• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 춘계학술대회 논문집
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• pp.1245-1246
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• 2012

• Current Optics and Photonics
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• 제3권2호
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• pp.150-153
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• 2019

Larynx cancer is a potentially terminal and severe type of neck and head cancer in which malignant cells start to grow and spread upwards in the larynx, or voice box. Smoking tobacco, drinking hot beverages and drinking alcohol are the main risk factors for these tumors. In this study, we aimed to develop a precise, accurate and rapid chemometrics assisted Raman spectroscopy method for diagnosis of larynx cancer in deparaffinized tissue samples. In the proposed method, samples were deparaffinized and 20 microns of each tissue were located on a coverslip. Both healthy (n = 13) and cancerous tissues (n = 13) were exposed to a Raman laser (785 nm) and excitations were recorded between wavenumbers of $50{\sim}1500cm^{-1}$. An Orthogonal Partial Least Square algorithm was applied to evaluate the Raman spectrum obtained. Sensitivity and specificity of the proposed method is high enough with the aid of Principal Component Analysis (PCA) to test the whole model. Healthy and cancerous tissues were accurately and precisely clustered. A rapid, easy and precise diagnosis algorithm was developed for larynx cancer. By this method, some useful data about differences in biomolecules of each group (phospholipids, amides, tyrosine, phenylalanine collagen etc.) was also obtained from the spectra. It is claimed that the optimized method has a great potential for clustering and separating tumor tissues from healthy ones. This novel, rapid, precise and objective diagnosis method may be an alternative for the conventional methods in literature for diagnosis of larynx cancer.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2010년도 춘계학술대회 논문집
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• pp.540-545
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• 2010

2009년 3월 19일 도시철도차량의 내구연한 관련 법령이 개정되면서 도시철도차량이 최장 40년까지 사용 가능하게 되었다. 이는 차량제작 기술의 발전과 더불어 소재와 부품의 품질 향상으로 내구성이 우수해졌고 체계적인 관리와 노후 부품의 교체 등으로 도시철도 차량의 수명이 길어졌기 때문이라고 판단된다. 도시철도 차량의 안전은 승객의 안전과 직접적인 관계가 있으므로 안전성을 최우선적으로 고려하여야 하며 내구연한 연장을 위해서는 더욱 정밀한 안전 검정이 필요하다. 이에 내구연한이 도래한 전동차는 개정된 "도시철도차량의 정밀진단지침"에 따라 정밀진단을 실시하여야 한다. 본 연구는 내구연한 연장 관련 법령 개정 이후 최초로 정밀진단을 시행하고 있는 부산교통공사의 사례를 통해 정밀진단 시행기관과 도시철도 운영기관에 정밀진단에 대한 진단기법의 방향을 제시하고자 한다.

• 한국구조물진단유지관리공학회 논문집
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• 제25권3호
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• pp.85-91
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• 2021

건축시설물 중 제1종 시설물과 제2종 시설물은 유지관리를 위해 정기적으로 정밀안전점검과 정밀안전진단을 실시한다. 건축물의 점검 및 진단을 실시하는 경우 상태평가, 기울기 및 침하, 안전성평가를 종합하여 건축물의 등급이 결정된다. 그리고 평가등급은 점검 및 진단의 주기를 결정한다. 평가 등급이 좋지 않다면 점검 및 진단 주기는 짧아지고, 이로 인한 유지관리 비용은 증가하게 된다. 따라서 건축물을 평가하는 방법은 명확하여야 한다. 상태평가는 부재단위 평가, 층단위 평가, 종합 평가로 이루어진다. 이 중 부재단위 평가는 현장조사와 시험 결과를 통해 등급을 판정한다. 본 연구에서는 상태평가의 첫 번째 단계인 부재단위 평가에 대해 평가방법과 평가기준을 분석하여 개선점을 도출하였으며, 이를 개선하여 현재 부재의 상태점수를 반영할 수 있는 함수식을 제시하였다.

• 한국지진공학회논문집
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• 제22권3호
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• pp.169-174
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• 2018

A total of 594 reservoirs (17%), which are managed by KRC, equipped with earthquake-resistant facilities whereas remaining ones did not. In addition, reservoirs were placed without the effect of geological structures (i.e., fault and lineament). Therefore, development on technique for alleviating the potential hazards by natural disasters along faults and lineaments has required. In addition, an effective reinforcement guideline related to the geological vulnerabilities around reservoirs has required. The final goal of this study is to suggest the effective maintenance for the safety of earth fill dams. A radius 2 km, based on the center of the reservoir in the study area was set as the range of vulnerability impacts of each reservoir. Seismic design, precise safety diagnosis, seismic influence and geological structure were analyzed for the influence range of each reservoir. To classify the vulnerability of geological disasters according to the fault distribution around the reservoir, evaluation index of seismic performance, precise safety diagnosis, seismic influence and geological structure were also developed for each reservoir, which were a component of the vulnerability assessment of geological disasters. As a result, the reservoir with the highest vulnerability to geological disasters in the pilot district was analyzed as Kidong reservoir with an evaluation index of 0.364. Within the radius of 100km from the epicenter of the Pohang earthquake, the number of agricultural infrastructure facilities subject to urgent inspections were 1,180 including reservoirs, pumping stations and intakes. Four reservoirs were directly damaged by earthquake among 724 agricultural reservoirs. As a result of the precise inspection and electrical resistivity survey of the reservoir after the earthquake, it was reported that cracks on the crest of reservoirs were not a cause of concern. However, we are constantly monitoring the safety of agricultural facilities by Pohang aftershocks.

• 대한치과의사협회지
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• 제54권9호
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• pp.684-691
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• 2016

The odontogenic cutaneous fistula in facial area is uncommon but, well defined disease. It is difficult to diagnose from the dental origin of cutaneous sinus tract. Most patients may visit to the dermatologists or general hospital without cause of disease. They usually be treated by repeated surgical excisions, biopsies, and antibiotic medications, but suffered from recurrences. We studied odontogenic cutaneous fistula through retrospective study in Jeju Special Self-Governing Province between 1 January 2009 and 12 December 2015. There were 3 males, 5 females from 14 to 78 years old with an average age of 50.4 years old. Only 2 patients felt the toothache, others didn't detect it. They suffered from recurrences and repeated treatments for 3 to 11 months with an average period of 7.9 months. They visited average 2.8 hospitals before a precise diagnosis in a dental clinic. All cases were fully healed endodontic treatment or extraction of origin teeth without recurrences. In conclusion, the cause of cutaneous fistula in facial area can be odontogenic. If dentists or doctors diagnose a patient with cutaneous fistula on face, they should check dental problems or take x-ray views for precise diagnosis. It could be helpful for differential diagnosis.

• Journal of Gastric Cancer
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• 제23권3호
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• pp.410-427
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• 2023

Recent advances in artificial intelligence (AI) have provided novel tools for rapid and precise pathologic diagnosis. The introduction of digital pathology has enabled the acquisition of scanned slide images that are essential for the application of AI. The application of AI for improved pathologic diagnosis includes the error-free detection of potentially negligible lesions, such as a minute focus of metastatic tumor cells in lymph nodes, the accurate diagnosis of potentially controversial histologic findings, such as very well-differentiated carcinomas mimicking normal epithelial tissues, and the pathological subtyping of the cancers. Additionally, the utilization of AI algorithms enables the precise decision of the score of immunohistochemical markers for targeted therapies, such as human epidermal growth factor receptor 2 and programmed death-ligand 1. Studies have revealed that AI assistance can reduce the discordance of interpretation between pathologists and more accurately predict clinical outcomes. Several approaches have been employed to develop novel biomarkers from histologic images using AI. Moreover, AI-assisted analysis of the cancer microenvironment showed that the distribution of tumor-infiltrating lymphocytes was related to the response to the immune checkpoint inhibitor therapy, emphasizing its value as a biomarker. As numerous studies have demonstrated the significance of AI-assisted interpretation and biomarker development, the AI-based approach will advance diagnostic pathology.

• 대한세포병리학회지
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• 제18권1호
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• pp.55-61
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• 2007

Once diagnosed as "cell paucity"or "atypia" by the cytospin (CS) preparation, this CS preparation does not secure a precise diagnosis by repeated testing alone. Although the ThinPrep (TP) preparation is acknowledged to show increased cellularity, performing the screening tests for the cases that have enough cellularity, according to CS, raises issues for the cost-effectiveness. To obtain a more precise diagnosis through increasing the cellularity by performing TP, we selected the cases that were diagnosed as "cell paucity" or "atypia" by CS, but they required a more precise diagnosis, and the samples were processed via both CS and TP to compare the results. 11 patients diagnosed as "cell paucity" and 22 patients diagnosed as "atypia" by CS participated in this study. When the detection rate of atypical cells in both preparations with repeated urine cytology was compared, the overall detection rate of TP (16cases, 48.5%) was superior than that of CS (11cases, 33.3%), with statistical significance. The cellularity of both preparations was compared on repeated urine cytology; the general cellularity of TP (29cases, 87.9%) was higher than that of CS (20cases, 60.6%), but there was no statistical significance. Particularly, we repeated the TP for the 1 case that was diagnosed as "atypia" and we performed polyoma virus immunohistochemical staining, which confirmed polyoma virus. In conclusion, we can avoid obtaining negative diagnosis from cases with uncertain "atypia" or "cell paucity" by performing repeated TP testing.

• Journal of Korean Neurosurgical Society
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• 제48권6호
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• pp.473-479
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• 2010

A cervical radiculopathy is the most common symptom of cervical degenerative disease and its natural course is generally favorable. With a precise diagnosis using appropriate tools, the majority of patients will respond well to conservative treatment. Cervical radiculopathy with persistent radicular pain after conservative treatment and progressive or profound motor weakness may require surgery. Options for surgical management are extensive. Each technique has strengths and weaknesses, so the choice will depend on the patient's clinical profile and the surgeon's judgment.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.194-197
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• 2012

본 논문에서는 심폐기능에 이상이 있는 중환자의 상태를 감시 및 진단하기 위한 방법으로 Swan-Ganz Catheter를 체내에 삽입하여, 지속적인 심박출량 데이터를 기존 장비들 보다 정밀하게 측정할 수 있는 모듈을 개발하고자 한다. 이전에 차가운 수액을 심장 내에 주입하여 심박출량을 측정하는 방법은 지속적인 환자의 감시 및 진단이 힘들다는 점을 보완하여 지속적인 심박출량 측정을 통해 심폐기능 문제를 가진 중환자를 보다 효과적이고 정확한 진단과 치료를 가능하게 한다.