• 한국실내디자인학회논문집
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• 제27권1호
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• pp.48-57
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• 2018

Recently, cosmetic shops are facing a complicate economy situation and a great number of brands are attempting two-way communication with customers, not one-way communication. 'Brand' equity is important to deliver virtual brand mark as visual image. We have 4 steps for brand identity structure, and this study is about the first 'brand-awareness' and the second step 'brand-image'. We investigated the correlation between brand-awareness and brand-image after searching which spatial elements are highly effective to both steps as we designated 5 cosmetic shops. We already organized the means of spatial analysis and we separated into two elements, constructive and decorative. For constructive element, a shop needs a distinct ceiling and wall design, and for decorative element, strong brand image communication is required through showcase design. We proved that brand awareness and brand image have the correlation, which also can be in direct proportion, by regression analysis. The result of this study shows that improving brand awareness as the primary element for cosmetic road shop can be an effective way to enhance brand image.

• Journal of Chest Surgery
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• 제12권3호
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• pp.151-158
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• 1979

This is a report of 3 cases of tumors, which primarily originated from ribs and the sternum. In the first case of multiple myeloma, the patient was 67 year old male with a tumor located on the middle sternum invading the manubrium and the body of the sternum manifesting symptoms after a contusion of the anterior sternum. The sternum was entirely resected and was replaced by tantalum plate to reconstruct the defective chest wall in order to prevent the paradoxical movement during respiration. In the second case of osteogenic sarcoma, the patient was 43 year old male with a tumor located on the costochondral junction of the left 5th rib for 6 months. The left 5th rib was resected between the middle part and sternochondral junction of it including tumor and adjacent soft tissues. In the third case of chondrosarcoma, the patient was 36 year old male with a tumor located near the posterior angles of the right 7th and 8th ribs manifesting back pain on the area where the tumor was located. Resection of right lower lobe was performed since direct invasion of tumor was seen in the superior segment of right lower lobe. This was followed by the resection of both 7th and 8th ribs at the area between the costovertebral junction and the portion 10 em apart from the tumor including the tumor and intercostal soft tissues. Diagnoses of 3 cases of tumors described above were confirmed by histopathologic examination postoperatively. The postoperative courses were uneventful.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 추계학술대회 논문집
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• pp.594-599
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• 2009

Recent developments such as concern over global warming, depletion of fossil fuels and increase in energy demands by the increasing world population has eventually lead to mass production of electricity using renewable sources. Apart from wind and solar, ocean holds tremendous amount of untapped energy in forms such as geothermal vents, tides and waves. The current study looks at generating power using waves and the focus is on the primary energy conversion (first stage conversion) of incoming waves for different models. Observation of flow characteristics and the velocity in the augmentation channel as well as the front guide nozzle are presented in the paper. A numerical wave tank was used to simulate the waves and after obtaining the desired wave properties; the augmentation channel plus the front guide nozzle and rear chamber were integrated to the numerical wave tank. The waves in the numerical wave tank were generated by a piston type wave maker which was located at the wave tank inlet. The inlet which was modeled as a plate wall moved sinusoidally with the general function, x=asin$\omega$t The augmentation channel consisted of a front nozzle, rear nozzle and an internal fluid region representing the turbine housing. The analysis was performed using the commercial CFD code ANSYS-CFX.

• The Korean Journal of Legal Medicine
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• 제42권4호
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• pp.159-163
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• 2018

Progressive muscular dystrophy (PMD) is a primary muscle disease characterized by progressive muscle weakness and wasting, which is inherited by an X-linked recessive pattern and occurs mainly in males. There are several types of muscular dystrophies classified according to the distribution of predominant muscle weakness including Duchenne and Becker, Emery-Dreifuss, facioscapulohumeral, oculopharyngeal, and limb-girdle type. Clinical manifestations of PMD are clumsy, unsteady gait, pneumonia, heart failure, pulmonary edema, hydropericardium, hydrothorax, aspiration, syncopal attacks, and sudden cardiac death. The deceased was a 34-year-old man, and the onset of the first clinical symptom, gait disturbance, was in his late teens. His elder brother had the same disease and experienced brain death after a head trauma and died after mechanical ventilation was discontinued. After an autopsy, we found contracture of the joints, pseudohypertrophy of the calf, wasting and fat replacement of the thigh muscle, pericardial effusion (80 mL), fibrosis and fat replacement of the cardiac ventricular wall, pulmonary edema, and froth in the bronchus. The cause of death was heart failure and dyspnea due to muscular dystrophy. There was no sign or suspicion of foul play in his death.

• 한국산학기술학회논문지
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• 제22권6호
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• pp.460-468
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• 2021

본 연구는 multi fan 방식의 "공랭식 연소설비"의 공정관리상의 문제점을 single F.D. fan 으로 대체하여 개선시키기 위해 CFD 진행하였고, 연소로 내 유동조건 변화를 분석하여 문제점을 확인하였다. 이를 개선하기 위해 연소공기 주입구조를 변경하였고, 구조 변화에 따른 연소효율 개선을 수치해석으로 평가하였다. 또한 실제 연소설비에 수치해석결과를 반영하여 구조개선을 한 후 개선 전·후의 연소효율을 실험적으로 측정하였다. 먼저 기존 Single F.D fan 이 적용된 연소설비에 대한 수치해석을 통해, 2개의 유로로 공급되는 연소공기가 각 유로의 마찰력 차이와 압력의 변화로 인해 연소로 내에서 공급비율이 불규칙하게 되어 선회방식의 연소조건을 위한 축 형태의 난류형성이 어려움을 확인하였다. 이를 개선하기 위해서 연소로에 주입하는 공기 공급 방식을 두 가지로 나누어 수치해석을 하였다. 첫 번째 방식은 연소공기를 외벽에서 180 ~ 360° 회전 후 예열된 연소공기가 주입되는 구조에 대하여 검토하였고, 두 번째는 연소로 내에는 선회할 수 있는 베인(vane) 구조를 적용하여 연소로 밖에서 1차 열교환 후 연소로 내부에 접선방향으로 연소공기가 주입되는 구조에 대하여 검토하였다. 그 결과, single F.D. fan을 가진 공랭식 연소로에 선회방식으로 공기를 주입할 경우, 연소로 외벽의 냉각과 연소로 내부의 완전혼합 유지를 위해 이중 냉각벽을 가지는 덕트 구조를 적용하는 것이 연소조건을 최적화하는데 바람직한 것으로 나타났으며, 실제 운영중인 설비에 적용하여 개선 전·후의 연소효율을 비교한 결과 연소효율이 개선되는 것을 확인할 수 있었다.

• 한국농촌건축학회논문집
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• 제19권2호
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• pp.9-16
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• 2017

The study analyzed the heat losses and the building energy efficiency grade by the energy simulation using the ENERGY# and ECO2 programs for the three types of Standard design of rural houses. It was calculated the energy efficiency rating by the ECO2 program for the rural housing standard design, and the energy demand and the energy consumption by each factor were compared and analyzed. And it analyzed energy consumption by element of each house by ENERGY # program. As a result, first in the evaluation of the energy efficiency grade of buildings by the ECO2 program, the rating for primary energy requirement for the housing newly built by the standard design of rural house is expected to range from 2 to 4 with 189.3 to $238.7kWh/m^2.a$. Second, the energy loss of each part of standard design of rural housing occurs in the order of ventilation 39%, window 33%, outer wall 14%, roof 9%, bottom 5%, and energy loss through ventilation and window occurs more than 70%. Third, the most beneficial effects on the energy efficiency grade is obtained the lowest grade of all three types by 2 when the lowering of the window and door heat transmission rate and the lowering of the light density, and the heat exchange ventilation device is not installed. Fourth, in the standard design of rural housing, the energy demand is occupied by heating > hot water > lighting order, and the order of the weight is changed in order of heating > lighting > ventilation > hot water. Fifth, building energy efficiency assessment system needs to establish policy for fixing rural housing energy as a practical device to ensure energy performance and quality.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.143-148
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• 2014

Marfan syndrome (MFS) is a dominantly inherited connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1) and is characterized by aortic dilatation and dissection, which is the primary cause of death in untreated MFS patients. However, disease progression-associated changes in gene expression in the aortic lesions of MFS patients remained unknown. Using a mouse model of MFS, FBN1 hypomorphic mouse (mgR/mgR), we characterized the aortic gene expression profiles during the progression of the MFS. Homozygous mgR mice exhibited MFS-like phenotypic features, such as fragmentation of elastic fibers throughout the vessel wall and were graded into mgR1-4 based on the pathological severity in aortic walls. Comparative gene expression profiling of WT and four mgR mice using microarrays revealed that the changes in the transcriptome were a direct reflection of the severity of aortic pathological features. Gene ontology analysis showed that genes related to oxidation/reduction, myofibril assembly, cytoskeleton organization, and cell adhesion were differentially expressed in the mgR mice. Further analysis of differentially expressed genes identified several candidate genes whose known roles were suggestive of their involvement in the progressive destruction of aorta during MFS. This study is the first genome-wide analysis of the aortic gene expression profiles associated with the progression of MFS. Our findings provide valuable information regarding the molecular pathogenesis during MFS progression and contribute to the development of new biomarkers as well as improved therapeutic strategies.

• 한국임상수의학회지
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• 제29권3호
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• pp.242-246
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• 2012

3살된 코리안 숏헤어 고양이(몸무게 5.2 kg)가 복수, 흉수, 호흡곤란으로 인해 강원대학교 수의과대학병원에 진료의뢰 되었다. 진단검사상, 유미성 흉수와 출혈성 복수, 심장비대, PW 도플러 초음파와 TDI 초음파의 restrictive filling pattern, 미비하게 비대된 좌심실 자유벽이 관찰되었다. 심장초음파 진단소견을 토대로 제한성 심근병증으로 잠정진단 내리게 되었다. 본 환자는 흉수를 제거하고 furosemide, enalapril, sildenafil, clopidogrel을 포함한 약물치료를 하였다. 이것은 국내에서 처음으로 발표하는 제한성 심근병증의 증례이다.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1983년도 제17차 학술대회연제순서 및 초록
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• pp.18.1-18
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• 1983

1923년 Pierre-Robin이 소하악증, 설하수증 및 고궁구개(high-arched palate)혹은 구개 파열의 3주징을 처음으로 기술하였다. 기도장애가 자주 발생하고, 신속하며 적절한 치료를 필요로 한다. 이 증후군은 출생아 5만명 중 1명 정도로 드물게 발생한다. 이 증후군의 원인은 불명확하지만 하악골발달의 일차적 부전 때문으로 알려져 있다. 소하악증으로 인해 혀의 기저부가 후방으로 이동하여 인두후벽에 접근하여 기도폐쇄의 증상이 발생하며 이는 영아가 앙와위를 취할 때 악화된다. 환자를 복와위로 유지시킴으로서 경한 기도폐쇄의 문제들은 해결되지만, 섭식장애가 있을 경우에는 기도폐쇄가 악화되므로 빨리 설고정술을 실시하는 것이 좋으나 기관절개술은 최대한 피하는 것이 좋다. 설고정술에는 Douglas 수술법, Kirschner wire 삽입법 및 Duhamel 봉합법 등이 있다고 알려져 있다. 저자들은 최근 호흡곤란 및 섭식장애를 주소로 내원한 출생 2개월 된 남아에서 소하악증, 설하수증 및 고궁구개 (high-arched palate)를 확인하였으며 Duhamel 봉합법으로 기도폐쇄의 증상이 호전되지 않아 기관절개술을 시행한 후 관찰 중인 이 환자를 Pierre-Robin Syndrome으로 생각하기에 보고하는 바이다.

• Molecules and Cells
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• 제46권12호
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• pp.746-756
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• 2023

A recent study revealed that the loss of Deup1 expression does not affect either centriole amplification or multicilia formation. Therefore, the deuterosome per se is not a platform for amplification of centrioles. In this study, we examine whether gain-of-function of Deup1 affects the development of multiciliated ependymal cells. Our time-lapse study reveals that deuterosomes with an average diameter of 300 nm have two different fates during ependymal differentiation. In the first instance, deuterosomes are scattered and gradually disappear as cells become multiciliated. In the second instance, deuterosomes self-organize into a larger aggregate, called a deuterosome cluster (DC). Unlike scattered deuterosomes, DCs possess centriole components primarily within their large structure. A characteristic of DC-containing cells is that they tend to become primary ciliated rather than multiciliated. Our in utero electroporation study shows that DCs in ependymal tissue are mostly observed at early postnatal stages, but are scarce at late postnatal stages, suggesting the presence of DC antagonists within the differentiating cells. Importantly, from our bead flow assay, ectopic expression of Deup1 significantly impairs cerebrospinal fluid flow. Furthermore, we show that expression of mouse Deup1 in Xenopus embryos has an inhibitory effect on differentiation of multiciliated cells in the epidermis. Taken together, we conclude that the DC formation of Deup1 in multiciliated cells inhibits production of multiple centrioles.