• International Journal of Precision Engineering and Manufacturing
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• v.7 no.3
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• pp.60-65
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• 2006

This paper proposes a new type of six degree-of-freedom fine positioner that can be used to align the condenser in X-ray microscopy precisely. The new concept was based on the requirements for an X-ray microscope. A proposed modeling method was used to obtain an optimal design, which was verified with a finite element analysis. The fine positioner was then constructed and an experiment was used to validate its performance.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.7
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• pp.45-51
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• 2000

지난 세기부터 MEMS 제작 기술을 이용하여 만들어진 시스템들을 의학이나 생물학적인 용도로 응용하기 위한 많은 연구가 활발히 이루어져 왔다. 기술적인 측면에서 이러한 연구들은 MEMS 분야의 초창기에 강조되어 온 표면 및 몸체 미세 가공 기술(surface ＆ bulk micromachining)과 같은 미세 구조물 제작 기술의 발전에 힘입은 바 크다. 그러나 MEMS 기술이 점차 발전되어 오면서, 가공 기술이 고도화되고 미세 시스템의 구조가 점차 복잡해짐에 따라, 많은 연구들이 단순한 가공기술을 넘어 미세 시스템을 조립하고 집적화할 수 있는 기술, 접합 (bonding) 기술, 패키징 (packaging) 기술, 3차원 형상의 제작 기술, 실리콘(silicon)이나 유리(glass)가 아닌 다른 재료를 이용한 미세 가공 기술 등의 개발을 중심으로 이루어지고 있다.(중략)

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.2
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• pp.145-152
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• 2017

The purpose of this study was to investigate the clinical research of Cold-Heat of pattern identification(PI) focused on quantitative indicators for general people in Korea, through the review of OASIS, KISS, DBpia, NDSL database. Ten clinical researches were analyzed in this study. These research gradually started from 2004 to 2009 but there was no research after 2010. Diagnosis of Cold-Heat PI all was done through a questionnaire, 7 or most researches had not used the intervention methods. Quantitative indicators related to the Cold-Heat PI mentioned in the selected 10 researches are seven, these indicators include heart rate variability(HRV), electroencephalogram, Yangdorak, respiratory index, electrogastrography, acoustic analysis index, western health test index. Related to the HRV were 3 researches, but correlation of significant indicators was a few levels(R=0.026-0.090). So far, studies regarding at the quantitative indicators of the prior the Cold-Heat PI were few, and the results of the study showed that low statistical precision, a lack of biological basis. Refer to the current state, in the future, we expect that research of quantitative indicators of scientific evidence-based through calculated and precise research concerning Cold-Heat PI be regarded as important in Korean Medicine.

• The Korean Journal of Pain
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• v.20 no.2
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• pp.186-189
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• 2007

The most important factors for successful stimulation of the spinal cord are strict patient selection and proper lead position. To ensure proper lead position, paresthesia produced by the stimulator should cover all of the areas in which pain is occurring. Until recently, only the quadripolar electrode lead has been used in for spinal cord stimulation in Korea, however, the 8 electrode lead was recently introduced to offer greater programming options and enhance the precision with which paresthesias is delivered to the desired sites. In addition, because the 8-electrode lead has a longer electrode span, it provides greater dermatomal coverage of up to 2 vertebral segments. Furthermore, the 8-electrode lead allows electronic repositioning of the stimulation to accommodate changing pain patterns, thereby reducing the need for lead revisions due to lead migration. Here, we present a case in which complex regional pain syndrome type I was successfully managed using an 8-electrode lead to induce spinal cord stimulation.

• Molecules and Cells
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• v.45 no.9
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• pp.610-619
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• 2022

Cellular senescence plays a paradoxical role in tumorigenesis through the expression of diverse senescence-associated (SA) secretory phenotypes (SASPs). The heterogeneity of SA gene expression in cancer cells not only promotes cancer stemness but also protects these cells from chemotherapy. Despite the potential correlation between cancer and SA biomarkers, many transcriptional changes across distinct cell populations remain largely unknown. During the past decade, single-cell RNA sequencing (scRNA-seq) technologies have emerged as powerful experimental and analytical tools to dissect such diverse senescence-derived transcriptional changes. Here, we review the recent sequencing efforts that successfully characterized scRNA-seq data obtained from diverse cancer cells and elucidated the role of senescent cells in tumor malignancy. We further highlight the functional implications of SA genes expressed specifically in cancer and stromal cell populations in the tumor microenvironment. Translational research leveraging scRNA-seq profiling of SA genes will facilitate the identification of novel expression patterns underlying cancer susceptibility, providing new therapeutic opportunities in the era of precision medicine.

• Tuberculosis and Respiratory Diseases
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• v.87 no.1
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• pp.1-11
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• 2024

Acute respiratory distress syndrome (ARDS) is a common cause of severe hypoxemia defined by the acute onset of bilateral non-cardiogenic pulmonary edema. The diagnosis is made by defined consensus criteria. Supportive care, including prevention of further injury to the lungs, is the only treatment that conclusively improves outcomes. The inability to find more advanced therapies is due, in part, to the highly sensitive but relatively non-specific current syndromic consensus criteria, combining a heterogenous population of patients under the umbrella of ARDS. With few effective therapies, the morality rate remains 30% to 40%. Many subphenotypes of ARDS have been proposed to cluster patients with shared combinations of observable or measurable traits. Subphenotyping patients is a strategy to overcome heterogeneity to advance clinical research and eventually identify treatable traits. Subphenotypes of ARDS have been proposed based on radiographic patterns, protein biomarkers, transcriptomics, and/or machine-based clustering of clinical and biological variables. Some of these strategies have been reproducible across patient cohorts, but at present all have practical limitations to their implementation. Furthermore, there is no agreement on which strategy is the most appropriate. This review will discuss the current strategies for subphenotyping patients with ARDS, including the strengths and limitations, and the future directions of ARDS subphenotyping.

• Journal of Sasang Constitutional Medicine
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• v.18 no.3
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• pp.57-63
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• 2006

1. Objectives The Face is an important standard for the classification of Sasang Contitutions. Now We are developing 3D Face Automatic Recognition Apparatus to analyse the facial characteristics. This apparatus show us 3D image of man's face and measure facial figure. We should examine accuracy of position recognition in 3D Face Automatic Recognition Apparatus. 2. Methods We took a photograph of Face status with Land Mark 8 times using Face Automatic Recognition Apparatus. Each taking-photo, We span Face statusby 10 degree. At last time, We took a photograph of Face status's lateral face. And We analysed Error Averige of Distance between seven Land Marks. So We examined the accuracy of position recognition in 3D Face Automatic Recognition Apparatus at indirectly in degree changing of Face status. 3. Results and Conclusions According to degree change of Face status, Error Averige of Distance between Seven Land Marks is 0.1848mm. In conclusion, We assessed that accuracy of position recognition in 3D Face Automatic Recognition Apparatus is considerably good in spite of degree changing of Face status

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.137-144
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• 2008

Positron emission tomography-computed tomography (PET/CT) provides both functional and anatomical images of high quality non-invasively with better precision in localization than PET alone. Increase in the use of PET/CT, coupled with increasing concerns about the quality of medical services accrued the demands for accurate evaluation of system performance and quality assurance. Thus, well designed programs for performance evaluation and quality assurance are needed. Widely used protocols for performance evaluation of PET are the methods proposed by National Electrical Manufacturers Association (NEMA) in 1994 and 2001. In addition, in order to maintain high quality of PET/CT images, quality assurance programs including periodic (daily, monthly, and yearly). Therefore, in this article, the methods and present state of performance evaluation and quality assurance of PET/CT are reviewed.

• Journal of Sensor Science and Technology
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• v.16 no.4
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• pp.263-269
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• 2007

Although variable resistance displacement transducer is widely applied for its technical simplicity, electrical point contact limits measurement resolution (precision). The present study introduced roller shaped structure for electrical line contact. Proto-type transducer was developed and measurement characteristics were compared with a commercialized product. When the displacement was varied with steps of 5 mm, 1 mm, and down to 0.1 mm, the correlation coefficient between resistance and displacement decreased lower than 0.9 in the commercialized product while the proto-type transducer maintained values higher than 0.99. Therefore, the measurement resolution was enhanced by approximately 10 times. Since manufacturing also seemed easier, the present results would enable more accurate and less expensive manufacturing of variable resistance displacement transducer.

• Biomolecules & Therapeutics
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• v.25 no.6
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• pp.569-577
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• 2017

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been considered as a primary reason for organ dysfunction and mortality, and advances in emergency intervention and improved intensive care management have reduced mortalities in the early phase. However it has been recognized that increased deaths in the late phase still maintain sepsis mortality high worldwide. Patients recovered from early severe illness are unable to control immune system with sepsis-induced immunosuppression such as immunological tolerance, exhaustion and apoptosis, which make them vulnerable to nosocomial and opportunistic infections ultimately leading to threat to life. Based on strategies to reverse immunosuppression, recent developments in sepsis therapy are focused on molecules having immune enhancing activities. These efforts are focused on defining and revising the immunocompromised status associated with long-term mortality.