• Title/Summary/Keyword: Primary response

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Primary Angle-Closure Glaucoma in a Maltipoo Dog

  • Jiwoo Park;Manbok Jeong
    • Journal of Veterinary Clinics
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    • v.40 no.3
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    • pp.221-224
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    • 2023
  • A two-year-old spayed female Maltipoo dog was presented with a two-month duration of glaucoma in the right eye. On the first presentation, menace response and dazzle reflex were absent in the right eye, but it was present in the left eye. Slit-lamp biomicroscopy showed buphthalmia, mild corneal edema, and conjunctival and episcleral hyperemia in the right eye. The intraocular pressures were 70 mmHg and 30 mmHg in the right and left eyes, respectively. On the gonioscopic and high-resolution ultrasound examinations, both the iridocorneal angle and ciliary cleft were completely closed in the right eye. However, gonioscopy revealed an opened iridocorneal angle even with some broader base of pectinate ligament fiber, but high-resolution ultrasound showed a narrowed ciliary cleft and increased contact of the iris base with the limbal cornea in the left eye. Based on these results, a diagnosis of primary angle-closure glaucoma was made in both eyes. This case report highlighted the importance of evaluating the ciliary cleft with high-resolution ultrasound as a critical diagnostic and prognostic role in canine glaucoma.

Thermal post-buckling and primary resonance of porous functionally graded beams: Effect of elastic foundations and geometric imperfection

  • Jia-Qin Xu;Gui-Lin She
    • Computers and Concrete
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    • v.32 no.6
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    • pp.543-551
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    • 2023
  • In this article, thermal post-buckling and primary resonance of the porous functionally graded material (FGM) beams in thermal environment considering the geometric imperfection are studied, the material properties of FGM beams are assumed to vary along the thickness of the beam, meanwhile, the porosity volume fraction, geometric imperfection, temperature, and the elastic foundation are considered, using the Euler-Lagrange equation, the nonlinear vibration equations are derived, after the dimensionless processing, the dimensionless equations of motion can be obtained. Then, the two-step perturbation method is applied to solve the vibration problems, the resonance and thermal post-buckling response relations are obtained. Finally, the functionally graded index, the porosity volume fraction, temperature, geometric imperfection, and the elastic foundation on the resonance behaviors of the FGM beams are presented. It can be found that these parameters can influence the thermal post-buckling and primary resonance problems.

A study on the Crashworthiness Design of Bow Structure of Oil Carriers -Collision Behaviour of Simplified Models(1) (유조선 선수부의 내충돌 구조설계에 관한 연구 -이상화 모델의 충돌거동 분석(1))

  • 신영식;박명규
    • Journal of Ocean Engineering and Technology
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    • v.15 no.3
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    • pp.120-127
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    • 2001
  • The potential pollution problems resulting from tanker collision necessitate the requirement for an effective structural design and the development of relevant safety regulations. During a few decades, the great effort has been made by the international Maritime Organization and the Administration, etc, to reduce oil spillage from collision accidents. However there is still a need for investigation in the light of structural evaluation method for the experiments and rational analysis, and design development for an operational purpose of ships. This study aims for investigating a complicated structural response of bow structures of simplified models and oil carriers for assessing the energy dissipation and crushing mechanics of the striking vessels through a methodology of the numerical analysis for the various models and its design changes. Through these study an optimal bow construction absorbing great portion of kinetic energy at the least penetration depth prior to reach to the cargo area and an effective location of collision bulkhead are investigated. In order to obtain a rational results in this study, three stages of collision simulation procedures have been performed step by step as follows; 1) 16 simplified ship models are used to investigate the structural response against bow collision with variation of primary and secondary members. Mass and speed are also varied in four conditions. 2) 21 models consisted of 5 sizes of the full scaled oil carriers are used to perform the collision simulation with the various sizes and deadweight delivered in a recent which are complied with SOLAS and MARPOL. 3) 36 models of 100l oil carrier are used to investigate the structural response and its influence to the collision bulkhead against bow collision in variation with location of collision bulkhead, primary members, framing system and colliding conditions, etc. By the first study using simplified models the response of the bow collision is synthetically evaluated for the parameters influencing to the absorbed energy, penetration depth and impact force, etc.

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Effect of Customer Value on Customer Loyalty in Primary Care: Focusing on the Mediating Role of Customer Satisfaction (일차 의료에서 고객가치가 고객충성도에 미치는 영향 고객만족의 매개역할을 중심으로)

  • Joung, Mee-Young;Yang, Hae-Sool
    • The Journal of the Korea Contents Association
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    • v.8 no.11
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    • pp.225-234
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    • 2008
  • The purpose of this study was to examine how Customer Value perceived by customers affected Customer Loyalty through Customer Satisfaction in Primary Care and to reveal the structural relationship of selected variables related to CRM. The major findings of the study were as follows: First, Convenience Value, Response Value and Reliability Value exerted an influence on Customer Satisfaction. Second, Customer Satisfaction affected Customer Loyalty that referred to Repurchase and Word-of-Mouth Intention. Third, Convenience Value, Response Value and Reliability Value had an effect on Repurchase through the perfect mediating role of Customer Satisfaction, and Convenience Value and Response Value exercised an influence on Word-of-Mouth Intention through the perfect mediating role of Customer Satisfaction. Reliability Value served to stir up Word-of- Mouth Intention even if there was no Customer Satisfaction.

A Study on the Crashworthiness Design of Bow Structure of Oil Carriers (유조선 선수부의 내충돌 구조설계에 관한 연구)

  • 신영식;박명규
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2001.05a
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    • pp.119-126
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    • 2001
  • The potential pollution problems resulting from tanker collision necessitate the requirement for an effective structural design and the development of relevant safety regulation. During a few decades, the great effort has been made by International Maritime Organization and the Administration, etc, to reduce oil spillage from collision accidents. However there is still a need for investigation in the light of structural evaluation method for the experiments and rational analysis, and design development for an operational purpose of ships. This study is aimed at investigating a complicated structural response of bow structures of oil carriers for assessing the energy dissipation and crushing mechanics of striking vessel through a methodology of the numerical analysts for the various models and its design changes. Through this study an optimal bow construction absorbing great portion of kinetic energy in the least penetration depth prior to reach to the cargo area and an effective location of collision bulkhead are investigated. In order to obtain a rational results in this study, three stages of response analysis procedures are performed as follows; 1). 16 simplified ship models are used to investigate the structural response against bow collision with variation of primary and secondary members. Mass and speed are also varied in two conditions. 2). 21 models conisted of 5 size of full scaled oil carriers are used to perform the collision simulation with the various sizes and deadweight delivered in a recent which are complied with SOLAS and MARPOL. 3). 36 models of 100k oil carrier are used to investigate the structural response and its influence to the collision bulkhead against bow collision in variation with location of collision bulkhead, primary mombers, framing system and colliding conditions, etc.

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Response Characteristics of S-HTP Tests - Seven Emotions and Cognitive Processes (S-HTP 검사의 반응 특성 - 한의학적 칠정과 인지과정을 중심으로)

  • Jeong, Seo-yun;Hur, Shin-chul;Bae, Jin-soo;Kim, Kyeong-ok
    • Journal of Oriental Neuropsychiatry
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    • v.31 no.4
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    • pp.249-258
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    • 2020
  • Objectives: S-HTP is a projective test of cognitive activity. The purpose of this study was to examine the response characteristics in the S-HTP test as they related to seven emotions and cognitive processes. Methods: 153 students underwent S-HTP testing. 10 students were excluded and a total of 143 students' data was used for the study. 143 students were classified into four groups by SCAT. A survey was conducted on seven emotions and cognitive processes painting the Whole picture, house, tree, and person, and after receiving IRB review exemption, the chi-square test was conducted to check homogeneity of the groups by gender and age. Finally, frequency analysis by constitution for each item was conducted. Results: The reaction characteristics of S-HTP, focusing on the seven emotions and cognitive processes detailed by Korean Medicine, are as follows: 1. The primary sentiment while drawing during S-HTP was 'Joy (hui)' followed by 'Thought (sah)'. 2. The sentiments while painting during the S-HTP test, and the emotions of looking at the picture after the S-HTP test, increased in 'Joy (hui)' and decreased in 'Thought (sah)'. 3. 'Thought (Sah)' was the highest scored process while drawing S-HTP, followed by 'jee (智)'. However, 'ryeo (慮)' was similar to 'jee (智)' in an unclassifiable constitution. Conclusions: The primary characteristics of the S-HTP test response are 'Joy (hui)' and 'Thought (sah)' in emotion, and 'sah (思)' and 'jee (智)' in cognitive processes. Therefore, it is necessary to verify this during the S-HTP test.

Interpretation of Rectal MRI after Neoadjuvant Treatment in Patients with Rectal Cancer (수술 전 선행보조치료를 받은 직장암 환자의 직장 자기공명영상의 해석)

  • Nieun Seo;Joon Seok Lim
    • Journal of the Korean Society of Radiology
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    • v.84 no.3
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    • pp.550-564
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    • 2023
  • MRI is currently the imaging modality of choice to evaluate rectal cancer after neoadjuvant treatment. The purposes of restaging MRI are to assess the resectability of rectal cancer and to decide whether organ preservation strategies can be applied in patients with a complete clinical response. This review article indicates the key MRI features needed to evaluate rectal cancer after neoadjuvant treatment using a systematic approach. Assessment of primary tumor response including MRI findings to predict a complete response is discussed. Additionally, MRI evaluation of the relationship between the primary tumor and adjacent structures, lymph node response, extramural venous invasion, and tumor deposits after neoadjuvant treatment is presented. Knowledge of these imaging features and their clinical relevance may help radiologists provide an accurate and clinically valuable interpretation of restaging rectal MRI.

Response of non-structural components mounted on irregular RC buildings: comparison between FE and EC8 predictions

  • Aldeka, Ayad B.;Chan, Andrew H.C.;Dirar, Samir
    • Earthquakes and Structures
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    • v.6 no.4
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    • pp.351-373
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    • 2014
  • This paper investigates the seismic response of lightweight acceleration-sensitive non-structural components (NSCs) mounted on irregular reinforced concrete (RC) primary structures (P-structures) using non-linear dynamic finite element (FE) analysis. The aim of this paper is to study the influence of NSC to P-structure vibration period ratio, peak ground acceleration, NSC to P-structure height ratio, and P-structure torsional behaviour on the seismic response of the NSCs. Representative constitutive models were used to simulate the behaviour of the RC P-structures. The NSCs were modelled as vertical cantilevers fixed at their bases with masses on the free ends and varying lengths so as to match the frequencies of the P-structures. Full dynamic interaction is considered between the NSCs and P-structures. A set of 21 natural and artificial earthquake records were used to evaluate the seismic response of the NSCs. The numerical results indicate that the behaviour of the NSCs is significantly influenced by the investigated parameters. Comparison between the FE results and Eurocode (EC8) predictions suggests that EC8 underestimates the response of NSCs mounted on the flexible sides of irregular RC P-structures when the fundamental periods and heights of the NSCs match those of the P-structures. The perceived cause of this discrepancy is that EC8 does not take into account the amplification in the dynamic response of NSCs induced by the torsional behaviour of RC P-structures.

Requirement of CD4 Help for Induction of CD8 T Cell Response Specific for Virally Derived H60

  • Ryu, Su-Jeong;Kang, Bo-Ra;Kim, Seok-Ho;Kim, Tae-Woo;Chang, Jun;Choi, Eun-Young
    • IMMUNE NETWORK
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    • v.12 no.3
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    • pp.118-125
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    • 2012
  • CD40-CD40L-mediated help from CD4 T cells is essential to induce primary CD8 T cell responses specific to the non-inflammatory cell-based antigen H60. In this study, using H60 as a model antigen, we generated recombinant vaccinia viruses (rVVs) expressing the H60 CD8 epitope and investigated whether CD4 help was required to activate the CD8 T cell response specific to the virally expressed H60. The immune response after infection with rVVs expressing H60 was similar to that after immunization with H60 congenic splenocytes, with a peak frequency of H60-specific CD8 T cells detected in the blood on day 10 post-infection. A CD8 T cell response specific for virally derived H60 was not induced in CD4-depleted mice, but was in CD40-deficient mice. These results provide insights into the characterization of the CD8 T cell response specifically for antigens originating from cellular sources compared to viral sources.

Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer

  • Choi, Chi Hwan;Kim, Won Dong;Lee, Sang Jeon;Park, Woo-Yoon
    • Radiation Oncology Journal
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    • v.30 no.3
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    • pp.99-107
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    • 2012
  • Purpose: The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. Materials and Methods: The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a boost of 5.4 Gy in 3 fractions to the primary tumor with 5 fractions per week. Three different chemotherapy regimens were used (5-fluorouracil and leucovorin, capecitabine, or tegafur/uracil). Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and pathologic complete response (ypCR). Statistical analyses were performed to identify clinical factors associated with pathologic tumor response. Results: Tumor downstaging was observed in 28 patients (54.9%), whereas ypCR was observed in 6 patients (11.8%). Multivariate analysis found that predictors of downstaging was pretreatment relative lymphocyte count (p = 0.023) and that none of clinical factors was significantly associated with ypCR. Conclusion: Pretreatment relative lymphocyte count (%) has a significant impact on the pathologic tumor response (tumor downstaging) after preoperative CRT for locally advanced rectal cancer. Enhancement of lymphocyte-mediated immune reactions may improve the effect of preoperative CRT for rectal cancer.