions for the future development of evidence-based nursing. Methods: To examine the current status of evidence-based nursing research, experimental research among studies published in the Journal of Korean Academy of Nursing from 2008 to 2010 were analyzed. We suggested a direction for the future development of evidence-based research based on the analysis and literature reviews. We also suggested a direction for the future development of evidence-based education and practice based on literature reviews. Results: The results showed that designs and methods of studies were insufficient to use evidences derived from the studies in terms of evidence-based research, and experimental studies consistent with themes were found to be deficient. In the future, the methods and rationale for the design of experimental studies need to be clearer In addition, a test for intervention effects through repetitive studies and a connection between the intervention effects and a protocol for clinical practice will be required. In terms of evidence-based education, curriculum revision and development of teaching methods including contents related to evidence-based practice and research methodology in undergraduate and graduate programs will be required. Evidence-based practice in Korea was less actively done than with that of foreign countries. Some large hospitals have recently attempted systemic activities to promote evidence-based nursing practice in clinical settings. To activate evidence-based practice, the perception of nurses for evidence-based practice needs to be changed and support for education and administration of the program is required. Also, evidence-based practice guidelines, protocols, and assessment tools need to be developed. Conclusion: Evidence-based nursing in Korea is in the process of evolving. To realize evidence-based nursing, we need to develop nursing science based on evidences of closer communication and cooperation in terms of nursing research, education, and practice.

• 한국재난정보학회 논문집
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• 제13권3호
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• pp.305-312
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• 2017

우리사회는 고도화, 첨단화, 정보화 산업들이 지속적으로 성장을 거듭하여 현재는 4차 산업 혁명의 시대에 살고 있다. 산업이 발달함에 따라 사용자의 부하도 다양하게 급증하였고 이는 에너지 부족 현상으로 심화되어 추가적인 에너지 시설의 건설이 요구되고 있는 실정이다. 이에 해안 지역을 중심으로 에너지 플랜트 건설공사가 활발히 진행되고 있다. 특히, 발전소 가스 석유화학 플랜트 등의 건설 시 국토가 부족한 우리나라의 실정을 고려하여 타 지역의 토양으로 해안을 매립하고 그 지반에 플랜트 시설을 건축하는 방식으로 시행되고 있다. 현재의 국내 접지 설계는 전기설비설계기술기준에 근거한 접지저항만을 용도에 맞게 결정하는 설계와 시공이 이루어지고 있다. 하지만 이렇게 검증되지 않은 매립된 토양에 건립한 플랜트 시설에 뇌격전류 및 이상전류 유입 시 대지 전위상승으로 인한 설비 운용자나 사용자가 감전재해 위험에 심각하게 노출 되게 된다. 따라서 플랜트 시설의 부하 특성에 최적화된 접지시스템이 요구되고 있어, 본 논문에서는 매립된 토양의 대지고유저항을 분석하고 KS C IEC 61936-1 규격을 적용한 컴퓨터 프로그램(CDEGS)을 활용하여 감전재해를 일으키는 접촉전압과 보폭전압을 해석하여 플랜트 설비에 최적화된 접지설계를 제안하고자 한다.

• 대한치과기공학회지
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• 제41권2호
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• pp.63-69
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• 2019

Purpose: The purpose of this study is to evaluate the effect of CAD/CAM system milling tool wear on the marginal and internal fit of PMMA implant interim prosthesis three-dimensional manner. Methods: A total of 20 crowns were fabricated with CAD/CAM method. Their designs were unified to first molar of the left maxilla. The Customized abutments were prepared and scanned with on optical model scanner. Five crowns were milled by the newly replaced tool (1st milling), and 15 crowns were milled by 2nd, 3rd, 4th milling tool. The marginal and internal fit of 20 interim crowns were measured using the triple-scan protocol. Results: Statistically significant difference was found between the $1^{st}$ milling group ($51.8{\pm}14.6{\mu}m$) and the $3^{rd}$, $4^{th}$ milling group ($128.6{\pm}43.8{\mu}m$, $146.2{\pm}38.1{\mu}m$, respectively) at the distal margins. In the mesial margins, There was a statistically significant difference between the $1^{st}$ milling group ($63.6{\pm}25.9{\mu}m$) and the $3^{rd}$, $4^{th}$ milling group ($137.2{\pm}25.9{\mu}m$, $186.8{\pm}70.6{\mu}m$, respectively). In the distal line angle, significant difference was found between the $1^{st}$, $2^{nd}$, $3^{rd}$ milling groups and the $4^{th}$ milling group. In the mesial axial wall, significant difference was found between the $1^{st}$ milling group ($52.2{\pm}20.3{\mu}m$) and the $3^{rd}$, $4^{th}$ milling groups ($22.8{\pm}8.8{\mu}m$, $7.8{\pm}5.7{\mu}m$). Conclusion: As a result of the experiment, decrease of the marginal and internal fit was statistically significant as the number of machining cycles increased. In order to produce clinically excellent restorations, it is recommandable to consider the condition of the milling tool wear, when designing the restoration with CAD program.

• 문화기술의 융합
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• 제9권1호
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• pp.111-118
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• 2023

본 연구는 새로운 제품에 대한 요구와 다양성을 추구하는 일반 소비자들에게 제시되고 있는 주얼리 디자인을 연구하는 데 목적이 있다. 기존에 판매되고 있는 여러 가지 제품 모듈을 서로 바꾸어 착용할 수 있도록 한 다변형 교체 방식의 주얼리와는 구별되는 구조와 결합 방식의 모듈형 주얼리디자인을 제시하고자 한다. 기존의 다소 작은 여러 부품들을 복잡한 결합 방식으로 제작하는 경우 문제점이 발생할 가능성이 높으며 소비자가 장식 부품을 교체하면서 작은 고정 장치 부품을 조립하는 과정에서 분실하는 어려움이 따를 수 있다. 따라서 이런 문제들을 줄이기 위해 다른 결합 부품 필요 없이 손쉽게 교체하여 착용할 수 있도록 심플하고 단순한 디자인 위주로 제작한 주얼리 제품들과는 차별화시키고 최신의 3D프린터(Rapid Prototyping)를 이용하여 제작하려 한다. 이 연구는 현장 실무에 종사하며 얻어진 경험 및 노하우를 바탕으로 실물 제작이 가능하고 제작 과정 시 문제점 발생을 최소한으로 줄이는 데 주력했으며, 이를 통해 시간적, 경제적인 손실을 줄일 수 있다. 3D프로그램(CAD)을 사용하여 제작함으로서 보다 정교하고 차별화된 형태를 표현하여 개선된 주얼리 제품을 제작하는 데 연구목적이 있다.

• 예술인문사회 융합 멀티미디어 논문지
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• 제6권10호
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• pp.373-382
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• 2016

우리나라의 농업은 사계절의 뚜렷함으로 기후의 영향을 받아 온실과 같은 시설을 이용하여 작물을 재배하는 농업이 발전하고 있다. 점차 첨단 기술의 농업으로 발전하고 있지만 아직 여러 자연 재해에 취약한 점이 나타나고 있다. 이러한 문제로 본 논문에서는 농업인의 고충을 줄이기 위해 폭설이나 풍해로 인한 작물 생산 및 시설 유지를 위한 비닐 회전을 이용하여 비닐하우스 제설 및 복구 시스템을 설계 하였다. 본 논문에서는 온실의 실시간 피드백 제어를 위한 기본 연구로써, 자체 기술력을 바탕으로 개발된 무선 IoT 센서 시스템 및 시설원예 관리 시스템을 결합하여, IoT 장치를 통한 적설량 및 바람의 세기를 평가하고자 하였다. 기존 비닐하우스 제설 시스템의 경우 온수를 분사하여 제설하거나 기존 시설의 구조를 새롭게 하여 피해를 방지하였지만 본 논문에서는 비닐하우스의 실질적 외관인 비닐을 회전함으로 적설된 눈을 치우거나 파손 부위를 복구함으로 피해를 복구한다. 이를 위하여 본 논문에서는 먼저 MEMS 소자 및 무선 통신 모듈 기반의 무선 IoT 센서 유닛, 실시간 응답 측정이 가능하도록 운영 프로그램 등을 개발하였다. 이로 인하여 기존의 노동력 절감과 작물 성장의 피해를 막아 효율적인 시설 운영에 도움을 주게 될 것이다.