• Bulletin of the Korean Chemical Society
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• 제25권10호
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• pp.1513-1520
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• 2004

We investigate a series of synthesized ${\beta}$-methoxyacrylate analogues for their 3D QSAR & HQSAR against Magnaporthe grisea (Rice Blast Disease). We perform the three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) studies, using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) procedure. In addition, we carry out a two-dimensional Quantitative Structure-Activity Relationship (2D-QSAR) study, using the Hologram QSAR (HQSAR). We perform these studies, using 53 compounds as a training set and 10 compounds as a test set. The predictive QSAR models have conventional $r^2$ values of 0.955 at CoMFA, 0.917 at CoMSIA, and 0.910 at HQSAR respectively; similarly, we obtain cross-validated coefficient $q^2$ values of 0.822 at CoMFA, 0.763 at CoMSIA, and 0.816 at HQSAR, respectively. From these studies, the CoMFA model performs better than the CoMSIA model.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2003년도 추계학술대회 논문집(II)
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• pp.229-234
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• 2003

In this paper, the elemental components and improving purpose in advanced safety management system are reviewed to cope with a railway fire accident. And a considering procedure(V-cycle) of long-term plan for railway fire safety improvement is proposed. For the purpose of preventing recurrence of accident, items which have to be considered in the course of accident investigation and cause analysis are presented according to the stage of investigation activity.

• 생명과학회지
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• 제14권1호
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• pp.193-197
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• 2004

A continuous enrichment culture procedure was used to isolate bacteria from various soil sources capable of suppressing large patch disease of turfgrass. Six isolates consistently suppressed large patch in turfgrass, and ranged in the spectrum of extracellular enzymes that they expressed. The best disease- suppressing isolate, TBM912, expressed protease, CMCase, and pectinase activity and inhibited the growth of Rhizectonin solani and Betrytis cinerea in vitro. Here we show that this strain also produces an antibiotic that was identified by TLC, SDS-PACE and HPLC analysis as lipopeptide.

• Journal of Microbiology
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• 제42권4호
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• pp.361-364
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• 2004

Internal ribosome entry site (IRES) of the hepatitis C virus (HCV) is known to be essential for HCV replication and most conserved among HCV variants. Hence, IRES RNA is a good therapeutic target for RNA-based inhibitors, such as ribozymes. We previously proposed a new anti-HCV modulation strategy based on trans-splicing ribozymes, which can selectively replace HCV transcripts with a new RNA that exerts anti-HCV activity. To explore this procedure, sites which are accessible to ribozymes in HCV IRES were previously determined by employing an RNA mapping method in vitro. In this study, we evaluate the intracellular accessibility of the ribozymes by comparing the trans-splicing activ­ities in cells of several ribozymes targeting different sites of the HCV IRES RNA. We assessed the intra­cellular activities of the ribozymes by monitoring their target-specific induction degree of both reporter gene activity and cytotoxin expression. The ribozyme capable of targeting the most accessible site iden­tified by the mapping studies then harbored the most active trans-splicing activity in cells. These results suggest that the target sites predicted to be accessible are truly the most accessible in the cells, and thus, could be applied to the development of various RNA-based anti-HCV therapies.

• 생약학회지
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• 제31권4호
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• pp.449-454
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• 2000

In search for plant-derived cytotoxic compounds, it was found that the $CHCl_3$ and EtOAC extracts obtained from the flowers of Paulownia coreana Uyeki (Scrophulariaceae) exhibited significant cytotoxic activity against human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15. Activity-guided fractionation on the basis of the inhibitory activity against the growth of human tumor cell lines, in vitro, and repeated column chromatography afforded several cytotoxic compounds from P. coreana. The structures and stereochemistry of these compounds were established, on the basis of analysis of spectra including IR, UV, EI-MS, $^{1}H-NMR,\;^{13}C-NMR$ and some chemical transformations, as Compound PCCl $(2-hydroxy-4(15),11(13)-eudesmadien-8{\beta},12-olide)$, Compound $PCC2(2,3-dihydro-4-hydroxy-1(15),11(13)-xanthadien-8{\beta},12-olide)$, Compound PCE1 (chrysophanol), Compound PCE2 (emodin), Compound PCE3 (physcion). Cytotoxic activity of compounds obtained from P. coreana. on five tumor cells lines was evaluated by procedure of SRB methods.

• Archives of Reconstructive Microsurgery
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• 제12권1호
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• pp.38-43
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• 2003

Purpose : Various free flaps and pedicled island flaps are effective for reconstruction of soft tissue defect developed after tumor excision. We want to know the advantage of dorsalis pedis island flap for reconstruction of soft tissue defect caused by soft tissue tumor excision. Materials and Methods : Between 1992 and 2002, we performed 4 dorsalis pedis island flap procedure for reconstruction of soft tissue defect of lower limb developed after soft tissue tumor excision. Average age was 54.7 years old $(40{\sim}68)$, and male 2 cases, female 2 cases. The kinds and number of soft tissue tumors were 2 squamous cell carcinoma and 2 malignant melanoma. The procedures that we performed were all dorsalis pedis island flap. The analysis for the result of treatment was retrospectively accessed by physical examination and questionnaire for whether the change of symptom after operation, range of adjacent joint motion. Also we reviewed associated complication after operative treatment. Results : All dorsalis pedis island flaps were alive. There is no problem for activity of daily living, no skin necrosis and no limitation of motion of adjacent joint. In 1 case of them, the patients died of distant metastasis. Conclusion: Dorsalis pedis island flap procedure as a pedicled island flap procedure is very effective and easy operative procedure for reconstruction of soft tissue defect of lower limb developed after tumor excision compared to free flap procedure because there is no need for microvascular surgery, we can obtain relatively large flap and the lesion and flap donor site locate in the same limb.

• 대한인간공학회지
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• 제25권3호
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• pp.77-83
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• 2006

The purpose of this study is to assess the organizational types and the job stress factors that affect the procedure-based job performances in nuclear power plants(NPPs). We derived 24 organizational factors affecting to the job stress in NPPs from the job stress analysis models of NIOSH(1989), Cooper(1990), and Karasek(1990). onsidering the safety characteristic in operating tasks of NPPs, we individuate among the tasks in NPPs through the division of duty and the analysis of cost activity. Through the questionnaire survey, a structured interview with the responsible employees, and expert panels, we assess 70 tasks among 777 tasks managed officially under the procedures. They are the representative tasks to the duties of each division and are directly related to the safety. We utilize the OPTI(organizational personality type indicators) to characterize the personality type of each organization in NPPs.

• 한국정보시스템학회지:정보시스템연구
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• 제15권2호
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• pp.173-193
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• 2006

This study first conceptualizes and investigates five dimensions of SCM activities, such as organizational capacity, revitalization support collaboration, appraisal and responsibility, and information system activities. Second, this study develops three dimensions of a supply chain structure, and proposes a balanced scorecard (BSC) model in order to measure business performance. And then, this study establishes too research hypotheses as follows: H1. The SCM activities varies with the supply chain structure. H2. The management performance varies with the supply chain structure. In the questionnaire survey for empirical analysis, this study carefully selected 809 of companies in Korea. We conducted a survey by mail and collected 127 data. Out of 127 data we actually used 103 responses for statistical analysis. After conducting statistical analysis, we could find the results as followed: 1) The supply chain structure was classified into three networks through a clustering procedure, such as supply network, conversion network, and distribution network, and these networks were used to testify hypotheses. As a result the effect of SCM activities varies according to three networks and especially, the companies in distribution network were more active than those in supply and conversion networks doing SCM activities. 2) We may conclude that business performance varies with three networks, and distribution network achieves better performance than supply and conversion networks do.

• Communications for Statistical Applications and Methods
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• 제7권2호
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• pp.513-523
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• 2000

The X-12-ARIMA program was utilized on the analysis of the time series trend on 76 Korean industrial activities data in order to ensure that the trading day effect adjustment as well as the seasonal effect adjustment is needed to extract the fundamental trend-cycle factors from various economic time series data. The trading day effect is strongly correlated with the activity of production and shipping but not with the activity of inventory. Furthermore, the industrial activities were classified with respect to the sensitivity on the tranding day effect.

• 한국도서관정보학회지
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• 제23권
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• pp.147-182
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• 1995

Marketing technique is used as effective management tool in library. The small size of the user group in special libraries provides good condition for marketing. Special libraries can accomplish the goals and objectives with using marketing technique. The purpose of this study is to examine key concepts and activity procedures of marketing, and marketing mix 4'P, and to suggest the information services which can be used in developing marketing strategies of special libraries. The conclusions are summarized as follows. 1. The key concepts and activity procedure of marketing for libraries consist of market segmentation, positioning, consumer analysis, marketing program and marketing audit. 2. The marketing mix 4P's that can be used in special libraries are examined. 3. The information services which can be used in marketing strategies are suggested.