• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.1
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• pp.43-48
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• 2006

The educational system has been changed owing to Web, which is most actively used on internet and has the characteristics of providing suitable environments for implementing constructivism study theory. WBI(Web Based Instruction), web-mediated teaching form for students at a long distance, has the advantages of possible interact between instructors and learners, offering a great variety of learning materials, and overcome the spatiotemporal restriction. This paper focuces on the construction of learning surroundings where the learner-centered, active learning can be done by design and Implementation of web based instruct system providing a sham examination with an item pool system. The web based Self-directed Learning system for word processor qualifying exams on this paper, can be mentioned as a real item pool that the question is not setting each time by the instructors but can be reused by reference on item pool bank, designed the number of question. It helps the learner Self-directed Learning study with evaluation during the web based instruct process and immediate feedback. It also provides the chance to research some similar using keyword. To sum up, this system can amplify the efficiency of study.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.381-386
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• 2016

Background: Bladder cancer is an international public health problem. It is the ninth most common cancer and the fourteenth leading cause of death due to cancer worldwide. Given aging populations, the incidence of this cancer is rising. Information on the incidence and mortality of the disease, and their relationship with level of economic development is essential for better planning. The aim of the study was to investigate bladder cancer incidence and mortality rates, and their relationship with the the Human Development Index (HDI) in the world. Materials and Methods: Data were obtained from incidence and mortality rates presented by GLOBOCAN in 2012. Data on HDI and its components were extracted from the global bank site. The number and standardized incidence and mortality rates were reported by regions and the distribution of the disease were drawn in the world. For data analysis, the relationship between incidence and death rates, and HDI and its components was measured using correlation coefficients and SPSS software. The level of significance was set at 0.05. Results: In 2012, 429,793 bladder cancer cases and 165,084 bladder death cases occurred in the world. Five countries that had the highest age-standardized incidence were Belgium 17.5 per 100,000, Lebanon 16.6/100,000, Malta 15.8/100,000, Turkey 15.2/100,000, and Denmark 14.4/100,000. Five countries that had the highest age-standardized death rates were Turkey 6.6 per 100,000, Egypt 6.5/100,000, Iraq 6.3/100,000, Lebanon 6.3/100,000, and Mali 5.2/100,000. There was a positive linear relationship between the standardized incidence rate and HDI (r=0.653, P<0.001), so that there was a positive correlation between the standardized incidence rate with life expectancy at birth, average years of schooling, and the level of income per person of population. A positive linear relationship was also noted between the standardized mortality rate and HDI (r=0.308, P<0.001). There was a positive correlation between the standardized mortality rate with life expectancy at birth, average years of schooling, and the level of income per person of population. Conclusions: The incidence of bladder cancer in developed countries and parts of Africa was higher, while the highest mortality rate was observed in the countries of North Africa and the Middle East. The program for better treatment in developing countries to reduce mortality from the cancer and more detaiuled studies on the etiology of are essential.

• Economic and Environmental Geology
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• v.41 no.3
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• pp.335-344
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• 2008

The acid rock drainage (ARD) production potential of rock was assessed for a tunnel construction area, Kimhae and the damage reduction strategy was discussed based on the ARD risk evaluation. The geology of the studied area consisted of Mesozoic quartz porphyry, sandstone, tuff and granite. Sulfides occurred as a disseminated type in quartz porphyry and granite, and a vein type in sandstone. Quartz porphyry and sandstone with a high content of sulfide were classified as a potentially ARD forming rock. The drainage originated from those rocks may acidify and contaminate the surrounding area during the tunnel construction. Therefore, the drainage should be treated before it is discharged. A slope stability problem due to the ARD was also expected and the coating technology was recommended for the reduction of ARD generation before the application of supplementary work for enhancing slope stability such as shotcrete and anchor. From the ARD risk analysis, those rocks should not be used as aggregate and be used as bank fill material with the system for the minimum contact with rain water and ground-water.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.2C
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• pp.209-216
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• 2009

The repeater for wireless broadband internet (Wibro) system using OFDM demands the short processing delay to eliminate inter-symbol interference resulted from the time delay greater than the guard time. Towards this, the total system delay of repeater is expected to be minimized as possible as it can without distorting signal quality. In general, the FIR-type of filter is commonly deployed as a channelization filter, but due to its large amount of coefficients for producing prerequisite filter response the excessive large time delay occurs. To withstand this problem, the paper proposes the method for designing IIR filter whose response almost identical to that of the original filter. Moreover, in order to linearize the phase response of the designed IIR filter, this paper also introduce the way of designing the all-pass filter to be cascaded works for linearizing phase response of the channelization as well as the de-channelization filter. To achieve the further improvement in linearization of the phase response and reduction of the overall complexity, this paper tries to transform the integrated IIR filter group into the structure in polyphase style. The computer simulation verifies that the integrated IIR filter group designed in this paper reveals the relatively short processing delay without harming the acceptible signal quality.

• Journal of the Economic Geographical Society of Korea
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• v.12 no.4
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• pp.477-493
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• 2009

This research aims to examine Korean regional innovation governance, find structural problems, and explore alternative strategies of regional innovation governance. Especially the alternative governance was searched through the case study of Daegu-Kyungbuk mobile cluster, of which formulation Samsung is the anchor institution. Regional innovation governance in this research is defined as a policy system to link knowledge generation & diffusion subsystem and knowledge application & exploitation subsystem, and institutional conditions to steer the system. "Social Capital Assessment Tool (SOCAT)" of the World Bank was utilized for the appreciation of cluster governance. The regional innovation governance of Daegu-Kyungbuk mobile cluster is characterized as production networks dominated by one-to-one relationship between Samsung and hardware/software developers, decentralized R&D networks and policy networks with multiple hubs. Major policy agents have not developed networks with local companies, and rare are interactions between the policy agents. Local companies, especially software developers, responded they have had experiences to cooperate for local problem solving and shared their community goal, however, the degree of trust in major local project leaders is not high. Local hardware/software developers with core technologies need to be cooperative to develop similar technologies or products in Daegu-Kyungbuk mobile cluster. Regional administrative actors, such as the City of Daegu and Kyungsangbuk-do, and diverse innovation-related institutes should build cooperative environment where diverse project-based cooperation units are incessantly created, taken apart, and recreated.

• Journal of Environmental Science International
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• v.2 no.2
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• pp.153-160
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• 1993

The problem of supply and transport of sediment from a mountainous catchment is very important in explaining dynamic geomorphology and the hydrological cycle. The discharge of suspended sediment is determined by a morphological system. Human interference to environment Is also an important, not negligible factor in sediment production. Moreover, growing concern in recent years for the problems of nonpoint pollution and for the transport of contaminants through terrestrial and aquatic ecosystems has highlighted the role of sediment-associated transport in fluvial systems. This study was conducted in forested and quarried catchments in order to clarify the different discharge process and the mechanism of suspended sediment dynamics for each catchment. As a forested catchment, the Yamaguchi River catchment which drains a $3.12km^2$ area was chosen. On the other hand, the Futagami River basin which is formed by three subbasins (1.07, 1.59 and $1.78km^2$), as a quarried catchment was selected. These catchments are situated to the north and east of Mt. Tsukuba, Ibaraki, Japan. The discharge pattern of suspended sediment from the Futagami River basin is more unstable and irregular than that from forested catchment, the Yamaguchi River catchment. Under the similar rainstorm conditions, suspended sediment concentration from quarried catchment during a rainstorm event increases from 43 to 27,340 mg/l. However, in the case of the forested catchment it changes only from nearly zero to 274 mg/l. Generally, the supply source of suspended sediment is classified into two areas, the in-channel and non-channel source areas. As a result of field measurements, in the case of the forested catchment the in-channel (channel bed, channel bank and channel margin) is the main source area of suspended sediment. On the other hand, remarkable sediment source area on the Quarried catchment is the non-channel that is unvegetated ground.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.8
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• pp.465-472
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• 2004

Proxy signatures is a signature scheme that an original signer delegates one's signature capability to a proxy signer, and then the proxy signer creates a signature on behalf of the original signer. Delegation of authority is a common practice in the real world, in particular, it happens naturally in hierarchical groups such as company, bank and army, etc. In this paper, we propose a new dynamic multi-proxy signature scheme allowing repetitive delegations in a hierarchical group. We adopt multi-proxy signatures to enhance the security of proxy signature. In multi-proxy signatures, plural proxy signers can generate a valid proxy signature collectively on behalf of one original signer. In our scheme, the proxy group is not fixed but constructed dynamically according to some situations. Delegations are processed from higher level to lower level in the hierarchy using delegation tickets. When the original signer wants to delegate one's signature authority, the original signer generates a delegation ticket based on secret sharing and Diffie-Hellman problems. The delegation ticket is shared among proxy signers and then all the proxy signers can generate a valid proxy signature collectively by reconstructing the original signer's delegation ticket. If a certain proxy signer can not attend the proxy signature generating protocol, the proxy signer can also delegate repetitively his partial signature authority to the lower level participants, and then the proxies are constructed dynamically.

• The KIPS Transactions:PartA
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• v.19A no.1
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• pp.51-60
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• 2012

IC(Integrated circuits)card, generally be named smard card, embedded MPU(Micro Processor Unit) of small-size, memory, EEPROM, Card Operating System(COS) and security algorithm. The IC card is used in almost all industry such as a finance(credit, bank, stock etc.), a traffic, a communication, a medical, a electronic passport, a membership management and etc. Recently, a application field of IC card is on the increase by method for payments of T-commerce, as T-commerce is becoming a new growth engine of the broadcating industry by trend of broadcasting and telecommunication convergence, smart mechanization of TV. For example, we can pay in IC credit card(or IC cash card) on T-Commerce. or we can be provided TV banking service in IC cash card such as ATM. However, so far, T-commerce payment services have weakness in security such as storage and disclosure of card information as well as dropping sharply about custom ease because of taking advantage of card information input method using remote control. To solve this problem, This paper developed processing payment module for implementing TV electronic payment system using IC credit card payment standard, EMV.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.3
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• pp.203-212
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• 2023

Since the coronavirus disease-2019 (COVID-19) outbreak, it has been generally believed that a medical technologists (MTs) are supposed to perform polymerase chain reaction tests and next-generation sequencing (NGS) in the hospitals. However, many do not recognize that the duty of MT for clinical genetic testing has not been stated in the Medical Laws (72.5% for MT, N=200; 62.8% for students, N=123). In this regard, to evaluate the feasibility of MT's role for NGS genetic testing, we requested our subjects to fill out an online survey and analyzed the data. Among them, it shows that the scope of MT's role, including NGS performance should include clinical genetic testing (99.5% for MT, N=200; 86.8% for students, N=123). Also, questions on clinical genetics, which is associated with both cellular genetics and molecular genetic questions should be included in the National MT License Problem Bank (97.5% for MT; 71.4% for students). Based on these results, the Korean Association of Medical Technologists needs to cooperate synergically with the Academic Association of Biomedical Laboratory Science with respect to genetic education and legislation for the future benefit of both MTs and students.

• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.123-135
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• 2024

Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat gemcitabine-resistant pancreatic cancer is urgently required. Piceamycin has been reported to exhibit antiproliferative activity against various cancer cells; however, its underlying molecular mechanism for anticancer activity in pancreatic cancer cells remains unexplored. Therefore, the present study evaluated the antiproliferation activity of piceamycin in a gemcitabine-resistant pancreatic cancer cell line and patient-derived pancreatic cancer organoids. Piceamycin effectively inhibited the proliferation and suppressed the expression of alpha-actinin-4, a gene that plays a pivotal role in tumorigenesis and metastasis of various cancers, in gemcitabine-resistant cells. Long-term exposure to piceamycin induced cell cycle arrest at the G₀/G₁ phase and caused apoptosis. Piceamycin also inhibited the invasion and migration of gemcitabine-resistant cells by modulating focal adhesion and epithelial-mesenchymal transition biomarkers. Moreover, the combination of piceamycin and gemcitabine exhibited a synergistic antiproliferative activity in gemcitabine-resistant cells. Piceamycin also effectively inhibited patient-derived pancreatic cancer organoid growth and induced apoptosis in the organoids. Taken together, these findings demonstrate that piceamycin may be an effective agent for overcoming gemcitabine resistance in pancreatic cancer.