• BMB Reports
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• 제39권6호
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• pp.649-655
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• 2006

The NSAID activated gene (NAG-1), a member of the TGF-$\beta$ superfamily, is involved in tumor progression and development. The over-expression of NAG-1 in cancer cells results in growth arrest and increase in apoptosis, suggesting that NAG-1 has anti-tumorigenic activity. This conclusion is further supported by results of experiments with transgenic mice that ubiquitously express human NAG-1. These transgenic mice are resistant to the development of intestinal tumors following treatment with azoxymethane or by introduction of a mutant APC gene. In contrast, other data suggest a pro-tumorigenic role for NAG-1, for example, high expression of NAG-1 is frequently observed in tumors. NAG-1 may be like other members of the TGF-$\beta$ superfamily, acting as a tumor suppressor in the early stages, but acting pro-tumorigenic at the later stages of tumor progression. The expression of NAG-1 can be increased by treatment with drugs and chemicals documented to prevent tumor formation and development. Most notable is the increase in NAG-1 expression by the inhibitors of cyclooxygenases that prevent human colorectal cancer development. The regulation of NAG-1 is complex, but these agents act through either p53 or EGR-1 related pathways. In addition, an increase in NAG-1 is observed in inhibition of the AKT/GSK-$3{\beta}$ pathway, suggesting NAG-1 alters cell survival. Thus, NAG-1 expression is regulated by tumor suppressor pathways and appears to modulate tumor progression.

• 한국환경복원기술학회지
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• 제22권1호
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• pp.73-84
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• 2019

In this research, it is a basic study to investigate the population of birds using UAVs. The research area is Ardeidae species(ASP) habitat and has long-term monitoring. The purpose of the study is to compare the ASP populations which analyzed ground observational survey and UAVs imagery. We used DJI's Mavic pro and Phantom4 for this research. Before investigating the population of ASP, we measured the escape distance by the UAVs, and the escape distances of the two UAVs models were statistically significant. Such a result would be different in UAV size and rotor(rotary wing) noise. The population of ASP who analyzed the ground observation and UAVs imagery count differed greatly. In detail, the population(mean) on the ground observation was 174.9, and the UAVs was 247.1 ~ 249.9. As a result of analyzing the UAVs imagery, These results indicate that the lower the UAVs camera altitude, the higher the ASP population, and the lower the UAVs camera altitude, the higher the resolution of the images and the better the reading of the individual of ASP. And we confirmed analyzed images taken at various altitudes, the individuals of ASP was not statistically significant. This is because the resolution of the phantom was superior to that of mavic pro. Our research is fundamental compared to similar studies. However, long-term monitoring for ASP of South Korea's by ground observation is a barrier of the reliability of the monitoring result. We suggested how to use UAVs which can improve long-term monitoring for ASP habitat.

• 한국환경교육학회지:환경교육
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• 제19권3호
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• pp.40-56
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• 2006

The purpose of this study is to enhance elementary students' awareness of environment-friendly life and help them to prepare for a better life in the future. To achieve this purpose we examined the effect typical environmental experience-based learning activities, which were based on the local circumstances with high environmental-educational potential, have on the attitudes toward environment-friendly life. This study was carried out on the basis of typical environmental experience-based learning in the small class size. The research group used was composed of one sixth grade elementary school class called Sangroksu, whose total students were 9. The research period lasted from March 2005 to February 2006. To analyze the result of this study, two research methods were applied simultaneously : quantitative research methods and qualitative research methods. Especially statistical analysis in quantitative research methods by self-administrated questionnaire was done with SAS program. Qualitative research methods were analyzed in a cyclic pattern, including the processes of domain analysis, classification analysis, and factor analysis which continued to be associated with data-collecting methods. This research shows the following results. First of all, students have shown meaningful differences after typical environmental experience-based learning activities.(p<.05). Followings are fields of the differences - students‘ interest on the subject, their understanding levels of necessity for basic environmental facilities around us as well as for the kinds of environmental experience-based learning, awareness levels of various environmental problems, consciousness on environment conservation, and the practicing ability of environment - friendly lifestyles. Secondly, We have discovered improvements in the following fields after this study - the knowledge and understanding levels on our environment and human relationships, students' fundamental abilities to work out environmental problems, right ideas and appropriate attitudes on environment protection, the practicing ability of environment-friendly life styles, and their parents' understanding levels on the education related to environment. In conclusion, typical environmental experience-based learning activities have a positive effect on the improvement of elementary school students' environment-friendly life styles.

• International Journal of Quality Innovation
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• 제6권3호
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• pp.173-189
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• 2005

A life-cycle assessment (LCA) is based on the attention given to the environmental protection and concerning the possible impact while producing, making, and consuming products. It includes all environmental concerns and the potential impact of a product's life cycle from raw material procurement, manufacturing, usage, and disposal (that is, from cradle to grave). This study assesses the environmental impact of the ultra pure water process of semiconductor manufacturing by a life-cycle assessment in order to point out the heavy environmental impact process for industry when attempting a balanced point between production and environmental protection. The main purpose of this research is studying the development and application of this technology by setting the ultra pure water of semiconductor manufacturing as a target. We evaluate the environmental impact of the Precoat filter process and the Cation/Anion (C/A) filter process of an ultra pure water manufacturing process. The difference is filter material used produces different water quality and waste material, and has a significant, different environmental influence. Finally, we calculate the cost by engineering economics so as to analyze deeply the minimized environmental impact and suitable process that can be accepted by industry. The structure of this study is mainly combined with a life-cycle assessment by implementing analysis software, using SimaPro as a tool. We clearly understand the environmental impact of ultra pure water of semiconductor used and provide a promotion alternative to the heavy environmental impact items by calculating the environmental impact during a life cycle. At the same time, we specify the cost of reducing the environmental impact by a life-cycle cost analysis.

• 벤처혁신연구
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• 제6권3호
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• pp.95-109
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• 2023

기후변화로 인해 다양한 환경문제를 전 세계적으로 겪고 있는 가운데 기존의 환경친화적 행위보다 더 효과적으로 제품 구매전부터 발생하는 폐기물의 양을 최소화 혹은 원천 차단하자는 '프리싸이클링(Pre-cycling)' 운동 등이 주목받고 있다. 본 연구는 최근 심각해지고 있는 쓰레기로 인한 환경문제를 개선할 수 있는 프리싸이클링 행동을 유도하기 위해, 메시지 소구 방식과 시간적 거리감에 따른 메시지 프레임이 프리싸이클링 행동의도에 미치는 어떠한 영향을 미치는지에 대해 조사하였다. 메시지 소구방식에 있어서 제안적 메시지가 강압적 메시지보다 프리싸이클링 행동의도를 더 높았으며, 시간적 거리감은 프리싸이클링 행동의도에 직접적인 영향을 주지 못했다. 강압적 메시지는 대상에 대하여 가까운 미래로 해석할 때 그리고 제안적 메시지는 먼 미래로 해석될 경우 프리싸이클링 행동의도가 높게 나타났다. 본 연구에서는 시간적 거리감은 프리싸이클링 행동 의도에 직접적인 영향을 미치지는 않으나, 강압적 메시지에 대한 소비자의 반감을 감소시키는 역할을 함으로써 그들의 친환경적 행동의도를 긍정적으로 유도하였다. 본 연구는 환경친화적인 메시지에 대한 소비자의 행동을 이끌어내기 위한 메시지 소구 방식에 대한 고찰을 제공하여 실무적 함의를 지닌다.

• Journal of Photoscience
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• 제9권2호
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• pp.436-438
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• 2002

Since solar radiation contains wavelength essential for photosynthesis accompanying with near-UV light, UV-B effects on biological parameters and acclimation mechanisms are influenced by photosynthetically active radiation (PAR). Therefore, to elucidate near-UV shielding mechanism in higher plants, we cultivated cauliflower under usual solar radiation and increased UV-B from fluorescent lamps, two- or three-fold excess over continuously estimated UV-B dose in PAR during daytime, using computer regulated systems. Increased UV-B radiation had little effect on growth expressed as fresh weigh and leaf area. Water soluble low molecular weight compounds showing absorption in near UV region were enhanced according to the irradiated UV-B dose. One of compounds in cauliflower leaves was identified as chlorogenic acid. This was found to have no near-UV photosenSitizerable activity and is known to have an ability to scavenge a wide species of active oxygen. Another pro-oxidant compound that generates superoxide anion radical under near-UV irradiation was not induced by increased UV-B during cultivation, and identified as lumazine, a degradation product from folic acid.

• 한국환경보건학회지
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• 제39권4호
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• pp.354-359
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• 2013

Objectives: The purpose of this study was to investigate exposure levels to K2 rifle noise at a military rifle range among soldiers in training, the left and right ears of shooters, and control managers in the day and night times. Methods: For this study, we visited military rifle ranges and measured the noise of a K2 rifle with a sound level meter (3M Quest SoundPro$^{TM}$) at four different locations with values of Peak (dB(A)) and Max (dB(A)). Results: The highest peak value of impulse noise level averaged 150.4 dB(A), ranging from 149.7 to 150.5 dB(A) at the left-ear side. Impulse noise levels in the daytime were also recorded as higher than during the night. This result was significantly different between daytime and nighttime locations, such as soldier training, right ear of shooter, and control manager (P < 0.001). Conclusion: This study confirmed that there is a need for proper management of impulse noise at military rifle ranges.

• 한국환경보건학회지
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• 제36권4호
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• pp.271-278
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• 2010

The appearance of Asian Dust (AD) originating from China and Mongolia during spring each year is a meteorological phenomenon periodically observed in extensive regions of East Asia. According to a previous epidemiological study, AD has adverse effects on both human beings and ecosystems. In this study, we collected total suspension particles (TSP) in the AD period and Non-AD (NAD) period. We extracted organic components from TSP using dichloromethane (DCM), and the polyaromatic hydrocarbons (PAHs) were analyzed. The DCM extracts contained PAHs such as benzo(b)fluoranthene, benzo[g,h,i]perylene, benzo(k)fluoranthene, benzo(a)pyrene, and pyrene. No significant difference was observed in cytotoxicity of the DCM extracts from AD versus NAD when tested on the human bronchial epithelial cells, BEAS-2B. e also examined the toxic mechanisms of AD extracts in cultured BEAS-2B cells and RAW264.7 cells, and in BEAS-2B cells observed increased levels of reactive oxygen species (ROS), decreased glutathione (GSH), and induced caspase-3 activity. Increased expression of oxidative stress-related and inflammation- related genes were also observed in BEAS-2B cells, while nitric oxide (NO) levels were increased in RAW264.7 cells. Taken together, the results suggest that in these cultured cells, AD may induce cytotoxicity through oxidative stress and pro-inflammatory signals.

• Journal of Korean Society for Atmospheric Environment
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• 제18권E3호
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• pp.165-174
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• 2002

A dual -column biofilter system with two different composts was used to investigate the macro-kinetics of dim-ethyl disulfide (DMDS) degradation. The biofilter columns were filled with compost mixtures up to one meter, The gas How rate and DMDS concentration to the biofilters were varied to study their effect on the removal characteris-tics of DMDS. It was found that the biodegradation of DMDS was governed by zero-order reaction -limited macro-kinetics for inlet DMDS concentrations between 10 and 55 ppmv. The overall average zero-order kinetic coeffi-cient for DMDS removal by compost was 0.50 ($\pm$0.1) ppm/sec for both compost mixtures studied. Variations in individual kinetic coefficients were observed due to varying environmental conditions, such as pH and temperature. The kinetic coefficients determined are specific to the system discussed in this work. During high acidity conditions in the filter beds, methyl mercaptan (MM) was observed in the gas samples collected. Appearance of MM was pro-bably due to decreased microbial activity in the lower portions of the biofilter. Considering the neutral pH range required and the presence of methyl mercaptan, it is likely that the microorganisms present in the biofilters used in this research are similar to the T. thioparus (strain E6) species.

• Journal of Microbiology and Biotechnology
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• 제17권5호
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• pp.853-857
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• 2007

The semi-outdoor cultivation of Spirulina platens is was attempted using an underground-water-based medium. Occurrence of contaminant organisms such as Chlorella sp. and Chlamydomonas sp. was not found from a microscopic observation and bacteria were not detected from denaturing gradient gel electrophoresis(DGGE) analysis of PCR-amplified 16S rDNA during the cultivation, owing to pH control and the high quality of the underground water. The mean productivity was high at $10.5g/m^2/d$ with a range of $4.2-12.3g/m^2/d$ despite the unfavorable weather conditions of the rainy season. The cultivated S. platens is included a normal protein content of 58.9%. Consequently, the underground water improved the biomass productivity and the biomass quality because of an abundant supplementation of natural minerals and through a contaminant-free culture.