• Journal of Veterinary Science
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• v.24 no.3
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• pp.23.1-23.16
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• 2023

Background: Irritable bowel syndrome (IBS) is a functional bowel disorder (FBD). Objectives: To assess the therapeutic effects of paeoniflorin (PF) on IBS in rats. Method: Sixty male Sprague-Dawley rats were randomly divided into normal, model, positive drug, low-dose PF, medium-dose PF and high-dose PF groups (n = 10). After gavage for 2 consecutive weeks, the effect of PF on abdominal pain symptoms was assessed based on the abdominal withdrawal reflex (AWR) score, fecal water content and pathological changes in colon tissues. D-lactate, interleukin-1β (IL-1β), transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α) were detected by enzyme-linked immunosorbent assay, and phosphorylated nuclear factor kappa B (p-NF-κB) p65 was detected by Western blotting. The abundance and diversity changes of intestinal flora were explored using 16S ribosomal RNA sequencing. Result: In PF groups, the mucosal morphology of colon tissues was intact, and the glands were arranged neatly and structured clearly, without obvious inflammatory cell infiltration. Compared with the model group, PF groups had significantly elevated pain threshold, and mRNA and protein levels of zonula occludens-1 (ZO-1) and occludin, decreased AWR score at 20 mmHg pressure, fecal water content, mRNA levels of IL-1β, TGF-β, and TNF-α, protein level of p-NF-κB p65 and level of serum D-lactate, and reduced levels of serum IL-1β, TGF-β, and TNF-α (p < 0.05, p < 0.01). PF groups had higher abundance of Lactobacillus, Akkermansia, Alistipes, and Bacteroides, but lower abundance of Desulfovibrio, Parasutterella, and Enterococcus than those of the model group. Conclusions: PF exerts therapeutic effects on IBS in rats probably by regulating the intestinal flora, and then up-regulating the expressions of ZO-1 and occludin in colon tissue while down-regulating the levels of IL-1β, TGF-β, TNF-α, D-lactate and p-NF-κB p65.

• Journal of Korea Entertainment Industry Association
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• v.14 no.7
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• pp.539-548
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• 2020

TTH(tension-type headache) is the most common primary headache among adults. Long-term headaches cause chronic headaches and have a better impact on daily life. The purpose of this study is to compare the contributions to TTH through AVE(audio-visual entertainment) and STM(soft tissue mobilization) suitable for management of pathogenic and psychogenic factors of TTH. The participants of this study were from 30 people who complained of intermittent or persistent headaches for more than 6 months, and 10 participants each in the AVE group, STM group, and AVE plus STM group. In the assigned group, a total of 12 sessions were performed three times a week for 4 weeks after the baseline, followed by post-test. Outcome measures measured PPTs(pressure pain thresholds), psychophysiological parameters, and EEG(electroencephalogram). The measured results were analyzed for interaction between time and group through a two way rmANOVA(repeated measurement variance analysis). As a result of the PPTs, interaction was found in the results of the right trapezius (p<.05), and the more improvement was observed in the AVE group. Therefore, through AVE based on psychological factors rather than direct access to the muscles of pathogenic factors, a positive impact on the PPTs was shown, but the average value of the psychophysiological parameters and brain waves that were not statistically significant. The amount of change was observed. Through this, it is suggested that audio-visual stimulation could be considered in the management of TTH.

• Korean Journal of Pharmacognosy
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• v.30 no.2
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• pp.137-144
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• 1999

Torilin was isolated from haxane fraction of Torilis Fructus extract. Torilin produced inhibition of the acetic acid-induced and phenylquinone-induced writhing syndrome at the oral doses of 30 and 90 mg/kg in mice. It also increased the pain threshold at the oral doses of 30, 90 and 270 mg/kg in the tail pressure method and the Randall-Selitto method. However, it did not show a hypothermic action at the oral doses of 30 and 90 mg/kg in mice. The compound exhibited strong anticarrageenan activity at the oral doses of 90 and 270 mg/kg in rats, and had inhibitory effect on the vascular permeability at the oral doses of 30 and 90 mg/kg in mice. It also showed potent inhibition of leucocyte emigration in CMC-pouch at the doses of 3 and 9 mg/rat, sc. The acute toxicity of torilin was very weak: the $LD_{50}$ values were more than 5000 mg/kg, po and 2000 mg/kg, ip in mice. From the above mentioned results, it was suggested that torilin had potent analgesic and anti-inflammatory activities.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.2
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• pp.63-72
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• 2013

Objectives : The aim of this study was to investigate difference of the effects of transcutaneous electrical nerve stimulation(TENS) with different frequencies in participants having delayed onset muscle soreness(DOMS). Methods : We recruited 36 healthy participants, but 3 of them were dropped out. They were randomly divided into 3groups : 3 Hz TENS(n=11), 100 Hz TENS(n=11) and sham TENS(n=11). DOMS of the both triceps surae muscle induced by repetitive concentric, ecentric exercise. The result measurements were pain perception(visual analogue scale, VAS), mechanical pain threshold(MPT) by pressure algometer, electrical contraction and fatigue by surface electromyography. The measurements were on first visit, before and after treatment except first. This study was prospective, randomized, controlled, single-blinded trial. Results : In 100 Hz TENS group, VAS was significantly decreased during whole session compared with 3 Hz and control group, and after each treatment, too. In 3 Hz TENS group, VAS was significantly decreased during whole session compared with control group, and after 2nd, 3rd treatment, too. In 100 Hz TENS group, MPT increased the most among 3 groups during whole session and after 1st treatment, but there were no statistical significances. Conclusions : Both 3 Hz and 100 Hz TENS improved delayed onset muscle soreness, but 100 Hz TENS group is more effective than 3 Hz TENS group.

• Physical Therapy Korea
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• v.3 no.2
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• pp.95-105
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• 1996

Type I, II, III are regarded as "true" joint receptors, type IV is considered a class of pain receptor. Type I, II and III mechanoreceptors, via static and dynamic input, signal joint position, intraarticular pressure changes, and the direction, amplitude, and velocity of joint movements. Type I mechanoreceptor subserve both static and dynamic physiologic functions. Type I are found primarily in the stratum fibrosum of the joint capsule and ligaments. Type I receptors have a low threshold for activation and are allow to adapt to changes altering their firing frequency. Type II receptors have a low threshold for activation. These dynamic receptors respond to joint movement. Type II receptors are thus termed rapidly adapting. Type II joint receptors are located at the junction of the synovial membrane and fibrosum of the joint capsule and intraarticular and extraarticular fat pads. Type III receptors have been found in collateral ligaments of the joints of the extremities. Morphologically similar to Golgi tendon organ. These dynamic receptors have a high threshold to stimulation and are slowly adating. Type IV receptors possess free nerve ending that have been found in joint capsule and fat pads. They are not normally active, but respond to extreme mechanical deformation of the joint as well as to direct chemical or mechanical irritation. Small amplitude oscillatory and distraction movements(joint mobilization) techniques are used to stimulate the mechanoreceptors that may inhibit the transmission of nociceptors stimuli at the spinal cord or brain stem levels.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.2 no.1
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• pp.9-19
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• 1996

Type I, II, III are regarded as "true" joint receptors, type IV is considered a class of pain receptor. Type I, II and III mechanoreceptors, via static and dynamic input, signal joint position, intraarticular pressure changes, and the direction, amplitude, and velocity of joint movements. Type I mechanoreceptor subserve both static and dynamic physiologic functions. Type I are found primarily in the stratum fibrosum of the joint capsule and ligaments. Type I receptors have a low threshold for activation and are allow to adapt to changes altering their firing frequency. Type II receptors have a low threshold for activation. These dynamic receptors respond to joint movement. Type II receptors are thus termed rapidly adapting. Type II joint receptors are located at the junction of the synovial membrane and fibrosum of the joint capsule and intraarticular and extraarticular fat pads. Type III receptors have been found in collateral ligaments of the joints of the extremities. Morphologically similar to Golgi tendon organ. These dynamic receptors have a high threshold to stimulation and are slowly adating. Type IV receptors possess free nerve ending that have been found in joint capsule and fat pads. They are not normally active, but respond to extreme mechanical deformation of the joint as well as to direct chemical or mechanical irritation. Small amplitude oscillatory and distraction movements(joint mobilization) techniques are used to stimulate the mechanoreceptors that may inhibit the transmission of nociceptors stimuli at the spinal cord or brain stem levels.

• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.261-276
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• 2001

본 연구는 구강안면동통 중에서 빈번히 나타나는 근육성 동통의 주 원인인 저작근의 과활성으로 유발된 근육의 피로 시에 운동단위전위, 압력통각역치, 근전도 power spectrum의 변화 양상과 이들 척도간의 연관성을 조사하기 위해 시행되었다. 두개하악장애의 병력 및 현증이 없고 정상적인 구치부 교합관계를 가진 평균연령 25.8세인 36명의 정상 성인(남자 26명, 여자 10명)을 대상으로 교근과 전측두근의 지속적인 등길이 수축 전후의 압력통각역치 및 운동단위전위를 측정하였고 인내시간까지의 근수축 동안 근전도 power spectrum을 분석하여 다음과 같은 결론을 얻었다. 1. 지속적인 등길이 수축 후 교근과 전측두근의 압력통각역치는 수축 전에 비해 유의하게 감소하였다. 2. 압력통각역치는 수축 전과 수축 후 모두에서 전측두근이 교근보다 유의하게 높게 나타났으며, 전체적으로 남성이 여성보다 높게 나타나는 양상을 보였으나 성별간의 차이는 전측두근의 수축 후 압력통각역치에서만 통계적으로 유의하게 나타났다. 3. 지속적인 등길이 수축말기의 중간주파수는 수축초기에 비하여 유의하게 감소하였고, 전측두근의 수축초기 중간주파수와 수축말기 중간주파수 모두 교근보다 유의하게 높게 나타났다. 4. 교근은 지속적인 등길이 수축 전에 비하여 수축 후의 운동단위전위의 지속시간,진폭, 면적, 상의 4가지 척도에서 유의한 증가를 보였고 전측두근은 진폭을 제외한 나머지 3가지 척도, 즉 지속시간, 면적, 상의 유의한 증가를 보였다. 5. 교근과 전측두근의 지속적인 등길이 수축 전의 압력통각역치와 운동단위전위 척도 사이에는 통계적으로 유의한 상관관계가 없었고 교근에서는 수축 후의 압력통각역치와 운동단위전위의 지속시간, 진폭, 면적, 상 사이에 유의한 상관관계가 존재하였다. 위의 실험결과를 통해 근육피로 검사에 압력통각역치, 근전도 power spectrum 검사 외에 근육수축의 기능적 최소 단위인 운동단위전위의 분석 또한 유용할 수 있고 추후 만성으로 진행된 근막동통환자와 정상 대조군간의 운동단위 수준에서의 비교연구와 근피로에 더욱 민감한 운동단위전위의 다른 척도에 대한 개발과 연구가 필요하다고 사료된다.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.18 no.1
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• pp.57-63
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• 2012

Background: The number of old people with degenerative osteoarthritis one of the chronic disease, were constantly increased. Many researchers have made a great effort to verify the effects of ultrasound and laser therapy in degenerative osteoarthritis treatment. This study applied ultrasound-laser integration therapy on knee joint degenerative osteoarthritis and compared its effect with ultrasound and laser. Methods: We assigned 60 patients age 65 to 85 who had been diagnosed as knee joint degenerative osteoarthritis in G nursing home in Daejeon city. Randomization was done in blocks of three, holding twenty people per each group to receive either ultrasound, laser, ultrasound-laser integration therapy. This study carried out the experiment for 6 weeks to from April 17, 2010. We measured variables using visual analog scale (VAS) and pressure threshold meter (PTM) of the effects by before and after exercise. Results: It has been found that VAS was reduced and PTM was increased in all three groups. Compare with the other groups, Ultrasound-laser integration therapy group had lower VAS and higher PTM than ultrasound therapy and laser therapy group. Conclusions: These results lead us to the conclusion that ultrasound-laser integration have influenced the pain reduction of the knee degenerative osteoarthritis.

• The Journal of Korean Physical Therapy
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• v.13 no.2
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• pp.293-303
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• 2001

The purpose of this study was to determine if there were any beneficial effects of massage or microwave diathermy regarding delayed onset muscle soreness (DOMS) and indices of muscle damage. Twenty-one adult women, randomly divided in two treatment groups and a control group, performed eccentric stepping exercise with the quadriceps until exhaustion. The treatment groups additionally performed massage or microwave diathermy after the stepping exercise. Pressure pain threshold measure for DOMS and muscle enzymes in the blood were obtained before, and 0, 24, 48 and 72 hours after exercise. The results were as follows; 1. Eccentric exercise caused DOMS and elevations of muscle enzymes in the blood, with peak values exercise levels by 24 hours after exercise and GOT and CRP by 72 hours after exercise. DOMS and CK activity remained elevated 72 hours after exercise. 2. DOMS and blood muscle enzymes response to eccentric exercise were reduces by massage or micro diathermy therapy. DOMS was significantly decreased at 72 hours after exercise by massage and microwave diathermy. CK activity was significantly decreased at 72 hours after exercise by microwave diathermy. There was the significant reduction in LDH at 48 hours, GOT at 24, 48, 72 hours. and CRP at 24, 48 hours after exercise by massage and microwave diathermy. These results indicate that massage or microwave diathermy is had effect on recovery from exercise-induced muscle damage. In our's suggestion. microwave diathermy is particularly more appropriate therapeutic modality because it is more simple and economic than massage.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.178-178
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• 1998

We reported that the hexane fraction of Torilis Fructus have an anti-inflammatory and analgesic effect. Therefore, in order to isolate the active compound, the hexan fraction of Torilis Fructus was chromatographed on silica gel column. The subfraction of hexane fraction was crystallized as colorless stout needles. The chemical structure of this compound was verified to be torilin through m.p., UV, IR, GC-MS, and NMR spectral data. In pharmacological tests, torilin exhibited strong anticarrageenan activity at the dose of 90 and 270 mg/kg, p.o. in rats, and it had inhibitory effect on the vascular permeability at the dose of 30 and 90 mg/kg, p.o. in mice. Torilin showed potent inhibition of leucocyte emigration in CMC-pouch at the dose of 3 and 9 mg/rat, s.c. Torilin have the analgesic effect at the dose of 30, 90 and 270 mg/kg, p.o. in both of the acetic acid- and phenyl-p-benzoquinone-induced writhing syndrome. It also increased the pain threshold at the dose of 30, 90 and 270 mg/kg, p.o. in the tail pressure method and the Randall-Selitto method. Torilin did not show a hypothermic action at the dose of 30 and 90 mg/kg, p.o. in mice. The acute toxicity of torilin was very weak: the LD$\_$50/ value was more than 5000 mg/kg, p.o. and 2000 mg/kg, Lp. in mice. From the above mentioned results, it was suggested that torilin had potent anti-inflammatory and analgesic activities in animals.