• 한국산학기술학회논문지
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• 제15권7호
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• pp.4087-4092
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• 2014

관절형 고속철도차량 갱웨이 통로연결막은 객차 끝단부 사이에 다양한 회전각 변위하에 통로의 기밀을 유지하는 이중 주름구조 고무부품이다. 비선형구조해석결과로부터 본 부품의 심각한 작용하중조건 중의 하나는 차량기지내 작은 곡선반경의 인입선 통과시 발생하는 혼합모드(롤링+요잉)회전 각변위조건이다. 본 연구에서는 고속철도차량 통로연결막의 안전성 향상 연구일환으로서, 통로연결막의 단면형상에 대하여 SIMP 기법을 이용하여 최적설계를 수행하였다. 비선형 구조해석결과로부터 본 최적설계안의 최대 주변형률은 혼합모드 및 롤링모드하에서 기존모델보다 각각 68% 및 39% 감소함을 확인하였다.

• 대한치과보철학회지
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• 제36권4호
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• pp.615-643
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• 1998

The purpose of this study was to evaluate the effect of cantilever length, load, and implant number on the stress distribution of implant supported fixed prosthesis. In the replica of an edentulous human mandible, four or five implants were placed and spaced evenly between the mental foramina and symmetrical gold alloy cast superstructures with cantilever were fabricated. Strain gauges were placed in buccal and lingual side of implants. 9, 15, 21kg of loads at varying cantilever lengths were applied to the occlusal surface of fixed prostheses. The strains were recorded from each gauge and principal stresses were calculated The results were as follows : 1. Increasing the length of the cantilever increased the stresses on the bone supporting implants. and the ratio of increase became high as increasing the load. 2. In the model with four implants, the highest compressive stress was measured on lingual side of the first implants nearest loading point and the highest tensile stress was measured on buccal side of the second implants. 3. In the model with five implants, the highest compressive stress was measured on lingual side of the first implants nearest loading point. And the highest tensile stress was measured on buccal side of the second implants, and lingual side of the third implants. 4. There was no significant change of the magnitude of stress on the most distal imp]ant of non cantilevered side as increasing the cantilever length or load. 5. In general, the superstructure supported by five implants reduced the stress and was less affected by cantilever length compared to the support provided by four implants.

• 한국지반공학회논문집
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• 제15권6호
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• pp.121-130
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• 1999

본 연구는 전응력 개념에 근거한 비등방경화 구성관계를 적용하여 유한요소해석을 수행하는 데 목적이 있다. 이에 대상문제에 적합한 비등방경화 구성관계를 개발하여 수학적으로 정식화하고 실험적으로 검증하였다. 동반논문에서는 유한요소해법의 정확도와 수렴성을 확보하도록 정식화하여 해석코드에 구현한 후 실제문제를 해석한다. 제안된 구성관계는 von Mises 형태의 파괴규준과 일반 등방경화규칙에 의거한 비등방경화규칙을 채택하여 비선형성과 비등방성이 심한 응력-변형률 관계를 모델하였다. 결과적으로 UU 삼축시험, 과압밀 상태에 대한 CU 삼축시험, $K_0$ 압밀조건의 주응력축 회전시 비등방적 거동에 대하여 검증할 수 있었다.

• Journal of Oral Medicine and Pain
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• 제24권4호
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• pp.361-374
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• 1999

F. nucleatum is a gram-negative obligate anaerobe which is the principal and most frequent cause of gingival inflammation and is the predominant pathogen isolated in subsequent periodontal breakdown. It is also one of the most numerous bacteria found in subgingival plaque samples from healthy sites; its numbers are about 10-fold greater in plaque from periodontally diseased sites. The purpose of this study is to examine the effects of outer membrane(OM), outer membrane vesicle(OMV), and lipopolysaccharide(LPS) from F. nucleatum ATCC 25586 strain on the growth of human gingival fibroblasts and HOS 941 cells, and on the $TNF-{\alpha}$ production / $TNF-{\alpha}$ mRNA expression of mouse splenocytes. For the examination of cytotoxic effects, $TNF-{\alpha}$ production and $TNF-{\alpha}$ mRNA expression, the MTT assay, the ELISA and the RT-PCR were performed, respectively. All extracts of F. nucleatum tested were cytotoxic to both of human gingival fibroblasts and HOS 941 cells, and the significant difference of cytotoxic activity among the extracts was not observed. In the effects of these extracts on the $TNF-{\alpha}$ production / $TNF-{\alpha}$ mRNA expression of mouse splenocytes, all extracts of F. nucleatum tested also stimulated the $TNF-{\alpha}$ production / $TNF-{\alpha}$ mRNA expression, but the effects of the OM extracts on the $TNF-{\alpha}$ production / $TNF-{\alpha}$ mRNA expression were higher than those of the OMV and the LPS extracts. The pattern of the $TNF-{\alpha}$ mRNA expression was similar to that of the $TNF-{\alpha}$ production. These results indicate that F. nucleatum seems to contribute to the pathogenesis of periodontal diseases at least by its cytotoxicity, directly and its $TNF-{\alpha}$ production, indirectly.

• Toxicological Research
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• 제23권1호
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• pp.65-72
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• 2007

This study was conducted to obtain information of the oral dose acute toxicity of PGB-2, a novel polyglucosamine polymer produced from Citrobacter sp. BL-4 (a new strain) in male and female mice. Mortality, body weight changes, clinical signs were monitored during 14 days after single oral dose of test article at dose levels of 2000, 1000, 500, 250 and 125 ml/kg. Gross lesions, organ weight and histopathology of principal organs were examined after necropsy. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings except for white foci in the liver. In addition, no PGB-2-treatment related abnormal changes on the organ weight and histopathology of principle organs were detected except for atypical signs of liver. White liver foci were confirmed as focal infiltration of inflammatory cells. The results suggest that the PGB-2 is relatively safe in mice but the possibility of hepatotoxicity could not be excluded. The $LD_{50}$ and approximate LD in mice after single oral dose of PGB-2 were considered over 2000 mg/kg, respectively. In future, the potential hepatotoxicity of PGB-2 should be evaluated through the repeat dose toxicity test prior to develop as a new agent.

• Advances in Traditional Medicine
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• 제8권2호
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• pp.111-124
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• 2008

In the present study, an attempt has been made to assess whether the effect of benzene extract of Ocimum sanctum leaves on the ultrastructural changes in the epithelial cells of the cauda epididymis, its subsequent recovery in the seminiferous epithelium and fertility of male albino rats. Wistar strain male albino rats were orally administered benzene extract of 250 mg/kg body weight of O. sanctum leaves followed by subsequent recovery maintaining suitable controls for 48 days. Results indicate decrease in the weights of testis, epididymis and seminal vesicles. Other accessory organs were not affected. Total count, cell and nuclei diameters of germ cells and Leydig cells were reduced. Cauda epididymis exhibited significant reduction in epithelial height and nuclei diameter of epithelial cells. Cells showed vacuolization with exhibit of signs of degeneration. Ultra study revealed that, in general, the cauda epididymis was affected and in particular, the principal, clear and basal cells were highly disturbed. Further, there was decrease in the size of lipid droplets, mitochondria, Golgi complex, endoplasmic reticulum and accumulation of lysosomal bodies. Fertility performance test showed no implantation in female rats mated with O. sanctum treated rats. Moreover, their recovery after withdrawal of treatment was observed suggesting that the effect of the treatment is transient and reversible. A recovery period resulted in normal spermatogenesis and fertility, suggesting reversible antispermatogenic and antifertility effects of the plant.

• International Journal of Concrete Structures and Materials
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• 제10권sup3호
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• pp.53-63
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• 2016

Steel fiber-reinforced prestressed concrete (SFRPSC) members typically have high shear strength and deformation capability, compared to conventional prestressed concrete (PSC) members, due to the resistance provided by steel fibers at the crack surface after the onset of diagonal cracking. In this study, shear tests were conducted on the SFRPSC members with the test variables of concrete compressive strength, fiber volume fraction, and prestressing force level. Their localized behavior around the critical shear cracks was measured by a non-contact image-based displacement measurement system, and thus their shear deformation was thoroughly investigated. The tested SFRPSC members showed higher shear strengths as the concrete compressive strength or the level of prestress increased, and their stiffnesses did not change significantly, even after diagonal cracking due to the resistance of steel fibers. As the level of prestress increased, the shear deformation was contributed by the crack opening displacement more than the slip displacement. In addition, the local displacements around the shear crack progressed toward directions that differ from those expected by the principal strain angles that can be typically obtained from the average strains of the concrete element. Thus, this localized deformation characteristics around the shear cracks should be considered when measuring the local deformation of concrete elements near discrete cracks or when calculating the local stresses.

• Steel and Composite Structures
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• 제36권2호
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• pp.163-177
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• 2020

Concentrically Braced Frames (CBFs) are commonly used in the construction of steel structures because of their ease of implementation, rigidity, low lateral displacement, and cost-effectiveness. However, the principal disadvantage of this kind of braced frame is the inability to provide deformation capacity (ductility) and buckling of bracing elements before yielding. This paper aims to present a novel Composite Buckling Restrained Fuse (CBRF) to be utilized as a bracing segment in concentrically braced frames that allows higher ductility and removes premature buckling. The proposed CBRF with relatively small dimensions is an enhancement on the Reduced Length Buckling Restrained Braces (RL-BRBs), consists of steel core and additional tensile elements embedded in a concrete encasement. Employing tensile elements in this composite fuse with a new configuration enhances the energy dissipation efficiency and removes the tensile strength limitations that exist in bracing elements that contain RL-BRBs. Here, the optimal length of the CBRF is computed by considering the anticipated strain demand and the low-cyclic fatigue life of the core under standard loading protocol. An experimental program is conducted to explore the seismic behavior of the suggested CBRF compare with an RL-BRB specimen under gradually increased cyclic loading. Moreover, Hysteretic responses of the specimens are evaluated to calculate the design parameters such as energy dissipation potential, strength adjustment factors, and equivalent viscous damping. The findings show that the suggested fuse possess a ductile behavior with high energy absorption and sufficient resistance and a reasonably stable hysteresis response under compression and tension.

• Computers and Concrete
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• 제17권1호
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• pp.1-27
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• 2016

Final construction project cost is significantly determined by construction rate. The Industrialized Building System (IBS) was promoted to enhance the importance of prefabrication technology rather than conventional methods in construction. Ensuring the stability of a building constructed by using IBS is a challenging issue. Accordingly, the connections in a prefabricated building have a basic, natural, and essential role in providing the best continuity among the members of the building. Deficiencies of conventional precast connections were observed when precast buildings experience a large induced load, such as earthquakes and other disasters. Thus, researchers aim to determine the behavior of precast concrete structure with a specific type of connection. To clarify this problem, this study investigates the capacity behavior of precast concrete panel connections for industrial buildings with a new type of precast wall-to-wall connection (i.e., U-shaped steel channel connection). This capacity behavior is compared with the capacity behavior of precast concrete panel connections for industrial buildings that used a common approach (i.e., loop connection), which is subjected to monotonic loading as in-plane and out-of-plane loading by developing a finite element model. The principal stress distribution, deformation of concrete panels and welded wire mesh (BRC) reinforcements, plastic strain trend in the concrete panels and connections, and crack propagations are investigated for the aforementioned connection. Pushover analysis revealed that loop connections have significant defects in terms of strength for in-plane and out-of-plane loads at three translational degrees of freedom compared with the U-shaped steel channel connection.

• 한국터널지하공간학회 논문집
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• 제8권2호
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• pp.87-100
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• 2006

본 연구에서는 화강암의 3차원 거동을 예측 분석할 수 있는 구성방정식을 마이크로플레인 모델을 이용하여 Westerly 화강암과 Bonnet 화강암의 시험데이터와 최적을 이루도록 개발하였다. 개발된 마이크로플레인 모델은 화강암의 일축압축 및 삼축압축 거동을 잘 예측하였다. 그리고 개발된 화강암의 마이크로플레인 모델을 유한요소법에 적용하여 암반 굴착시의 발파 모사를 통해 화강암의 비선형 거동을 효과적으로 해석하였다. 발파 응력파의 감쇠계수, 파쇄 영역 그리고 여굴을 방지할 수 있는 화약 장전조건 등이 연구되었다. 마이크로플레인 모델에서는 암석의 비선형 거동 및 균열발생으로 인한 에너지 감소가 잘 반영되었으며 발파 응력파의 감쇠계수는 선형탄성모델보다 크게 계산되었다. 또한 마이크로플레인 모델에서는 발파 응력파 진행에 따른 최대 주변형율을 이용하여 파쇄 영역을 직접적으로 계산할 수 있었다.