• 제목/요약/키워드: Predominant Frequency

검색결과 205건 처리시간 0.025초

한국인에 있어서 MDRI 유전자(exon 12, 21 및 26)의 일배체형 분석 (Haplotype Analysis of MDRI Gene (Exon 12, 21 and 26) in Korean)

  • 김세미;박선애;조혜영;이용복
    • Journal of Pharmaceutical Investigation
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    • 제38권6호
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    • pp.365-372
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    • 2008
  • The aim of this study was to investigate the frequency of the SNPs on MDR1 exon 12, 21 and 26 in Korean population and to analyze haplotype frequency on MDR1 exon 12, 21 and 26 in Korean population. A total of 426 healthy subjects was genotyped for MDR1, using polymerase chain reaction-based diagnostic tests. Haplotype was statistically inferred using an algorithm based on the expectation-maximization (EM). MDR1 C1236T genotyping revealed that the frequency for homozygous wild-type (C/C), heterozygous (C/T) and for homozygous mutant-type (T/T) was 20.19%, 46.48% and 33.33%, respectively. MDR1 G2677T/A genotyping revealed that the frequency for homozygous G/G, heterozygous G/T, homozygous T/T, heterozygous G/A, heterozygous T/A and for homozygous A/A type was 30.75%, 42.26%, 9.86%, 7.51 %, 7.04% and 2.58%, respectively. MDR1 C3435T genotyping revealed that the frequency for homozygous wild-type (C/C), heterozygous (C/T) and for homozygous mutant-type (T/T) was 38.73%, 50.24% and 11.03%, respectively. Twelve haplotypes were observed. Of the three major haplotypes identified (CGC, TTT and TGC), the CGC haplotype were mainly predominant in the Korean populations and accounted for 29.96% of total haplotype in Korean.

THE CLINICAL STUDY OF MANDIBULAR FRACTURE

  • 이동근;임창준
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제11권1호
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    • pp.69-77
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    • 1989
  • This is a retrospective study on 219 patients with mandibular fracture. The patients were treated in the Dept. of Oral Maxillofacial Surgery of WON KWANG UNIV. HOSPITAL from Aug. 1, 1984 to Sept. 30. 1988. The results were as follows. 1. The mandibular fractures occured most frequently in the twenties(35%) and male were predominant (74.7%) than females. 2. The most frequent etiologic factor was traffic accident(34.3%). 3. The most common location of fracture was symphysis(37.1%). And angle(27.6%), condyle(25.7%), ramus(1.6%) were next in order of frequency. 4. In mandible fracture, they have an average 1.8 fracture line. 5. The use of plate & screw system were more increased in the comparison of each year. 6. Intermaxillary fixation period was more reduced from the concept of 6 weeks fixation, due to the use of Plate & screw system. 7. Postoperative acute wound infection was developed 9.6% in 219 mandibular fracture patients. The compression osteosynthesis was most common cause of acute wound infection than any other treatment method. 8. Postoperative malocclusion was developed 4% in 219 mandibular fracture. And the compression osteosynthesis was most common cause of malocclusion. 9. Acute wound infection was detailed by the approach method. The Intraoral & extraoral combination method was most common cause on acute infection and intraoral, extraoral approach method was next in order of frequency. 10. Normal mouth opening process was proportioned to IMF period. The short IMF period have a fast normal mouth opening process.

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국내 임상분리주 Streptococcus pneumoniae의 혈청형에 따른 유전적 상관성 (The Genetic Correlations Among Serotypes and PFGE Patterns of Streptococcus pneumoniae Isolated in Korea)

  • 정경석
    • 한국환경보건학회지
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    • 제30권1호
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    • pp.15-21
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    • 2004
  • In an attempt to analyze the characteristics of domestic pathogenic strains of S. pneumoniae, the basic epidemiological charactristics of pathogenic strains such as their serotypes and frequency of penicillin resistance, and pattern of chromosomal DNA from PFGE(pulsed-field gel electrophoresis) were observed. For this study,56 strains of S. pneumoniae isolated from inpatients and outpatients in the four domestic university hospitals were collected from January to December in 1998. Among those strains, a total of 56 pathogenic strains from blood(39 isolates), cerebrospinal fluid(8 isolates) and other specimen(9 isolates) were selected and isolated. The penicillin resistance frequency of those 56 strains was identified with disk diffusion method with 66.1%. From the invasive strains, predominant serotypes were isolated in the order of 19F(12.5%), 23F(10.7%), 14(10.7%) and 9V(10.7%), totalling 45 percent. This experiment also used PFGE patterns to compare the correlations among genetic subtypes in several serotypes. The DNA fragments digested with Sma I and Apa I were resolved by PFGE. The PFGE patterns digested with Sma I were better than Apa I for analysis. In the DNA fragments digested with Sma 1, PFGE analysis of 56 S. pneumoniae isolates showed 25 different patterns. As a result, serotype was on the whole correlated to PFGE pattern on the ground that each different PFGE pattern by serotype was observed. This study can be utilized not only fur the study of incidence trend of domestic pneumococcal diseases but also as a useful basic data for the development of identification tool and treatment.

Aerodynamic response of articulated towers: state-of-the-art

  • Zaheer, M. Moonis;Islam, Nazrul
    • Wind and Structures
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    • 제11권2호
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    • pp.97-120
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    • 2008
  • Wind and wave loadings have a predominant role in the design of offshore structures in general, and articulated tower in particular for a successful service and survival during normal and extreme environmental conditions. Such towers are very sensitive to the dynamic effects of wind and wind generated waves. The exposed superstructure is subjected to aerodynamic loads while the submerged substructure is subjected to hydrodynamic loads. Articulated towers are designed such that their fundamental frequency is well below the wave frequency to avoid dynamic amplification. Dynamic interaction of these towers with environmental loads (wind, waves and currents) acts to impart a lesser overall shear and overturning moment due to compliance to such forces. This compliancy introduces geometric nonlinearity due to large displacements, which becomes an important consideration in the analysis of articulated towers. Prediction of the nonlinear behaviour of these towers in the harsh ocean environment is difficult. However, simplified realistic mathematical models are employed to gain an important insight into the problem and to explore the dynamic behaviour. In this paper, various modeling approaches and solution methods for articulated towers adopted by past researchers are reviewed. Besides, reliability of articulation system, the paper also discussed the design, installation and performance of articulated towers around the world oceans.

개체발생에 따른 황소개구리(Rana catesbeiana) 위장관에서 neurotensin, pancreatic polypeptide 및 gastrin/cholecystokinin 면역반응세포에 대한 면역조직화학적 연구 (Immunohistochemical study of neurotensin-, pancreatic polypeptide- and gastrin/cholecystokinin-immunoreactive cells in the gastrointestinal tract of the bullfrog, Rana catesbeiana during developmental stages)

  • 이형식;구세광;이재현
    • 대한수의학회지
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    • 제39권1호
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    • pp.20-26
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    • 1999
  • To investigate the regional distribution and relative frequency of the neurotensin-, pancreatic polypeptide(PP)- and gastrin/cholecystokinin(Gas/CCK)-immunoreactive cells in the gastrointestinal tract of the bullfrog(Rana catesbeiana) with developmental stages, group of bullfrogs subdivided into the tadpole with hindlegs, metamorphosed bullfrog with tail, 2 weeks after metamorphosed bullfrog and adult bullfrog, were stained by immunohistochemical methods (PAP methods). Neurotensin-immunoreactive cells were observed from the pylorus of the metamorphosed bullfrog with tail, but these cells were not detected after that periods. PP-immunoreactive cells were detected from the adult bullfrog in the pylorus, duodenum and ileum. These cells were most predominant in the pylorus. Gas/CCK-immunoreactive cells were observed from the adult bullfrog in the pylorus. According to these results, most of immunoreactive cells in the gastrointestinal tract of the bullfrog were appeared after the complete metamorphosed periods, in which the complete differentiation of structure of gastrointestinal tract were occurred, and variable changes of the regional distribution and relative frequency with developmental stages were observed.

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한국재래산양 태자의 위장관에 있어서 gastrin, secretin 및 pancreatic polypeptide 면역반응세포의 분포 및 출현빈도에 관한 연구 (Regional distribution and relative frequency of the gastrin, secretin and pancreatic polypeptide-immunoreactive cells in the gastrointestinal tract of the fetus of Korean native goat)

  • 이형식;구세광;이재현
    • 대한수의학회지
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    • 제39권1호
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    • pp.12-19
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    • 1999
  • The regional distributions and relative frequencies of the gastrin, secretin and pancreatic polypeptide(PP)-immunoreactive cells in the gastrointestinal tract of the fetus(180 days of gestation) of Korean native goat were studied with immunohistochemical(ABC) methods. Gastrin-immunoreactive cells were detected in fundus, pylorus and duodenum and these cells were most predominant in pylorus. Secretin-immunoreactive cells were observed in pylorus, duodenum and ileum. PP-immunoreactive cells were restricted to fundus. These immunoreactive cells were situated in surface epithelium and mucosal gland regions. The regional distribution and relative frequency of PP-immunoreactive cells was somewhat different to the adult Korean native goat. Immunoreactive cells in the surface epithelial regions were open typed cells which were spindle shaped cells but closed typed cells which were round or/to spherical shaped cells were observed in the mucosal gland regions.

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전통 초가삼간 가옥의 내진성능 평가 실험(I) : 암반지반 조건 (A Test on the Aseismic Capacity of a Traditional Three-bay-straw-roof House(I) : Rock Site Condition)

  • 서정문;최인길;전영선;이종림;신재철
    • 한국지진공학회논문집
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    • 제1권4호
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    • pp.11-20
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    • 1997
  • 우리나라 전통 초가삼간의 1/4 축소모델을 제작하여 암반지반 조건에 대한 내진성능실험을 수행하였다. Nahanni 지진파를 사용하여 최대 가속도 0.1g~0.6g 범위에서 거동을 분석하였다. 탄성한계에서 초가삼간의 고유진동수는 장방향의 경우 약 1.66Hz, 단방향의 경우 215Hz이다. 탄성한계에서의 감쇠비는 약 7%이다. 수평방향의 가속도응답은 입력에 비해 감소하며 입력가속도 수준이 증가할수록 감소율이 증가한다. 이는 사개맞춤으로 만들어진 목조 프레임의 비선형.비탄성 특성 때문이다. 전통 초가삼간 가옥은 고진동수가 지배적인 암반지반에서 매우 큰 내진성능을 나타내었다.

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Changes in the Serotonin-, Somatostatin- and Motilin-Immunoreactive Cells in the Gastrointestinal Tract of the Bullfrog, Rana catesbeiana, at Various Developmental Stages

  • Hyeung-Sik Lee;Sae-Kwang Ku;Jae-Hyun Lee
    • Animal cells and systems
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    • 제3권1호
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    • pp.97-102
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    • 1999
  • In order to investigate the regional distribution and relative frequency of the serotonin-, somatostatin- and motilin-immunoreactive cells in the gastrointestinal tract GIT) of the bullfrog (Rana catesbeiana) with developmental stages, group of bullfrogs subdivided into the tadpole with hindlegs, metamorphosed bullfrog with tail, 2 wk after metamorphosed bullfrog and adult bullfrog, were stained by immunohistochemical methods (PAP methods). Multifarious changes of the regional distribution and relative frequency of the gastrointestinal endocrine cells were observed as developmental stages but motilin-immunoreactive cell ere not detected in this study. Serotonin-immunoreactive cells were detected from 2 wk after metamorphosed bullfrog in the whole GIT. The positive cells were predominant in the pylorus regions. In the adult bullfrog, these cells increased in fundus. On the other hand, somatostatin-immunoreactive cells were observed from the tadpole with hindlegs in the stomach regions. In the metamorphosed bullfrog with tail, they were found in the whole GIT except for the ileum, and increased with developmental stages except for rectum. In the rectum, these cells were not detected after that period. Our results show that most of the immunoreactive cells appear from completed metamorphosed periods when the histological structure of GIT is completely differentiated.

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Response of square anchor plates embedded in reinforced soft clay subjected to cyclic loading

  • Biradar, Jagdish;Banerjee, Subhadeep;Shankar, Ravi;Ghosh, Poulami;Mukherjee, Sibapriya;Fatahi, Behzad
    • Geomechanics and Engineering
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    • 제17권2호
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    • pp.165-173
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    • 2019
  • Plate anchors are generally used for structures like transmission towers, mooring systems etc. where the uplift and lateral forces are expected to be predominant. The capacity of anchor plate can be increased by the use of geosynthetics without altering the size of plates. Numerical simulations have been carried out on three different sizes of square anchor plates. A single layer geosynthetic has been used as reinforcement in the analysis and placed at three different positions from the plate. The effects of various parameters like embedment ratio, position of reinforcement, width of reinforcement, frequency and loading amplitude on the pull out capacity have been presented in this study. The load-displacement behaviour of anchors for various embedment ratios with and without reinforcement has been also observed. The pull out load, corresponding to a displacement equal to each of the considered maximum amplitudes of a given frequency, has been expressed in terms of a dimensionless breakout factor. The pull out load for all anchors has been found to increase by more than 100% with embedment ratio varying from 1 to 6. Finally a semi empirical formulation for breakout factor for square anchors in reinforced soil has also been proposed by carrying out regression analysis on the data obtained from numerical simulations.

국내 연구용원자로 전출력 내부사건 1단계 확률론적안전성평가 (Internal Event Level 1 Probabilistic Safety Assessment for Korea Research Reactor)

  • 이윤환;장승철
    • 한국안전학회지
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    • 제36권3호
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    • pp.66-73
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    • 2021
  • This report documents the results of an at-power internal events Level 1 Probabilistic Safety Assessment (PSA) for a Korea research reactor (KRR). The aim of the study is to determine the accident sequences, construct an internal level 1 PSA model, and estimate the core damage frequency (CDF). The accident quantification is performed using the AIMS-PSA software version 1.2c along with a fault tree reliability evaluation expert (FTREX) quantification engine. The KRR PSA model is quantified using a cut-off value of 1.0E-15/yr to eliminate the non-effective minimal cut sets (MCSs). The final result indicates a point estimate of 4.55E-06/yr for the overall CDF attributable to internal initiating events in the core damage state for the KRR. Loss of Electric Power (LOEP) is the predominant contributor to the total CDF via a single initiating event (3.68E-6/yr), providing 80.9% of the CDF. The second largest contributor is the beam tube loss of coolant accident (LOCA), which accounts for 9.9% (4.49E-07/yr) of the CDF.