• The Korean Journal of Pharmacology
• /
• 제31권2호
• /
• pp.145-152
• /
• 1995

The effects and interactions of $4{\beta}-phorbol$ 12,13-dibutyrate(PDB) and polymyxin B(PMB) with adenosine on the electrically-evoked norepinephrine (NE) release were studied in the rat hippocampus. Slices from the rat hippocampus were equilibrated with $^3H-noradrenaline$ and the release of the labelled product, $^3H-NE$, which evoked by electrical stimulation$(3\;Hz,\;2\;ms,\;5\;VCm^{-1},\;rectangular\;pulses)$ was measured. PDB$(0.3{\sim}10\;{\mu}M)$, a selective protein kinase C(PKC) activator, increased the evoked NE release in a dose related fashion while increasing the basal rate of release. And the effects of $1\;{\mu}M$ PDB were significantly inhibited by $0.3\;{\mu}M$ tetrodotoxin(TTX) pretreatment or $Ca^{++}-free$ medium. $PMB(0.03{\sim}1\;mg)$, a specific PKC inhibitor, decreased the NE release in a dose dependent manner while increasing the basal rate of release. Adenosine $(1{\sim}10\;{\mu}M)$ decreased the NE release without changing the basal rate of release, and this effect was significantly inhibited by 8-cyclopentyl-1,3-dipropylxanthine$(2\;{\mu}M)$, a selective $A_1-receptor$ antagonist, treatment. Also, adenosine effects were significantly inhibited by PDB-and PMB-pretreatment. These results suggest that the PKC plays a role in the NE release in the rat hippocampus and might be participated in a post-receptor mechanism of the $A_1-adenosine$ receptor.

• Proceedings of the Safety Management and Science Conference
• /
• 대한안전경영과학회 2001년도 춘계학술대회
• /
• pp.117-126
• /
• 2001

본 연구는 TL 9000 성과지표 : R 2.5 및 이를 QUEST FORUM Web Site에서 등록하기 위한 절차 및 Data Flow를 소개한다. 끝으로 TL 9000 성과지표 : R 3.0 및 Product Category 중 R 2.5에서 개정된 주요부분을 소개하며 향후 성과지표 개발 가이드라인에 대해 언급한다.

• Proceedings of the Korean Nuclear Society Conference
• /
• 한국원자력학회 2002년도 춘계공동학술발표회요약집
• /
• pp.158-158
• /
• 2002

• Proceedings of the Korean Nuclear Society Conference
• /
• 한국원자력학회 2002년도 추계학술발표회요약집
• /
• pp.213-213
• /
• 2002

• Proceedings of the Korean Nuclear Society Conference
• /
• 한국원자력학회 2005년도 추계학술발표회
• /
• pp.29-30
• /
• 2005

• Asian-Australasian Journal of Animal Sciences
• /
• 제14권3호
• /
• pp.333-337
• /
• 2001

This study investigated the effects of fermented product from Bacillus subtilis (FPBS) on feed conversion efficiency, fat accumulation and ammonia production in broiler chicks. Sixty female broilers (strain Chunky, 7-day old) were divided into four groups and raised in individual cages. One group was fed a commercial diet without supplementation of FPBS as the control and the other three groups were fed commercial diets containing FPBS, either 0.5, 1.0 or 2.0%, for 21 days from 7 to 28 days of age. Water and feed were given ad libitum. Feed conversion efficiency was significantly improved in chicks supplemented with 0.5 or 1.0% of FPBS as compared with the control (p<0.05). The activities of hepatic acetyl-CoA carboxylase and fatty acid synthetase, and contents of triglyceride and cholesterol in the liver were significantly decreased in treatment groups (p<0.05) as compared with the control group. FPBS had no effect on the concentration of plasma triglyceride, phospholipids and cholesterol. Feeding FPBS at 1 % or 2% levels reduced ammonia gas release (p<0.05). The inclusion of FPBS at 1 % level may be recommended both to improve production efficiency and to reduce air pollution caused by ammonia gas release. For production efficiency to reach maximal profit, the inclusion of FPBS at 0.5% level can be recommended. Feeding FPBS reduced fat accumulation in the liver.

• Bulletin of the Korean Chemical Society
• /
• 제27권10호
• /
• pp.1618-1622
• /
• 2006

Bacteriophage T7 gp4A' is a ring-shaped hexameric DNA helicase that catalyzes duplex DNA unwinding using dTTP hydrolysis as an energy source. To investigate the effect of single-stranded DNA (ssDNA) on the kinetic pathway of dTTP hydrolysis by the T7 DNA helicase complexed with ssDNA, we have first determined optimal concentration of long circular M13 single-stranded DNA and pre-incubation time in the absence of $Mg^{2+}$ which is necessary for the helicase-ssDNA complex formation. Steady state dTTP hydrolysis in the absence of $Mg^{2+}$ by the helicase-ssDNA complex provided $k_{cat}$ of $8.5\;{\times}\;10^{-3}\;sec^{-1}$. Pre-steady state kinetics of the dTTP hydrolysis by the pre-assembled hexameric helicase was monitored by using the rapid chemical quench-flow technique both in the presence and absence of M13 ssDNA. Pre-steady state dTTP hydrolysis showed distinct burst kinetics in both cases, indicating that product release step is slower than dTTP hydrolysis step. Pre-steady state burst rates were similar both in the presence and absence of ssDNA, while steady state dTTP hydrolysis rate in the presence of ssDNA was much faster than in the absence of ssDNA. These results suggest that single-stranded DNA stimulates dTTP hydrolysis reaction by T7 helicase by enhancing the rate of product release step.

• Korean Journal of Applied Biomechanics
• /
• 제22권2호
• /
• pp.131-140
• /
• 2012

This study was to investigate the relationship between the distance and projection factors, angle factors of javelin in women's javelin throwing. The data were collected in the 2011 National Sports Festivals for 11 players. Three-Dimensional motion analysis using a system of 4 video cameras at a sampling frequency of 60 fields/s was performed for this study. The factors of release conditions calculated using Matlab 2009a program. The statical analysis on the records(n=42) included mean and standard deviation of the mean(SD), Pearson's product moment correlation coefficient(SPSS Version 16.0 for Windows). There was a statistically significant positive relationship between the records and release velocity(r=.866, p<.01), height(r=.433, p<.01) and height rate(r=.340, p<.05). The attitude angle, release angle, and attack angle showed not a statistically significant relationship between the records. The medial-lateral tilt angle of javelin showed not a statistically significant relationship between the records, but the yaw angle of javelin(r=.549, p<.01) showed a statistically significant positive relationship between the records.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
• /
• 제7권9호
• /
• pp.141-149
• /
• 2017

Numerous products are on the market every day and consumption is becoming increasingly polarized. Some products have been introduced to the market for the first time and others are the existing products that have upgraded performance. For companies, new products must be released constantly to prevent losing existing customers and to increase loyalty. However, when companies released new product, they communicate consumer brand name and core benefits of the new product. Moreover, if a new product fails, the amount that the company has to pay is bound to grow. So companies often use brand extension strategies that use the names of famous brands that are already loved by their customers for new products. In this study, the effect of extension similarity, time of release, and message type on brand extension was investigated. Result shows that using abstract messages rather than specific messages is more effective when similarities with existing brands are poor. In particular, the closer the release period is, the more effective these effects are. However, in case of extending the brand with high similarity products, it is effective to focus on concrete messages when the release time is near, and to communicate abstract messages when the release time is long. This result suggests that companies should take into consideration not only the similarity of extension but also the timing and characteristics of messages when extending the brand.

• Journal of Radiation Protection and Research
• /
• 제42권2호
• /
• pp.114-129
• /
• 2017

Background: The purpose of this paper is to confirm the event timings and the magnitude of fission product aerosol release from the Fukushima accident. Over a few hundreds of technical papers have been published on the environmental impact of Fukushima Daiichi accident since the accident occurred on March 11, 2011. However, most of the research used reverse or inverse method based on the monitoring of activities in the remote places and only few papers attempted to estimate the release of fission products from individual reactor core or from individual spent fuel pool. Severe accident analysis code can be used to estimate the radioactive release from which reactor core and from which radionuclide the peaks in monitoring points can be generated. Materials and Methods: The basic material used for this study are the initial core inventory obtained from the report JAEA-Data/Code 2012-018 and the given accident scenarios provided by Japanese Government or Tokyo Electric Power Company (TEPCO) in official reports. In this research a forward method using severe accident progression code is used as it might be useful for justifying the results of reverse or inverse method or vice versa. Results and Discussion: The release timing and amounts to the environment are estimated for volatile radioactive fission products such as noble gases, cesium, iodine, and tellurium up to 184 hours (about 7.7 days) after earthquake occurs. The in-plant fission product behaviors and release characteristics to environment are estimated using the severe accident progression analysis code, MELCOR, for Fukushima Daiichi accident. These results are compared with other research results which are summarized in UNSCEAR 2013 Report and other technical papers. Also it may provide the physically based arguments for justifying or suspecting the rationale for the scenarios provided in open literature. Conclusion: The estimated results by MELCOR code simulation of this study indicate that the release amount of volatile fission products to environment from Units 1, 2, and 3 cores is well within the range estimated by the reverse or inverse method, which are summarized in UNSCEAR 2013 report. But this does not necessarily mean that these two approaches are consistent.