• Journal of Communications and Networks
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• v.5 no.3
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• pp.215-221
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• 2003

It is expected that per-user customized services are widely used in next generation Personal Communication Network. To provide personalized services for each call, per-user service profiles are frequently referenced and signaling traffic is considerably large. Since the service calls are requested from the places where user stays, we can expect that the traffic is localized. In this paper, we propose a new service profile replication scheme, named Follow-Me Replication with local Anchor (FMRA). By replicating user's service profile in a user-specific location area, local anchor of each region, the signaling traffic for call and mobility can be distributed to local network. We compared the performance of the FMRA with two typical schemes: Intelligent Network-based !Central scheme and IMT-2000 based full replication scheme, as we refer it to Follow-Me Replication Unconditional (FMRU). Performance results indicate that FMRA lies between Central and FMRU schemes according to call to mobility ratio, and we identified the efficient ranges of CMR for FMRA depending on the various network parameters.

• Journal of KIISE:Information Networking
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• v.30 no.4
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• pp.545-558
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• 2003

It is expected that per-user customized services are widely used in next generation Personal Communication Network. The ultimate goal for personalized service is the Virtual home Environment (VHE) providing ´same-look-and-feel´ services for the subscriber wherever he roams to. To provide personalized services for each call, per-user service profiles are frequently referenced, so efficient service profile management is essentially required. To realized the VHE, typically two schemes, can be employed; One is Intelligent Network based service control and the other is a full replication scheme that always replicates profile in user´s current zone. The first scheme is referred as Central scheme and th second scheme is the modified replication scheme of IMT-2000, we refer to as Follow-Me Replication Unconditional (FMRU). Since the Central scheme only depends on the service cal rate and the FMRU is merely dependent on the movement rate, it is apparent that FMRU scheme outperforms the Central scheme if the call to mobility ratio (CMR) is large, and vice versa. In this paper, we propose a new service profile replication schemes, Adaptive Follow-Me Replication (AFMR) that determine replication automatically according to the user´s CMR. We compared the performance of the AFMR with the non-adaptive Follow-Me Replication unconditional on Demand (FMRUD) scheme. Performance results indicate that as the CMR of a user changes AFMR adapts well compared to the existing schemes.

• Korean Journal of Microbiology
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• v.38 no.3
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• pp.221-229
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• 2002

Japanese encephalitis virus (JEV) persistence was established and maintained in Vero cell culture for over 1 year. Eleven clones of plaque morphology mutant JEV, with large and small plaque sizes, were obtained from the cell culture supernatant. Genomic RNA replication efficiency of the mutants in naive Vero cell appeared to correspond to their different plaque sizes. No significant changes in envelop protein ORF or in non-coding regions at both ends of the RNA genome suggested that there could be an unidentified factor(s) playing role in JEV attenuation. Unlike to the replication of wild-type JEV, the mutants did not induce severe degree of cytopathic effect in Vero cells upon infection. While obvious decrease of Bcl-2 and its mRNA expression and sharp increase of p53 in naive Vero cells infected with either wild-type JEV or the large plaque-forming mutant, those changes were not observed with the small plaque-forming one. Together with these observation, internucleosomal DNA fragmentation and chromosomal DNA profile in the Vero cells infected with the mutants suggest that an overall changes in cytopathic effect in the plaque morphology mutants-infected cells should be primarily due to the reduced genomic RNA replication and the compromised degree of p53-independent apoptosis by the virus infection at least in part.

• Proceedings of the Korean Information Science Society Conference
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• 1999.10c
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• pp.748-750
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• 1999

본 논문에서 우리는 통신 비용과 데이터베이스 비용을 감소시키기 위해 사용자 프로파일 복제본을 이용한 동적 위치 관리 기법을 제안한다. 이 기법에서는 위치등록과 호 설정 과정이 통신비용을 감소시킬 수 있는 복제본이 있는 VLR에서 수행되고, 복제본이 있는 VLR에서 호의 빈도커서 데이터베이스 비용을 감소시킨다. 제안한 기법의 성능을 분석하기 위해 분석 모델을 작성하고 제안 기법, IS-41 기법, 복제 기법의 성능 분석을 한다. 사용된 비교 척도는 통신 비용, 데이터 베이스 비용, 총비용 그리고 호 설정 지연이다. 이 척도들에 대해서 제안 기법이 IS-41 기법, 복제 기법보다 더 좋은 성능을 보인다.

• Transactions of The Korea Fluid Power Systems Society
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• v.5 no.3
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• pp.15-22
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• 2008

The road simulators have become common tools within the automotive industry for evaluation of vehicle and vehicle system durability performance. These simulators need appropriate input signal generation algorithms to realize the actual driving conditions due to non-linear vehicle and test rig behaviour. Although somewhat unconventional from a control standpoint, the iteration approach has proven to be a very effective method for control of complex, multiple degree-of-freedom systems where the tracking parameter is known a priori. In this paper, the road profile replication algorithm is verified by applying Belgian road to the developed road simulator. The simulation and experimental results are included to evaluate the performance of this simulator. This road simulator provides considerable savings in cost, development time, and testing risk during developing automotive components.

• Korean Journal of Poultry Science
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• v.42 no.3
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• pp.191-196
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• 2015

The current experiment was conducted to evaluate the effects of adding Salicornia extract to the drinking water on the performance, egg quality, and blood profile of laying hens. A total of 216 Hy-Line Brown laying hens at 40 weeks of age were used in a 10-week experiment. The birds were allotted into three experimental treatments with three replications per treatment and 24 birds per replication. The treatments were CON (basal diet), T1 (1 cc of Salicornia extract per liter of drinking water), and T2 (5 cc of Salicornia extract per liter of drinking water). The collected data were analyzed using the SAS package program. The results indicated that addition of Salicornia extract to the drinking water of laying hens did not cause any negative effects on the performance, egg quality, or blood profile. Compared to the control treatment, the treatments with Salicornia extract remarkably increased egg production (P<0.05) in the last week of the study, improved egg shell thickness and significantly reduced the egg breaking rate (P<0.05). The results of this study showed that the addition of Salicornia extract improved egg shell quality; thus, Salicornia extract can decrease the egg breaking rate and increase production on commercial farms.

• Journal of Microbiology and Biotechnology
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• v.31 no.7
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• pp.912-920
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• 2021

SOS response is a conserved response to DNA damage in prokaryotes and is negatively regulated by LexA protein, which recognizes specifically an "SOS-box" motif present in the promoter region of SOS genes. Myxococcus xanthus DK1622 possesses a lexA gene, and while the deletion of lexA had no significant effect on either bacterial morphology, UV-C resistance, or sporulation, it did delay growth. UV-C radiation resulted in 651 upregulated genes in M. xanthus, including the typical SOS genes lexA, recA, uvrA, recN and so on, mostly enriched in the pathways of DNA replication and repair, secondary metabolism, and signal transduction. The UV-irradiated lexA mutant also showed the induced expression of SOS genes and these SOS genes enriched into a similar pathway profile to that of wild-type strain. Without irradiation treatment, the absence of LexA enhanced the expression of 122 genes that were not enriched in any pathway. Further analysis of the promoter sequence revealed that in the 122 genes, only the promoters of recA2, lexA and an operon composed of three genes (pafB, pafC and cyaA) had SOS box sequence to which the LexA protein is bound directly. These results update our current understanding of SOS response in M. xanthus and show that UV induces more genes involved in secondary metabolism and signal transduction in addition to DNA replication and repair; and while the canonical LexA-dependent regulation on SOS response has shrunk, only 5 SOS genes are directly repressed by LexA.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.309-323
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• 2011

MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs of about 22 nucleotides that have recently emerged as important regulators of gene expression at the posttranscriptional level. Recent studies provided clear evidence that microRNAs are abundant in the lung, liver and kidney and modulate a diverse spectrum of their functions. Moreover, a large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as infectious diseases, sickle cell disease and endometrium diseases as well as lung, liver and kidney diseases. As a consequence of extensive participation of miRNAs in normal functions, alteration and/or abnormalities in miRNAs should have importance in human diseases. Beside their important roles in patterning and development, miRNAs also orchestrated responses to pathogen infections. Particularly, emerging evidence indicates that viruses use their own miRNAs to manipulate both cellular and viral gene expression. Furthermore, viral infection can exert a profound impact on the host cellular miRNA expression profile, and several RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Here I briefly summarize the newly discovered roles of miRNAs in various human diseases including infectious diseases, sickle cell disease and enodmetrium diseases as well as lung, liver and kidney diseases.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.2
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• pp.217-224
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• 2014

A total of 150 growing ducks were assigned to five dietary treatments to study the effect of sea tangle and charcoal (STC) supplementation on growth performance and meat characteristics in a completely randomized design. There were six replicates and five ducklings in each replication. The five dietary treatments were control, antibiotic, and 0.1%, 0.5%, and 1% STC supplemented diets. No significant differences were found on ADG, ADFI, and gain:feed among treatments in different weeks. The overall (0 to 3 weeks) ADFI decreased in antibiotic treatment (p<0.05) whereas the gain:feed increased significantly upon 1.0% STC supplementation compared to control (p<0.05). No significant variation was found in meat chemical composition except crude fat content which was high in 1.0% STC dietary group (p<0.05). Meat cholesterol was reduced in 0.1% STC group (p<0.05) compared to other dose levels while serum cholesterol was unaffected. High density lipoprotein (HDL) content was high in 1.0% STC (p<0.05) and low density lipoprotein (LDL) was low in 0.1% and 1.0% STC dietary groups (p = 0.06). No significant effect was found on the thiobarbituric acid reactive substances (TBARS) of fresh meat, whereas the TBARS value of meat preserved for 1 week was reduced significantly in STC dietary groups (p<0.05). The 0.1% STC dietary group showed an increased myristic acid (p = 0.07) content whereas, the content of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids increased in STC supplementation than antibiotic group (p<0.05). An increased concentration of omega-3 fatty acids and a reduced ratio of n-6/n-3 PUFA ratio was found upon 1.0% STC supplementation compared to antibiotic dietary group (p<0.05). Therefore, 1.0% STC dietary supplementation can be used as alternatives to antibiotics in duck production.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.1
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• pp.20-33
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• 2017

Objective: Superstimulatory treatment of one-month-old lambs can achieve synchronous development of numerous growing follicles. However, these growing follicles cannot complete maturation and ovulation. Oocyte maturation and competence are acquired during follicular development, in which granulosa cells play an essential role. Methods: In this study, we applied RNA sequencing to analyze and compare gene expression between prepubertal and adult superstimulated follicle granulosa cells in sheep. Results: There were more than 300 genes that significantly differed in expression. Among these differently expressed genes, many extracellular matrix genes (EGF containing Fibulin Like Extracellular Matrix Protein 1, pentraxin 3, adrenomedullin, and osteopontin) were significantly down-regulated in the superstimulated follicles. Ingenuity pathway and gene ontology analyses revealed that processes of axonal guidance, cell proliferation and DNA replication were expressed at higher levels in the prepubertal follicles. Epidermal growth factor, T-Box protein 2 and beta-estradiol upstream regulator were predicted to be active in prepubertal follicles. By comparison, tumor protein P53 and let-7 were most active in adult follicles. Conclusion: These results may contribute to a better understanding of the mechanisms governing the development of granulosa cells in the growing follicle in prepubertal sheep.