• Asian-Australasian Journal of Animal Sciences
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• 제13권3호
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• pp.292-299
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• 2000

Forty-four Javanese thin-tail ewes were used to study the effect of superovulation prior to mating and of ration quality on lamb birth weight at parturition. Twenty-two ewes weaning at least one lamb were used to measure lamb preweaning growth. Prior to mating, the experimental ewes were injected twice with prostaglandin, with an 11 d interval between injections to synchronize the estrous cycle. At the last prostaglandin injection, 24 ewes were also injected with 700 IU of pregnant mare serum gonadotropin (PMSG) to stimulate superovulation and the remainder were injected with saline as control. During pregnancy and lactation, the experimental ewes were fed either on a low (12% CP and 65% TDN) or a high (15% CP and 75% TDN) quality ration. During lactation, the milk was collected twice a day and was refed to the lambs by bottle feeding immediately after collection. Superovulation or ration quality as a main factor did not significantly affect lamb birth weight. Litter size significantly affected lamb birth weight (p<0.05), and there was an interaction of superovulation and litter size. Nonsuperovulated ewes giving birth to multiple lambs had significantly lower average lamb birth weight (1.34 kg) as compared to those giving birth to a single lamb (1.97 kg) (p<0.05). However, superovulated ewes giving birth to multiple lambs had no significant difference in average lamb birth weight (1.68 kg) as compared to those giving birth to a single lamb (1.91 kg) (p>0.05). Superovulation of ewes prior to mating resulted in a significant improvement in lamb birth weight in the multiple litter size, without significant effect on average preweaning daily gain (p=0.07). Superovulation had a promising use in improving animal production through improvement of prenatal growth during pregnancy and milk production during lactation.

• 한국식품영양과학회지
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• 제13권2호
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• pp.156-162
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• 1984

casein, soy protein, corn gluten의 세가지 단백질 식이를 임신기 및 수유기 동안 어미쥐에게 섭취시킨후 출생시부터 생후 21 일까지의 새끼쥐의 세포 발달을 관찰한 결과는 다음과 같다. 1) 새끼쥐의 출생시 체중은 corn gluten군이 case군에 비하여 매우 유의적으로 낮았고 수유기 중에도 그 경향은 계속되었다. 2) 출생시 새끼쥐의 기관별 무게는, 뇌와 콩팥은 실험군간 유의적 차이가 없었으며 간의 무게는 corn gluten군이 casein군에 비하여 유의적으로 적었다, 그러나 출생 3일이후 뇌, 간, 콩팥의 무게는 생후 21일까지 corn gluten 군이 casein에 비하여 유의적으로 적었으므로 아미노산 조성의 블균형이 기관의 무게를 감소시킴을 나타내었다. 3) 세포의 수를 짐작할 수 있는 DNA함량은 세 기관에서 일반적으로 casein군, soy protein군, corn gluten군의 순서였으나 뇌의 경우는 출생 14일에 , 간의 경우는 14일과 21일에 casein군에 비하여 corn gluten 군이 유의적으로 적었다. 그러므로 아미노산 조성의 불균형에 따른 영향은 세포 발달과정에서 세포수에 큰 영향은 아니지만 간 세포수를 감소 시킴을 알 수 있었다. 4) 총 단백질과 RNA 함량은 뇌의 경우 생후 3일 이후 corn gluten군이 casein군에 비하여 유의적으로 적었으며 100 mg 젖은 무게당 함량은 유의적 차이는 없었다. 간에서는 총 RNA 함량은 corn gluten 군이 출생시부터 유의적으로 적었고 총단백질 함량은 출생 3일이후 매우 유의적으로 적었다. 그러나 100 mg 젖은 무게당 두 지표의 함량은 21일에 RNA 함량이 유의적으로 적었을 뿐 실험군 간 차이가 없었다. 그러므로 기관별 세포의 크기는 세 실험식이간에 차이가 없었다.

• 농업과학연구
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• 제43권1호
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• pp.72-79
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• 2016

It has long been known that nutritional and environmental influences during the early developmental period affect the biological mechanisms which determine animal metabolism. This phenomenon, termed 'metabolic imprinting', can cause subtle but long-lasting responses to prenatal and postnatal nutrition and even be passed onto the next generation. A large amount of research data shows that nutrient availability, in terms of quantity as well as quality, during the early developing stages can decrease the number of newborn piglets and their body weight and increase their susceptibility to death before weaning. However, investigation of potential mechanisms of 'the metabolic imprinting' effect have been scant. Therefore, it remains unknown which factors are responsible for embryonic and early postnatal nutrition and which factors are major determinants of body weight and number of new born piglets. Intrauterine undernutrition, for example, was studied using a rat model providing dams 50% restricted nutrients during pregnancy and the results showed significant decreases in birth weight of newborns. This response may be a characteristic of a subset of modulations in embryonic development which is caused by the metabolic imprinting. Underlying mechanisms of intrauterine undernutrition and growth retardation can be explained in part by epigenetics. Epigenetics modulate animal phenotypes without changes in DNA sequences. Epigenetic modifications include DNA methylation, chromatin modification and small non-coding RNA-associated gene silencing. Precise mechanisms must be identified at the morphologic, cellular, and molecular levels by using interdisciplinary nutrigenomics approaches to increase pig production. Experimental approaches for explaining these potential mechanisms will be discussed in this review.

• 부모자녀건강학회지
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• 제7권1호
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• pp.73-88
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• 2004

Purpose: The Purpose of this study was to analyze the trend of research related with unmarried mother. Method: 81 theses about unmarried mother from 1972 to 2003 were analyzed according to the theses' characteristics, sources by publication period, research design, nursing intervention effect of experimental study and theme of qualitative research. Results: 1. The number of studies related with unmarried mother has progressively increased by year from 1972, and that of theses was highest during the period between 2000 to 2003. 2 As for study design, the number of quantitative studies were 73 and that of qualitative studies were 8. The majority of research design were survey and correlational studies. 3. Nursing intervention used in the experimental design were stress management program, eco-system support group, group art treatment, career education program, musical activities, prenatal education. All of experimental design were used in the after 2000. 4. The themes of qualitative studies were childbirth experience, a participatory on the life, mother's keeping a child, experience of pregnancy and delivery, the self-group program, the process and experience of becoming unmarried adolescent mother, needs of single mothers with child and policy of social welfare service, lived experience of hope. All of these were used in the after 1999. Conclusions: The summary of the above results shows a tendency that the study has increased by year. Especially, experimental study proved affirmative effect. However, for the unmarried mother, more experimental and qualitative studies are to be required.

• 한국콘텐츠학회논문지
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• 제17권4호
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• pp.500-509
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• 2017

본 연구는 일반 대학생의 생명의료윤리의식과 공감능력의 정도를 평가하고 그 연관성을 살펴보고자 하였다. 연구대상은 지역대학생 469명이었다. 연구 결과로서 대학생의 생명윤리의식 정도는 2.89점이었고 그중 신생아 생명권과 태아의 생명권이 각각 3.32, 3.20점으로 가장 높았다. 대학생의 공감능력은 2.41로 중간 수준이었다. 생명의료윤리의식은 공감과 정적상관관계를 보였고, 생명윤리의 하위요인 중 태아의 생명권, 인공임신 중절, 인공 수정, 태아 진단, 신생아의 생명권이 인지적 공감 및 정서적 공감과 정적 상관관계를 나타내었다. 또한 공감 능력 중 정서적 공감이 생명윤리의식에 영향을 나타내었으며, 정서적 공감 중 공감적 관심 요인이 생명윤리의 하위 요인에서 태아의 생명권, 인공임신 중절, 인공수정, 태아진단, 신생아의 생명권, 안락사, 뇌사 요인에 영향을 미치는 것으로 나타났다. 향후 대학생들에서 공감과 관련된 생명윤리의식 교육이 필요할 것으로 생각된다.

• 여성건강간호학회지
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• 제8권3호
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• pp.371-379
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• 2002

The purpose of the present study is to consider its effect on the childbirth of a woman. This is a quasi-experimental study with nonequivalent control group post-test design. The subjects of this study are 60 primiparas (30 in the control, and another 30 in the experimental group) who have had a regular prenatal care from February 5 to March 20, 2002, in an outpatient obstetrics and gynecology of S university medical center located in Seoul. The result is as follows: 1. The hours of labor pains in the entire delivery period: the average hours are 7 hr. 9 min. in the experimental group, and 10 hr. 39 min. in the control group. The hours of labor pains are shorter in the woman with a family delivery experience in LDR. The difference is statistically significant (t=-3.34, p=.001). 2. The degree of pains in the entire delivery period: the average degree is 7.38 in the experimental group, and 7.68 in the control group. The degree of labor pains are lower in the woman with a family delivery experience in LDR. But, the difference is statistically insignificant (t=-0.86, p=.396). 3. The perceptions of the delivery experience: the average score of the perception is 73.63 in the experimental group, and 63.57 in the control group. The women with a family delivery experience in LDR have more positive perception of the delivery procedure, and, the difference is statistically significant (t=4.65, p=.000). In summary of the above result, a family-participated delivery in LDR is proved to be an effective nursing intervention that shortens the hours spent in the delivery procedure and promotes positive perceptions of the delivery experience.

• 치과방사선
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• 제27권1호
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• pp.203-216
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• 1997

The purpose of this study was to investigate the radiation effect on the stages of amelogenesis. Twenty ll-day-old rats which were irradiated by 4Gy of garmna radiation on the 19th prenatal day were used for the experimental group and twenty ll-day-old rats which were not irradiated were used for the control group. The length of each zone of amelogenesis were measured on the sagittal section using a light microscopic enlargement at 400 x the normal view while the morphologic changes of ameloblasts of each zone were observed electron­microscopically. The obtained results were as followed : 1. The length of the region of facing pulp and facing dentin of the zone of presecretion were increased by 11.5％(P<0.05) and 17.7％(P<0.01), respectively. 2. The length of the zone of secretion was increased by 17.3％(P<0.01), but the zone of maturation was decreased by 15.3％(P<0.01). 3. The total length of the zone of amelogenesis was not changed significantly(P>0.05). 4. Electron-microscopically, enlargement of the cell membrane, rER, mitochondria, and nuclear membrane were observed. These changes were mostly severe in the zone of maturation.

• Clinical and Experimental Pediatrics
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• 제56권9호
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• pp.369-376
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• 2013

A complex interplay between genetic and environmental factors partially contributes to the development of allergic diseases by affecting development during prenatal and early life. To explain the dramatic increase in the prevalence of allergic diseases, the hygiene hypothesis proposed that early exposure to infection prevented allergic diseases. The hygiene hypothesis has changed to the microbial hypothesis, in which exposure to microbes is closely linked to the development of the early immune system and allergic diseases. The intestinal flora may contribute to allergic disease through its substantial effect on mucosal immunity. Based on findings that exposure to microbial flora early in life can change the Th1/Th2 balance, thus favoring a Th1 cell response, probiotics may be beneficial in preventing allergic diseases. However, evidence from clinical and basic research to prove the efficacy of probiotics in preventing allergy is lacking. To date, studies have yielded inconsistent findings on the usefulness of probiotics in allergic diseases. It is difficult to demonstrate an exact effect of probiotics on asthma, allergic rhinitis, and food allergy because of study limitations, such as different first supplementation period, duration, different strains, short follow-up period, and host factors. However, many studies have demonstrated a significant clinical improvement in atopic dermatitis with the use of probiotics. An accurate understanding of the development of human immunity, intestinal barrier function, intestinal microbiota, and systemic immunity is required to comprehend the effects of probiotics on allergic diseases.

• 대한감각통합치료학회지
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• 제18권1호
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• pp.56-72
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• 2020

목적 : 주의력결핍 과잉행동장애(Attention Deficit Hyperactivity Disorder; ADHD)의 증상을 완화시키는데 있어 부모 훈련 중재(Parent Training Intervention)의 효과를 분석하고 어떠한 효과가 있는지 그 근거를 제시하는데 목적이 있다. 연구방법 : 2009년부터 2019년까지 10년간 해외 학술지에 게재된 문헌을 Proquest, Scopus 데이터베이스를 통하여 수집하였다. 검색용어는 (ADHD OR Attention Deficit Hyperactivity Disorder) AND (Parent OR Mother OR Father) AND (Training OR Program OR Therapy OR Intervention) AND (Randomized OR Randomised OR Randomly)를 사용하였다. 연구의 질적 평가를 위해 PEDro척도를 활용하였고, Comprehensive Meta-Analysis 3.0을 통해 메타분석을 실시하였다. 결과 : 1차 검색된 628개의 연구를 확인하였고, 최종 20개의 논문을 선정하였다. ADHD 아동에 대한 부모 훈련 중재의 전체효과크기(0.431) 및 부모 대상 중재(0.391), 부모-아동 대상 중재(0.639)는 모두 중간 효과크기로 나타났다. 부모 대상 중재는 ADHD 증상-과잉행동 및 충동성(0.921), 아동 행동(1.075), 아동 정서(0.834)에서 큰 효과크기가 나타났으며, 부모-아동 대상 중재는 ADHD 증상-과잉행동 및 충동성(0.922), 아동 정서(1.335), 반항성 및 품행장애(2.555), 학교 기능 및 사회기술(0.990)에서 큰 효과크기가 나타났다. 이질성 검정 결과 유의미한 결과가 나타나 랜덤효과모형을 선택하였다. 결론 : 부모 훈련 중재가 ADHD 아동의 증상에 미치는 효과를 알 수 있었다. 이는 작업치료사에게 임상적 근거를 제공하기 위한 근거 자료로 사용될 수 있을 것이다. 추후에는 국내실정에 맞는 부모 훈련 중재와 관련된 다양한 연구들이 진행되어야 할 것이다.

• 대한간호학회지
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• 제50권3호
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• pp.459-473
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• 2020

Purpose: This study was conducted to identify the effects of a lifestyle intervention program on weight gain, dietary habits, fatigue and pregnancy stress, blood pressure, and neonatal birth weight, using Cox's interaction model of client health behavior for overweight and obese women. Methods: This was a quasi-experimental research with a non-equivalent control group pre-post test design. A total of 52 patients who met the selection criteria, including 25 in the experimental group and 27 in the control group, were the subjects of the study; they comprised overweight and obese pregnant women who were receiving prenatal care at A and B women's hospital in J province. The lifestyle intervention program ran for 12 weeks in total and consisted of interactions involving affective support, health information, and professional/technical competencies. The data collection period was from February 1, 2017 to August 31, 2017. Results: This study showed differences in the appropriate weight gain rate (χ²=6.17, p=.013), suppression of an increase in fatigue (t=-2.32, p=.012), and an increase in pregnancy stress (t=-1.87, p=.034). Yet, no differences in physical activity, dietary habits change, blood pressure, and neonatal birth weight (p>.05) were found. Conclusion: The study findings indicate that this program could be an effective intervention for the control of appropriate weight gain, fatigue, and pregnancy stress. Therefore, a lifestyle intervention program based on Cox's interaction model of client health behavior could be an efficient strategy for a positive health outcome of overweight and obesity pregnant women.