• Title/Summary/Keyword: Productivity Enhancement

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Relationship between Cell Size and Specific Thrombopoietin Productivity in Chinese Hamster Ovary Cells during Dihydrofolate Reductase-mediated Gene Amplification

  • Kim, Tae-Kyung;Chung, Joo-Young;Sung, Yun-Hee;Lee, Gyun-Min
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.6 no.5
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    • pp.332-336
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    • 2001
  • When parental Chinese hamster ovary (CHO) cell clones that are capable of producing thrombopoietin (TPO) were subjected to high methotrexate (MTX) concentrations, clonal variations in cell growth were apparent. In the clones that had no significant enhancement in specific TPO productivity (q$\_$Tpo/)when a higher level of MTX was administered, their growth was not depressed significantly nor their cell size changed significantly. On the other hand, those clones that showed a significant-enhancement in q$\_$Tpo/ at higher a MTX dosage, cell growth was depressed initially but recovered during successive sub-cultures. Furthermore, their cell size increased, which suggested that changes in cell size may be indicative of an enhanced q$\_$Tpo/. When the enhancement of the q$\_$Tpo/ of 9 clones after a high MTX dosage was plotted against the extent of the increase of their size, there was a linear correlation (γ$^2$=0.80, p<0.001, ANOVA), which suggested that an enhancement of q$\_$Tpo/ after high MTX administration can be measured by the increase in their cell size. Taken together, our data demonstrate that the selection of amplified CHO cell clones with enhanced q$\_$Tpo/ can be done upon their increased size and growth pattern. This facilitates the development of highly productive recombinant CHO cell lines.

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Development Strategy of Production Management Systems in Korean firms (한국제조업(韓國製造業)의 생산관리(生産管理) 체제(體制)의 발전전략(發展戰略))

  • An, Mun-Yeong;Lee, Geun-Hui
    • Journal of Korean Society for Quality Management
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    • v.19 no.1
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    • pp.170-187
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    • 1991
  • Investments in factory automation do not guarantee productivity enhancement. Much unknown losses may exist in all aspects of production resources such as in material, manpower, machine, etc. Total productivity in korean firms has decreased in recent years. Labor and capital productivity index fall to 0.82 point and 0.73 point, respectively. Investment in FA has Increased rapidly. Tangible fixed assets per capita increased 64% during the past Three years. But, this high-technology oriented systems such as NC, robotics, CAD/CAM, FMS, etc. are often out of keeping with the old production process control, and thus do not result in satisfactory performance. This review paper concerned with these problems and suggests some future directions for production control and development strategy of korean firm's.

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A Study on Influencing Factors on User's Adoption Resistance to Personal Cloud Computing Service (개인용 클라우드 컴퓨팅 서비스 수용저항에 영향을 미치는 요인에 관한 연구)

  • Jo, In-Jea;Kim, Sun-Kyu;Yang, Sung-Byung
    • Knowledge Management Research
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    • v.16 no.1
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    • pp.117-142
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    • 2015
  • Recently, the personal cloud computing service has been being spotlighted as an individual tool of productivity enhancement. However, compared to the rosy forecast, its diffusion rate in the domestic (Korean) market is much slower than expected. In order to find the reason for the slow growth of personal cloud computing service, we attempt to identify influencing factors on user's adoption resistance, while most prior research has focused on the factors affecting its adoption. Based on both the person-technology fit model and the privacy calculus model, we propose technostress and perceived value as key antecedents of adoption resistance. In addition, we identify (1) technical (pace of change and complexity) and personal (self-efficacy) influencing factors on technostress, and (2) beneficial (perceived mobility and perceived availability) and harmful (perceived vulnerability) influencing factors on perceived value. To validate our research model, 133 individual samples were gathered from undergraduate and graduate students who had actual experience of using at least one of personal cloud computing services. The results of the structural equation modeling confirm that both technostress and perceived value have significant effects on adoption resistance, but they have different influencing mechanisms to different types of adoption resistance (indifference, postponement, and rejection). Theoretical and practical contributions are discussed in the conclusion.

Implementation of Cable Drum Scheduling Algorithm for Productivity Enhancement of Power Plant Electrical Installations (발전소 전기설비의 생산성 향상을 위한 케이블 드럼 스케줄링 알고리즘 구현)

  • Lee, Yang-Sun;Park, Ki-Hong;Choi, Hyo-Beom;Oh, Ji-Hyun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.770-771
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    • 2015
  • In this paper, we proposed and implemented the automation of cable drum scheduling which is required a considerable construction cost for electrical equipment in power plant. Implemented cable drum scheduling can be reduced the calculation time of cable drum scheduling, and it is possible to minimize the consuming time of cable drum scheduling than conventional methods. Some experiments are conducted to verify the proposed method, and as a result, the automation of cable drum scheduling is well performed, enabling cables can be optimized and scheduled to fit the drum capacity with productivity enhancement of electrical installations.

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Continuous Alcohol Fermentation by a Tower Fermentor with Cell Recycle Using Flocculating Yeast Strain (Flocculating 효모균주의 재순환에 의한 Tower 발효조를 이용한 연속알콜발효)

  • 페차랏칸자나시리완;유연우김공환
    • KSBB Journal
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    • v.4 no.1
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    • pp.11-14
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    • 1989
  • A study on the continuous fermentation with cell recycle by a tower fermentor to produce ethanol has been carried out. ethanol fermentation was conducted with flocculating yeast strain, Saccharomyces cerevisiae TS4, to compare the ethanol productivity with conventional continuous process. Employing a 15% glucose feed, a cell density of 50 g/l was obtaind. The ethanol productivity of the cell recycle system was found to be 26.5g EtOH/1-hr, which was nearly 7.5 times higher than the conventional continuous process without cell recycle. A cell recycle ratio of 7 to 8 resulted in the highest ethanol productivity and cell concentration. Thus the cell recycle ratio was found to be a key factor in controlling the production of clarified overflow liquid. An aeration rate above 3.8 $\times$ 10-3 VVM seemed to decrease the ethanol productivity. The continuous fermentation with cell recycle was successfully used in the separation of cells from fermentation broth with enhancement of mixing in the tower fermentor.

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A Study of Construction Methods for Quality and Productivity Enhancement of Form Works in the Bearing Wall Systems (벽식구조 거푸집공사의 품질 및 생산성향상을 위한 공법개선 연구)

  • Lee Jung-Ho;Joo Jin-Kyu;Kim Sun-Kuk;Han Choong-Hee
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • autumn
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    • pp.523-526
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    • 2002
  • In the bearing wall systems, a form work has a lot of room that saves cost because it takes a substantial proportion of construction cost. Therefore the systemic and efficient methods are required in the form work. This study focuses on methods that enhance the quality and the productivity of form work and presents the kicker form as an alternative plan to simplify the form work through being modular and automatical it. Work sampling method is used for productivity measurement. It is expected that it will reduce the work process and improve the Qualify and the podructivity of construction.

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Effect Analysis of a Deep Learning-Based Attention Redirection Compensation Strategy System on the Data Labeling Work Productivity of Individuals with Developmental Disabilities (딥러닝 기반의 주의환기 보상전략 시스템이 발달장애인의 데이터 라벨링 작업 생산성에 미치는 효과분석)

  • Yong-Man Ha;Jong-Wook Jang
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.24 no.1
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    • pp.175-180
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    • 2024
  • This paper investigates the effect of a deep learning-based system on data labeling task productivity by individuals with developmental disabilities. It was found that interventions, particularly those using AI, significantly improved productivity compared to self-serving task. AI interventions were notably more effective than job coach-led approaches. This research underscores the positive role of AI in enhancing task efficiency for those with developmental disabilities. This study is the first to apply AI technology to the data labeling tasks of individuals with developmental disabilities and highlighting deep learning's potential in vocational training and productivity enhancement for this group.

Design and Implementation of Monitoring Solution for Improving Productivity (생산성 향상을 위한 모니터링 솔루션 설계 및 구현)

  • Lim, Jae-Hyun;Kong, Heon-Tag
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.8 no.6
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    • pp.1458-1464
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    • 2007
  • Today, domestic and foreign manufacturing industries have to cope with obsolescence of manufacturing equipment because the shifting market trends drive the rapid changes in the production process resulting in stressful operation. Quality control process for manufacturing and production involves a familiar step - when the production process is completed, every item is subjected to various routine tests to determine that it meets the minimum quality standards. Typically, when a faulty product is found, the production line has to be stopped and the current batch is marked for further inspected and exhaustive testing. In this research, we propose a quality monitoring system for productivity enhancement. Our approach aims to reduces the operational down time in the production line of a car-component factory. The proposed monitoring system for productivity enhancement is designed to collect the data through testing at each phase of the assembly line and uses predictive methods on the collected data to achieve early detection of faults in the production process and minimize the number of products in a faulty batch thus minimizing the losses incurred from defective products. More importantly, this system aims to forecast and proactively detect faults and activate warnings when they are detected thus minimizing items in the defective batch, reducing the damage to manufacturing equipment and ultimately reducing the operational downtime or the delay in the resumption of normal factory operation.

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The Effects of Profit-Sharing Schemes on Productivity through Firm's Contribution to the Employee Welfare Fund (사내근로복지기금제도를 통한 이윤공유참여의 생산성효과)

  • Cin, Beom Cheol
    • Journal of Labour Economics
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    • v.26 no.3
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    • pp.115-147
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    • 2003
  • This paper scrutinizes the robustness of the profit-sharing findings first employing an original panel data on the Employee Welfare Fund over the period from 1992 to 2000. In examining the effects of profit-sharing schemes on labor productivity, it controls for simultaneity among profit-sharing, production factors, and productivity using both the two-stage least squares procedure and the lagged variable method. The empirical results show that an increase in firm's contribution to the Employee Welfare Fund is associated with capital-embodied and disembodied productivity enhancement, which is both statistically and economically highly significant. The empirical results are in contrast with predictions of both agency and transaction cost theories, and they imply that more tax benefits and financial incentives for expansion of the Employee Welfare Fund should be required to get productivity gains.

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Manufacturing and Molding Technology of $500{\mu}m$ 8Cavity Injection Molding System (500um급 8캐비티 사출금형설계 제작 및 성형기술)

  • Lee, S.H.;Cho, K.H.;Lee, J.W.;Ko, Y.B.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2008.10a
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    • pp.444-447
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    • 2008
  • Recently, the need of thin-walled injection molding and enhancement of its productivity is greatly increased. In this study, we designed and manufactured a injection molding system, which can mold a part with the thickness of $500{\mu}m$ and 8 cavity. And processing technique for the multi-cavity injection molding system, which is capable of mass productivity on the plastic parts, was considered. The problems of unbalance/imbalance on the molding process for the multi-cavity mold were predicted by numerical analysis using plastic injection molding commercial code. In addition, controllable system of melt front filling was introduced for a balanced filling using the mold temperature sensor on injection mold. It was shown that balanced filling with the suggested injection molding system was possible for $500{\mu}m$ plastic parts with 8 cavity layout.

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