• Radiation Oncology Journal
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• 제7권1호
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• pp.81-83
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• 1989

This study, involving thirty-two patients with carcinoma of uterine cervix treated by high dose rate intracavitary irradiation using a remotely controlled afterloading system, compares the doss at point A and 8 with the Curie-minutes prescription. A linear least-square regression analysis was used to compare the two sets of date. Correlation coefficients between doses at points A and B and the Ci-min prescription are 0.92 (p<0.001) and 0.90 (p<0.001), respectively, and linear relationship is observed between these two system. The limitation and significance of the comparison of the two approaches to intracavitary dosimetry is discussed.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2000년도 제52차 추계학술대회 연제집
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• pp.169-170
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• 2000

• 사상체질의학회지
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• 제9권2호
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• pp.245-261
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• 1997

The investigation were carried out the 37 patient with cerebrovascular accidents who had been treated in Oriental Medical Hospital in Kyung Hee University and in KangNam Uy Lim, and the 10 examinees who had been worked in Medical Hospital in Kyung Hee University. The consitution which had discriminated by survey, which had discriminated by study on the morphological diagrammings, which had discriminated by the result of the impatient of hospital on a dosage of constitutial prescription. The Prostaglandin E2 in blood for 47 persons (37 patients & 10 examinees) was measured. The following results were obtained. 1.In the constitution which had discriminated by survey, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 2.In the constitution which had discriminated by study on the morphological diagrammings, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 3.In the constitution which had discriminated by the result of patient of hospital on a dosage of constitutial prescription, the value of Prostaglandin E2 in blood of among four constitutions didn,nt showed signicant differance. 4.In the constitution which had discriminated by colligated three methods(survey, morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription), the value of Prostaglandin E2 in blood of ammong four constituion didn,t showed significant differnce. 5.In the constitution which had discriminated by survey, a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of female showed significant differance. 6.In the constitution which had discriminated by study on the morphological diagrammings,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the SO-EUM-IN(少陰人) and the others of male showed significant differance. 7.In the constitution whichhad discriminated by the result of patient of hospital on a dosage of constitutial prescription,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of male showed significant differance. 8.In the constitution which had discriminated was the colligated three methods(survey,morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription),a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others didn,t showed significant differnce. In this connected study is inadequete at present. But if the study is done persistently,the analysis of various ingredient in the body enables objectification in differentiation of four types of physical constitution as the supplemental method.

• 한국임상약학회지
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• 제21권2호
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• pp.106-114
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• 2011

1) 제주도 사업의 경우에 고양시보다 의료기관의 참여도가 높았는데 이것은 처방내에서 혹은 동일 의사의 처방내에서 병용금기나 중복의 발생을 줄이는 노력을 기울인 사실을 의미하였다. 빈도수에 있어서 병용금기는 고양시에서 처방전 1만 건당 0.45건 발생에서 제주도는 0건으로, 중복의 경우는 고양시에서 1만 건당 197건에서 제주도는 23건으로 감소하였다. 2) 하지만 제주도의 의료기관 참여도가 높음에도 불구하고 다른 의사 처방과의 점검에서는 병용금기 및 중복이 뚜렷이 감소하지 않았다. 병용금기의 발생은 고양시에서 1만 건당 4.95건에서 제주도의 경우 4.16건으로, 중복의 경우에 고양시의 경우 1만 건당 426건에서 제주도는 381건으로 감소하였지만 그 차이는 동일 의사 점검에서와 같은 뚜렷한 감소가 아닌 미세한 것이었다. 3) 두 지역을 통합하여 계산하였을 때 병용금기 발생의 동일 의사 점검: 다른 의사 점검의 비(比)(ratio)는 1:23으로 계산되었다. 4) 고양시 지역에서 중복의 발생은 동일 의사 점검: 다른 의사 점검의 비(比)(ratio)는 1: 2.12이었으며 제주도의 경우 그 비(比)(ratio)는 1:16.5이다. 5) 병용금기나 중복의 발생 문제 대부분이 다른 의사가 발행한 복수 처방에 의한 의약품의 병용에서 비롯하는 문제이며 이것은 의도하거나 인지하지 못한다는 점에서 단순 다제병용보다 심각한 문제를 포함할 수 있다. 6) 연구의 발견점은 의료 및 약사용 측면에서 통합성을 높이는 정책대안의 시급성을 시사하고 있으며 DUR제도의 확대강화와 단골약국 이용을 통하여 이러한 목표를 향한 정책을 지지해주는 결과라고 볼 수 있다.

• 생물정신의학
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• 제28권2호
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• pp.50-57
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• 2021

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%-70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore, augmentation with other medications for clozapine is frequently applied. However, the prescription pattern of clozapine and combined medications in Korea is yet to be examined. This study aims to investigate the maintenance treatment pattern of clozapine and augmentation agents in one Korean tertiary hospital. Methods The patients with schizophrenia spectrum disorders under clozapine maintenance, defined as one-year clozapine continuation, were subjected for analysis. Medication data at one-year time-point after clozapine initiation was extracted and analyzed. Results Among total 2897 patients having clozapine prescription experience from January 2000 to December 2018, 1011 patients were on clozapine maintenance. The mean age of clozapine initiation was 30.2 ± 11.3 years, and the maintenance dose of clozapine was 217.8 ± 124.3 mg/day. Combination rate of antipsychotics, mood stabilizers, and antidepressants were 43.5%, 25.3%, 38.6%, respectively. Most frequently prescribed drugs in each category were aripiprazole, valproate, and sertraline. Olanzapine equivalent dose of combined antipsychotics was 10.4 ± 7.7 mg/day. Male patients were prescribed higher dose of combined antipsychotics and higher rate of antidepressants. Female patients had later onset of clozapine prescription. Patients with two or more combined antipsychotics were prescribed higher dose of clozapine and higher rate of antidepressants compared to patients with one combined antipsychotic. Conclusions Taken together, among the patients taking clozapine, a substantial rate of patients were under polypharmacy. The present findings based on the real-world prescription pattern could provide the valuable clinical information on the treatment of TRS-related conditions.

• 대한한의학원전학회지
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• 제27권4호
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• pp.121-131
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• 2014

Objectives : The objectives of this study is to compare the differences in medical herbs combination of Taepyeonghyeminhwajegukbang, Somunsunmyungronbang and Nansilbijang. Methods : This study was proceeded by using Access 2007 and SQL Server and prescriptions of which herbal configuration could be indicated by weight unit were analysed from 765 prescriptions of Taepyeonghyeminhwajegukbang, 350 prescriptions of Somunsunmyungronbang and 277 prescriptions of Nansilbijang. Results : If more than 80% similarity, it is considered similar prescription. Only 6 Prescriptions of Nansilbijang similar to Prescriptions of Taepyeonghyeminhwajegukbang. And 20 Prescriptions of Somunsunmyungronbang similar to Prescriptions of Taepyeonghyeminhwajegukbang. Conclusions : Configuration patterns of Somunsunmyungronbang and Nansilbijang are different from Taepyeonghyeminhwajegukbang. So We can prove that theory of Somunsunmyungronbang and Nansilbijang are different from Taepyeonghyeminhwajegukbang.

• 대한한의학원전학회지
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• 제33권3호
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• pp.49-61
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• 2020

Objectives : The purpose of this paper is to collect basic data about Seo, Byung-Hyo and lay the groundwork for future analysis of his medical ideas. Methods : The life of Seo in regards to family and relationships was reconstructed through his genealogy and newspaper articles. His medical ideas were analyzed through the treatment records in books and historical material. Results : 1. Seo was primarily a clinician rather than a social worker throughout the Korean Empire and Japanese colonial era. 2. 『Summary of Experienced Old Prescriptions (經驗古方要抄)』 was a concise book that mainly took after the 『New Edition on Universal Relief (濟衆新編)』, supplemented by contents from the 『DongUiBogam(Treasured Mirror of Eastern Medicine)』. 3. It is meaningful that Seo's book restored and developed the single-ingredient prescription tradition of the 『DongUiBogam(Treasured Mirror of Eastern Medicine)』. 4. Seo faithfully followed the tradition of royal court medicine and utilized new prescriptions that were proven effective. Analysis of the prescription contents of 『A royal palace's diary(內殿日記)』 displays such characteristic. Conclusions : Seo, Byung-Hyo could be regarded as a clinician who faithfully inherited and developed 『DongUiBogam(Treasured Mirror of Eastern Medicine)』 and 『New Edition on Universal Relief (濟衆新編)』.

• 대한한의학방제학회지
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• 제24권2호
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• pp.71-79
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• 2016

Objectives : To verify the equivalence between Atractylodis Rhizoma Alba herbal prescription(HP-ARA) and Atractylodis Rhizoma Alba herbal sub stance(HS-ARA). Methods : Safety tests by microbial regulation and heavy metal analysis (total heavy metal, Pb, As) and a stability test by long term shelf test for HP-ARA according to notification of the Ministry of Food and Drug Safety were carried out. Then, multi component profile of HP-ARA and HS -ARA were analyzed by HPLC. Results : The safety and stability of HP-ARA confirmed by several tests. Correlation coefficient of equivalence of HP-ARA and ARA-HS showed 0.992. Conclusion : Based on this result of equivalence between HP-ARA and HS-ARA, HP-ARA can substitute HS-ARA used to make herbal medicines (herbal decoction, pills and powder).

• 한국의사학회지
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• 제22권2호
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• pp.33-41
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• 2009

The objective of this article is to analysis of Acupuncture & Moxibustion Fix-a-day Method (AMFDM) shown in the acupuncture documents of the Chosun-Korea dynasty. Through such inquisition, The development process of AMFDM could be found. cross-comparison analysis of the contents of three medical books, Chim-Gu-Tek-Il-Pien-Zip(CGTIPZ), Dong-Eui-Bo-Gam(DEBG) and Chim-Gu-Gyung-Hum-Bang (CGGHB) of the Chosun-Korea dynasty. The development process of AMFDM of the three books is different from each other, depending on the purpose of writing books. But The three books contain common parts. It could be divided into three types, Simple-AMFDM, Extensive-AMFDM and Spirit-Existence-AMFDM. The development process of AMFDM of the Chosun-Korea dynasty has three steps. First, Integration and specialization phase in CGTIPZ. CGTIPZ sum many kind of AMFDMs up, and compare them to be specialized area. Second, Setting theory phase in DEBG. DEBG theorize AMFDM made of Spirit-Existence-AMFDM. Third, Practical use phase in CGGHB. CGGHB invented practical reinforcement to replace complicated ones.

• 대한한의학원전학회지
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• 제32권1호
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• pp.61-74
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• 2019

Objectives : The purpose of this study is to help select an appropriate word embedding method when analyzing East Asian traditional medicine texts as data. Methods : Based on prescription data that imply traditional methods in traditional East Asian medicine, we have examined 4 count-based word embedding and 2 prediction-based word embedding methods. In order to intuitively compare these word embedding methods, we proposed a "prescription generating game" and compared its results with those from the application of the 6 methods. Results : When the adjacent vectors are extracted, the count-based word embedding method derives the main herbs that are frequently used in conjunction with each other. On the other hand, in the prediction-based word embedding method, the synonyms of the herbs were derived. Conclusions : Counting based word embedding methods seems to be more effective than prediction-based word embedding methods in analyzing the use of domesticated herbs. Among count-based word embedding methods, the TF-vector method tends to exaggerate the frequency effect, and hence the TF-IDF vector or co-word vector may be a more reasonable choice. Also, the t-score vector may be recommended in search for unusual information that could not be found in frequency. On the other hand, prediction-based embedding seems to be effective when deriving the bases of similar meanings in context.