• 한국디지털정책학회:학술대회논문집
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• 2005.06a
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• pp.505-516
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• 2005

According to Mead's (1934) symbolic interaction theory, social roles are learned through interaction and experiences in everyday life. Over time, these rules of behavior become internalized and serve to structure one's actions accordingly. Ultimately, these rules provide us with a powerful means of controlling our actions, and in time, they define our identity. Transforming the socialization process is one's conscious interpretation of stimuli through the use of symbols. Furthermore, society's perceptual processes can be shaped by the symbols we learn. The meaning of symbols can be learned from a variety of social influences, one of which may be mediated messages and advertising. This paper attempts to establish a link between media exposure and one's perception of social reality regarding character judgments made of unknown others based on the target's product or brand usage. Using magazine advertisements for fictitious products, the experiment herein seeks to establish two fundamental goals: 1) to determine if perceptions can be manipulated via association with companion symbolic elements: and 2) to detect whether television exposure is a moderating factor. Respondents were asked their perceptions of both product quality and of product users.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.9 no.1
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• pp.33-42
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• 1997

The reciprocating compressors are widely used in industrial fields for its simplicity in principle and high efficiency. But the design of it requires rigorous experiments due to its high dependence on many design parameters. In this work, a mathematical model is developed so that we can analyze the gas-solid interaction during the whole working processes of a reciprocating compressor. The governing equations, which represent the fluid-solid interaction, was derived from the unsteady Bernoulli's equation with the assumption of quasi-steady working process. The valve itself was assumed to be a one degree of freedom spring-mass-damper system. A simple thermodynamic relation, the ideal gas state equation, was used to give it an external force term assuming that the refrigerant behaves like an ideal gas. It was suggested to use a motor of higher driving frequency to enhance the performance of the reciprocating compressor without causing a faster failure of the valve.

• Molecules and Cells
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• v.44 no.9
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• pp.670-679
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• 2021

Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N-ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. They are involved in diverse physiological processes in plants by interacting with distinct plasma membrane (PM) syntaxins. Here, we show that synaptotagmin 5 (SYT5) is involved in plant defense against Pseudomonas syringae pv tomato (Pst) DC3000 by regulating SYP132-VAMP721/722 interactions. Calcium-dependent stimulation of in vitro SYP132-VAMP722 interaction by SYT5 and reduced in vivo SYP132-VAMP721/722 interaction in syt5 plants suggest that SYT5 regulates the interaction between SYP132 and VAMP721/722. We interestingly found that disease resistance to Pst DC3000 bacterium but not to Erysiphe pisi fungus is compromised in syt5 plants. Since SYP132 plays an immune function to bacteria, elevated growth of surface-inoculated Pst DC3000 in VAMP721/722-deficient plants suggests that SYT5 contributes to plant immunity to Pst DC3000 by promoting the SYP132-VAMP721/722 immune secretory pathway.

• Journal of the Korea Safety Management & Science
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• v.14 no.4
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• pp.107-116
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• 2012

The issues raised so far in the development of safety-critical systems have centered on how effectively the safety requirements are met in systems design. The systems are becoming more complex due to the increasing demand on the functionality and performance. As such, the integration of both the systems design and systems safety processes becomes more important and at the same time quite difficult to carry out. In this paper, an approach to solving the problem is presented, which is based on an integrated data model. To do so, the data generated from the inputs and outputs of the systems design and systems safety processes are analyzed first. The results of analysis are used to extract common attributes among the data, thereby making it possible to define classes. The classes then become the cores of the interface data model through which the interaction between the two processes under study can be modeled and interpreted. The approach taken has also been applied in a design case to demonstrate its value. It is expected that the results of the study could play a role of the stepping stone in extending to the architecture development of the integrated process.

• International Journal of Computer Science & Network Security
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• v.22 no.11
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• pp.255-259
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• 2022

The new social reality emerging amid the global rise of communication links and integration processes acutely emphasizes the problems of communication in large and small social systems. The method of their communication becomes one of the keys to ensuring global security. It has become the mission of humanitarian education to prepare the younger generations for life in a changing world with no image of the future and increasing uncertainty. In psychological and pedagogical research, there is a growing scientific interest in the problems of interaction of the individual with the social environment. The mental trace of a person's practice in society shapes the experience of social interaction, which constitutes simultaneously the source, tool, and condition for the emergence and development of personality. The study outlines the methodological foundations for the study of individual experiences of social interaction. A hypothesis about the productivity of the functional matrix method is tested. Materials for the training of specialists in the humanities include interdisciplinary approaches to the study and transformation of the experience of social interaction and systematic methodology for the study of complex objects. Fundamental to the study is the systematic-dialectical method, and the matrix method is employed as the instrumental-technological method. The paper presents the results of a multidisciplinary overview of scientific literature concerning the essential characteristics and functions of social interaction and the respective experience. The overview points to the fragmented nature of scientific understanding of the elements of experience outside its integrity and systemic properties. Based on the formula "personality interacts with the social environment", the study presents an algorithm for the application of a systematic methodology for the study of complex objects, which made it possible to identify the system parameters of experience at three levels of cognition and develop the reference structural and functional matrices for the didactic system of its pedagogical enrichment.

• Proceedings of the KSPS conference
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• 2006.11a
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• pp.99-108
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• 2006

Three experiments were conducted to determine the exact locus of the frequency effect in speech production. In Experiment 1. a picture naming task was used to replicate whether the word frequency effect is due to the processes involved in lexical access or not. The robust word frequency effect of 31ms was obtained. The question to be addressed in Experiment 2 is whether the word frequency effect is originated from the level where a lemma is selected. To the end, using a picture-word interference task, the significance of interactions between the effects of target frequency, distractor frequency and semantic relatedness were tested. Interaction between the distractor frequency and semantic relatedness variables was significant. And interaction between the target and distractor frequency variables showed a significant tendency. In addition, the results of Experiment 2 suggest that the mechanism underlying the word frequency effect is encoded as different resting activation level of lemmas. Experiment 3 explored whether the word frequency effect is attributed to the lexeme level where phonological information of words is represented or not. A methodological logic applied to Experiment 3 was the same as to Experiment 2. Any interaction was not significant. In conclusion, the present study obtained the evidence supporting two assumptions: (a) the locus of the word frequency effect exists in the processes involved in lemma selection, (b) the mechanism for the word frequency effect is encoded as different resting activation level of lemmas. In order to explain the word frequency effect obtained in this study, the core assumptions of current production models need to be modified.

• Genomics & Informatics
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• v.21 no.2
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• Molecules and Cells
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• v.41 no.9
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• pp.842-852
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• 2018

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

• Molecules and Cells
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• v.26 no.1
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• pp.100-105
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• 2008

Glycogen synthase kinase $3{\beta}$ (GSK $3{\beta}$) is a serine/threonine kinase that phosphorylates substrates such as ${\beta}$-catenin and is involved in a variety of biological processes, including embryonic development, metabolism, tumorigenesis, and cell death. Here, we present evidence that human GSK $3{\beta}$ is associated with Fe65, which has the characteristics of an adaptor protein, possessing a WW domain, and two phosphotyrosine interaction domains, PID1 and PID2. The GSK $3{\beta}$ catalytic domain also contains a putative WW domain binding motif ($^{371}PPLA^{374}$), and we observed, using a pull down approach and co-immunoprecipitation, that it interacts physically with Fe65 via this motif. In addition, we detected co-localization of GSK $3{\beta}$ and Fe65 by confocal microscopy, and this co-localization was disrupted by mutation of the putative WW domain binding motif of GSK $3{\beta}$. Finally, in transient transfection assays interaction of GSK $3{\beta}$ (wt) with Fe65 induced substantial cell apoptosis, whereas interaction with the GSK $3{\beta}$ AALA mutant ($^{371}AALA^{374}$) did not, and we noted that phosphorylation of the Tyr 216 residue of the GSK $3{\beta}$ AALA mutant was significantly reduced compared to that of GSK $3{\beta}$ wild type. Thus, our observations indicate that GSK $3{\beta}$ binds to Fe65 through its $^{371}PPLA^{374}$ motif and that this interaction regulates apoptosis and phosphorylation of Tyr 216 of GSK $3{\beta}$.

• Journal of the Korean Society for Marine Environment & Energy
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• v.19 no.3
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• pp.185-193
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• 2016

In this study, the present deployment of the multiple wave energy converters (WECs) in a floating wind-wave hybrid power generation platform was estimated considering the interaction effect among WEC buoys. The interaction processes of multiple buoys were very complex, since scattered and radiated waves from each buoy affected the others in the array. The interaction analysis of the diffraction and radiation problem by the array of WECs was applied by matched eigenfunction expansion method (MEEM). The analytical solutions were compared with the results of numerical calculation based on WAMIT. The overall performance of 24 WECs installed in the hybrid power generation platform was evaluated by the q-factor representing the interaction effect among buoys.