• Clinical and Experimental Reproductive Medicine
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• 제21권2호
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• pp.137-147
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• 1994

Controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVFET) often results in the production of more embryos than can be efficaciously transferred at one time. However, embryo cryopreservation provides a mechanism by which additional embryos can be stored for later thawing and transfer. From November, 1990 to October, 1992, we completed 42 transfer cycles of cryopreserved pronucleus(PN) l-cell embryos using the fixed protocol of hormonal replacement therapy in a physiological manner regardless of individual ovarian function. Artificial endometrial stimulation was performed with only exogenous estradiol and progesterone(E-P) in 36 transfer cycles (Group I) and with gonadotropin-releasing hormone agonist(GnRHa) and exogenous estradiol and progesterone(GEEP) in 6 transfer cycles(Group II ). The results were as follows. 1. The Survival rate of total cryopreserved-thawed embryos was 64.9%(198/305): 64.9% (172/265) in Group I and 65.0% (26/40) in Group II. 2. Total 168 embryos were transferred with an average of 4.7 per ET in Group I and total 26 embryos were transferred with an average of 4.3 per ET in Group II. 3. The pregnancy rate(PR) per cryopreserved-thawed ET and the implantation rate was 33.3 %(14/42) and 6.7%(13/194), respectively. The PRs per cryopreserved-thawed ET were 30.6% (11/36) in Group I and 50.0% (3/6) in Group II without significant difference. 4. The take home baby rate was 11.1%(4/36) in Group I and 33.3% (2/6) in Group II.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4127-4131
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• 2015

Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1347-1350
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• 2016

Background: Breast cancer prognosis is influenced by several histopathology and clinical factors including expression of Ki67 which may have a predictive role in lymph node negative breast cancer patients. The aim of this study was to assess Ki67 expression in breast cancers without axillary lymph node involvement and to evaluate its prognostic value with regard to disease-free survival. Materials and Methods: Subjects were selected from non-metastatic invasive breast cancer patients who were referred to the oncology department of Ghaem hospital during 1 April 2001 to 1 April 2008. Ki67 levels were measured using immunohistochemistry (IHC) and compared with clinicopathological features. The relation of Ki67 expression with disease-free survival was also analysed. Results: A total of 106 women with a mean age of 49 were examined. Some 94.3% were classified as having invasive ductal carcinomas and the mean tumour diameter at the time of diagnosis was 2.8 cm. Some 50.9% of cases were ER positive and 47.2% were PR positive. P53 expression was positive in 48.1% of the cases. According to the IHC results, only 8.5% of the patients were Her2/neu positive. Ki67 was positive in 66 (62.3%) with a significant relation to lower age (p=0.0229) and P53 positivity (p=0.005). After an average of 40-months follow up, 13 (12.3%) demonstrated recurrence, most commonly systemic. Of 13 cases with relapse, 10 patients (77%) were Ki67 positive. Conclusions: In our population Ki67 appeared to be an independent prognostic factor for three-year survival. However, we stress that a survival study with a bigger sample size would help to support this conclusion.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7195-7200
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• 2014

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.

• 문화기술의 융합
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• 제6권3호
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• pp.83-90
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• 2020

최근 방송, 영화, 음악 등 저작물을 불법으로 복제해 게시하고 광고를 게재하여 수익을 올리는 저작권 침해 웹사이트가 늘어나고 있다. 본 연구는 저작권 침해 웹사이트 내 광고현황을 내용분석을 통해 알아봄으로써 문제점을 찾아내고 해결방안을 모색하는데 있다. 본 연구결과는 다음과 같다. 우선, 저작권 침해 웹사이트 내 광고 업종으로 카지노, 베팅, 게임, 성인용품, 성인만남 등 청소년에게 유해한 광고물이 많이 나타나 이에 대한 대책이 필요하다. 두 번째로 저작권 침해 웹사이트 내 비윤리적인 성격의 광고들도 많았지만 유명 업체의 광고물도 상당수가 있었다. 대기업, 유명 브랜드의 광고물도 지속적으로 집행되고 있어 불법 사이트에 대한 신뢰가 형성될 수 있다. 따라서 단속만으로는 근절이 불가능하여 정부, 광고주, 시민, 학계가 참여하는 '불법 사이트 이용 근절 캠페인'이 필요하다. 특히 국제적 협력체계방안의 하나로 세계지식재산기구(WIPO)가 운영하는 프로젝트에 우리 기업의 참여가 필요하며, 정부도 저작권 문제 개선과 해결을 위해 지속적인 공조 노력이 필요하다. 우리는 이 논문에서 저작권 침해 웹사이트 주수입원인 광고집행의 현실적인 문제점을 지적하고 종합적인 해결방안을 제시하였다.

• 암석학회지
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• 제12권3호
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• pp.135-153
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• 2003

선캠브리아기 변성퇴적암류를 관입하고 있는 탄산염암에 배태하는 홍천 철-희토류 광상은 자철석, 안케라이트, 능철석, 마그네사이트, 스트론티아나이트 등의 다양한 탄산염광물과 모나자이트, 아지린휘석, Na가 섬석 및 황화광물들이 산출되어 이들 암석의 지화학적특성과 성인을 규명하고자 주 원소, 미량원소, 희토류원소 및 산소-탄소의 안정동위원소의 광물 및 암석화학연구가 이루어졌다. 각 원소(주원소, 미량원소, 희토류원소)들을 본 연구지역의 탄산염암과 유사한 철질 카보나타이트(ferro-carbonatite)와 비교하면 주 원소에서는 농집된 FeO와 결핍된 CaO가 관찰되며, $SiO_2$가 증가하면서 $TiO_2$와 $A1_2O_3$증가, CaO, FeO, MgO 및 $P_2O_{5}$의 약한 감소가 인지되나 분산되어 뚜렷한 경향은 아니다. 미량원소는 Nb, Zr 및 Zn이 철질 카보나타이트보다 결핍되어 나타나며, $SiO_2$의 증가에 따른 V 및 Ni의 증가, U 및 Rb의 미약한 증가가 확인되나 타 원소들은 분산되어 뚜렷한 경향을 나타내지 않는다. 희토류원소는 전희토류(TREE)함량이 매우 높고 La, Ce, Pr, Nd 및 Sm 같은 경희토류의 농집, 그리고 결핍된 중희토류로 인하여 높은 La/Lu 값을 보이고 있다. 안케라이트, 스트론티아나이트 및 전암의 산소 및 탄소 안정동위원소 결과는 본 암이 화성기원의 카보나타이트용융체에서 유래된 것으로 나타난다. 홍천 철-희토류 광상 탄산염암의 암석화학적 특성은 일반적인 철질 카보나타이트와는 차이가 있으며 러시아 Kovdor 및 핀랜드 Sokli 지역에서 산출되는 카보나타이트의 일종인 포스코라이트(phoscorite)의 암석화학성분과 매우 유사하다.

• 한국언론정보학보
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• 제60권
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• pp.52-74
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• 2012

입법안은 법률조문 자체로 이해하기 보다는 입법 주체간의 정치사회적 관계 속에서 파악할 필요가 있다. 입법안은 국회의원이나 공무원의 고유권한이라기 보다는 정당, 시민단체, 이익집단, 미디어 등 다양한 입법 주체간의 참여와 역동적 커뮤니케이션을 통해 달성된다. 이 연구는 입법과정에서의 커뮤니케이션 특징과 기능을 살펴보기 위해 국내 입법 현장 전문가들을 대상으로 포커스그룹 인터뷰와 개별 심층 인터뷰를 실시했다. 연구결과는 다음과 같다. 첫째, 국내 입법형성 과정은 입법주체 간의 역동적 상호소통 관계 축에서 이루어졌다. 그러나 그 과정에 커뮤니케이션의 난맥으로 효율적이고 생산적인 입법의제를 산출하고 있다고 보기는 어려웠다. 둘째, 국내 입법형성 과정이 제한적이긴 하지만 과거에 비해 행정부라는 폐쇄적인 공간에서 국회라는 정치적 공론장으로 점차 옮겨가고 있음을 발견했다. 셋째, 입법과정에 전문가 집단의 영향력 확대와 시민단체들의 세력화가 두드러지게 강화되는 특징을 보였다. 국회 입법 보좌관을 비롯해 국회 입법조사관, 국회 전문위원, 국회입법 심의관 등 입법 실무자들이 법안 형성과정에 보이지 않게 영향을 미치는 '인사이더(insider)' 역할을 했으며, 동시에 과거 입법형성 과정에 소외됐던 NGO 등 시민단체들의 부상은 주목할 만한 변화였다. 넷째, 의제형성 과정에서 미디어는 국회에 대해서는 공적이슈 개발의 주체이자 입법의제의 전달자로 그 영향력이 컸지만, 정부에 대해서는 입법의제 형성에 미치는 기능이 매우 제한적이었다. 이 논문은 국내 입법안 과정에 커뮤니케이션이 왜 중요하며, 그 과정에 촉진요인과 장애요인이 무엇인지에 대한 함의를 중심으로 논의했다.

• 한국독어학회지:독어학
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• 제10집
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• pp.175-200
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• 2004

Bei verschiedenen $Gespr\"{a}chen$ zwischen Frauen und $M\"{a}nnern$ sind mehrere Unterschiede in $Gespr\"{a}chsstrategien$ und -verhalten des jeweiligen Geschlechts zu beobachten. Herkemmlichen Ansichten nach $f\"{u}hrten$ $M\"{a}inner$ $Gespr\"{a}iche$ mit Frauen eher dominativ, $w\"{a}hrend$ Frauen eine deutliche Vorliebe $f\"{u}r$ kooperativ erlaufende $Gespr\"{a}che$ zeigen. Um die $G\"{u}ltigkeit$ dieser Perspektive zu $pr\"{u}fen$, wurden in dieser Albeit insgesamt $zw\"{o}lf$ Beratungsgesprache herangezogen. Daraus ergab sich, dass $M\"{a}nner$ im $Gespr\"{a}ich$ statistisch $h\"{a}ufiger$ die anderen $Gespr\"{a}chsteilnehmer$ unterbrechen. Da ein $Gespr\"{a}ch$ ein komplex vernetztes soziales Geschehen ist, sollte diese Statistik bei der Bestimmung der $Gespr\"{a}chsverhalten$ von zwei Geschiechtern keine entscheidende Rolle spielen. Im Anschluss daran habe ich mick mit Hilfe einiger im Internet gesammelten Daten, mit den $Gesp\"{a}chsverhalten$ bei der so genannten Online-Kommunikation befasst. Bei der Online-Kommunikation lassen sich zwei kontrastive verbale $Umg\"{a}nge$ der Geschlechtern beobachten, $n\"{a}mlich$ ein reibungslos ablaufendes IRC(Internet Relay Chatting) und eine $auff\"{a}llige$ Debatte, die mehrfache Konflikte zwischen den Beteiligten zeigt. Um diese $Ph\"{a}nomene$ auf der Basis der $Gespr\"{a}chsanalyse$ zu $erl\"{a}utern$, werden vol allem das Konzept der Kooperation beim $Gespr\"{a}ch$ und die Dynamik der $Gespr\"{a}chsstruktur$ erneut begriffen. $Schlie{\ss}lich$ werden die unterschiedlichen $Gespr\"{a}chsverhalten$ von Frauen und $M\"{a}nnern$ folgend wiedergegeben: Bei realen Face-To-Face-$Gespr\"{a}chen$ setzen Frauen den Schwerpunkt auf die emotionale und interaktive Kooperation, $w\"{a}hrend$ Manner ihn auf die kognitive Kooperation setzen. Dieser Sachverhait $\"{a}ndert$ sich aber bei der Online-Kommunikation. Auch Manner halten die emotionale und interaktive Kooperation $f\"{u}r$ wichtig und $f\"{u}hren$ mehr kooperative und reibungslose $Gespr\"{a}iche$ mit Frauen. Doch in einer Debatte um ein Thema $verh\"{a}lt$ sich jeder Beteiligte anders. Die moisten benutzen die Strategien, die den geringen Unterschied zwischen den Geschlechtern in Anfangsbedingungen $vergr\"{o}{\ss}ern$, und gleichzeitig die individuellen Unterschiede zwischen demselben Geschiecht verschleichen. Dadurch kann eine Debatte zwischen Geschlechten in Streit ohne Kompromisse geraten.

• 대한치과마취과학회지
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• 제13권1호
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• pp.1-7
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• 2013

Background: Intravenous sedation is effective for dental patients who are anxious. Recently, target-controlled infusion (TCI) has begun to be used widely to administer and titrate propofol and remifentanil during sedation. To investigate the effect and safety of the pharmacologic agents used in anesthetic department, we performed a retrospective study. Methods: Retrospective study of a series of dental procedure under intravenous sedation performed in department of anesthesiology in Dental Hospital of Dankook University was carried out with propofol or propofol/remifentanil between January and August 2011 and January and April 2012. All patients received oxygen by nasal cannula. The average propofol and remifentanil target was 0.5 ${\mu}g/ml$ and 1.0 ng/ml, respectively using a TCI pump. The average peripheral oxygen saturation ($SpO_2$), heart rate, blood pressure, respiratory rate, nasal end-tidal $CO_2$ were recorded at 5-10 minute intervals. The age, gender, weight, procedure and sedation time, type of procedure were also recorded. Results: We included 22 cases of 19 adults (group A) and 6 cases of children (group B). In group A, 4 patients received propofol (group A-P), and 15 patients received propofol with remifentanil (group A-PR). In group B, 6 patients received propofol only. The mean age of group A was 41.1 years old and that of group B was 9.5 years old. No clinically significant complications were noted. There were no case of de-saturation <90%. The median respiratory rate was 13.1 (range 6 to 36) in group A and 19 (range 13 to 25) in group B. The median end tidal $CO_2$ was 36.7 mmHg(range 8 mmHg to 56 mmHg) in group A and 41.7 mmHg (range 30 mmHg to 53 mmHg) in group B. Conclusions: Based on our results, dental sedation using propofol/remifentanil in adult and propofol in children with TCI pump seems to appear as a safe and effective procedure while performing dental procedure.

• 대한전자공학회논문지SD
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• 제37권4호
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• pp.7-14
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• 2000

Bi/sub 4/Ti/sub 3/O/sub 12/ (BIT) 박막을 acetate 계 precursor 를 이용한 sol-gel 법으로 제작한 후, 구조적 및 전기적 특성을 조사하여 NVFRAM (Won-Volatile Ferroelectric RAM)으로의 응용가능성을 조사하였다. DT-TG (Differential Thermal-Thermal Gravimetric) 분석으로 drying 온도와 annealing 온도가 각각 400℃ 와 650℃ 인 BIT 박막의 열처리조건을 확립하였다. Pt/Ta/Sio/sub 2//Si 기판 위에 제작된 BIT 박막은 완전한 orthorhombic perovskite상을 가지며, 입자크기가 약 100nm 이고 표면 거칠기는 약 70.2Å 으로 비교적 치밀한 형상을 나타내었다. 10㎑ 의 주파수에서 비유전률과 유전손실은 각각 176 과 0.038 이었으며, 100 ㎸/cm 의 전기장에서 누설전류밀도는 4.71㎂/㎠ 이었다. ±250㎸/㎝ 에서 이력곡선을 측정한 결과, 잔류분극 (Pr)과 항전계 (Ec)는 각각 5.92μC/㎠ 과 86.3㎸/㎝ 이었다. BIT 박막에 ±5V 의 사각펄스를 인가하여 피로특성을 측정한 결과, 잔류분극은 초기값 5.92μC/㎠ 에서 10/sup 9/회에서는 3.95μC/㎠ 로 약 33% 감소하였다.