• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.1
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• pp.100-113
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• 2018

The Proximity Service, which is one of the most popular network capacity improvement methods, uses the frequency reuse in order to increase the frequency efficiency. As a result, inter-cell interference between cellular and proximity service users occurs at a cell edge. In this paper, we proposed a mitigation scheme for inter-cell interference, where we suggested a new function of and eNB with ProSe function exchanging information about ProSe parameters and ProSe user equipment with neighboring cells via the X2 interface. As the first step, the resource which did not cause the inter-cell interference problem were pre-allocated through the frequency sensing in the ProSe direct discovery. As the next step, the inter-cell interference problem was solved by reallocating appropriate resources based on the ProSe application code, the ProSe application QoS, the ProSe application ID and validity timer in ProSe direct communication.

• Journal of Convergence for Information Technology
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• v.12 no.5
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• pp.290-297
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• 2022

This study was conducted to determine the cell cytotoxicity, astringency, nitrite oxide scavenging, iNOS protein expression level, pro-inflammatory cytokine, elastase inhibition, and type I pro-collagen synthesis as a functional cosmetics material of Salvia miltiorrhiza root. We prepared the 80% ethanol(SE) and hot-distilled water(SW), respectively. Both SE and SW showed no toxicity from 0.05 to 0.5 mg/mL concentration as a result of MTT assay in NHDF or RAW264.7 cells. In the measurement of astringent effect, SE reveled 74.6% of astringent activity in 10 mg/mL. SE showed that LPS-induced nitric oxide production, iNOS protein expression, and cytokines were inhibited in a dose-dependent manner. Furthermore, two extracts significantly inhibited elastase activity and increased the type I pro-collagen production. Therefore, it is expected that Salvia miltiorrhiza extract is used as a natural material for functional cosmetics that can effectively prevent skin-related inflammation and wrinkles, and aging.

• BMB Reports
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• v.35 no.2
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• pp.239-243
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• 2002

Angiotensin I that converts the enzyme (ACE) inhibitory peptide, Gly-Pro-Leu, previously purified and identified from the Alaskan pollack skin gelatin hydrolysate, were synthesized. In addition, the peptides Gly-Leu-Pro, Leu-Gly-Pro, Leu-Pro-Gly, Pro-Gly-Leu, Pro-Leu-Gly, Gly-Pro, and Pro-Leu, which consisted of glycine, proline, and leucine, were synthesized by the solid-phase method. The $IC_{50}$ values of each tripeptide - namely Leu-Gly-Pro, Gly-Leu-Pro, Gly-Pro-Leu, Pro-Leu-Gly, Leu-Pro-Gly, and Pro-Gly-Leu - were 0.72, 1.62, 2.65, 4.74, 5.73, and $13.93{\mu}M$, respectively. The ACE inhibitory activity of these tripeptides was higher than that of dipeptides, such as Gly-Pro and Pro-Leu with $IC_{50}$ values of 252.6 and $337.3\;{\mu}M$, respectively. Among the tripeptides, Leu-Gly-Pro and Gly-Leu-Pro had higher inhibitory activity than Gly-Pro-Leu that was isolated from the Alaskan pollack skin gelatin hydrolysate. Among the different types of tripeptides that were examined, the highest ACE inhibitory activity was observed for Leu-Gly-Pro. It had the leucine residue at the N-terminal and proline residue at the C-terminal.

• Bioinformatics and Biosystems
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• v.1 no.1
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• pp.46-50
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• 2006

According to the advancement of experimental techniques in molecular biology, genomic and protein sequence databases are increasing in size exponentially, and mean sequence lengths are also increasing. Because the sizes of these databases become larger, it is difficult to search similar sequences in biological databases with significant homologies to a query sequence. In this paper, we present the N-gram indexing method to retrieve similar sequences fast, precisely and comparably. This method regards a protein sequence as a text written in language of 20 amino acid codes, adapts N-gram tokens of fixed-length as its indexing scheme for sequence strings. After such tokens are indexed for all the sequences in the database, sequences can be searched with information retrieval algorithms. Using this new method, we have developed a protein sequence search system named as ProSeS (PROtein Sequence Search). ProSeS is a protein sequence analysis system which provides overall analysis results such as similar sequences with significant homologies, predicted subcellular locations of the query sequence, and major keywords extracted from annotations of similar sequences. We show experimentally that the N-gram indexing approach saves the retrieval time significantly, and that it is as accurate as current popular search tool BLAST.

• 한국정보디스플레이학회:학술대회논문집
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• 2000.01a
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• pp.59-60
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• 2000

We have developed the LCD Simulator, which is called "ProLCD", in order to reduce time and efforts for the design and analysis of LCDs. We describe the numerical models implementing the computation of LC directors and electro-optics, the graphic user interface and the visualization modules. Many applications show that ProLCD is a very useful, interactive design tool with good reliability.

• Korean Journal of Applied Biomechanics
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• v.26 no.2
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• pp.213-220
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• 2016

Objective: The purpose of this study was to investigate the effect of an 8-week ProBody massage program on body alignment and plantar pressure balance in middle-aged men with musculoskeletal diseases. Method: The subjects of this study were 20 middle-aged men with musculoskeletal diseases in B Metropolitan City who participated in an 8-week ProBody massage program conducted twice a week. Physical characteristics (height, weight, and body mass index), body alignment, and plantar pressure were assessed before and after the experiment. Results: The 20 middle-aged men with musculoskeletal diseases who underwent the ProBody massage program showed positive changes in physiological characteristics, body alignment, and plantar pressure balance. Conclusion: Consequently, the 8-week ProBody massage program was suggested to be effective for improving and preventing postural imbalance in middle-aged men with musculoskeletal diseases. The ProBody massage program could also be utilized to improve the body alignment and plantar pressure balance in middle-aged women with musculoskeletal diseases.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.3
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• pp.263-273
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• 2013

Objectives This study was designed to investigate the anti-inflammatory effect of extracts from Ligustrum obtusifolium S. fruits(LOF) in RAW 264.7 Macrophages stimulated with lipopolysaccharide(LPS). Methods We examined productions of nitric oxide(NO), reactive oxygen species(ROS), inducible isoforms of NO synthase(iNOS), cyclooxygenase-2(COX-2) to investigate the anti-inflammatory effect of LOF extracts. In addition, we measured generation of pro-inflammatory cytokines(TNF-${\alpha}$, IL-6). Results Cell viability showed that LOF extracts had no cytotoxicity in Raw 264.7 cells. The treatment with LOF extracts significantly decreased the generation of NO and pro-inflammatory cytokines(TNF-${\alpha}$, IL-6) in LPS-stimulated macrophage cells. Furthermore LOF extracts inhibited intracellular ROS generation dose dependently and reduced the expression of iNOS, COX-2 proteins. Conclusions These results showed that the LOF extracts had an anti-inflammatory effect on LPS-stimulated Raw 264.7 cells. These findings provide scientific support for the use of this Ligustrum obtusifolium S. for inflammatory-related diseases.

• Restorative Dentistry and Endodontics
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• v.28 no.2
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• pp.146-155
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• 2003

여러 가지 장점으로 인해 Ni-Ti 전동 파일을 근관성형에 사용하는 빈도가 점차 증가되는 추세이지만, 초심자를 대상으로 한 연구는 부족한 실정이다. 이에 본 연구에서는 초심자에서 Ni-Ti 전동 파일을 사용할 때 근관 형성의 효용성을 평가하고, 어떤 방법이 초심자에게 적절한지를 알아보고자 하였다. 근관형태가 재현된 레진 블록을 이용하여 12명의 초심자와 4명의 숙련자가 근관 형성을 시행하였다. 각 술자는 ProFile, ProTaper, Hybrid (ProFile＋ProTaper)를 이용하여 각각의 레진 블록을 세 개씩 근관형성하고, 각 파일 별의 근관 형성 시간을 기록하였다. 근관 형성 전과 후의 digital 이미지를 중첩하여 치근단으로부터 1, 2, 3, 4, 5, 6, 7mm level에서 근관단면의 총길이 변화량, 만곡 외측의 길이 변화량, 만곡 내측의 길이 변화량, 중심이동량, 중심이동율과 치근단에서의 apical transportation을 구하고, 초심자와 숙련자 사이의 차이를 비교 평가하였다. 실험결과 ProFile군의 1, 3, 5, 6, 7mm level과 ProTaper군의 6mm level, Hybrid군의 3mm level에서 초심자의 근관단면의 총길이 변화량이 숙련자보다 많았다. 모든 군에서 치근단으로부터 4, 5, 6, 7mm level에서는 근관 중심이 만곡내측으로 이동하였고, 1 2, 3mm level 에서는 만곡외측으로 이동하였으나, 숙련자가 시행한 Hybrid군의 3mm level과 비숙련자가 시행한 ProTaper 군의 3mm level에서는 만곡내측으로 이동하였다. 모든 군의 3mm level과 ProFile 군의 5mm level에서 초심자의 중심이동율이 숙련자에 비해 컸으며, 초심자가 ProTaper를 사용시 더 큰 apical trans portation을 보였고, 모든 군에서 초심자가 근관형성시 더 많은 시간이 걸렸다. ProFile과 ProTaper를 이용한 Hybrid technique이 초심자에게 추천되며, 초심자들도 충분히 교육받는다면 만곡된 근관의 근관형성에 있어서 Ni-Ti rotary file의 이용이 가능하리라고 사료된다.

• Phonetics and Speech Sciences
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• v.7 no.4
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• pp.67-76
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• 2015

The purpose of this study was to compare professional (Pro) and non-professional (Non-pro) voice users with voice disorders in self-reporting voice evaluation using Korean-Voice Handicap Index (K-VHI) and Korean-Voice Related Quality of Life (K-VRQOL). In addition, those were compared by voice quality and voice disorder type. 94 Pro and 106 Non-pro were asked to fill out the K-VHI and K-VRQOL, perceptually evaluated on GRBAS scales, and divided into three types of voice disorders (functional, organic and neurologic) by an experienced speech-language pathologist and an otolaryngologist. The results showed that the functional (F) and physical (P) scores of K-VHI in Pro group were significantly higher than those in Non-pro group. As the voice quality evaluated by G scale got worse, the scores of all aspects except emotional (E) of K-VHI and social-emotional (SE) of K-VRQOL were higher. All scores of K-VHI and K-VRQOL in neurologic voice disorders were significantly higher than those in functional and organic voice disorders. In conclusion, professional voice users are more sensitive to their functional and physical handicap resulted by their voice problems and that goes double for the patients with severe and neurologic voice disorders.

• Information and Communications Magazine
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• v.33 no.3
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• pp.36-45
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• 2016

LTE는 3GPP Rel-8부터 시작되어 현재 Rel-13까지 진화해오고 있으며 앞으로도 계속해서 진화할 것으로 예상된다. LTE는 단말의 이동성을 제공하면서 단말과 무선 접속 망 사이에 수십~수백 Mbps 급 고속의 패킷 통신이 가능하도록 하는 기술이며, LTE를 이용해서 서비스를 제공하기 위해서는 추가적으로 서비스 기술에 대한 표준화도 함께 고려가 되어야 한다. 공공안전사용기관인 주요 국가 정부를 중심으로 LTE을 공공안전용도로 사용 할 경우 최적 솔루션이 될 수 있음을 인지하고 3GPP 과제 제안을 통해, Rel-12부터 표준화를 시작하였다. 처음으로 표준화를 시작한 기술은 ProSe, D2D 및 GCSE이라는 기술이며, 2015년 3월에 완료되었다. 현재 진행 중인 Rel-13에서는 MCPTT, eProSe, eD2D, IOPS, MBMS_enh 기술에 대한 표준화가 진행 중이며 2016년 3월에 표준 완료 예정이다. 또한 2016년 3월부터는 Rel-14 표준화 기술로 선정된 MCVideo 및 MCData 표준화가 진행될 것으로 예상된다. 본 고에서 공공안전 용도로 특화되어 3GPP Rel-13 및 Rel-14에서 표준화가 진행되고 있는 주요 PS-LTE 기술의 표준화 현황과 계획에 대해 언급하고자 한다.