• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1C
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• pp.43-52
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• 2006

Despite several constitutive models have been proposed and applied, it is still difficult to choose a suitable model and to estimate adequate analysis parameters. Furthermore, a cyclic shear behavior under the volume change caused by the seepage is more complex. None of the constitutive model is available at present in the expression of the cyclic behavior of soil under an additional volume change condition by seepage. Therefore, a new geotechnical hybrid simulation system which can control the pore water immigration was developed. The system enables a quantitative evaluation of the residual deformation such as lateral spreading and settlement caused by the liquefaction. The seismic responses in a one-dimensional slightly inclined multilayered soil system are taken into consideration, and the soils are governed by both equation of motion and the continuity equation. Furthermore, the estimation and the selection of the soil parameter for the representation of the strong nonlinearity of the material are not required, because soil behaviors under the earthquake motions are directly introduced instead of a numerical soil constitutive model. This paper presents the concept and specifications of the system. By applying the system to an example problem, the permeability effect on the seismic response during cyclic shear is studied. The importance of the volume change characteristics of sandy soil during and after cyclic shear is shown in conclusion.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.2D
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• pp.275-286
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• 2009

As a government building transferred to the outskirts of a city, it's easy to foresee a doughnut effect from advancement process of the city. In the case of Busan city comparing different cities a doughnut effect is being advanced seriously. To the access method for a city center activation the possibility which there will be a various branch, but in this research we analyzed factors of the stagnation in the public Government building neighboring area. And then made a proposal for the city activation plan by transferring the public Government building, analyze influence to surrounding areas using factor analysis. Hence, the object of this paper is to propose a plan for the activation of existig city and evaluates it which is presented consequently. In the case of Dongrae government office, a problem of the neighboring area and condition of present were surveyed and causes of the stagnation in existing city analyzed. Consequently the important five factors were extracted as follows; 1) historical and the cultural factor, 2) factor of creating the special street, 3) urban planning factor, 4) factor of transferring government office.

• Journal of the Korean Society for Environmental Technology
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• v.18 no.2
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• pp.165-172
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• 2017

In current stage, it is hard to predict the scale of damage caused by natural disaster and it is hard to deal with it. However, in case of disaster planning level, if it is possible to predict the scale of disaster then quick reaction can be done which will reduce the damage. In the present study, therefore, function of wind wave damage estimation among various disaster is developed. Damage of wind wave and typhoon in eastern and Jeju coastal zone was collected from disaster report (1991~2014) published by Ministry of Public Safety and Security and to reflect inflation rate, 2014 damage cost was converted. Also, wave height, wind speed, wave direction, wave period, etc was collected from Meteorological Administration and Korea Hydrographic and Oceanographic Administration web site. To reflect the characteristic of coastal zone when wave damage occurs, CODI(Coastal Disaster Index), COSI(Coastal Sensitivity Index), CPII(Coastal Potential Impact Index) published by Korea Hydrographic and Oceanographic Agency in 2015 were used. When damage occurs, function predicting wind wave damage was developed through weather condition, regional characteristic index and correlation of damage cost.

• Journal of The Korean Astronomical Society
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• v.56 no.2
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• pp.231-252
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• 2023

We present the analysis results of the simultaneous multifrequency observations of the blazar 4C +28.07. The observations were conducted by the Interferometric Monitoring of Gamma-ray Bright Active Galactic Nuclei (iMOGABA) program, which is a key science program of the Korean Very Long Baseline Interferometry (VLBI) Network (KVN). Observations of the iMOGABA program for 4C +28.07 were conducted from 16 January 2013 (MJD 56308) to 13 March 2020 (MJD 58921). We also used γ-ray data from the Fermi Large Array Telescope (Fermi-LAT) Light Curve Repository, covering the energy range from 100 MeV to 100 GeV. We divided the iMOGABA data and the Fermi-LAT data into five periods from 0 to 4, according to the prosody of the 22 GHz data and the presence or absence of the data. In order to investigate the characteristics of each period, the light curves were plotted and compared. However, a peak that formed a hill was observed earlier than the period of a strong γ-ray flare at 43-86 GHz in period 3 (MJD 57400-58100). Therefore, we assumed that the minimum total CLEANed flux density for each frequency was quiescent flux (S_q) in which the core of 4C +28.07 emitted the minimum, with the variable flux (S_var) obtained by subtracting S_q from the values of the total CLEANed flux density. We then compared the variability of the spectral indices (α) between adjacent frequencies through a spectral analysis. Most notably, α_22-43 showed optically thick spectra in the absence of a strong γ-ray flare, and when the flare appeared, α_22-43 became optically thinner. In order to find out the characteristics of the magnetic field in the variable region, the magnetic field strength in the synchrotron self-absorption (B_SSA) and the equipartition magnetic field strength (B_eq) were obtained. We found that B_SSA is largely consistent with B_eq within the uncertainty, implying that the SSA region in the source is not significantly deviated from the equipartition condition in the γ-ray quiescent periods.

• Journal of Industrial Convergence
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• v.22 no.4
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• pp.31-38
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• 2024

The purpose of this study was to examine the current status of elderly sports both domestically and internationally, and to explore strategies for the activation of Silver Taekwondo as one of the sports disciplines for the elderly. To investigate the status of elderly sports globally, press releases and statistical data from various national public institutions and sports facilities (including the Ministry of Culture, Sports and Tourism, the Ministry of Health and Welfare, the Korean Statistical Information Service, e-National Indicators, and the Korea Sports Promotion Foundation) were collected. Comparative analysis with related papers, journals, and books led to the following findings for activating Silver Taekwondo. Firstly, elderly sports in South Korea are primarily conducted through welfare centers, with a preference for dance, yoga, and music, while martial arts, including Taekwondo, had a lower preference rate. To increase participation in Silver Taekwondo, a variety of marketing approaches, similar to those used internationally, such as experiential case studies in media, film production, distribution, and telephone promotions, are necessary. Secondly, the development of Silver Taekwondo programs tailored to the training targets and the cultivation of instructors capable of executing these programs are needed. The development of programs should involve collaboration with Taekwondo institutions, dojangs, universities, and lifelong education centers, requiring the participation of majoring students and elderly sports instructors.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.1168-1174
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• 2022

Immunoglobulin G4 (IgG4)-related disease is a rare systemic fibroinflammatory condition characterized by elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells in various organs. IgG4-related lung disease shows varied radiologic features on chest CT. Patients usually present with a solid nodule or mass mimicking lung cancer; therefore, distinguishing between IgG4-related disease and other conditions is often challenging. Additionally, co-existing radiologic findings of IgG4-related lung disease may mimic metastasis or lymphangitic carcinomatosis of the lung. We report two cases of histopathologically confirmed IgG4-related lung disease mimicking lung cancer. Chest CT revealed a solid nodule or mass with ancillary radiologic findings, which suggested lung cancer; therefore, IgG4-related lung disease was radiologically indistinguishable from lung cancer in both cases. Measurement of serum IgG4 levels and clinical evaluation to confirm involvement of various organs may be useful to establish the differential diagnosis. However, surgical biopsy evaluation is needed for confirmation.

• The Journal of Engineering Geology
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• v.34 no.2
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• pp.217-228
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• 2024

During deep drilling, confined aquifers can present various challenges such as the inability to remove cuttings, rapid groundwater influx, and mud loss. Particularly in flowing well conditions, it is essential to apply the suitable mud density since the aquifer can generates an overpressurized condition. This paper proposes a method for determining the suitable mud density while drilling (SMD) through confined aquifers using mud window analysis and applies it to a case study. The minimum mud density at each depth, which represents the lower limit of the mud window, is determined by the equivalent mud density pore pressure gradient (or by adding a trip margin) at that depth. The pore pressure gradient of a confined aquifer can be calculated using the piezometric level or well head pressure of the aquifer. As the borehole reaches the confined aquifer, there is a significant increase in pore pressure gradient, which gradually decreases with increasing depth. The SMD to prevent a kick can be determined as the maximum value among the minimum mud densities in the open hole section. After entering the confined aquifer, SMD is maintained as the minimum mud density at the top of the aquifer during the drilling of the open hole section. Additionally, appropriate casing installation can reduce the SMD, minimizing the risk of mud loss or invasion into the highly permeable aquifer.

• Journal of Microbiology and Biotechnology
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• v.33 no.12
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• pp.1635-1647
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• 2023

Muscle atrophy, which is defined as a decrease in muscle mass and strength, is caused by an imbalance between the anabolism and catabolism of muscle proteins. Thus, modulating the homeostasis between muscle protein synthesis and degradation represents an efficient treatment approach for this condition. In the present study, the protective effects against muscle atrophy of ethanol extracts of Morus alba L. (MA) and Angelica keiskei Koidz. (AK) leaves and their mixtures (MIX) were evaluated in vitro and in vivo. Our results showed that MIX increased 5-aminoimidazole-4-carboxamide ribonucleotide-induced C2C12 myotube thinning, and enhanced soleus and gastrocnemius muscle thickness compared to each extract alone in dexamethasone-induced muscle atrophy Sprague Dawley rats. In addition, although MA and AK substantially improved grip strength and histological changes for dexamethasone-induced muscle atrophy in vivo, the efficacy was superior in the MIX-treated group. Moreover, MIX further increased the expression levels of myogenic factors (MyoD and myogenin) and decreased the expression levels of E3 ubiquitin ligases (atrogin-1 and muscle-specific RING finger protein-1) in vitro and in vivo compared to the MA- and AK-alone treatment groups. Furthermore, MIX increased the levels of phosphorylated phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) that were reduced by dexamethasone, and downregulated the expression of forkhead box O3 (FoxO3a) induced by dexamethasone. These results suggest that MIX has a protective effect against muscle atrophy by enhancing muscle protein anabolism through the activation of the PI3K/Akt/mTOR signaling pathway and attenuating catabolism through the inhibition of FoxO3a.

• Journal of Korean Medicine for Obesity Research
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• v.24 no.1
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• pp.25-40
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• 2024

Objectives: In the present study, we investigated the effects of clean-diabetes mellitus 3 (C-DM3), a herbal formula with Trichosanthis Radix, Coptidis Rhizoma, Crataegi Fructus, and Cinnamomi Cortex, on the pathological and serological symptoms of diabetes and its related molecular mechanisms in diet-induced obese mice. Methods: We prepared an obese mouse model using a high-fat diet for 8 weeks and then administered the C-DM3 extract for 4 weeks. The changes of pathological and serological biomarkers for diabetes assessment were measured in the mice and histological changes were observed in the liver and pancreas tissues. We also identified the main compounds in the C-DM3 extract using high pressure liquid chromatography (HPLC) and analyzed the molecular mechanism of the disease condition by network pharmacological analysis. Results: In the in vivo, the administration of C-DM extract to obese mice significantly reduced body weight gain, fatty liver symptoms, and muscle loss, and decreased the levels of fasting blood glucose, insulin, aspertate aminotransferase, triglycerides, and low-density lipoprotein-cholesterol. In addition, C-DM extract significantly increased the phosphorylation of insulin receptor substrate 1, protein kinase b (AKT), phosphoinositide 3-kinase (PI3K), adenosine monophosphate-activated protein kinase, and glucose transporter 4 in all pancreatic and liver tissues, with inhibition of histopathological changes in obese mice. HPLC analysis identified hyperoside, berberine, epiberberine, columbamin, coptisine, coumarin, jatrorrhizine, and citric acid as the main compounds. In the network pharmacological analysis, the molecular targets of C-DM3 extract on obesity and diabetes were shown as the insulin, AKT, PI3K, and mitogen-activated protein kinase pathways with the regulation of inflammatory molecules interleukin 6 (IL-6), jun proto-oncogene, and IL-1β, which matched our in vivo targets. Conclusions: Based on these results, C-DM3 extract is expected to be effective in improving obesity and preventing diabetic progression.

• Journal of Bio-Environment Control
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• v.33 no.2
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• pp.107-113
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• 2024

For efficient soil water management in open fields, the proper use of soil moisture sensors is a prerequisite. Particularly in open-field environments like orchards with extensive root systems, the appropriate positioning of sensors is very important. The present study was conducted to identify the optimal placement of soil moisture sensors by assessing changes in soil water potential across various positions within orchard field soils after installing tensiometers. In apple and Asian pear orchards located in two regions of Korea, nine soil water potential sensors (TEROS 21, METER Group) were installed at distances of 20, 40, and 60 cm from the tree trunk and depths of 10, 20, and 30 cm from the soil surface, and monitored the soil water potential changes over two years. Results indicated that the positions closer to the tree trunk and the soil surface exhibited more pronounced changes in soil water potential. The greatest magnitude of change in soil water potential was observed at a distance of 20 cm and a depth of 10 cm, suggesting this position as the most suitable for soil moisture sensor installation. However, variations in the degree and pattern of changes in soil water potential were noted across sensor positions due to root system growth over time. Therefore, periodic observation and adjustments in sensor placement would be advisable to accurately monitor the soil moisture condition in long-term crops such as fruit trees in open fields.