• Archives of Pharmacal Research
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• v.26 no.5
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• pp.358-366
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• 2003

Some N-p-substituted phenyl uracil-5-sulphonamide derivatives have been synthesized to be evaluated as molluscicides against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Schistosoma mansoni infected mice were treated with hemolymph obtained from pre-treated Biomphalaria alexandrina snails with the products 4a, 10a, 10b and 4b or obtained from non-treated snails. The selection of the concentration based on the predetermined dose which caused mortality of less than 50% of snails/24 h. $LC_{50}$ of compounds 4a, 10a, 10b and 4b was 50, 100, 200 and 50 ppm respectively. The result showed that immuno-stimulatory effect of treated hemolymph with compounds 4a, 10a and 4b was related to significant protective effects (44.4, 34.6 and 50.4% reduction in worm burden respectively). In addition, mean total worm burdens were significantly reduced in non treated hemolymph by 33.8%. The effect of hemolymph obtained from treated or non treated snails on S. mansoni adult worms antigens was studied by indirect immunofluorescence technique using chronic mouse sera (CMS). The results indicated that there was a strong reaction with epitopes in gut epithelium, tubercles, teigument and subtegumental musculature of untreated and treated S. mansoni adult worms antigens. Therefore, treatment of hemolymph obtained from pre-treated snails with compounds 4a, 10a, and 4b can stimulate specific immune response and induce protective effects against S. mansoni infection.

• Journal of Plant Biotechnology
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• v.48 no.2
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• pp.93-99
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• 2021

This study was conducted to develop an Agrobacterium-mediated genetic transformation protocol for the carnation cv. "Jinju" to counteract its ethylene sensitivity. The new protocol involves the use of an improved shoot regeneration medium, optimized minimal concentrations of the selective agent, a pre-culture period, and co-cultivation periods. Silver nanoparticles (NAg) added at a concentration of 2.0 μM to the Murashige and Skoog (MS) basal shoot regeneration medium supplemented with 0.1 mg/L indole-3-butyric-acid (IBA) and 0.2 mg/L thidiazuron (TDZ) improved the shoot regeneration efficiency, number of shoots per explant, and plant growth compared to the control without the addition of NAg. The phosphinothricin (PPT) concentration of 1.0 mg/L was determined to be the minimal and optimal concentration for the selection of putative transgenic plants. When the explants were infected with Agrobacterium cells harboring the acdS gene, the explants that were pre-cultured for three days induced more putative transgenic plants than those that were co-cultivated for four days. Therefore, we expect that the results of this study will benefit researchers who are developing genetic transformations of carnations.

• Korean Journal of Comparative Education
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• v.27 no.3
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• pp.49-73
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• 2017

This study aims to clarify background and peculiarity of teacher policy in Finland. Especially we focus on the historical changes of teacher policy, the way of decision for teacher quota and the recruitment of teacher. The following two points of the teacher policies were characterized. First, municipalities have the rights of teacher selection on their own. And the universities for teacher education have strict two phases to select the pre-teacher. The teacher quota was decided by managing the pre-teacher quota in advance. Second, universities and municipalities have a high degree of autonomy in designing their curricula and teacher policy. To date, Finnish teacher policy has not faced any problems in attracting applicants and managing quota. Some suggestions were obtained about the improvement of teacher policy in our country.

• Journal of Chest Surgery
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• v.55 no.4
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• pp.265-273
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• 2022

Lung transplantation is considered a viable treatment option for patients with end-stage lung disease. Recent decades have seen a gradual increase in the number of lung transplantation patients worldwide, and in South Korea, the case number has increased at least 3-fold during the last decade. Furthermore, the waiting list time is becoming longer, and more elderly patients (>65 years) are undergoing lung transplantation; that is, the patients placed on the waiting list are older and sicker than in the past. Hence, proper management during the pre-transplantation period, as well as careful selection of candidates, is a key factor for transplant success and patient survival. Although referring and transplant centers should address many issues, the main areas of focus should be the timing of referral, nutrition, pulmonary rehabilitation, critical care (including mechanical ventilation and extracorporeal membrane oxygenation), psychological support, and the management of preexisting comorbid conditions (coronary artery disease, diabetes mellitus, gastroesophageal reflux disease, osteoporosis, malignancy, viral infections, and chronic infections). In this context, the present article reviews and summarizes the pre-transplantation management strategies for adult patients listed for lung transplantation.

• The Korean Journal of Emergency Medical Services
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• v.26 no.3
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• pp.71-91
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• 2022

Purpose: This study aimed to provide baseline data for implementing advanced life-support for 119EMTs. This is done with an in-depth examination of the emergency care experiences of the 119EMTs on-site and during transportation. Methods: Interviews were conducted with twelve 119EMTs, and the data were analyzed using the phenomenological method. Results: The 34 topics had 19 sub-components and were analyzed according to seven categories: 'A work environment where you cannot focus only on emergency care on-site and during transportation', '119EMTs struggling with manpower shortage', 'Current status of education blocking the upward standardization of 119EMT', 'Implementation of professional emergency care was held back due to the limited legal scope of 119EMT', 'Medical oversight makes it difficult to implement emergency care due to low flexibility', '119EMTs who cannot choose hospital selection and find it difficult to receive help', 'An evaluation system not reflecting reality at all that only leaves high scores'. Conclusion: This study was undertaken to implement specialized emergency care for 119EMTs; not only the necessity of reviewing the expansion of the work scope of 119EMTs but also the necessity of effective 'Medical Oversight system' reorganization raised as well.

• Journal of Korean Clinical Nursing Research
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• v.15 no.3
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• pp.75-84
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• 2009

Purpose: The aim of this study was to examine the effects of a music-based group reminiscence program on interpersonal relationships, self-esteem and depression in elderly people who are hospitalized. Methods: A quasi-experimental research was implemented, and a nonequivalent control group pre-posttest design was used. The participants were 52 elders who met the selection criteria and were assigned to the experimental group (26) and the control group (26). Both groups took the pre and posttest at the same time, and both groups received regular hospital care with the experimental group participating in the program for 12 sessions over six weeks. The instruments used in the study were, for interpersonal relationships, the Interpersonal Change Scale by Schlein and Guerney (1971), for self-esteem, the Self-Esteem Scale by Rosenberg (1965) and for depression, the Depression Inventory by Zung (1965). The collected data were analyzed with the SPSS 15.0 program. Results: Compared to the control group, the experimental group had significantly better interpersonal relationships and significantly higher self-esteem and less depression. Conclusion: The findings of the study suggest that a music-based group reminiscence program is effective in improving the interpersonal relationships, self-esteem and depression of hospitalized elders.

• Journal of The Korean Association For Science Education
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• v.30 no.2
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• pp.291-303
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• 2010

The purpose of this study is to investigate the difficulties in engaging in open-inquiry activities of elementary pre-service teachers. Data were collected from in-depth interviews with 22 pre-service teachers and their open-inquiry products. The 22 pre-service teachers who participated in this study were enrolled in college openinquiry course and performed open-inquiry activities for fifteen weeks. The results of this study show that pre-service teachers struggled with several difficulties; selection of the subject, the lack of understanding about the science process skills and content knowledge, background knowledge, environment matters and self confidence about open inquiry. However, they thought open-inquiry is interesting in spite of much difficulties, and is necessary for science education.

• Korean Chemical Engineering Research
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• v.51 no.5
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• pp.561-567
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• 2013

Mixed hardwood chips were pre-pulping extracted with green liquor prior to kraft pulping in order to recover hemicelluloses for use as biofuels. This green liquor solution containing mainly sodium sulfide and sodium carbonate was applied at different alkali charges (expressed as $Na_2O$) of 0, 1, 3, and 5% on dry wood weight. The extractions were performed at $160^{\circ}C$ for residence times ranging from about 1-2 h to determine the effect of extraction severity on composition of the pre-pulping extract. The severity of hemicellulose extraction time and green liquor charge controls the concentration of acetic acid and monosaccharide sugars available for downstream processing, the accumulation of degradation products such as organic acids and furans in the extract. As the alkali charge was increased, the amount of acetate side chains on the hemicelluloses and the dissolved lignin in the extract increased but the carbohydrate and sugars in the extract decreased appreciably. Hot water extraction (0% alkali addition) released the greatest amount of carbohydrates, up to 29.80 g/L measured as component sugars, but resulted in the greatest decrease in pulp yield. Meanwhile, pre-pulping extraction with 3% green liquor increased the pulp yield while greatly reducing the component sugars to 7.08 g/L. Fundamental data obtained in this study will allow selection of optimum hemicellulose extraction conditions for integrating the extraction operation into the Kraft pulping process.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.8
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• pp.981-986
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• 2010

Genetic parameters of growth traits were estimated in the German Angora rabbit reared in the sub-temperate region of India. Estimates of (co)variance components were obtained for body weights at weaning (42 days) and post-weaning at 84, 126 and 168 days. A total of 8,324 animal records were used for the analysis of these traits. The data were analyzed by restricted maximum likelihood (REML) fitting six animal models with various combinations of direct and maternal effects. A log likelihood ratio test was used to select the most appropriate univariate model for each trait. Direct heritability estimates were observed to be moderate for the traits under study. Heritability estimates for weaning (42 d), 84, 126 and 168 d weights obtained from the best models were $0.25{\pm}0.05$, $0.17{\pm}0.05$, $0.21{\pm}0.06$ and $0.12{\pm}0.05$. Maternal effects had higher importance at weaning, and declined with the advancement of age. Significant maternal permanent environmental effect on weaning and post-weaning weights was a carryover effect of maternal influences during pre-weaning age. The estimated repeatabilities of doe effects on body weights were 0.37, 0.22, 0.18 and 0.28 at weaning, 84, 126 and 168 d body weight, respectively. Results indicated that modest rate of genetic progress is possible for body weight traits of Angora rabbit through selection. Similarly, these growth traits could be included in selection criteria along with wool traits for early selection of the animals.

• Journal of the Korean Operations Research and Management Science Society
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• v.40 no.2
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• pp.1-17
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• 2015

In this paper, we propose a portfolio selection model utilizing a Markov chain for investing in the foreign exchange market based on market forecasts and exchange rate movement predictions. The proposed model is utilized to compute optimum investment portfolio weights for investing in margin-based markets such as the FX margin market. We further present an objective investment algorithm for applying the proposed model in real-life investments. Empirical performance of the proposed model and investment algorithm is evaluated by conducting an experiment in the FX market consisting of the 7 most traded currency pairs, for a period of 9 years, from the beginning of 2005 to the end of 2013. We compare performance with 1) the Dollar Index, 2) a 1/N Portfolio that invests the equal amount in the N target assets, and 3) the Barclay BTOP FX Index. Performance is compared in terms of cumulated returns and Sharpe ratios. The results suggest that the proposed model outperforms all benchmarks during the period of our experiment, for both performance measures. Even when compared in terms of pre- and post-financial crisis, the proposed model outperformed all other benchmarks, showing that the model based on objective data and mathematical optimization achieves superior performance empirically.