• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.502-509
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• 2007

Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats. Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too. Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LD H activity in vitro Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.

• Journal of the Korean Ceramic Society
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• v.32 no.7
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• pp.777-782
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• 1995

The scale up production test for the hydrothermal synthesis of clay mineral from the anorthite, which is distributed in San Chung-District of Korea and called as the ground rock for halloysite-kaolin, has been investigated by using the gaitator type reactor. The automatic control system has been developed and applied for the more effective producibility and the reduction in the defect of this intermittent batch processing property, and finally for the feasibility of this system in actual use. It was observed that this agitator type reactor can reduce the synthesis reaction tme from 5 days to 3 days, only with the condition of 20rpm. The automatic control system could regulate the vessel temperature and pressure precisely at an optimum condition during the treatment. Therefore, from these test results the application-possibility for this system was found to be feasible in actual use.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.29 no.1
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• pp.38-42
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• 2017

This study proposes an idea for energy saving in apartment machine rooms. A conventional district heating system is equipped with constant-flow pumps and bypass valves to regulate pump differential pressure. Each family unit is equipped with a constant-flow on/off valve. This leads to excessive hot water circulation and a high return temperature. To reduce energy loss, this study assumes that each family unit is renovated with a heating valve which regulates the return temperature at $35^{\circ}C$. The hot water supply pump is also replaced with a pump with an inverter to vary flow rate. Expected energy savings is then estimated from field test data. According to the results, pump electricity consumption was reduced by 6,100 kWh for a family unit building over about half a year. The supply temperature can also be lowered by $5^{\circ}C$, which can contribute to a production of electricity of 10.3 kWh/ton of hot water.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.849-859
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• 2022

Feed-water valves (FWVs) are used to regulate the flow rate of water entering steam generators, which are very important devices in nuclear power plants. Due to the working environment of relatively high pressure and temperature, there is strength failure problem of valve body in some cases. Based on the thermo-fluid-solid coupling model, the valve body stress of the feed-water valve in the opening process is investigated. The flow field characteristics inside the valve and temperature change of the valve body with time are studied. The stress analysis of the valve body is carried out considering mechanical stress and thermal stress comprehensively. The results show that the area with relatively high-velocity area moves gradually from the bottom of the cross section to the top of the cross section with the increase of the opening degree. The whole valve body reaches the same temperature of 250 ℃ at the time of 1894 s. The maximum stress of the valve body meets the design requirements by stress assessment. This work can be referred for the design of FWVs and other similar valves.

• The Journal of Korean Medicine
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• v.27 no.4
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• pp.198-208
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• 2006

Background : Ginseng has traditionally been used in oriental countries to recover vital energy from Qi deficiency, and has shown various biomedical effects in the scientific literature. Recent reports suggest that ginseng could regulate blood pressure (BP), but much controversy still remains. Therefore, we intended to assess the anti-hypertensive effect of several ginseng types frequently used in clinics. We also investigated the anti-hypertensive effect on Koreans and Chinese, and by the body type according to Sasang Constitution Medicine (SCM). Methods : The study subjects were recruited from mildly hypertensive patients who exhibited pre-hypertension(120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, a red, and an American ginseng group by randomization, we prescribed ginseng at a dose of 4.5 g per day for 4 weeks. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication using a 24-hour ambulatory blood pressure monitor (24 hr ABPM. We also monitored adverse effect and laboratory findings to secure the subjects' safety. In addition, all of the subjects in Korea consulted a specialist of Sasang Constitution Medicine to identify their constitutional type. Results : There were 64 subjects treated with Korean ginseng, 58 treated with Chinese ginseng, 33 treated with red ginseng, and 64 treated with American ginseng. Korean, Chinese, and American ginseng all reduced subjects' BP; Korean and Chinese ginseng showed more effect. The secondary analysis on the subjects' nationality revealed that all of the ginseng types showed more significant anti-hypertensive effect in Chinese patients than in Koreans. The third analysis on the constitutional type of SCM showed there was no significant difference in the effectiveness and the safety of ginseng among the constitutional types. Conclusions : We suggest ginseng, especially Panax ginseng without any steaming-drying process, could be useful for mild hypertension. Further, ginseng is safe regardless of subjects' constitutional type or type of ginseng within a dosage of 4.5g per day.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.734-739
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• 2016

The globe valve is a linear motion valve that is designed primarily to stop, start, and regulate flow. The disk of a globe valve can be removed totally from the flow path or it can completely close the flow path. In this study, numerical analysis using ANSYS-CFX was initially performed to predict the flow coefficient and build a prototype model of a globe valve. The flow coefficient is the volume of water at $15.6^{\circ}C$ that will flow per minute through a valve with a pressure drop of 1 psi across the valve. In other words, it is an important factor for determining the size of the valve. From the analysis results, the fluid flux of water and flow coefficient of the valve were extracted. From the numerical results, a prototype of ultra-fine precision control valve, which can regulate the fluid flow of range 0 ~ 0.1 gal per min, was developed. The experimental results were compared with the numerical results using the flow coefficient ($C_v$) graph. From the comparative results, the flow coefficient ($C_v$) error percentage between the numerical and experimental results was very low, which is acceptable, proving that the proposed prototype model is convincing. In addition, it is possible to predict the flow coefficient using only numerical analysis.

• Clinical and Experimental Pediatrics
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• v.53 no.1
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• pp.21-27
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• 2010

Purpose : In contrast with traditional time-cycled, pressure-limited ventilation, during volume-controlled ventilation, a nearly constant tidal volume is delivered with reducing volutrauma and the episodes of hypoxemia. The aim of this study was to compare the efficacy of pressure-regulated, volume controlled ventilation (PRVC) to Synchronized intermittent mandatory ventilation (SIMV) in VLBW infants with respiratory distress syndrome (RDS).Methods : 34 very low birth weight (VLBW) infants who had RDS were randomized to receive either PRVC or SIMV with surfactant administration : PRVC group (n=14) and SIMV group (n=20). We compared peak inspiratory pressure (PIP), duration of mechanical ventilation, and complications associated with ventilation, respectively with medical records. Results : There were no statistical differences in clinical characteristics between the groups. After surfactant administration, PIP was significantly lower during PRVC ventilation for 48hrs and accumulatevive value of decreased PIP was higher during PRVC ventilation for 24hrs (P<0.05). Duration of ventilation and incidence of complications was no significant difference. Conclusion : PRVC is the mode in which the smallest level of PIP required to deliver the preset tidal volume in VLBW infants with RDS, adaptively responding to compliance change in lung after surfactant replacement.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.277-287
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• 2004

Objective : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might playa major role. Therefore, many efforts have been made to regulate oxygen free radicals for treating diabetes and its complications. Because Jindangwon has been known to be effective in treatment of diabetes, the methanol extract of Jindangwon was tested for its effectiveness in reducing the oxidative stress induced by Streptozotocin. Methods : Jindangwon was washed, dried in the shade and crushed. The crushed Jindangwon was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ for 24 hours. The extract was filtered and evaporated under reduced pressure using a rotary evaporator to yield 30.6 g. Jindangwon extract was oral-administered to the diabetic rats induced by streptozotocin 50 mg per 1 kg of body weight for 15 days. The efficacy of the Jindangwon extract was examined with regard to the enzymatic pathways involved in the oxygen free radical production and the glutathione balance. Results : he effects of the methanol extract of Jindangwon in streptozotocin-induced diabetics rats with regard to body weight, blood glucose level, hepatic lipid peroxide level, hepatic xanthine oxidase activity and type conversion rate, hepatic glutathione level, hepatic glutathione peroxidase activity, hepatic glutathione reductase activity, hepatic aldose reductase activity, and hepatic sorbitol dehydrogenase activity were favorable enough to suggest that it is a cure for diabetes and its complications. Conclusions :These results support Jindangwon as an effective reducing agent for oxidative stress in the tissues and organs by regulating the production of oxygen free radicals. Jindangwon, in particular, shows promising results for its use as a cure, or preventative medicine for diabetes and its complications by reducing oxidative stress in beta-cells of the pancreas.

• Journal of the Korean Society of Propulsion Engineers
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• v.18 no.2
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• pp.27-34
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• 2014

Buzz margin scheduling and control technique which are suitable to regulate stable and high pressure air in wide range of Mach number are suggested for fixed geometry of a supersonic intake. From the analysis of preceding study, most effective control variable is induced and scheduling law is newly suggested in a real application point of view. The appropriateness of the control law in wide range of Mach number is addressed by numerical simulation of controlled propulsion system. Also, the simulation for stabilization and tracking performances of the controller are studied to investigate the phenomena under flight maneuver and disturbances.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.127-127
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• 2018

Probiotics are microorganisms that have beneficial effects on the health of the host. The health promoting effect by probiotics influences suppressing harmful bacteria, prevention of constipation, blood cholesterol reduction and regulation of blood pressure. Prebiotics are used to promote the growth or activity of microorganisms. Synbiotics, which are a mixture of probiotics and prebiotics, synergize in the intestines by complementing each other. Synbiotics not only improves the viability of the probiotics while passing through the gastrointestinal tract, maintain intestinal homeostasis, but also regulate balance of harmful and useful bacterial growth. Glycine max Merr (GMM) has been widely used in Asian countries to treat cancer, obesity, oxidative stress and imbalanced immune diseases. In addition, it has been reported that dietary fiber-rich grains promote bowel movements and prevent constipation. In this study, we investigated the viability of LactobacillIus buchneri (L.buchneri) strains, known as lactic acid bacteria under conditions of gastric fluid and intestinal fluid to determine the suitability of L.buchneri as probiotics. The adhesion ability of L.buchneri to caco-2 cells was also confirmed. The present studies showed that GMM extract promoted the growth and activity of L.buchneri strains as prebiotics. Also, this results suggested that the mixture of L.buchneri and GMM extract can helps maintain intestinal health and healthy body as synbiotics and health functional food material.