• Journal of Ginseng Research
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• v.47 no.1
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• pp.97-105
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• 2023

Background: Hyperactivated airway mucosa cells overproduce mucin and cause severe breathing complications. Here, we aimed to identify the effects of saponins derived from Panax ginseng on inflammation and mucin overproduction. Methods: NCI-H292 cells were pre-incubated with 16 saponins derived from P. ginseng, and mucin overproduction was induced by treatment with phorbol 12-myristate 13-acetate (PMA). Mucin protein MUC5AC was quantified by enzyme-linked immunosorbent assay, and mRNA levels were analyzed using quantitative polymerase chain reaction (qPCR). Moreover, we performed a transcriptome analysis of PMA-treated NCI-H292 cells in the absence or presence of Rg5, and differential gene expression was confirmed using qPCR. Phosphorylation levels of signaling molecules, and the abundance of lipid droplets, were measured by western blotting, flow cytometry, and confocal microscopy. Results: Ginsenoside Rg5 effectively reduced MUC5AC secretion and decreased MUC5AC mRNA levels. A systematic functional network analysis revealed that Rg5 upregulated cholesterol and glycerolipid metabolism, resulting in the production of lipid droplets to clear reactive oxygen species (ROS), and modulated the mitogen-activated protein kinase and nuclear factor (NF)-kB signaling pathways to regulate inflammatory responses. Rg5 induced the accumulation of lipid droplets and decreased cellular ROS levels, and N-acetyl-ⳑ-cysteine, a ROS inhibitor, reduced MUC5AC secretion via Rg5. Furthermore, Rg5 hampered the phosphorylation of extracellular signal-regulated kinase and p38 proteins, affecting the NF-kB signaling pathway and pro-inflammatory responses. Conclusion: Rg5 alleviated inflammatory responses by reducing mucin secretion and promoting lipid droplet-mediated ROS clearance. Therefore, Rg5 may have potential as a therapeutic agent to alleviate respiratory disorders caused by hyperactivation of mucosa cells.

• Journal of Life Science
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• v.33 no.5
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• pp.429-435
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• 2023

Epidemiological studies suggest that maternal infection, maternal stress, and environmental risk factors during pregnancy increase the risk of brain development abnormalities associated with cognitive impairment in the offspring and increase susceptibility to schizophrenia and autism spectrum disorder. Several animal models have demonstrated that maternal immune activation (MIA) is sufficient to induce abnormal brain development and behavioral defects in the fetus. When polyinosine:polycytodylic acid (poly I:C) or lipopolysaccharide (LPS), which is commonly used in maternal immune activation animal models, was introduced into a pregnant dam, an increase in pro-inflammatory cytokines and microglial activity was observed in the offspring's brain. Microglia are brain-resident immune cells that play a mediating role in the central nervous system, and they are responsible for various functions, such as phagocytosis, synapse formation and branching, and angiogenesis. Several studies have reported that microglia are activated in MIA offspring and influence offspring behavior through interactions with various cytokines. In addition, it has been reported that they play an important role in brain circuits through interactions with neurons and astrocytes. However, there is controversy concerning whether microglia are essential to brain development or lead to behavioral defects, and the exact mechanism remains unknown. Therefore, for the potential diagnosis and treatment of brain developmental disorders, a functional study of microglia should be conducted using MIA animal models.

• Journal of Korea Entertainment Industry Association
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• v.13 no.3
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• pp.231-248
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• 2019

The purpose of this study was to implement a cognitive stimulation activity program and examine its effects elderly people who is capable of daily life and community activities but suffering from per sistent cognitive decline on the elderly's cognitive function, self-efficacy, and depression. The purpose of this study was to help elderly people who is capable of daily life and community activities but suffering from persistent cognitive decline improve their ability to perform and adapt to activity-based tasks incorporating a variety of actions of different subdomains and difficulty levels, ac cording to their characteristics and cognitive levels. The aim of the program created was to systemati cally improve the subdomains of cognitive functions and eventually preventing these conditions develo ping into dementia in those affected. This study also enabled the subjects to improve their self-effica cy through newly gained positive perceptions and attitudes toward their own abilities by successfully expressing their experience or thoughts about circumstantially and relationally meaningful events and memories, and performing activities that promote sensory stimulations. The group activities conducted as part of the study helped the subjects reduce their symptoms of depression not only by expressing their thoughts and emotions, but also by encouraging empathy with, understanding of, and caring for others. Given that this study confirmed the potential of the cognitive stimulation program designed fo r it as a clinical intervention for elderly people with cognitive impairment, it is suggested as a useful preventive program for early stage dementia.

• Journal of Intelligence and Information Systems
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• v.28 no.1
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• pp.217-242
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• 2022

With the launch of Artificial Intelligence(AI)-based intelligent products on the market, innovative changes are taking place not only in business but also in consumers' daily lives. Intelligent products have the potential to realize technology differentiation and increase market competitiveness through advanced functions of artificial intelligence. However, there is no new product development methodology that can sufficiently reflect the characteristics of artificial intelligence for the purpose of developing intelligent products with high market acceptance. This study proposes a KANO-QFD integrated model as a methodology for intelligent product development. As a specific example of the empirical analysis, the types of consumer requirements for hair loss prediction and treatment device were classified, and the relative importance and priority of engineering characteristics were derived to suggest the direction of intelligent medical product development. As a result of a survey of 130 consumers, accurate prediction of future hair loss progress, future hair loss and improved future after treatment realized and viewed on a smartphone, sophisticated design, and treatment using laser and LED combined light energy were realized as attractive quality factors among the KANO categories. As a result of the analysis based on House of Quality of QFD, learning data for hair loss diagnosis and prediction, micro camera resolution for scalp scan, hair loss type classification model, customized personal account management, and hair loss progress diagnosis model were derived. This study is significant in that it presented directions for the development of artificial intelligence-based intelligent medical product that were not previously preceded.

• Design Convergence Study
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• v.14 no.1
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• pp.99-114
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• 2015

This study aims to find a way to realize gender identity in product design. After reviewing the present research, it was found out that it is necessary to extend notion of gender and to redefine the concept of gender design. Specific products were selected in order to analyze the characteristics of femininity. Refrigerators, which represent the femininity the best, were chosen and analyzed based on the graphic elements. As a result, the concept of gender have been used quite limitedly in a refrigerator. Since the stereotype of women has already been implicit, it was considered difficult to propose an alternative plan for realizing the extended concept of gender. Therefore, digital devices have been proposed for a potential alternative group. This product group, of course, has a limitation like the refrigerators. However, when functions, frequency of use, and use of space are considered in depth, It can be a possible group that holds the meaning of gender in design. This study is significant that it attempted to examine the possibility of convergence in identity and usability when the graphic elements of a product are constructed by gender design that considers the identity of a user through redefining the concept of gender.

• Journal of Environmental Impact Assessment
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• v.32 no.6
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• pp.488-502
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• 2023

Ecosystem service accounting must measure ecosystem supply functions, demand, and the actual service flows that occur between them. In order to measure flows, supply and demand relationships must be defined, and a methodology that can objectify complex connections is needed. Although various studies on ecosystem services have been conducted in Korea, but researches on accounting for ecosystem services are not enough. The purpose of this study is to evaluate flood control ecosystem services by applying the EU methodology studied in the Experimental Ecosystem Account (EEA) of System of Environmental Economy Account (SEEA) and explore ways to introduce ecosystem account. To conduct the study, the ecosystem's runoff retention potential, social and economic demand for flood control, and actual service benefit flows formed from the relationships between them were modeled and quantified on a spatial basis. As a result of calculating the actual flow of flood control ecosystem services, the total domestic service amount was calculated to be 165,595 (ha), and it was confirmed that much of it was concentrated in agricultural land. In order to account for domestic flood control services in the future, key spatial data such as land cover maps must be continuously established and managed, and researches on input data and methodologies applicable to various spatial scopes such as national, regional, and unit watersheds are expected to be necessary.

• Korean Journal of Remote Sensing
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• v.39 no.6_1
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• pp.1467-1475
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• 2023

The public-interest direct payment program involves providing direct payments to agricultural producers and rural residents through public funds, premised on performing public functions such as environmental conservation, stable food supply, and maintaining rural communities via agricultural activities. Scientific estimation of crop cultivation areas and production levels is crucial for formulating agricultural policies linked to regulating food supply, which increasingly impacts the national economy. Conducting comprehensive on-site inspections for compliance monitoring of direct payment programs has shown very low efficiency in relation to budget and time. The expansion of areas subject to compliance monitoring and various challenges in on-site inspections necessitate streamlining current monitoring methods and devising effective strategies. As a solution, the application of Remote Sensing technology and spatial information utilization, allowing swift acquisition of necessary information for policies without overall on-site visits, is being discussed as an efficient compliance monitoring method. Therefore, this study evaluated the potential use of remote sensing for improving operational efficiency in monitoring compliance with public-interest direct payment programs. Using satellite images during farming seasons in Gimje and Hapcheon, vegetation indices and spatial variations were utilized to identify cultivated areas, presence of mixed crops, validated against on-site inspection data.

• Korean Journal of Remote Sensing
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• v.39 no.6_2
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• pp.1529-1539
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• 2023

The data from Geostationary Ocean Color Imager-II (GOCI-II), which observes the color of the sea to monitor marine environments, undergoes various correction processes in the ground station system, producing data from Raw to Level-2 (L2). Quality issues arising at each processing stage accumulate step by step, leading to an amplification of errors in the satellite data. To address this, improvements were made to the GOCI-II ground station system to measure potential optical quality and geolocation accuracy errors in the Level-1A/B (L1A/B) data. A newly established Radiometric and Geometric Performance Assessment Module (RGPAM) now measures five optical quality factors and four geolocation accuracy factors in near real-time. Testing with GOCI-II data has shown that RGPAM's functions, including data processing, display and download of measurement results, work well. The performance metrics obtained through RGPAM are expected to serve as foundational data for real-time radiometric correction model enhancements, assessment of L1 data quality consistency, and the development of reprocessing strategies to address identified issues related to the GOCI-II detector's sensitivity degradation.

• Journal of the Korea Society of Computer and Information
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• v.28 no.12
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• pp.147-153
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• 2023

As it spreads to all industries of artificial intelligence technology, AIaaS equipped with artificial intelligence services is emerging. In particular, non-IT companies are suffering from the absence of software experts, difficulties in training big data models, and difficulties in collecting and analyzing various types of data. AIaaS makes it easier and more economical for users to build a system by providing various IT resources necessary for artificial intelligence software development as well as functions necessary for artificial intelligence software in the form of a service. Therefore, the supply and demand for such cloud-based AIaaS services will increase rapidly. However, the quality of services provided by AIaaS becomes an important factor in what is required as the supply and demand for AIaaS increases. However, research on a comprehensive and practical quality evaluation metric to measure this is currently insufficient. Therefore, in this paper, we develop and propose a usability, replacement, scalability, and publicity metric, which are the four metrics necessary for measuring reusability, based on implementation, convenience, efficiency, and accessibility, which are characteristics of AIaaS, for reusability evaluation among the service quality measurement factors of AIaaS. The proposed metrics can be used as a tool to predict how much services provided by AIaaS can be reused for potential users in the future.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.237-244
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• 2023

Today, AI is being applied to various industrial fields, leading to a paradigm shift in the overall industry. In the fashion industry, AI is also used to predict trends and provide various services for consumers, and in particular, AI image creation tools have the potential as a tool for fashion design development. This study investigated the possibilities and limitations of using Midjourny for fashion design development by creating images using Midjourney among AI image creation tools and identifying its characteristics. The characteristics of images created in Midjourney are as follows. First, it has the intuitiveness to create images by intuitively applying or combining images corresponding to commands. Second, there is randomness in which different images are generated when the same command is entered at different times. Third, when using existing images and commands together, the image created in Midjourney is more dependent on the existing image than the command. In conclusion, Midjourny's various image creation functions and the ability to change images according to commands can be helpful in developing original fashion designs. However, it is important to note that fashion designs that cannot be worn or made are sometimes presented. It is expected that the results of this study will serve as basic data for the use of AI image creation tools for fashion design development.