• Journal of Communications and Networks
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• 제5권3호
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• pp.215-221
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• 2003

It is expected that per-user customized services are widely used in next generation Personal Communication Network. To provide personalized services for each call, per-user service profiles are frequently referenced and signaling traffic is considerably large. Since the service calls are requested from the places where user stays, we can expect that the traffic is localized. In this paper, we propose a new service profile replication scheme, named Follow-Me Replication with local Anchor (FMRA). By replicating user's service profile in a user-specific location area, local anchor of each region, the signaling traffic for call and mobility can be distributed to local network. We compared the performance of the FMRA with two typical schemes: Intelligent Network-based !Central scheme and IMT-2000 based full replication scheme, as we refer it to Follow-Me Replication Unconditional (FMRU). Performance results indicate that FMRA lies between Central and FMRU schemes according to call to mobility ratio, and we identified the efficient ranges of CMR for FMRA depending on the various network parameters.

• 한국정보과학회논문지:정보통신
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• 제30권4호
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• pp.545-558
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• 2003

이동단말의 사용이 보편화 됨에 따라 통신 서비스의 개인화 및 맞춤화 요구가 증가하고 있다. 개인화 서비스의 궁극적인 목표는 사용자가 임의의 망으로 로밍해 가더라도 당초 가입한 서비스와 유사한 형태로(same look and feel) 서비스를 제공하는 가상 홈 환경의 실현에 있다. 가상 홈 환경에서는 개인의 서비스를 정의하는 서비스 프로파일의 관리가 필수 절차가 된다. 이러한 가상 흠 환경을 구현하기 위한 두 가지 방법은 가입자가 로밍하는 곳에 프로과일을 중복하여 방문망 내에서 서비스론 제공하는 무조건추종중복[Follow-Me Replication Unconditional(FMRU)] 기법과, 홈 망의 서비스시스템으로부터 서비스를 실행하는 중앙집중(Central) 기법으로, 전자는 call-to-mobiligy ratio(CMR)이 높은 가입자에게, 후자는 CMR이 낮은 가입자에게 적합하다. 그러나 해당 가입자가 어떤 경우에나 고정된 CMR을 갖는 것은 아니므로 평균적인 CMR로 위 두 기법을 선택하여 적용하는 것은 성능 저하의 문제가 있다. 본 논문에서는 가상 홈 환경에서 서비스 프로파일 관리를 위한 두 가지 기법을 구체화하고, FMRU를 개선한 요구기반 무조건추종중복[Follow-Me Replication Unconditional on-Demand(FMRUD)]기법을 제시하였다. 또한 가입자의 변화하는 CMR에 따라 자동적으로 두 기법을 선택하도록 하는 적응적 추종 중복[Adaptive Follow-Me Replication(AFMR)]기법을 제안하였으며 이들을 비교하였다. 반응 수식을 통한 성능분석 결과 프로파일 크기 관점에서 효율성을 판단하며 CMR 변화를 고려하는 AFMR이 더욱 높은성능을 가짐을 알 수 있다.

• 미생물학회지
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• 제38권3호
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• pp.221-229
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• 2002

일본뇌염바이러스(Japanese encephalitis virus, JEV) Nakayama strain을 초기 multiplicity of infection 5.0으로 Vero세포에 감염하여 1년 이상 안정적으로 바이러스를 방출하는 지속감염(persistently-infected)세포주를 확립하였다. 지속감염 세포에서 지속적으로 방출되는 총 11 개의 Plaque 형태 변이바이러스(morphology mutants)클론을 확보하였다. 분리된 변이바이러스의 복제효율을 분석한 결과 생물학적 표현형과 복제효율은 유의하게 상관하였다. 변이바이러스 RNA 게놈 양 말단의 non-coding region 및 envelop 단백질의 ORF에서는 유의한 염기서열 변화가 관찰되지 않아 JEV 약독화에 새로운 인자가 추가로 관여할 가능성을 제시하였다. 변이바이러스에 감염된 신선한 Vero세포는 wild-type JEV의 일반적 감염성상과 다르게 대다수의 세포가 유의할 만한 세포병변현상을 나타내지 않았다. 감염된 Vero세포에서 wild-type JEV 및 large plaque을 형성하는 변이바이러스의 경우 mRNA와 함께 Bcl-2의 발현은 모두 유의하게 감소하였으며 p53은 뚜렷하게 증가하였다. 반면 small plaque을 형성하는 변이바이러스의 감염세포에서는 Bcl-2와 p53 모두 유의한 변화를 볼 수 없었다. 이상의 결과들과 함께, 감염된 Vero세포의 internucleosomal DNA fragmentation과DNA profile의 유형분석에 따르면 궁극적 인 세포병변효과의 변화는 변이바이러스의 복제효율과 더불어 p53에 비의존적인 apoptosis 수위의 전반적인 감소에 기인하는 것으로 판단된다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 1999년도 가을 학술발표논문집 Vol.26 No.2 (3)
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• pp.748-750
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• 1999

본 논문에서 우리는 통신 비용과 데이터베이스 비용을 감소시키기 위해 사용자 프로파일 복제본을 이용한 동적 위치 관리 기법을 제안한다. 이 기법에서는 위치등록과 호 설정 과정이 통신비용을 감소시킬 수 있는 복제본이 있는 VLR에서 수행되고, 복제본이 있는 VLR에서 호의 빈도커서 데이터베이스 비용을 감소시킨다. 제안한 기법의 성능을 분석하기 위해 분석 모델을 작성하고 제안 기법, IS-41 기법, 복제 기법의 성능 분석을 한다. 사용된 비교 척도는 통신 비용, 데이터 베이스 비용, 총비용 그리고 호 설정 지연이다. 이 척도들에 대해서 제안 기법이 IS-41 기법, 복제 기법보다 더 좋은 성능을 보인다.

• 유공압시스템학회논문집
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• 제5권3호
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• pp.15-22
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• 2008

The road simulators have become common tools within the automotive industry for evaluation of vehicle and vehicle system durability performance. These simulators need appropriate input signal generation algorithms to realize the actual driving conditions due to non-linear vehicle and test rig behaviour. Although somewhat unconventional from a control standpoint, the iteration approach has proven to be a very effective method for control of complex, multiple degree-of-freedom systems where the tracking parameter is known a priori. In this paper, the road profile replication algorithm is verified by applying Belgian road to the developed road simulator. The simulation and experimental results are included to evaluate the performance of this simulator. This road simulator provides considerable savings in cost, development time, and testing risk during developing automotive components.

• 한국가금학회지
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• 제42권3호
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• pp.191-196
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• 2015

함초추출물을 산란계에 급여하여 난생산성, 난품질 및 혈액의 성상에 미치는 영향을 구명하고자 총 216수의 40주령 하이라인 브라운 산란계를 10주간 공시하였다. 함초추출물의 급여수준은 0(대조구), 1cc/L(T1) 및 5cc/L(T2)로 음수로 급여하였으며, 공시계는 처리구당 3반복, 반복당 24수씩 배치하였다. 사양시험의 결과, 함초추출물은 산란계의 난생산성, 난품질 및 혈액의 특성에 부정적인 영향을 미치지 않았으며, 시험 마지막 주의 산란율과 난각 두께를 개선시켰고, 파란율은 유의하게 감소시켰다.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.912-920
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• 2021

SOS response is a conserved response to DNA damage in prokaryotes and is negatively regulated by LexA protein, which recognizes specifically an "SOS-box" motif present in the promoter region of SOS genes. Myxococcus xanthus DK1622 possesses a lexA gene, and while the deletion of lexA had no significant effect on either bacterial morphology, UV-C resistance, or sporulation, it did delay growth. UV-C radiation resulted in 651 upregulated genes in M. xanthus, including the typical SOS genes lexA, recA, uvrA, recN and so on, mostly enriched in the pathways of DNA replication and repair, secondary metabolism, and signal transduction. The UV-irradiated lexA mutant also showed the induced expression of SOS genes and these SOS genes enriched into a similar pathway profile to that of wild-type strain. Without irradiation treatment, the absence of LexA enhanced the expression of 122 genes that were not enriched in any pathway. Further analysis of the promoter sequence revealed that in the 122 genes, only the promoters of recA2, lexA and an operon composed of three genes (pafB, pafC and cyaA) had SOS box sequence to which the LexA protein is bound directly. These results update our current understanding of SOS response in M. xanthus and show that UV induces more genes involved in secondary metabolism and signal transduction in addition to DNA replication and repair; and while the canonical LexA-dependent regulation on SOS response has shrunk, only 5 SOS genes are directly repressed by LexA.

• IMMUNE NETWORK
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• 제11권6호
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• pp.309-323
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• 2011

MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs of about 22 nucleotides that have recently emerged as important regulators of gene expression at the posttranscriptional level. Recent studies provided clear evidence that microRNAs are abundant in the lung, liver and kidney and modulate a diverse spectrum of their functions. Moreover, a large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as infectious diseases, sickle cell disease and endometrium diseases as well as lung, liver and kidney diseases. As a consequence of extensive participation of miRNAs in normal functions, alteration and/or abnormalities in miRNAs should have importance in human diseases. Beside their important roles in patterning and development, miRNAs also orchestrated responses to pathogen infections. Particularly, emerging evidence indicates that viruses use their own miRNAs to manipulate both cellular and viral gene expression. Furthermore, viral infection can exert a profound impact on the host cellular miRNA expression profile, and several RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Here I briefly summarize the newly discovered roles of miRNAs in various human diseases including infectious diseases, sickle cell disease and enodmetrium diseases as well as lung, liver and kidney diseases.

• Asian-Australasian Journal of Animal Sciences
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• 제27권2호
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• pp.217-224
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• 2014

A total of 150 growing ducks were assigned to five dietary treatments to study the effect of sea tangle and charcoal (STC) supplementation on growth performance and meat characteristics in a completely randomized design. There were six replicates and five ducklings in each replication. The five dietary treatments were control, antibiotic, and 0.1%, 0.5%, and 1% STC supplemented diets. No significant differences were found on ADG, ADFI, and gain:feed among treatments in different weeks. The overall (0 to 3 weeks) ADFI decreased in antibiotic treatment (p<0.05) whereas the gain:feed increased significantly upon 1.0% STC supplementation compared to control (p<0.05). No significant variation was found in meat chemical composition except crude fat content which was high in 1.0% STC dietary group (p<0.05). Meat cholesterol was reduced in 0.1% STC group (p<0.05) compared to other dose levels while serum cholesterol was unaffected. High density lipoprotein (HDL) content was high in 1.0% STC (p<0.05) and low density lipoprotein (LDL) was low in 0.1% and 1.0% STC dietary groups (p = 0.06). No significant effect was found on the thiobarbituric acid reactive substances (TBARS) of fresh meat, whereas the TBARS value of meat preserved for 1 week was reduced significantly in STC dietary groups (p<0.05). The 0.1% STC dietary group showed an increased myristic acid (p = 0.07) content whereas, the content of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids increased in STC supplementation than antibiotic group (p<0.05). An increased concentration of omega-3 fatty acids and a reduced ratio of n-6/n-3 PUFA ratio was found upon 1.0% STC supplementation compared to antibiotic dietary group (p<0.05). Therefore, 1.0% STC dietary supplementation can be used as alternatives to antibiotics in duck production.

• Asian-Australasian Journal of Animal Sciences
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• 제30권1호
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• pp.20-33
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• 2017

Objective: Superstimulatory treatment of one-month-old lambs can achieve synchronous development of numerous growing follicles. However, these growing follicles cannot complete maturation and ovulation. Oocyte maturation and competence are acquired during follicular development, in which granulosa cells play an essential role. Methods: In this study, we applied RNA sequencing to analyze and compare gene expression between prepubertal and adult superstimulated follicle granulosa cells in sheep. Results: There were more than 300 genes that significantly differed in expression. Among these differently expressed genes, many extracellular matrix genes (EGF containing Fibulin Like Extracellular Matrix Protein 1, pentraxin 3, adrenomedullin, and osteopontin) were significantly down-regulated in the superstimulated follicles. Ingenuity pathway and gene ontology analyses revealed that processes of axonal guidance, cell proliferation and DNA replication were expressed at higher levels in the prepubertal follicles. Epidermal growth factor, T-Box protein 2 and beta-estradiol upstream regulator were predicted to be active in prepubertal follicles. By comparison, tumor protein P53 and let-7 were most active in adult follicles. Conclusion: These results may contribute to a better understanding of the mechanisms governing the development of granulosa cells in the growing follicle in prepubertal sheep.