• BMB Reports
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• v.35 no.2
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• pp.244-247
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• 2002

Replacement of the Asp-84 residue of the deoxyguanosine kinase subunit of the tandem deoxyadenosine kinase/deoxyguanosine kinase (dAK/dGK) from Lactobacillus acidophilus R-26 by Ala, Asn, or Glu produced increased $K_m$ values for deoxyguanosine on dGK. However, it did not seem to affect the binding of Mg-ATP. The Asp-84 dGK replacements bad no apparent effect on the binding of deoxyadenosine by dAK. However, the mutant dGKs were no longer inhibited by dGTP, normally a potent distal end-product inhibitor of dGK. Moreover, the allosteric activation of dAK activity by dGTP or dGuo was lost in the modified heterodimeric dAK/dGK enzyme. Therefore, it seems very likely that Asp-84 participates in dGuo binding at the active site of the dGK subunit of dAK/dGK from Lactobacillus acidophilus R-26.

• Journal of Technology Innovation
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• v.24 no.3
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• pp.81-105
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• 2016

The purpose of this study is to estimate the cost-saving effect of R&D investment in the ICT industry. As is well known, the R&D investment induces both the product innovation and the process innovation, in turn leads the effect of creating profit and cutting cost. However, it appears that studies concerned with the cost-saving effect of R&D investment have been unproductive, while most existing studies concentrate on the topic involved with the creating profit of R&D investment. Therefore, we extend the effect of R&D investment to a framework of the cost-saving focusing on the ICT industry. To empirically analyze the effect, we built a simultaneous three-equation model comprising a translog cost function and two cost share equations, and employed the SUR analysis. As a result, we found out that the cost-saving effect on the total cost is statistically significant. In addition, we examined relationships between the R&D investment and each cost of production elements. The results show that on the one hand, the R&D investment and the intermediate good cost have the substitution relationship. On the other hand, the complementary relationship is observed between the R&D investment and each labor or capital cost.

• Bulletin of the Korean Mathematical Society
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• v.52 no.5
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• pp.1549-1557
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• 2015

Characterizations of closed subgroups in abelian groups have been generalized to modules in essentially dierent ways; they are in general inequivalent. Here we consider the relations between these generalizations over commutative rings, and we characterize the commutative rings over which they coincide. These are exactly the commutative noetherian distributive rings. We also give a characterization of c-injective modules over commutative noetherian distributive rings. For a noetherian distributive ring R, we prove that, (1) direct product of simple R-modules is c-injective; (2) an R-module D is c-injective if and only if it is isomorphic to a direct summand of a direct product of simple R-modules and injective R-modules.

• Design & Manufacturing
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• v.8 no.2
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• pp.37-40
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• 2014

A discharge electrode plays a role of shaving off workpiece with spark generated by current in discharge machining. Accordingly, for the discharge electrode, an electrode with excellent wear resistance is necessary. Generally, Graphite and Cu are used as the materials of the electrode, and recently Cu-W is mainly used as an electrode with excellent wear resistance. However, the form of the electrode generally used is produced mostly using cutting work, so a lot of costs incur if several similar forms are needed. Thus, this study developed a Cu-W electrode using Metal Injection Molding (MIM) process to produce similar forms with excellent productivity and a great quantity of electrodes in a similar form in discharge machining and carried out a discharge machining test. In developing an electrode applying MIM, predicting contraction of a product in a sintering process, a mold expansion ratio of 1.29486 was given, but the actual product showed a percentage of contraction 24% to 32%, which showed a difference of 3% to 5%. In addition, to verify wear resistance of the discharge electrode, abrasion loss was measured after the discharge.

• Journal of Plant Biotechnology
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• v.35 no.1
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• pp.5-12
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• 2008

The transgenic technologies and their product (living modified organisms) have been developed and commercialized enough to get much attention in terms of their potentials to solve the current global difficulties such as shortage of food and energy. Furthermore, they are expected to make a big role in improving human health levels and creating bio-economy as innovative tools to pursue environmentally sound economic development. However, for the technologies and products to be developed and used in such a way that they continuously give a good impact to human society, first and foremost safety issues surrounding them should be dealt with. Every stage from in-house R&D, pilot field application to on the shelves should be managed to ensure safety following them because many consumers tend to have fear before they get the right or needed information on the modern biotechnology. In this sense, managing research facilities and LMOs for R&D from the point of safety is very crucial in that they are in the early stage of technology or product development. This paper especially deals with those to be complied with by researchers according to the Act on transboundary movement of LMOs, etc, entered into the effect from Jan. 1 2008.

• Journal of Powder Materials
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• v.24 no.6
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• pp.494-507
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• 2017

A three-dimensional physical part can be fabricated from a three-dimensional digital model in a layer-wise manner via additive manufacturing (AM) technology, which is different from the conventional subtractive manufacturing technology. Numerous studies have been conducted to take advantage of the AM opportunities to penetrate bespoke custom product markets, functional engineering part markets, volatile low-volume markets, and spare part markets. Nevertheless, materials issues, machines issues, product issues, and qualification/certification issues still prevent the AM technology from being extensively adopted in industries. The present study briefly reviews the standard classification, technological structures, industrial applications, technological advances, and qualification/certification activities of the AM technology. The economics, productivity, quality, and reliability of the AM technology should be further improved to pass through the technology adoption lifecycle of innovation technology. The AM technology is continuously evolving through the introduction of PM materials, hybridization of AM and conventional manufacturing technologies, adoption of process diagnostics and control systems, and enhanced standardization of the whole lifecycle qualification and certification methodology.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.3
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• pp.12-18
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• 2014

This paper describes about the development of new concept's rear wheel guards for the reduction of Road Noise in the passenger vehicle using test. The new wheel guards are proposed by various frequency chamber concept and different textile layers concept. Two wheel guards were verified by small cabin resonance test and vehicle test. Through new developing process without vehicle test, Result of road noise will be expected when new concepts and materials of wheel guard is applied into automotive vehicle. As a result of the application of Aimed Helmholtz and Multi-layers concept, this paper classifies the road noise, cost and weight are reduced by new concepts and the solutions are adopted into the 2 cars.

• Applied Chemistry for Engineering
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• v.3 no.4
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• pp.588-594
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• 1992

Polyisocyanurate has been obtained from toluene diisocyanate(TDI) in the presence of potassium octoate catalyst and the effects of water and butanol in solvent were studied for the determination of the change of viscosity, the reaction time (length of time required for 5 poise of viscosity of product), molecular dispersity of product, and TDI conversion. When butyl acetate contains 0.1% of water by weight, uretidione was formed and a higher conversion was obtained at the condition. The uretidione was not formed by adding butanol to the solvent. At a higher concentration of butanol, a higher TDI conversion and a wider molecular dispersity were obtained.

• Design & Manufacturing
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• v.14 no.3
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• pp.1-7
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• 2020

This paper predicts the mass and the length of injection-molded products through the Artificial Neural Network (ANN) method. The ANN was implemented with 5 input parameters and 2 output parameters(mass, length). The input parameters, such as injection time, melt temperature, mold temperature, packing pressure and packing time were selected. 44 experiments that are based on the mixed sampling method were performed to generate training data for the ANN model. The generated training data were normalized to eliminate scale differences between factors to improve the prediction performance of the ANN model. A random search method was used to find the optimized hyper-parameter of the ANN model. After the ANN completed the training, the ANN model predicted the mass and the length of the injection-molded product. According to the result, average error of the ANN for mass was 0.3 %. In the case of length, the average deviation of ANN was 0.043 mm.

• Journal of Information Technology Applications and Management
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• v.20 no.2
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• pp.39-56
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• 2013

There have been many studies that open innovation activities have positive effects on firm performance. However, the previous studies have shown conflicting results, depending on the characteristics of companies or the timing of the product launch. This study empirically compares open innovation performance of first-mover companies and follower companies. The analyses are performed on the samples of the Korean Innovation Survey 2010 companies that explored external information and performed R&D cooperation. The results indicate that open innovation activities can have different effects depending on a company's status in the market. For the first-mover companies, the intensity of utilizing external information has greater impact on the firm's performance than the diversity of it. By contrast, for the follower companies, the diversity of utilizing external information has greater impact on the firm's performance than the intensity of it. In terms of R&D cooperation, the external cooperation is found not to have significant effects on a first-mover company's performance. However, external R&D cooperation of a follower company is showing positive impact on the firm's performance. The implication of the study is to analyze the firm's Open-Innovation performance by comparing first-mover companies with follower companies. Therefore, companies need to execute the Open-Innovation strategy by considering firm characteristics or the timing of the product launch.