• Journal of Preventive Medicine and Public Health
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• 제35권1호
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• pp.41-48
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• 2002

Objectives : To review the drug prescription pattern of antiulcerative agents for elderly inpatients, Methods : The study population comprised inpatients of community hospitals who were members of the Korean Elderly Pharmacoepidemiologic Cohort (KEPEC), aged 65 years or over, beneficiaries of the Korea Medical Insurance Corporation (KMIC) and residing in Busan city in 1993. The drug prescription information was collected from the claims data of hospitals where the cohort members received medical care between January 1993 and December 1594. The information included personal identification, age, gender, diagnosis, drug dosage, date of hospital admission and name of medical institutions where the study subjects received drug prescriptions. The data analysis produced outcomes in terms of distribution of antiulcerative agents by class and by medical institution and trend of relative prescription, Analysis was also performed in terms of combined prescriptions of antiulceratives and drugs that could induce risk from drug interaction with antiulceratives. Results : The number of patients prescribed antiulcerative agents was 1,059 (64,9%) male and 1,724 (65.5%) female among the total inpatients. An antacid and composite agent was the most frequently prescribed antiulcerative agent (70.8%), followed by $H_2$ antagonist (16.0%), Among the potential drugs that could induce risk from drug interaction with the antiulcerative agents, diazepam was the most frequently prescribed. The proportion of diazepam co-prescription was 22.5% of the total cimetidine prescriptions and 14.5% of the fetal omeprazole prescriptions. Conclusions : Antiulcerative drugs were frequently prescribed in the elderly inpatients. The adverse drug reaction could possibly be due to drug interaction. The study results could be used as fundamental data for further drug utilization review of antiulceratiye agents.

• Journal of Preventive Medicine and Public Health
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• 제41권4호
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• pp.209-213
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• 2008

Following the Anthrax bioterrorism attacks in the US in 2001, the Korean government established comprehensive countermeasures against bioterrorism. These measures included the government assuming management of all infectious agents that cause diseases, including smallpox, anthrax, plaque, botulism, and the causative agents of viral hemorrhagic fevers (ebola fever, marburg fever, and lassa fever) for national security. In addition, the Korean government is reinforcing the ability to prepare and respond to bioterrorism. Some of the measures being implemented include revising the laws and guidelines that apply to the use of infectious agents, the construction and operation of dual surveillance systems for bioterrorism, stockpiling and managing products necessary to respond to an emergency (smallpox vaccine, antibiotics, etc.) and vigorously training emergency room staff and heath workers to ensure they can respond appropriately. In addition, the government's measures include improved public relations, building and maintaining international cooperation, and developing new vaccines and drugs for treatments of infectious agents used to create bioweapons.

• Journal of Preventive Medicine and Public Health
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• 제20권1호
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• pp.1-9
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• 1987

항암제와 세포독성과의 관계를 알아보고자 인혈배양 임파구에서 SCE빈도, 세포분열지수 및 세포분열주기변동을 조사한 결과는 다음과 같다. 1) 항암제 농도증가에 따라 SCE빈도는 대조군에 비해 유의하게 증가되었으며 (P<0.01), methotrexate에서는 유의성이 인정되지 않았다(P>0.05). 2) 세포분열지수는 cyclophosphamide를 제외한 공시 항암제에 대하여 현저하게 감소되었다. 3) 항암제의 농도증가에 따라 세포분열주기는 현저하게 지연되었으며 고농도에서는 현저한 세포분열 억제로 정상적인 세포분열이라 할 수 없는 강한 세포독성효과를 보였다. 이 결과는 알킬계 약제가 다른 항암제에 비해 강한 SCE 유발제이며 SCE유발과 세포분열주기 지연과는 깊은 상관성이 인정되지만 methotrexote경우에서는 그 상관성을 인정할 수 없었다. 이는 SCE유발과 세포분열주기지연이 서로 다른 기전에 의해서도 나타남을 제시해주고 있다.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.317.2-318
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• 2001

• Journal of Oral Medicine and Pain
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• 제21권1호
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• pp.7-14
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• 1996

This study was performed to compare the anticarious effects of different fluoride agents(NaF, $NH_4F, TIF_4,$ APF gel, Elmex gel ) on artificial carious lesion. Enamel samples treated with 5 kinds of fluoride agents by pH cycling method were evaluated for fluorine uptake, enamel solubility, and microhardness. The results were as follows : 1. Greater fluoride uptakes were obtained in carious lesion treated with APF gel and $TiF_4$ solution than in that treated with other fluoride solutions. 2. TiF4 group was more resistant to acid than otter groups, but it was not significantly different with APF gel group. 3. Surface of enamel specimen was harkened by fluoride application and pH cycling. APF gel was more effective on enhancing surface hardness than control group. 4. APF gel, $NH_4F, TIF_4,$ solution were effective on fluoride uptake, enamel solubility, and microhardness.

• Journal of Preventive Medicine and Public Health
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• 제7권2호
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• pp.377-381
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• 1974

Determination of lead in urine is important in industrial hygiene and toxicology. Dithizone method has been principally used for the determination of lead in urine, which gives accurate results in skilful hands but is usually complex and time-consuming. Atomic absorption spectrophotometry is a new simple method and several procedures have been described. However, the influences of pH and the presence of chelating agents during treatment of lead poisoning are not clear. The purpose of this study was to find out the effect of pH and chelating agents on the determination of lead using Shimadzu atomic absorption/flame spectrophotometer, model AA-610. The results obtained were as follows: 1. The atomic absorption spectrophotometry(AAS) could be applied without prior acid digestion to specimens in the absence of chelating agents. The absorbance at $2,170\;{\AA}$, though more sensitive, was more noisy electronically. Therefore, we selected the wavelength of $2,833\;{\AA}$ plus scale expansion. 2. The optimal pH was in the range from 2 to 3. 3. The sensitivity was $0.075{\mu}g/ml/%$ and detection limit was about $0.2{\mu}g/ml$. 4. In the presence of EDTA, lead could not be completely determined without prior acid digestion. 5. On specimens from patients receiving penicillamine therapy, a comparison was made between the values obtained with dithizone method and AAS method with prior acid digestion. The results of comparison showed a very good agreement.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.22-23
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• 2001

Based on the success of green tea as a cancer preventive, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using inhibition of TNF-$\alpha$ release assay, we studied Acer nikoense (Megusurino-ki in Japanese): Inhibitory potential was found in the leaf extract, and the main active constituents were identified as geraniin and corilagin. The $IC_{50}$/ values for TNF-$\alpha$ release inhibition were 43 $\mu$M for geraniin and 76 $\mu$M for corilagin, whereas that for (-)-epigallocatechin gallate (EGCG)was 26 $\mu$M.(omitted)

• 대한예방한의학회지
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• 제2권1호
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• pp.1-11
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• 1998

This experimental study was carried out to evaluate the effort of Lulianwendang on number of white blood cells and blood platelets in anti-neoplastic agents treated mice. The results were as follows; 1. The group of adriamycine treated and Lulianwendang administered mice were increased significantly in WBC as compared with control group.: 2. The group of cyclophosphamide injected and Lulianwendang administered mice were increased significantly in WBC as compared with control group. 3. The group of vincristin injected and Lulianwendang administered mice were increased significantly in W5C as compared with control group. 4. The group of adriamycine treated and Lulianwendang administered mice were increased significantly in blood platelets as compared with control group. 5. The group of cyclophosphamide injected and Lulianwendang administered mice were increased significantly in blood platelets as compared with control group. 6. The group of vincristin injected and Lulianwendang administered mice were increased significantly in blood platelets as compared with control group. According to the results, we can suggest that Lulianwendang has the hematopoiesis effects against anti-neoplastic agents treated mice.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.44.1-44.11
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• 2023

Background: A series of breast cancer cases were recently reported in a tertiary university hospital in South Korea. Nurses are generally exposed to risk factors for breast cancer such as night shift work, antineoplastic agents, and job strain. However, the epidemiological evidence of excess incidence among nurses remains lacking. This study aims to investigate the excess incidence of breast cancer among nurses in a tertiary university hospital and provide epidemiological evidence of occupational risk factors. Methods: A retrospective cohort was developed using personnel records of female workers in the nursing department who worked from January 2011 to June 2021 in a tertiary university hospital in South Korea. Sick leave records were used to identify cases of breast cancer. The standardized incidence ratio of breast cancer among nurses was compared to the general population. Results: A total of 5,509 nurses were followed up for 30,404 person-years, and 26 breast cancer cases were identified. This study revealed a significantly increased breast cancer incidence among all included nurses, with a standardized incidence ratio of 1.65 (95% confidence interval [CI]: 1.08-2.41), compared to the general population. Workers, who handle antineoplastic agents in their representative department and current and/or former department, had significantly elevated breast cancer standardized incidence ratios of 2.73 (95% CI: 1.008-5.94) and 3.39 (95% CI: 1.46-6.68), respectively. Conclusions: This study provides significant evidence of increased breast cancer risk among nursing staff in a hospital setting, particularly those who handle antineoplastic drugs. Measures that reduce exposure to risk factors should be implemented, especially anticancer drugs, to protect healthcare professionals. Further research at a national level that focuses on healthcare workers is necessary to validate breast cancer incidence and its contributing factors.

• Journal of Preventive Medicine and Public Health
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• 제28권4호
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• pp.911-923
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• 1995

유기용제와 같은 신경독성 물질에 폭로되지 않은 제조업체 여성 근로자를 대상으로 세계보건기구의 Neurobehavioral core Test Battery(NCTB) 7가지 검사 항목 중 사업장 여건을 고려하여 산타아나 민첩성검사와 목적점 찍기, 숫자 기호화, 단순반응시간, 시각기억 검사 등 5가지 항목을 세계보건기구 표준방법에 따라 실시하여, 신경독성 물질폭로로 인한 신경행동학적인 영향을 평가하기 위한 대조군 자료를 마련하고자 본 연구를 시행하였다. 잘 쓰는 손과 반대편 손의 산타아나 민첩성검사 수행능력은 각각 $45.7{\pm}7.1$ 및 $41.9{\pm}6.4$개, 목적점 찍기는 $191.9{\pm}38.6$개였다. 숫자 기호화와 시각기억검사는 각각 $57.7{\pm}16.0$ 및 $7.8{\pm}1.7$개, 단순반응시간의 평균은 $274.8{\pm}44.6msec$였고 평균 표준편차는 $70.5{\pm}69.0msec$였다. 대부분의 신경행동검사 항목들은 피검자의 연령, 교육수준의 영향을 받는 것으로 나타났다. 산타아나 민첩성검사는 양손 모두에서 피검자의 교육년한에 영향을 받는 것으로 나타났다. 목적점 찍기 검사에서 올바르게 한 것은 피검자의 연령과 교육년한에 영향을 받는 것으로 나타났다. 숫자 기호화는 연령과 교육년한에, 단순반응시간은 교육년한에, 그리고 시각기억검사도 교육년한에 영향을 받는 것으로 나타났다. 전체적으로 볼 때 피검자의 교육수준은 모든 검사항목에서 주요한 영향 변수로 작용하고 있었고 연령은 일부 검사의 영향 변수로 작용하였다.