• Natural Product Sciences
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• 제14권3호
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• pp.182-186
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• 2008

Scutellaria baicalensis Georgi (SBG) is traditionally used medicinal herb that has anti-oxidant, anticancer and anti-inflammatory effects. In this study, we investigated whether the extracts of SBG have the inhibitory activity in the osteoclast differentiation by using mouse monocytes RAW264.7 cells and primary mouse bone marrow-derived macrophages (BMMs). Methanol extract (ME) from SBG was successively fractionated into methylene chloride (MF), ethylacetate (EF) and n-butanol fraction (BF). The activity assay for tartrateresistant acid phosphatase (TRAP) and Western blot analysis were employed to evaluate the osteoclasts differentiation and the activation of mitogen-activated protein (MAP) kinases, respectively. ME, MF, EF and BF significantly and dose-dependently inhibited osteoclast differentiation without the decrease of cell viability at the concentrations used in this study. In addition, ME significantly inhibited the activation of c-jun-N-terminal kinase (JNK). In conclusion, this study firstly demonstrated that ME of SBG has the potential to inhibit the osteoclast differentiation through the suppression of JNK activation partially.

• Natural Product Sciences
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• 제16권4호
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• pp.291-294
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• 2010

In obesity, adipocytes undergo abnormal growth characterized by increased cell numbers and differentiation. Thus, inhibition of mitogenesis of preadipocytes and their differentiation to adipocytes would be beneficial for the prevention and progression of obesity. In the present study, we attempted to evaluate antiadipogenic activity of adlay (Coix seed, the seed of Coix lacryma-jobi L. var. ma-yuen Stapf) employing preadipocytes cell line, 3T3-L1 as an in vitro assay system. Because several varieties of adlay are in use in Korea, anti-adipogenic activity of three varieties of adlay such as Sang-Gang, Jo-Hyun and Yulmu-Ilho was evaluated. All the three varieties of adlay showed significant inhibitory activity on adipocyte differentiation as assessed by measuring fat accumulation using Oil Red O staining. Adlay, however, showed little effects on adipocyte proliferation. Further studies with interval treatment demonstrated that adlay exerted inhibitory activity on adipocyte differentiation via acting on early stage of adipogenesis. Taken together, adlay might be useful in the prevention of obesity.

• 감성과학
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• 제9권spc3호
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• pp.225-234
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• 2006

최근 차량용 Navigation은 우리나라에서 급속도로 발전하는 Emerging Market으로 실시간 교통정보와 DMB TV, 영화, 음악, 게임 등 다양한 복합기능을 추가하면서 Car Infotainment(Information & Entertainment) 핵심 기기로 진화해가고 있다. 반면 시장진입에 따른 기술 장벽이 낮고 경쟁이 치열한 상황에서 제품디자인 차별화가 중요한 요소로 부각되고 있다. 이에 본 사례연구에서는 A/V 전문기업 인켈이 $\ulcorner$와이드터치(WideTouch)$\lrcorner$라는 신규 브랜드로 차량용 Navigation 시장에 진출한 사례를 중심으로 선행 수요자 니즈 조사를 통한 Concept 발굴과 신세대 및 중 장년층, 여성 Targe시장 세분화에 의한 디자인 차별화 전략 및 그 성공 요인을 분석하였다.

• 복식
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• 제60권4호
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• pp.1-17
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• 2010

There had been studied for a function of fashion illustration that has various capability of differentiation among fashion products since year 2000. A fashion products adopted the illustration is stand out not only to increase the goods profits by consumers who is willing to purchase the products with specified identity but also to execute differentiation strategy in a market. The aim of this study is the theoretical approach of fashion illustration and examined the development process of the products based on the supporting documents of cooperations, other records and actual application cases. Also, expression techniques of fashion illustration, image features and etc. are mainly studied and following representative results are projected through the data. First, the success of fashion commercialization using fashion illustration should have mutual organic function which requires three factors such as product project, marketing, the role of illustration. Second, An illustration of hand drawing expression technique is more helpful in differentiation of fashion product than using computer graphic, embroidery, collage technique and the fashion products vividly expressed with sensuous illustration tend to have higher preference. Third, the possibility of success the fashion products is often affected by the distinct identification and the precise positioning while the illustration is used.

• 응용통계연구
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• 제34권1호
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• pp.9-23
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• 2021

본 논문에서는 평균장 방법(mean-field methods)을 기반으로 사후 분포(posterior distribution)를 근사하는 방법인 변분 베이즈 방법(variational Bayes methods)에 대해 소개한다. 특히, 모수들을 실수공간으로 변환 후의 결합 사후분포를 가우시안 분포(Gaussian distribution)들의 곱(product)으로 근사하는 방법인 자동 미분 변분 추론(automatic differentiation variational inference)방법에 대해 자세히 소개하고, 환자에게 약물을 투여한 후 시간에 따라 약물의 흐름을 파악하는 연구인 약물동태학 모형(pharmacokinetic models)에 적용한다. 소개된 변분 베이즈 방법을 이용하여 자료분석을 실시하고 마코프 체인 몬테 카를로(Markov chain Monte Carlo)방법을 기초로한 자료분석의 결과와 비교한다. 알고리즘의 구현은 Stan을 이용한다.

• 한국프랜차이즈경영연구
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• 제13권1호
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• pp.19-33
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• 2022

Purpose: Based on the resource-based view and the competitive advantage theory, the study views marketing capabilities (product, pricing, delivery/inventory, and promotional support) as sources of competitive advantage (differentiation advantage and low-cost advantage) and examines their impacts on competitive advantage, which in turn, will influence non-business and business performance. Research design, data and methodology: Data were collected from 149 representatives of franchising companies in South Korea and analyzed with SmartPLS 3.3.7. Results: First, promotional support and product have a significant impact on differentiation advantage. Second, pricing and promotional support have a significant impact on low-cost advantage. Third, differentiation advantage has an influence on non-financial and financial business performance. Fourth, low-cost advantage has an impact on non-financial performance but has no significant direct impact on financial performance. Fifth, non-financial performance is related to financial performance. Finally, the result of IPMA shows that importance and performance values of exogeneous variables are different depending on firm size. Conclusions: The findings suggest that franchisors should focus on different marketing capabilities depending on their strategic focus and objectives. Finally, the findings based on an IPMA suggest that small companies perceive low-cost advantage as important, while their counterparts do not. Several theoretical and managerial implications are offered.

• 경영과학
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• 제21권3호
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• pp.1-12
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• 2004

The paper demonstrates that versioning of digital products occurs more frequently than that of physical products because of low marginal cost. The versioning occurs no matter what a customer knows his/her reservation price. Low-quality version will not be produced when the difference between reservation prices is very large. The paper also shows that a firm tries to lower the quality of low-quality product to prevent customers with high reservation prices from purchasing low-quality product.

• 한국IT서비스학회지
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• 제8권2호
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• pp.205-228
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• 2009

This paper examines how online product information changes the customers' purchase intentions from subjectivity-objectivity dichotomy perspective. Quality and Preference are proposed as product evaluation criteria and their marginal changes with product information differentiation are hypothesized. An experimental survey was conducted to 57 subjects and the hypotheses were partially supported through PLS path comparison method. The study contributes to IS research by proposing a simple and effective product evaluation framework and by abstracting the impact of product information from other factors. Finally, we suggest the utilization of product information with the optimization of the cost-benefit structure between information and purchase intention.

• 한국IT서비스학회지
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• 제8권1호
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• pp.217-229
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• 2009

Manufacturers have recently faced such problems like limitation of product differentiation, product commoditization and increased service request level from customers, Some manufacturers have responded the problems by introducing new business model, 'product and service integrated offering', which integrate product and its services as a bundled package, This article introduces innovative 7 cases of 'product and service integrated offering', and provides case analyses : types, methods, purposes, and risks of integration, The result of analysis, 4 strategic directions for product and service integration offering, could help manufacturers to adopt and build their model successfully, Further research topics are field survey with meaningful sample size including Business-to-Consumer and finding new causal relationships among variables like characteristics of industry, product, Integration, interaction between provider and customer, A development of design methodology on how to plan and develope a sound product service integration is the second next step for the research.

• 한국가금학회지
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• 제26권1호
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• pp.43-50
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• 1999

The features of special brand eggs are growing more and more diverse and it is hard to draw a clear distinction between these and ordinary (no-brand) eggs. Special brand eggs range from those with objectively recognizable characteristics to those given only an unsubstantial product image and price differentials are among them great, too. The relation between product features and prices is unclear. Special brand eggs are the commodity whose characteristics are the vaguest of all livestock products. Farm's brand eggs produce a high profitability to producers is they are directly sold to consumers, by, for example, home-delivery service. But if they are sold to supermarkets, etc., producer's (poultry farmer's) income becomes lower by the amount of distributors' margin, reducing the profitability substantially. Thus how to increase the ration of retailing is important for farmers to secure a high profit. The sales strategies of poultry are the combination of two elements, that is, new product development (product differentiation) and creation of new market. But it is difficult for special brand egg producers to develop products with clear characteristics (use value) distinct form ordinary eggs and so these producers depend on the factors of appearance, such as the color of egg shells and package. Special brand eggs manage to keep their marketable value by the combination of the few product features and product image. Thus NB eggs from feed producers have a great market-ability since they can take advantage of the power of patents and TV commercials. However, market differentiation affects profitability much more than product features and price gaps are very wide between directly sold and wholesaled eggs. The producers of special brand eggs have come to the turning point where they have to decide whether they will content with being the subcontractors for NB and PB eggs or they will continue to keep their independence in production and marketing.