• Journal of Agricultural Extension & Community Development
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• v.5 no.1
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• pp.93-102
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• 1998

The objectives of the study were 1) to make the reasonable standard, 2) to select the objective and scientific method and process for the location-allocation of a new provincial capital city. The Main standard of location-allocation were suggested as follows ; 1) Integration of province 2) Convenience of Administration service 3) Accomodations of new provincial capital city 4) Balanced development by region. The validity of location-allocation were reviewed the population potentials and nodal accessibilities. The population potential was examined to find the maximum point of administrative demand, and the locationallocation model was examined to find the minimum point of the aggregated travel-cost to a proposed provincial government office. The nodal accessibilities measured in travel-time distance and actual values. Two major concerns in locating public facilities are efficiency and equity.

• Genomics & Informatics
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• v.5 no.2
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• pp.41-45
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• 2007

Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced by many different genes. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patients' genotype, to maximize efficacy with minimal adverse drug reactions. Pharmacogenomics has the potential to revolutionize the practice of medicine, and promises to usher in an area of personalized medicine, in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Indeed, pharmacogenomics is exploited as an essential step for target discovery and drug development in the pharmaceutical industry. The goal of the personalized medicine is to get the right dose of the right drug to the right patient at the right time. In this article, we will review the use of pharmacogenomics in drug discovery and development.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.3
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• pp.43-48
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• 2007

The medical imaging processing area with the development of high-speed Internet and the portable embedded system under prevailed ubiquitous environment is quick in research and development for the system that can search and decipher the patient's information in anytime and anywhere. Especially, the new applications demand utilizing scout images besides diagnostic purposes. With the development of ubiquitous system, medical image viewers are utilizing to the hospitals combined with PACS system and Web browser. This paper implements the mobile terminal based medical image viewing system that shows the potential in wireless environment.

• Journal of Powder Materials
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• v.13 no.2 s.55
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• pp.108-111
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• 2006

Aluminum hydroxides were synthesized by a simple electrolytic reaction of aluminum plates. The aluminum hydroxide, boehmite (AlO(OH)), was predominantly formed in the application of electrical potential at and above 30V, while the mixture of bayerite ($Al(OH)_3$) and boehmite (AlO(OH)) phases were formed below 20V. The boehmite has a clear fibrous structure controlled on nanometer scale. On the contrary, the bayerite consists of the typical hourglass or semi-hourglass shaped coarse crystals as a result of aggregation of various crystals stacked together. The specific surface area of the boehmite nanofiber was markedly high, approaching at about $302\;m^2/g$.

• Korean Journal of Geomatics
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• v.1 no.1
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• pp.75-83
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• 2001

Due to the fast industrial growth and unplanned urban underground development in Korea, systematic management for water lines could not be accomplished. Unsystematic water line management has resulted in difficulty in finding the exact location and the age of the lines, which has the potential of leading to a disastrous situation. The objective of this study is a development of safety management system for water lines using GIS. This system is constructed to easily estimate water line deterioration by the geographic output system on it, search for damaged objectives near the surrounding area in a situation of destruction, and offer the emergency information by which one can quickly take action. Also, it is constructed to prevent accidents from occurring during work by presenting underground utilities and states of work.

• International Journal of High-Rise Buildings
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• v.5 no.2
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• pp.105-115
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• 2016

In the process of exploring sustainable development, major cities in China are expanding metro systems as a strategy to reduce the negative environmental and social consequences of fast-paced motorization. A metro station is not only a transportation node, but also a place where diverse activities can be performed. Therefore, the realization of the spatial potential for human interaction is the essence of the strategy for integrated development in metro station areas. For this paper, 10 well-developed metro stations in Central Shanghai were selected to investigate the correlation between accessibility and spatial performance in station areas. The spatial performance in station areas is significantly affected by metro configuration. However, both vehicle and pedestrian accessibility show weak influence on spatial performance. A synergistic model was then developed to provide quantitative support for transit-oriented development in metro station areas.

• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.13-24
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• 2024

Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor microenvironment (TME). Therefore, cytokines have been considered potential anti-cancer immunotherapy, and cytokine-based anti-cancer therapies continue to be an active area of research and development in the field of cancer immunotherapy, with ongoing clinical trials exploring new strategies to improve efficacy and safety. In this review, we examine past and present clinical developments for major anticancer cytokines, including interleukins (IL-2, IL-15, IL-12, IL-21), interferons, TGF-beta, and GM-CSF. We identify the current status and changes in the technology platform being applied to cytokine-based immune anti-cancer therapeutics. Through this, we discuss the opportunities and challenges of cytokine-based immune anti-cancer treatments in the current immunotherapy market and suggest development directions to enhance the clinical use of cytokines as immuno-anticancer drugs in the future.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.671-674
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• 2005

Atmospheric correction over the ocean part is more important than that over the land because the signal from the ocean is very small about one tenth of that reflected from land. In this study, the Spectral Shape Matching Method (SSMM) developed by Ahn and Shanmugam (2004) is evaluated using Landsat imagery acquired over the highly turbid Saemangeum Coastal Area. The result of SSMM is compared with COST model developed by Chavez (1991 and 1997). In principle, SSMM is simple and easy to implement on any satellite imagery, relying on both field and image properties. To assess the potential use of these methods, several field campaigns were conducted in the Saemangeum coastal area corresponding with Landsat-7 satellite's overpass on 29 May 2005. In-situ data collected from the coastal waters of Saemangeum using optical instruments (ASD field spectroradiometer) consists of ChI, Ap, SS, aooM, F(d). In order to perform SSMM, we use the in-situ water-leaving radiance spectra from clear oceanic waters to estimate the the path radiance from total signal recorded at the top of the atmosphere (TOA), due to the reason that the shape of clear water-leaving radiance spectra is nearly stable than turbid water-leaving radiance spectra. The retrieved water-leaving radiance after subtraction of path signal from TOA signal in this way is compared with that estimated by COST model. The result shows that SSMM enabled retrieval of water-leaving radiance spectra that are consistent with in-situ data obtained from Saemangeum coastal waters. The COST model yielded significantly high errors in these areas.

• Korean Journal of Environment and Ecology
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• v.24 no.2
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• pp.130-138
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• 2010

The purpose of this study is the investigation and analysis of information on the conservation and the sustainable use of coastal wetlands based on the awareness of local residents in Suncheon Bay and Taeanhaean National Park. To accomplish the purpose of study, a questionnaire survey was chosen and the 98 valid samples(38 from Taeanhaean National Park and 60 from Suncheon Bay) among them were analyzed. The results are summarized as follows: The degree of the satisfaction on the natural environment is alike between Taeanhaean National Park and Suncheon-bay area. This is accorded with the order of the goodness of natural environment. The order for the degree of the satisfaction on the living environment is same as the order for the satisfaction degree on the natural environment. The residents of two regions are not satisfied with the socio·economic environment. The local resident of Suncheon Bay and Taeanhaean National Park Area where natural environment is well-conserved, prefer conservation to development of the region. These results show the following consideration for the ideal method of management for the conservation and sustainable development of coastal wetlands. In case of Suncheon Bay area, where the condition the natural environment is well conserved, should be managed with the minimum development with maintenance of the current state must be driven. In case of Taeanhaean National Park Area, where the condition of the natural environment is well conserved and the development potential exists, such as sustainable development and ecotourism destination the development that is in harmony with the nature must to be driven.

• Ocean and Polar Research
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• v.36 no.3
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• pp.303-318
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• 2014

The rising global demand for energy resources may lead to greater interest in the Arctic region. Since it has various resources, such as oil and gas, and large potential as a strategic location in exploration and production (E&P), there is likely to occur island sovereignty issues between the five arctic costal states and other countries. While global warming has led to the opening of the Northeast Passage and the Northwest Passage, several obstacles may impede the development of this area such as the low temperature environment, infrastructure problems in a limited area, flow assurance, environmental regulations, etc. To overcome these problems, various techniques have been applied in the exploration, development, production, transportation, and environment fields and it seems to be made technical development in extreme environment. In this study, the E&P status of representative states and development technologies in the Arctic region have been summarized with regard to carrying out E&P related to drilling, development, production, and operation in oil and gas fields. Furthermore, environmental factors have been taken into account to enhance progress with regard to E&P and ensure sustainable development in the Arctic. On that basis, it will be possible to secure oil and gas field development, production technology and R&D infrastructure in the Arctic.