• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3759-3765
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• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• Geosciences Journal
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• 제22권6호
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• pp.955-973
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• 2018

Twenty-eight beach sand samples from the shorelines of Aegean islands adjacent to the plutonic rocks of the Atticocycladic zone were analyzed for major and rare earth element (REE) contents. Results are compared with the adjacent plutonic rocks, in order to determine relative enrichments or depletions and assess the potential for REE exploitation. Among the samples, several are significantly enriched in REE, being deposits of heavy minerals and their concentrations are controlled by the sea waves and local winds. These samples contain Th, U and REE rich minerals such as zircon, xenotime and allanite. The available geochemical characteristics were also used to confirm the parent rocks of the beach sands. The heavy fractions (total, total magnetic and total non-magnetic) of the beach sands are very well correlated with the Heavy REE (HREE) concentrations. Among the minerals of the heavy magnetic fraction, allanite seems to control the REE content in the heavy mineral-enriched samples, while from the heavy non-magnetic fraction, zircon controls mainly the HREE fraction. One site from Mykonos and 3 from Naxos could have potential for REE exploitation as they present the highest ${\Sigma}REE$ and HREE contents than other beach sand placers measured in Greece (Kavala, Sithonia, Maronia, Samothraki, NE Chalkidiki).

• 대한조선학회논문집
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• 제43권1호
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• pp.32-42
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• 2006

This study aims at establishing a technique for sailing yachts model tests with sailing condition. It is very important to estimate a ship's potential speed performance before building a real ship. Several methods are used to estimate a ship's potential speed performance such as using parent ship data, standard vessel chart and model test. Model test is the most precise among these options. In korea. model testing is widely used with general vessels but not with sailing yachts. Because sailing yachts are propelled with heeling and leeway. using the wind. another method is needed to estimate their speed. The new model test. which is different from tests for upright general vessels, is in a great demand. In this paper. we describe a test method for the sailing yacht model test. based on Masuyama's equation of motion. And we describe choosing scale ratio. production process and materials of the model. Also. various ways of measuring instruments. attaching jigs and adjusting calibration are described so that they can be utilized as useful data for model testing.

• 한국가정과학회지
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• 제8권4호
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• pp.57-69
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• 2005

An aging society in which the proportion of the aged of a society is growing faster than the of the young is becoming an worldwide phenomenon owing to low birth rate, the upgraded medical art and so on. Korea is one of the most rapidly aging societies in the world today. Since aging society is totally different from the traditional society in the many field, potential problems must be expected and countermeasure must be considered. One of the potential problems it may cause is the issue of supporting subject of the aged. Parent-supporting and welfare for the aged become important social issues. Especially the supporting of the aged woman is more important issue because of their longer average life than man and their exposure to sexual discrimination and their welfare is very important issue of social welfare system. Accordingly the purpose of this study is to present the practical counter measure to the supporting of the aged woman. These studies can be divided into traditional approach which insists on the family supporting and modern approach which asserts government(or social) supporting. Comprehensive literature study reveals that both of government and family are responsible for the supporting of the aged woman.

• 한국생활과학회지
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• 제19권2호
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• pp.361-374
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• 2010

Using the first wave of the Korean Longitudinal Study of Ageing, this research examines the effect of elderly parent's financial structure on private income transfers from their adult children. The results show that low income elderly households are more likely to receive income transfers from their children. Generally, Korean elderly households were found to have very low liquidity in their asset structure, as the average household holds over 90% of their assets in real estate. However, it seems that the parents' potential income based on their real estate assets is unimportant in determining children's transfer decisions. Rather, the parents' labor income is found to be a key factor in children's income transfer decisions.

• Bulletin of the Korean Chemical Society
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• 제25권2호
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• pp.260-262
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• 2004

In agreement with the results of previous MP2 calculations by Sauers, B3LYP, CASSCF, and CASPT2 calculations on the parent 2-carbena-1,3-dioxolane show that it fragments to ethylene plus $CO_2$ by a concerted pathway with only a small energy barrier. Not only is fragmentation via stepwise C-O bond cleavage computed to be a much higher energy pathway, but the singlet diradical that would be an intermediate along such a reaction path is not even computed to be a local minimum on the potential energy surface.

• 반도체디스플레이기술학회지
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• 제6권4호
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• pp.29-32
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• 2007

Zinc gallate, $ZnGa_2O_4:Mn^{2+}$ co-doped with different concentrations of $Mg^{2+}$ (0.001- 0.5 mol%) was prepared by solid state synthesis method. These compositions were investigated for their photoluminescence and cathodoluminescence properties. The optimized composition $Zn_{0.990}Mg_{0.005}Ga_2O_4:Mn_{0.005}$ shows higher luminescence intensity compared to the parent phosphor. The intense green emission peak was found at 504 nm. The $Mg^{2+}$ doping does not affect much the decay time. It remains <10 ms for these compositions which make them potential candidate for application in TV screens.

• Journal of Pharmaceutical Investigation
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• 제18권2호
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• pp.49-53
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• 1988

Pivaloyloxymethyl ester of piperacillin was synthesized by reacting sodium piperacillin with chloromethyl pivalate, and its chemical structure was determined by infrared and $^1H$ nuclear magnetic resonance spectroscopic methods. The pharmaceutical properties of the ester were investigated to assess its potential as a novel prodrug of piperacillin. The interface transfer of piperacillin and the ester was studied in a two-phase in vitro system composed of aqueous pH buffers and n-octanol. The ester was more lipophilic, and less water soluble above pH 4.0 than piperacillin. Significant antibacterial activity was not observed in the ester in vitro, but the ester was hydrolyzed into the parent drug in the rat liver homogenate. The serum levels of orally administered ester suspension containing 0.1% Tween 80 were measured in rabbits. It was found that the ester showed higher blood level, comparing with no observation of piperacillin in serum, but the time reaching the maximum serum concentration was 5 hr.

• Journal of Advanced Marine Engineering and Technology
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• 제25권6호
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• pp.1330-1335
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• 2001

A present study is the flow characteristics of impinging jet by PIV measurement and numerical analysis. The flow characteristics of impinging jet flow are affected greatly by nozz1e inlet velocity An circular sharp edged nozzle type($45^{\circ}$ ) was used to achieve uniform mean velocity at the nozz1e inlet, and its diameter is 10 mm(d). Therefore, the flow characteristics on the impinging jet can be changed largely by the control of main flow In this parent study, we investigate the effects of inlet velocity, its variable is nozzle inlet Reynolds numbers (Re=1500, 3000, 4500, 6000 and 7500)

• 셀메드
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• 제6권4호
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• pp.22.1-22.19
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• 2016

The biologically active compounds derived from different natural organisms such as animals, plants, and microorganisms like algae, fungi, bacteria and merine organisms. These natural compounds possess diverse biological activities like anthelmintic, antibacterial, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. These biological active compounds were acted by variety of molecular targets and thus may potentially contribute to several pharmacological classes. The synthesis of natural products and their analogues provides effect of structural modifications on the parent compounds which may be useful in the discovery of potential new drug molecules with different biological activities. Natural organisms have developed complex chemical defense systems by repelling or killing predators, such as insects, microorganisms, animals etc. These defense systems have the ability to produce large numbers of diverse compounds which can be used as new drugs. Thus, research on natural products for novel therapeutic agents with broad spectrum activities and will continue to provide important new drug molecules.