• 한국철도학회:학술대회논문집
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• 한국철도학회 2000년도 춘계학술대회 논문집
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• pp.143-150
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• 2000

Like conventional railways, improving running performance of vehicle in curve is more effective than improving maximum speed to reduce traveling time. But some vehicles have problems concerning running performance in cure because of insufficient study for our conventional railway characteristics. So, these problems brought about increasement of maintenance cost. This study was started to deliberate several plans to solve problems concerning running performance in curve. Some modifications of primary suspension and tests were carried out to improve curve negotiation. Here, we describe some results.

• 대한기계학회논문집A
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• 제33권8호
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• pp.773-778
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• 2009

Chevron rubber springs are used in primary suspensions for rail vehicle. Chevron rubber spring have function which reduce vibration and noise, support load carried in operation of rail vehicle. Prediction and evaluation of characteristics are very important in design procedure to assure the safety and reliability of the rubber spring. The computer simulation using the nonlinear finite element analysis program executed to predict and evaluate the load capacity and stiffness for the chevron spring. The non-linear properties of rubber which are described as strain energy functions are important parameters. These are determined by material tests which are uniaxial tension, equi-biaxial tension and shear test. The appropriate shape and material properties are proposed to adjust the required characteristics of rubber springs in the three modes of flexibility.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권2호
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• pp.99-105
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• 2000

Cell-Cell interaction and the extracellular matrix (ECM) are belisved to play essential roles during in vitro culturing of primary hepatocytes in the control of differentiation and in the maintenance of tissue spcific functions. The objective of this study was to examine the effects of degree of cell-cell contact (DCC) on liver sperific function of rat promary hepatocytes. Hepatocyte aggregates with various with various degrees of cell-cell contantact, I. e., dispersed cell, longish aggregate, rugged aggregate, and smooth spheroid were obtained at 1, 5-6, 15-20, and 36-48 hrs, respectively in suspension cultures grown in spinner flasks embedded in Caalginate bead and collagen gel in order. The may result from mass transfer limitation and shear damage caused by agitation during aggregation. The rugged aggregate showed a higer viability and albumin secretion rate than the dispersed cells or the other aggregates. This result indicates the possible enhancement of a bioartificial liver's (BAL) performance using primary hepatocytes and the reduction in time to prepare a BAL through optimization of the immobilization time.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 제2회 추계심포지움
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• pp.135-140
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• 1994

Over past decades, numerous in vitro model has been developed to investigate drug metabolism. In the order of complexity we found the isolated perfused liver, hepatocytes in co-culture with epithelial cells, hepatocytes in suspension and in primary culture and subcellular hepatic microsomal fractions. Because they can be easily prepared from both animals (pharmacological and toxicological species) and humans (whole livers as well as biopsies obtained during surgery) hepatocytes in primary culture provide the most powerful model to better elucidate drug behavior at an early stage of preclinical development such as : 1. the characterization of main biotransformation reactions. 2. the identification of phase I and phase II isozymes involved in such reactions 3. the evaluation of interspecies differences allowing the selection of a second toxicological animal species more closely related to man on the basis of metabolic profiles 4. the detection of the inducing and/or inhibitory effects of a drug on metabolic enzymes, the prediction of drug interactions 5. the estimation of inter-individual variability in biotransformation reactions. The use of hepatocytes, and in particular those obstained from humans, at an early stage of drug development allows the obtention of more predictive preclinical data and a better knowledge of drug behavior in humans before the first administration of the drug in healthy volunteers.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1095-1098
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• 2005

Most electronic chassis control systems until today have been designed with optimization on its own performance. However, According to the increase of the interest regarding a vehicle safety and development of information technique, the integration technique of current chassis systems is being emphasized. Each enterprise proposed it with name of GCC(Global Chassis Control) or UCC(Unified Chassis Control). This study realizes control algorithm of suspension and brake by using the vehicle model of low degree of freedom as the primary stage of realization of integrated chassis control system. The proposed algorithm build the simulation environment connected to the CarSim having full vehicle model of 27 degree of freedom for raising the thrust of results

• 한국물환경학회지
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• 제36권3호
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• pp.185-193
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• 2020

Bimodal flocculation describes the aggregation and breakage processes of the flocculi (or primary particles) and the flocs in the water environment. Bimodal flocculation causes bimodal size distribution with the two separate peaks of the flocculi and the flocs. Extracellular polymeric substances and ionic species common in the water environment increase the occurrence of bimodal flocculation and flocculi-floc size distribution, under the flocculation mechanisms of electrostatic attraction and polymeric bridging. This study investigated bimodal flocculation and flocculi-floc size distribution, with respect to the extracellular polymeric substance concentration and ionic strength in the kaolinite-containing suspension. The batch flocculation tests comprising 0.12 g/L of kaolinite showed that the highest flocculation potential occurred at the lowest xanthan gum (as extracellular polymeric substances) concentration, under all the ionic strengths of 0.001, 0.01, and 0.1 M NaCl. Also, it was important to note that the higher ionic strength resulted in the higher flocculation potential, at all the xanthan gum concentrations. The bimodal flocculation and flocculi-floc size distribution became apparent in the experimental conditions, which had low and intermediate flocculation potential. Besides the polymeric bridging flocculation, steric stabilization increased the flocculi mass fraction against the floc mass fraction, thereby developing the bimodal size distribution.

• 대한기계학회논문집A
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• 제33권10호
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• pp.1132-1138
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• 2009

The spring constants of primary suspensions for a railway vehicle are optimized by a robust design process, in which the response surface models(RSMs) of their dynamic responses are constructed via the design of experiment(DOE). The robust design process requires an intensive computation to evaluate exactly a probabilistic feasibility for the robustness of dynamic responses with their probabilistic variances for the railway vehicle. In order to overcome the computational process, the process capability index $C_{pk}$ is introduced which enables not only to show the mean value and the scattering of the product quality to a certain extent, but also to normalize the objective functions irrespective of various different dimensions. This robust design, consequently, becomes to optimize the $C_{pk}$ subjected to constraints, i.e. 2, satisfying six sigma. The proposed method shows not only an improvement of some $C_{pk}$ violating the constraints obtained by the conventional optimization, but also a significant decrease of the variance of the $C_{pk}$.

• Journal of Power Electronics
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• 제15권6호
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• pp.1508-1516
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• 2015

A single phase H-bridge inverter is employed in conventional Inductive Power Transfer (IPT) systems as the primary side power supply. These systems may not be suitable for some high power applications, due to the constraints of the power electronic devices and the cost. A high-frequency cascaded multi-level inverter employed in IPT systems, which is suitable for high power applications, is presented in this paper. The Phase Shift Pulse Width Modulation (PS-PWM) method is proposed to realize power regulation and selective harmonic elimination. Explicit solutions against phase shift angle and pulse width are given according to the constraints of the selective harmonic elimination equation and the required voltage to avoid solving non-linear transcendental equations. The validity of the proposed control approach is verified by the experimental results obtained with a 2kW prototype system. This approach is expected to be useful for high power IPT applications, and the output power of each H-bridge unit is identical by the proposed approach.

• 한국식품영양과학회지
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• 제32권1호
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• pp.29-34
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• 2003

가공식품의 개발에 있어서 식품의 맛과 더불어 저장성, 열안정성 및 색조유지는 소비자의 기호도에 중요한 영향을 미친다. B. subtilis EK11 유래의 PPase는 식물조직 중엽부의 주성분인 불용성 protopectin을 분해하여 단세포화하는 효소이다. PPase를 단감에 작용시켜 단감 고유의 세포 속에 함유되어 있는 세포내 성분들의 파손 없이 단세포를 유리하였다 PPase처리된 단감 단세포화물의 착즙 후 회수율과 잔사율은 각각 95%와 5%로서, 기계적 마쇄물에서 의 85%와 15%에 비하여 높은 회수율과 낮은 잔사율을 나타내었다. 총당, 환원당, 자당, 조단백질, 조지방 및 조섬유의 함량변화는 큰 차이가 없었으며, 이는 단세포 처리에 의하여 이들 성분이 안정하게 유지됨을 알 수 있었다. 식품중 열 또는 빛 에 가장 불안정한 비타민 C의 경우 단감 단세포화물은 1일 경 과 후에도 50% 이상이 보존되는 것으로 보아 단세포에 의한 일반적인 구성 성분이 안정하게 유지, 보호됨을 알 수 있다. PPase로 처리된 단감 단세포화물을 4$^{\circ}C$에서 9일간 저장하며 색조를 관찰한 결과, 단세포화물에서는 뚜렷한 색조의 차이가 없었고 기계적 마쇄물에서는 변색이 일어났다. 또한 단감 단세포화물을 10$0^{\circ}C$에서 60분간 열처리한 후 관찰한 결과, 기계적 마쇄물의 경우 짧은 처리에도 변화를 보였으나 단세포화물에서는 그다지 큰 변화가 없었으며 이는 효소적 단세포화물의 높은 열 안정성을 의미한다. PPase를 이용한 단감의 단세포화는 음료제조 및 원료보존에 유용하게 응용가능하며, 나아가 단감 단세포화물의 폭넓은 식품소재화 가능성과 고부가가치 기능성 식품제조에 이용될 수 있음을 의미한다.

• 한국철도학회논문집
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• 제20권3호
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• pp.311-319
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• 2017

철도차량의 1차 현가장치는 윤축과 대차를 구속하는 장치로써 각 방향의 강성에 따라 차량의 동특성에 큰 영향을 미치며, 동특성을 향상시키기 위해서는 각 방향 강성을 다르게 요구하는데 일반적인 현가장치의 형상으로는 각 방향의 강성을 다르게 설계하기란 어렵다. 따라서 본 논문에서는 코니칼 러버 스프링(Conical rubber spring)을 이용하여 각 방향의 강성을 다르게 설계할 수 있도록 최적화 기법을 적용하여 목표값과 해석값의 RMS(Root Mean Square) 값을 이용하여 최적화를 수행하고 최적형상을 토대로 모델의 취약부의 형상을 보완하여 최종 모델을 제안한다. 실제 모델을 개발하여 정하중 시험을 통해 목표 강성값과 약 7.7%의 편차평균을 나타내 최적화 모델의 신뢰성을 입증하였다. 또한 최종 강성값을 다물체 동역학 모델에 적용하여 안정성과 곡선 주행성능 해석을 수행하였으며 적용모델의 임계속도는 대상 모델의 주행 최고속도인 110km/h 보다 높은 190km/h이며 차륜의 마모지수는 기존대비 34% 감소하여 조향 성능이 향상되었음을 확인하였다.