• Biomolecules & Therapeutics
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• 제9권3호
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• pp.167-175
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• 2001

Recent studies have shown that cytokines are capable of modulating cardiovascular function and that some drugs used in the treatment of heart failure variably modulate the production of cytokines. Hige- namine, a positive inotropic isoquinoline alkaloid, has been used traditionally as cardiac stimulant, and reported to reduce nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression in LPS- and/or cytokine-activated cells in vitro and in vivo. Therefore, we investigated whether higenamine modulates the production of proinflammatory cytokines in myocardial infarction. In addition, effects of higenamine on antioxidant action and antioxidant enzyme expression (MnSOD) were studied. Myocardial infarction (MI) was confirmed by measuring left ventricular (LV) pressure after occlusion of the left anterior descending coronary artery (LAD) for 5 weeks in rats. Treatment of higenamine (10 mg/kg/day) reduced infarct size about 35 %, which accompanied by reduction of production TNF-$\alpha$, IL-6, but not IFN-${\gamma}$ and IL-1$\beta$ in the myocardium. The expression of TNF-$\alpha$ mRNA in infracted myocardium was significantly reduced by higenamine. Although iNOS mRNA was not detected, nitrotyrosine staining was significantly increased in myocardium of Ml compared to higenamine-treated one, Indicating that peroxynitrite-induced damage is evident in MI. Cytochrome c oxidation by peroxynitrite was concentration-dependently reduced by higenamine, an effect which was almost compatible to glutathion. Higenamine treatment did not affect the expression of MnSOD mRNA in myocardial tissues in MI. Taken together, higenamine may be beneficial in oxidative stress conditions such as ischemic-reperfusion injury and MI due to antioxidant action as well as modulation of cytokines.

• 한국화재소방학회논문지
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• 제30권6호
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• pp.48-56
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• 2016

지난 2014.4.4.(금)14:50, 울산소재 대형 옥외저장탱크에 원유 충전 중 누출사고가 발생하여 사고현장에 긴급구조통제단이 가동됐다. 사고업체, 소방기관 및 유관기관이 지휘소에 모여 대응과 수습방안을 논의한 뒤 전원차단 및 시설작동금지, 가스농도 측정, 유증기 발생 억제, 누출 원유를 타탱크와 공정과정으로 이송, 해양오염 방지조치 등의 협업체계를 구축하여 수습하였다. 이 수습과정에서 유증기 발생방지와 점화원 차단을 가장 중시하여 조치함으로써 사고업체와 소방기관이 가장 우려했던 폭발과 화재사고는 발생하지 않았다. 이에 본 연구는 일반적인 재난의 긴급구조통제단과는 달리 운영해야 할 옥외탱크의 유류 누출, 폭발 및 화재 시의 긴급구조통제단 운영체계개선을 제시하고, 옥외탱크 유류 누출로 인한 폭발과 화재사고로 전이했을 경우를 가정한 방유제 바닥 종류에 따른 화염 확산속도와 연소시간을 실험 비교하였다. 또한, 소방차 포 노즐의 방사각도와 펌프압력에 따른 방사거리와 포의 도포면적을 실험 분석하여, 이후 옥외저장탱크의 유류 누출로 인한 폭발과 화재 시를 대비한 효과적인 현장대응과 수습방안을 제시하는 데 중점을 두었다.

• Archives of Plastic Surgery
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• 제39권5호
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• pp.540-545
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• 2012

Background Patients have anxiety and fear of complications due to general anesthesia. Through new instruments and local anesthetic drugs, a variety of anesthetic methods have been introduced. These methods keep hospital costs down and save time for patients. In particular, the target-controlled infusion (TCI) system maintains a relatively accurate level of plasma concentration, so the depth of anesthesia can be adjusted more easily. We conducted this study to examine whether intravenous anesthesia using the TCI system with propofol and remifentanil would be an effective method of anesthesia in breast augmentation. Methods This study recruited 100 patients who underwent breast augmentation surgery from February to August 2011. Intravenous anesthesia was performed with 10 mg/mL propofol and 50 ${\mu}g/mL$ remifentanil simultaneously administered using two separate modules of a continuous computer-assisted TCI system. The average target concentration was set at 2 ${\mu}g/mL$ and 2 ng/mL for propofol and remifentanil, respectively, and titrated against clinical effect and vital signs. Oxygen saturation, electrocardiography, and respiratory status were continuously measured during surgery. Blood pressure was measured at 5-minute intervals. Information collected includes total duration of surgery, dose of drugs administered during surgery, memory about surgery, and side effects. Results Intraoperatively, there was transient hypotension in two cases and hypoxia in three cases. However, there were no serious complications due to anesthesia such as respiratory difficulty, deep vein thrombosis, or malignant hypertension, for which an endotracheal intubation or reversal agent would have been needed. All the patients were discharged on the day of surgery and able to ambulate normally. Conclusions Our results indicate that anesthetic methods, where the TCI of propofol and remifentanil is used, might replace general anesthesia with endotracheal intubation in breast augmentation surgery.

• 한국터널지하공간학회 논문집
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• 제19권4호
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• pp.651-668
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• 2017

터널 굴착에 따른 초기 안정성 확보를 위해 1차 지보재인 숏크리트와 록볼트를 가장 적절한 시기에 터널 굴착면 주면으로 타설하여야 한다. 이러한 지보재의 역할은 장 단기적인 터널 안정성에 매우 중요한 역할을 하기 때문이다. 여기서 록볼트는 터널 굴착시 응력이완에 따라 발생되는 외압을 축력으로 받아들여 터널 굴착면의 숏크리트에 전달하여 전체적인 안정성을 도모하는 중요한 지보재이다. 현재까지 록볼트의 재료는 현장 수급이 유리한 이형강봉을 많이 이용하였으나 최근들어 불확실한 품질의 중국산 자재의 시장진입과 록볼트 주면 모르타르 충전시 흘러내림에 의한 밀실한 충전불량, 용수에 의한 부식 등 다양한 문제점이 나타나고 있다. 특히, 현재의 설계기준상 이형강봉에 대한 기계적 성질의 기준은 있으나 그 외 섬유보강 플라스틱(FRP) 등이 사용될 수 있으나 명확한 기준은 제시되지 않고 있다. 그래서 새로운 소재로 개발되더라도 실제 현장 적용에 있어서는 해결해야 할 부분이 많다. 따라서, 본 연구에서는 상기의 기존 록볼트가 지니고 있는 여러 문제점을 해결, 개선하고자 Autobeam 재료를 이용한 고강도 강관 록볼트(Samrt Pipe-록볼트, 이하 SP-록볼트)를 개발한 내용을 다루고 있다. 개발된 록볼트의 성능평가를 위해 현장시험을 수행하고, 기존 모르타르 충전을 개선할 수 있는 충전재를 개발하여 록볼트의 성능을 더욱 향상하고자 하였다. 또한, 실무현장의 적용성 확보를 위해 설계 및 시공기준에 대한 연구를 수행하였다.

• Ocean and Polar Research
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• 제23권2호
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• pp.77-95
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• 2001

2000년 1월에 남극 남쉐틀랜드군도(South Shetland Islands) 주변해역에서 수심 200 m 까지 수온, 염분, 영양염, 엽록소, 일차생산력 등을 측정하였다. 표층수온은 남쉐틀랜드군도 북쪽 드레이크해협(Drake Passage)에서 높았고 남극반도 북동해역에서 낮았다. 반대로 염분은 드레이크해협에서 낮았고 남극반도쪽으로 갈수록 점차적으로 증가하여 남극반도 북동해역에서 최고 값을 보였다. 표층해수의 영양염 농도는 대체로 드레이크해협에서 낮은 값을 보였고 남쉐틀랜드군도 인접해역에서 높은 값을 보였다. 엽록소 농도는 드레이크해협과 남극반도 인접해역에서 낮았고 킹조오지섬(King George Island) 북쪽해역에서 높았다. 연구해역은 T-S diagram의 특징적인 형태에 따라 4개 해역으로 구분된다; 드레이크해협, 브랜스필드해협 (Bransfield Strait), 혼합 해역(Mixed zone), 웨델해(Weddell Sea) 해역. 이들 4개 해역들은 각각 특징적인 물리, 화학, 생물학적 특성을 보였다. 식물플랑크톤 생물량은 드레이크해협과 웨델해 해역에서 상대적으로 낮았고 브랜스필드해협과 혼합 해역에서 높았다. 웨델해 해역에서 식물플랑크톤 생물량이 낮은 것은 낮은 수온과 수심 200 m 이상의 깊은 표층혼합 때문이라고 생각되고 드레이크해협 해역에서는 높은 동물플랑크톤 포식압과 낮은 철농도 때문인 것으로 생각된다.

• Journal of Biosystems Engineering
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• 제32권6호
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• pp.430-439
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• 2007

This study was carried out to(1) visualize the installation effect of an anti-wind net; (2) evaluate structural stability of typical anti-wind nets in Jeju; and (3) present the optimal specification of pipes in an anti-wind net for maximum instant wind velocities of 40 m/s and 45 m/s. The analyses were done for anti-wind nets with a mesh of 4 mm and a height of 3 m by using CFX and ANSYS. The results showed that the wind went down due to flow resistance when passing through an. anti-wind net. The anti-wind net with the supporting pipe being installed every two main columns was certainly unstable because the main column not sustained by the supporting pipe became cantilever. With regard to the position of a fixing point of the supporting pipe, von Mises stress on pipes was certainly increased as vertical positions of the supporting pipe were changed to be too lower or higher than an adequate position but there was little difference according to horizontal positions. The adequate vertical position was $2{\sim}2.5\;m$ high from the ground. For a maximum instant wind velocity of 40 m/s, the optimal specification of pipes was a main column of ${\varphi}48.1{\times}2.1$ t@2,000, cross beams(bottom and top) of ${\varphi}26.7{\times}1.9\;t$, cross beams(center) of ${\varphi}33.5{\times}2.1$ t/2ea and a supporting pipe of ${\varphi}31.8{\times}1.5$ t@2,000. In case of a maximum instant wind velocity of 45 m/s, the optimal specification of pipes with structural stability was a main column of ${\varphi}48.6{\times}3.25$ t@2,000, cross beams(bottom and top) of ${\varphi}26.7{\times}1.9\;t$, cross beams(center) of ${\varphi}48.1{\times}2.1$ t/2ea and a supporting pipe of ${\varphi}31.8{\times}1.5$ t@2,000.

• 동의신경정신과학회지
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• 제21권4호
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• pp.219-231
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• 2010

Objectives : School refusal is usually considered as individual's behavioral problem. These days. however. the adolescents' school refusal needs some kind of medical approaches because it is related to mental disorder of the adolescents. Due to too much pressure and stress from the competition between classmates and from good performance in school. the number of adolescents who refuse to go to school is increasing. Despite this circumstance. school refusal is neither regarded as a single independent disorder nor endorsed as an officially classified disease. which makes difficult to conduct research on this issue and to establish standardized treatment for it. In addition. there is a lack of research on this topic. especially in oriental medicine. so there is no a case report or study on school refusal. This study is trying to comment on school refusal from the perspective of oriental medicine. Methods : We tried to examine the effect of oriental medicine treatment for school refusal with four adolescent cases. The patients commonly have at least more than one mental disorder (including depression disorder. anxiety disorder. and anorexia nervosa). have some problem with the relationship with their family. in particular with mother. do not have father or not be loved by their father. and have irregular eating habits. Thus. we diagnosed them as qi transforming into fire (氣鬱化矢) spleen-stomach deficiency cold (脾胃虛寒) and heart blood deficiency (心血虛) due to stress from the family issues and unhealthy eating habits. The patients received supportive therapy. family therapy. etc among many oriental mental treatments and their progress had been observed through hospitalization and outpatient treatment. Results : All four cases were reported positive progress on their symptoms and started coming back to school. We also examined whether they were well fitting into the school while they received outpatient treatment. and the results show that all four patients continue to settle down in normal school life. Conclusions : This study closely reviewed the mental disorder of school refusal cases and showed that the Oriental medical treatment was effective in helping the patients come back to school. More future research is required to better treatment for school refusal cases in oriental medicine.

• Journal of Chest Surgery
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• 제22권2호
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• pp.220-224
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• 1989

In candidates for aortic valve replacement [AVR]it is our primary intention to implant the largest possible vale prosthesis of at least 23 mm in diameter in patients with severe valvular aortic stenosis. However, in many patients there is an additional subvalvular asymmetric septal hypertrophy which in some cases may cause an postextrasystolic increase of the LV-aortic gradient. Another component of the aortic stenosis syndrome is a narrow valvular ring, or a combination of both. After complete removal of the diseased valve and decalcification the narrow aortic ring [< 23 mm] can be widened firstly by transaortic subvalvular septal myectomy- [TSM] thus unfolding the left ventricular outflow tract[LVOT]and secondly by extending the oblique aortic incision into the aortic valve ring or further down into the anterior leaflet of the mitral valve. The sub-and supra-valvular defect will be closed by patch enlargement of the aortic root [PEAR] using autologous pericardium. These techniques allow a considerable enlargement of the valvular ring of about 4 to 10 mm in circumference. In a retrospective study using a computerized program, 847 patients with AVR [1980-1984]were reviewed to evaluate the intraoperative hemodynamic results mainly concerning relief of the transvalvular gradient. In 626 patients AVR was performed, 151 patients had double valve replacement [AVR+MVR], and 70 patients had AVR plus additional surgical procedures. Concentrating on the AVR-group [n=626] there were 103 patients with TSM, 24 patients with PEAR and 20 patients with TSM+PEAR which demonstrated that in a total, of 147 patients of this groups [23.5%] an additional procedure was necessary. The Statistical evaluation of the intraoperative pressure measurements before and after AVR in relation to the size of the implanted prostheses indicated the lowest preoperative mean gradient in patients with AVR alone, the highest in patients who afforded TSM plus PEAR. However, after AVR the mean gradients in all three groups were very low [mean 5 to 10 mmHg]. These data indicate that in patients with a narrow aortic ring and additional considerable ASH, TSM and PEAR are suitable techniques to enlarge the aortic root to enable the implantation of an adequate aortic valve prosthesis. Long-term controls have shown that autologous pericardium is a qualified graft material for the ascending aorta.

• 수산해양기술연구
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• 제21권1호
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• pp.12-18
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• 1985

고압변압기의 1차측을 제어하고 2차측에 유도된 전압을 이용한 수중방전음원의 전기음향학적 제특성을 분석.검사한 결과는 다음과 같다. 1. 방전시 2차측 전류는 초기에는 Ohm 법칙을 따르다가 전류가 최고 6.3A 흘러 절연 파괴되었으며, 그 순간 방전음이 생성되었다. 2. 전류인가점과 방전음 생성문의 시간차는 약 3ms였으며, 전압이 최고일 때 절연파괴가 일어나 방전음이 생성되었다. 3. 전극의 끝이 뾰족할수록 2차측 전압이 높을수록 음압수준은 높았다. 4. 뾰족한 형태의 전극은 전극간격이 100cm일 때도 방전이 일어났으며 전극간격이 1cm이상부터 비교적 안정된 방전음이 생성되었다. 5. 방전음의 펄스폭은 약 0.15ms인 Shock Wave였으며, 10HKz 이하의 합성저주파 성분이었다.

• Journal of Trauma and Injury
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• 제27권4호
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• pp.126-132
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• 2014

Purpose: The field trauma triage for injured patients is essential for trauma care system. In this study, agreement of patient evaluation between by prehospital EMS personnel and by hospital staffs and the appropriateness of prehospital triage were evaluated. Methods: This observational study was conducted from September to October 2012 for 5 weeks. During this period, EMT evaluated patient's severity according to guideline for field triage and recorded. Same guideline was applied in 26 hospitals for patients with EMS use. Kappa statistics were used to measure agreement for each item of guideline. Finally, over-triage and under-triage rate of EMT were calculated. Results: During study period, total 3,106 patients were transferred to 26 hospital emergency departments with EMS use. Kappa statistics for "vital signs" items were 0.45 for mentality lower than V and 0.44 for systolic blood pressure lower than 90 mmHg as a moderate agreement. In "anatomy of injury" items Kappa statistics were very low. In "mechanism of injury" items Kappa statistics were 0.28 for high-rise fall down and 0.27 for high energy traffic accident but in other items Kappa statistics were very low. 362 patients (12.0%) were over-triaged and 281 patients (9.3%) were under-triaged. Conclusion: Field triage can be applied but need to evaluate and modify in order to become accurate and sensitive for decision of transportation.