• Journal of the Korean Society for Precision Engineering
• /
• v.11 no.2
• /
• pp.189-196
• /
• 1994

Quality assurance in the process of manufacturing high strengh bolt sets used in the frictional joints of structures in one of important concern to users as well as to manufactures. In case of occurrences of either defective or low-quality products, even if they are quite rare, some systematic means of localizing the cause-characteristics and matching to corresponding production process is necessary. Control chart of torque factor is the primary indicatir in finding defectiveness of the products. Use of correlation diagrams ofnhardness of the bolt set presents in part a way of screening the cause. Retest data of the bolt set provide additional ideas of localizing the cause, for which theoretical background is presented in this regard. A process-characteristics matrix relating the causes of low quality to the corresponding process of manufacturing, which is of prime importance for the feedback control of production, is also proposed. Finally general features of control to assure quality of the set is described.

• Journal of Microbiology
• /
• v.39 no.1
• /
• pp.67-73
• /
• 2001

A validation study was conducted to evaluate the efficacy and mechanism of the cryo-precipitation, monoclonal anti-FVIIIc antibody (mAb) chromatography, Q-Sepharose chromatography, and lyophilization steps involved in the manufacture of high purity factor VIII (GreenMono) from human plasma, in the removal and/or inactivation of hepatitis A virus (HAV). Samples from the relevant stages of the production process were spiked with HAV and subjected to scale-down processes mimicking the manufacture of the high purity factor VIII concentrate. Samples were collected at each step and immediately titrated using a 50% tissue culture infectious dose (TCID$\_$50/) and then the virus reduction factors were evaluated. HAV was effectively partitioned from factor VⅢ during cryo-precipitation with the log reduction factor of 3.2. The mAb chromatography was the most effective step far removal of HAV with the log reduction factor of $\geq$4.3. HAV infectivity was not detected in the fraction of factor VⅢ, while most of HAV infectivity was recovered in the fractions of flow through and wash during mAb chromatography. Q-Sepharose chromatography showed the lowest efficacy for partitioning HAV with the log reduction factor of 0.7. Lyophilization was an effective step in inactivating HAV with the log reduction factor of 2.3. The cumulative lag reduction factor, $\geq$10.5, achieved for tile entire manufacturing process was several magnitudes greater than the potential HAV load of current plasma pools.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2000.10a
• /
• pp.124-127
• /
• 2000

The finite element analyses of the wrinkling initiation and growth in the sheet metal forming process provide the detailed information about the wrinkling behavior of sheet metal. The direct analyses of the wrinkling initiation and growth, however, bring about a little difficulty in complex industrial problems because it needs large memory size and long computation time. For the description of wrinkling growth, the mesh elements should be sufficiently small and the size of finite element matrix becomes large. In the static implicit finite element method therefore, the direct analysis of wrinkling growth in a complex sheet metal forming process is rather difficult. From the industrial viewpoint of tooling design, the readily available information of possibility and location of wrinkling is sometimes more preferable to the detailed time-consuming information. In the present study, therefore, the wrinkling factor that shows locations and relative possibility of wrinkling initiation is proposed as a convenient tool of relative wrinkling estimation based on the energy criterion. The location and relative possibility of wrinkling initiation are predicted by calculating the wrinkling factor in various sheet metal forming processes such as cylindrical cup deep drawing, spherical cup deep drawing, and elliptical cup deep drawing. The wrinkling factor is also implemented in the analysis of the door inner stamping process to predict wrinkling.

• Transactions of Materials Processing
• /
• v.17 no.8
• /
• pp.627-632
• /
• 2008

The cross sectional shape of intermediate die is one of important parameters to improve dimensional accuracy of final product in shaped drawing process. Until now, it has been designed by the experience or trial and error of the expert. In this study, the cross sectional shape of intermediate die for spline shape is determined by the electric fields analysis and scale factor method. The result of the electric fields analysis and scale factor method have been compared with that of the expert method. The effects of cross sectional shape on the dimensional accuracy were investigated by using FE-simulation. And then the multi-stage shaped drawing experiments were performed to verify the results of FE-simulation. As a result, the cross sectional shape from the electric fields analysis and scale factor method had the good dimensional accuracy. These two methods can be used for the method to obtain the cross sectional shape of intermediate die in shaped drawing process.

• Journal of Pharmaceutical Investigation
• /
• v.38 no.6
• /
• pp.381-385
• /
• 2008

Isosorbide dinitrate is an oral assiatant therapy agent of angina pectoris, myocardial infarction and congestive heart failure. The objective of this study was to formulate sustained release containing isosorbide dinitrate and assess their formulation variables. Pellets were prepared by fluid bed process and consist of drug layer and membrane layer. The pellets were coated with ethylcellulose along with $5{\sim}15%$ of plasticizer such as triacetin and diethyl butylrate. In vitro evaluation study was performed by comparative dissolution test between test and reference isosorbide dinitrate preparation. We could prepare sustained pellets of isosorbide dinitrate by fluid bed process which were reduced process time and had high content. The pellet coated with 1% ethylcellulose and triacetin(l5%) had a similar dissolution behavior compare to reference isosorbide dinitrate preparation controlling initial dissolution and those of dissolution at 30 min were 17.25 and 17.09%, respectively. Difference factor and similarity factor were $0{\sim}15$ and $50{\sim}100$ and there was no significant difference in bioequivalence between formulations. It might be concluded that our sustained release pellet of isosorbide dinitrate could be an alternatively delivery system to reference drug preparation.

• 한국생물공학회:학술대회논문집
• /
• 2000.04a
• /
• pp.219-222
• /
• 2000

Physiological changes of Escherichia coli during the fed-batch fermentation process were characterized in this study. Overall cellular protein samples prepared at the different stage of fermentation were separated by 2-dimensional gel electrophoresis (2-DE), and differently expressed 15 proteins, Phosphotransferase enzyme I, GroEL, Trigger factor, ${\beta}$ subunit of ATP synthase, Transcriptional regulator KDGR, Phosphoglycerate mutase 1, Inorganic pyrophosphatase, Serine Hydroxymethyl-transferase, ${\alpha}$ subunit of RNA polymerase, Elongation factor Tu, Elongation factor Ts, Tyrosine-tRNA ligase, DnaK suppressor protein, Transcriptional elongation factor, 30S ribosomal protein S6 were identified using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS). When bacterial cells grow to high cell density, and IPTG-inducible heterologous protein is produced, expression level of overall cellular proteins was decreased. According to their functions in the cell, identified proteins were classified into three groups, proteins involved in transport process, small-molecule metabolism, and synthesis and modification of macromolecules.

• Journal of Information Display
• /
• v.10 no.1
• /
• pp.28-32
• /
• 2009

The correlation between the optical performance of the reflective polarizer, which is a key optical component for the brightness enhancement of the liquid crystal display (LCD), and the configuration of optical sheets was investigated in a direct-lit CCFL (cold-cathode fluorescent lamp) backlight. The optical gain of the reflective polarizer, the polarization state of the light emitted from each film, and the loss factor for the polarization conversion process occurring in the lower part of the backlight were determined using a phenomenological approach for the polarization recycling process. The present study suggests that the correlation between the optical performance of the brightness enhancement films and the backlight configuration should be carefully considered in the optimization of the backlight structure.

• Wind and Structures
• /
• v.36 no.1
• /
• pp.15-29
• /
• 2023

To better estimate the non-Gaussian extreme wind pressures for high-rise buildings, a data-driven revised Hermitetype peak factor estimation model is proposed in this papar. Subsequently, a comparative study on three types of methods, such as Hermite-type models, short-time estimate Gumbel method (STE), and new translated-peak-process method (TPP) is carried out. The investigations show that the proposed Hermite-type peak factor has better accuracy and applicability than the other Hermite-type models, and its absolute accuracy is slightly inferior to the STE and new TPP methods for non-Gaussian wind pressures by comparing with the observed values. Moreover, these methods generally overestimate the Gaussian wind pressures especially the STE.

• Journal of environmental and Sanitary engineering
• /
• v.23 no.3
• /
• pp.39-46
• /
• 2008

In order to study the estimate of $CH_4$ emission factors in the municipal wastewater treatment plants, the active sludge process, 5-stage process, Denipho process, and SBR process were investigated. When active sludge process, 5-stage process, and Denipho process were used in wastewater treatment plant, the $CH_4$ emission factors were 2.88, 1.61, and 0.57 g-$CH_4/kg$-BOD, respectively. On the other hand, in the case of SBR process, it was 4.14 g-$CH_4/kg$-BOD. These results indicate that SBR process was effective for $CH_4$ emission in municipal wastewater treatment plants. Using the above processes, the methane emission factor and amount of waste water sludge were $4.78m^3/t$ and $12,204,506m^3/yr$, respectively. The remove of BOD was a range of $93.91{\sim}98.63%$.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.21 no.5
• /
• pp.79-87
• /
• 2021

This study suggests a design process for vibrotactile interface that can apply haptic perception factors reflecting human tactile mechanisms. This process consists of 4 stages: the haptic sense requirement analysis stage, the haptic element analysis stage, the haptic perception factor analysis stage, the haptic requirement detailed design, and the prototype implementation stage. The advantage of this design process is that unnecessary tasks can be excluded in deriving and implementing user requirements, by applying haptic perception factor analysis, and the biggest feature is that research results on ergonomic mechanisms can be reflected in the haptic design, completes prototype development simultaneously while determining the haptic requirements statement by performing user evaluation, usability testing, and haptic feature optimization tasks simultaneously. This design process includes all stages from user requirements to haptic function detailed design and prototype implementation, so it is expected that general developers who lack expertise in haptic will also be able to design user-centered designs, enabling design and implementation of haptic functions at a certain level.