• Journal of Periodontal and Implant Science
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• 제34권1호
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• pp.101-112
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• 2004

Osseointegrated implnats have proven to be successful in both full and partial edentulous patients since the 1960s and recently have shown successful results when used to restore single tooth missing. However, in most studies reporting the success of single implants, single implants replacing anterior teeth are more frequently mentioned than posterior single implants. Moreover, in studies regarding posterior single implants, the replaced region seemed to be variable; the maxilla, mandible and areas from the first premolar to the second molar were mentioned. However, considering the difference in bone quality in the mandible and maxilla, and the increased occlusal force in the posterior region, the success rates in each region may be different. In this study, the cumulative success rates and amount of bone loss of single implants replacing the mandibular first and second molar, respectively, were compared and analyzed to come to the following conclusion. 1. The 20 (20 persons) single implants that were placed in the mandibular first molar region were all successful and showed a 100% 5 year cumulative success rate. Among the 27 (24 persons) single implants replacing the mandibular second molar, 8 failed (27.63%) showing a 5 year cumulative success rate of 70.37%. 2. Among the 8 failed implants, one showed symptoms of postoperative infection and one complained of parenthesia. 6 implants failed after functional loading; 5 showed mobility and one resulted in fixture fracture. 3. After the attachment of the prosthesis, there was no significant statistical difference regarding the marginal bone loss in group 1 and group 2 during the checkup period (P>0.05). In conclusion, restoration of the mandibular first molar using single implants was found to be an excellent treatment modality, and when replacing mandibular second molars with single implants, poor bone quality and risk of overloading must be considered.

• Journal of Periodontal and Implant Science
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• 제50권2호
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• pp.106-120
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• 2020

Purpose: A new form of porous polyethylene, characterized by higher porosity and pore interconnectivity, was developed for use as a tissue-integrated implant. This study evaluated the effectiveness of porous polyethylene blocks used as an onlay bone graft in rabbit mandible in terms of tissue reaction, bone ingrowth, fibrovascularization, and graft-bone interfacial integrity. Methods: Twelve New Zealand white rabbits were randomized into 3 treatment groups according to the study period (4, 12, or 24 weeks). Cylindrical specimens measuring 5 mm in diameter and 4.5 mm in thickness were placed directly on the body of the mandible without bone bed decortication, fixed in place with a titanium screw, and covered with a collagen membrane. Histologic and histomorphometric analyses were done using hematoxylin and eosin-stained bone slices. Interfacial shear strength was tested to quantify graft-bone interfacial integrity. Results: The porous polyethylene graft was observed to integrate with the mandibular bone and exhibited tissue-bridge connections. At all postoperative time points, it was noted that the host tissues had grown deep into the pores of the porous polyethylene in the direction from the interface to the center of the graft. Both fibrovascular tissue and bone were found within the pores, but most bone ingrowth was observed at the graft-mandibular bone interface. Bone ingrowth depth and interfacial shear strength were in the range of 2.76-3.89 mm and 1.11-1.43 MPa, respectively. No significant differences among post-implantation time points were found for tissue ingrowth percentage and interfacial shear strength (P>0.05). Conclusions: Within the limits of the study, the present study revealed that the new porous polyethylene did not provoke any adverse systemic reactions. The material promoted fibrovascularization and displayed osteoconductive and osteogenic properties within and outside the contact interface. Stable interfacial integration between the graft and bone also took place.

• Advances in pediatric surgery
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• 제3권2호
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• pp.98-107
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• 1997

To determine whether bile juice exclusion can prevent the mucosal damage, and Insulin-like growth factor-I can promote mucosal regeneration in ischemia-reperfusion injury of the bowel, 39 weanling rats with 10 cm of Thiry-Vella loop were studied. Animal groups were; Control, BL(common bile duct ligation), IGF{insulin-like growth factor-I(IGF-I) infusion} and IGF-BL(combined treatment). IGF-I(1.5 mg/kg/day) was continuously delivered through a subcutaneously implanted miniosmotic pump. After 15 minutes of superior mesenteric artery clamping, a tissue specimen(P) was taken after 30 minutes of reperfusion. Intestinal continuity was restored to allow oral feeding. A specimen of main tract(M) and another of the Thiry-Vella loop(T) were collected for histomorphometry after 48 hours of reperfusion and free feeding. Villus size ratio(VSR), crypt depth(CD), crypt-depth/villus-height ratio(CVR) and injury score(IS) were measured in 15 consecutive villi. The postoperative mortalities of bile duct ligation groups(BL and IGF-BL) were higher than those of other groups. In control group, VSR of M was lower(P<0.05) than P or T, but not in the other groups. VSR of M in control was lower than those in other groups. CD of T in control, IGF and IGF-BL group were higher than those of M. CD of M and T showed gradual increments from control, IGF and IGF-BL group, respectively. CVR of M and T in IGF group were higher than those in control. CVR in IGF-BL group, T was higher than M, and M was higher than P. About IS, M of BL($20.1{\pm}2.5$) and IGF-BL($20.9{\pm}3.3$) groups were significantly lower than that of control($32.4{\pm}2.5$). These results suggest that the exclusion of bile juice reduces the severity of the reperfusion injury of the mucosa, by inability to activate pancreatic enzymes and IGF-I stimulates mucosal regeneration in injured bowel, and the effect is potentiated by bile juice exclusion.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4217-4222
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• 2016

Purpose: To compare the expression level of CK 15 in normal esophageal and esophageal squamous-cell carcinoma (ESCC) tissues and analyse possible functions of CK15 in occurrence and development. Materials and Methods: Immunohistochemistry was used to compare CK14, CK15 and proliferating cell nuclear antigen (PCNA) expression levels in ESCCs. Expression level of CK15 was also assessed by Western blotting. In addition, levels of CK15, cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and PCNA were detected in serum by enzymelinked immunosorbent assay (ELISA) and chemiluminescence methods. Relationships between clinicopathological parameters and CK14 and CK15 expression were then analyzed. Results: According to immunohistochemistry, in esophageal and intraepithelial neoplasia (SIN) tissues, the expression of CK14, CK15 and PCNA localized to basal layer of the epithelium. CK14 and CK15 levels were higher in normal esophageal squamous epithelial tissue than in SIN and ESCC, and greater in highly differentiated than poorly differentiated carcinoma tissue. By Western blotting, we found more pronounced expression of CK15 in normal esophageal tissue, compared with carcinoma tissue. The specificity of changed CK15 and CYFRA21-1 expression was respectively 90.0% and 96.7% in serum of ESCC patients. Joint detection could improve the sensitivity of esophageal carcinoma diagnosis. Relationships between CK14, CK15 expression and clinical parameters were not statistically significant (P>0.05). Postoperative survival in patients of CK14, CK15 positive expression was longer than with negative expression ($x^2=4.35$, P=0.037; $x^2=9.852$, P=0.002). Conclusions: CK15 expression decreased in esophageal squamous cell carcinoma tissue and serum of esophageal squamous carcinoma patients. We infer that CK15 may play an important role for the occurrence and development of esophageal squamous-cell carcinoma. In the future, CK15 may be used for the diagnosis, treatment and prognostic evaluation of esophageal squamous-cell carcinoma.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1982년도 제16차 학술대회연제순서 및 초록
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• pp.15.1-15
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• 1982

1979년 7월부터 1981년 8월까지 부산 침례병원 이비인후과에 내원한 환자중 삼출성중이염으로 진단된 95례 (159이)에서 임상적인 고찰을 했으며, 고막절개와 중이내 튜브 유치술을 시행한 성인 및 소아군과 T＆A를 동시에 시행한 소아군을 비교 검토하여 다음과 같은 결과를 얻었다. 1) 성별 분포는 남자가 48례, 여자가 47례 차이가 없었고 연령 분포는 6∼10세 군이 34례 (35%)로 가장 많았다. 2) T & A를 요하는 소아중 14%가 삼출성중이염으로 진단되어 고막절개 및 중이내 튜브 유치술을 동시에 시행했고 이는 같은 기간중의 삼출성중이염 환자의 19%에 해당했다. 3) 양측성 (67%)이 일측성 (33%)인 경우의 두배 였고, 소아환자에서는 양측성이 88%로 현저했으며 T & A를 요하는 소아군에서는 전부가 양측성이었다. 4 ) 중이내 저류액의 성상은 장액성이 49%, 점액성이 33%, 농성이 5%, 혈성이 3%등이었고 성인군에서는 장액성이 59%였으나 소아군 (15세이하)에서는 장액성(41%)과 점액성(43%)의 빈도가 비슷했다. 5) 술전 Tympanogram은 A형이 6%, B형이 91%, C형이 3%였고 이상 Tympanogram(B형 혹은 C형)의 출현 빈도는 T & A를 요하는 소아군(95%)과 요하지 않은 소아군(95%)에서 동일했으며 성인군에서는 93%였다. 6)고막절개 중이내 튜브 유치술후의 기도청력은 T & A를 동시에 시행한 소아군에서 더욱 개선되었다.

• 대한두경부종양학회지
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• 제8권2호
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• pp.72-81
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• 1992

Thyroid cancer, the most common cancer of endocrine neoplasms, has tremendous variation in tumor biologic behavior. There is no consensus about treatment mode to prevent recurrences despite of recent advance in understanding characteristics of thyroid cancer. So, we have made a clinical analysis and follow-up study of recurred 27 cases among 189 cases treated under the diagnosis of thyroid carcinoma in the department of surgery, Chonnam University Hospital from February, 1982 to February, 1992 to clarify our experience about the characteristics of recurred thyroid cancer. The results were as follow: According to the pathological classification of recurred thyroid cancer, recurrence rate was 11.6% in papillary carcinoma, 15.6% in follicular carcinoma, 37.5% in medullary carcinoma, 66.7% in undifferentiated carcinoma, respectively, and the mean recurrence rate of thyroid cancer was 14.3%. The recurrence rate according to age was 28.6% in 8th decade and 17.9% in 4th decade. The recurrence rate according to sex was not singificant(15.6% in male: 14% in female). The mean period to relapse was 4 years 6 months in papillary carcinoma, 2 years 5 months in follicular carcinoma, 2 years 1 months in medullary carcinoma, 2 years 6 months in undifferentiated carcinoma. The recurrence rate according to previous operating methods, such as performing lymph node dissection or not, mode of thyridectomy, type of lymph node dissection was statisfically non-specific. Common recurrent sites of papillary and follicular carcinoma was cervical lymph node and remained thyroid tissue. Medullary and undifferentiated carcinoma was noted in multiregional or systemic involvement Reoperation was performed with complete resection of recurred or metastatic mass, such as radical neck dissection or mass extirpation from involved organs as possible. The postoperative complications were 2 cases of horseness, and 1 case with hematoma, transient hypocalcemia, wound infection, and pulmonary insufficency, respectively. 5-year survival rate was 85.5% in papillary carcinoma, 66.7% in follicular carcinoma. 50% in medullary carcinoma, and 50% in undifferentiated carcinoma. We concluded that recurrence in thyroid cancer give a reconsideration to previous conservative therapy and more extensive surgical procedures for thyroid cancer including lymphatic dissection are recommanded to prevent recurrences in selected cases if possible.

• 대한두경부종양학회지
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• 제7권2호
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• pp.120-128
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• 1991

Reconstruction of the pharynx and cervical esophagus presents a tremendous surgical challenge to the Head and Neck Surgeon. Because life expectancy of patients with advanced carcinoma of the hypopharynx, and cervical esophagus is limited, treatment must be aimed at palliation. A variety of techiques have been proposed over the years with none proving entirely satisfactory. These techiques include prosthesis; skin graft; cervical flaps; tubed cutaneous and myocutaneous chest flaps; visceral reconstruction with stomach, colon. and jejunum; and jejunal free autografts. Many factors dictate the best method of reconstruction in any given clinical situation. The goal of the surgery is a one-stage reconstruction of swallowing function with minimal morbidity to allow as short a hospital stay as posible. Nine patients underwent the free jejunal autograft reconstruction of the pharyngoesophagus after the ablative surgery for the advanced hypopharyngeal cancer. Postoperative complications included one perioperative death, two abdominal wound dehiscences, two neck hematomas, one carotid rupture, one funtional dysphagia, one late strictures. There were no graft failure, no immediate stenosis and no fistula. An oral diet was started between days 8 and 16, with an average of 9 days and median of 8 days. Patients left the hospital between days 9 and days 38, with an average of 23.4 days and median of 23 days. This method of reconstruction is advocated as reliable palliative procedure with short-term follow-up. In conclusion, we at Korea Cancer Center Hospital are of the opinion that the free jejunal autograft offers an excellent, safe and relative easy method of the pharyngeal and cervical esophageal reconstruction with significant advantages over other techiques.

• Archives of Reconstructive Microsurgery
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• 제4권1호
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• pp.58-64
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• 1995

사지의 연부조직 결손으로 고려대학교 의과대학 정형외과학 교실에서 입원했던 12명의 환자 13례에 대하여 전완부 유리 피판술을 시행 후 최저 3개월에서 최고 37개월간 평균 14.3개월간 추시하여 다음과 같은 결론을 얻었다. 1. 13례 전례에서 연부조직 결손의 치료로 만족할만한 결과를 얻었다. 2. 이식피판의 크기는 평균 $54cm^2$였으며 유리피판의 평균 혈류 차단시간은 74분 이었다. 3. 술후 3례에서 합병증이 발생하였으며 3례중 2례는 동맥 문합부위에 혈전이 발생하였으나 술후 제 2일에 혈전 재거술을 시행하여 해결하였으며, 1례는 이식 정막내의 혈전으로 이식피판의 표층괴사가 발생하여 고식적인 피부이식술로 치료하였다. 4. 체중 부하를 받는 족저부의 재건에는 감각신경을 포함한 전완부 유리피판술이 좋은 방법의 하나이다. 5. 전완부 피판술은 비교적 넓은 연부조직 결손을 치료할 수 있고 이식 혈관의 내경이 커서 문합이 비교적 쉬워 숙련된 미세수술 수기를 익힌 외과의사에게는 성공률이 높은 유리피판술 중의 하나이다.

• 대한후두음성언어의학회지
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• 제10권1호
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• pp.5-11
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• 1999

최근 음성장애에 관한 관심이 높아지면서 성대질환 내지는 후두질환의 정확한 진단을 위한 발성기능의 측정이 더욱 중요시되기에 이르렀다 이에 본 연구에서는 정상 한국인 남자 81명, 여자 76명과 성대용종 환자 남자 78명, 여자 65명을 대상으로 공기역학적 검사 중 컴퓨터화된 측정기구와 기류저지법으로 최대발성지속시간, 발성기류량, 평균호기류율, 및 성문하압을 연령별 및 성별에 따라 평균치를 측정, 이를 비교 분석하였다. 최대발성지속시간은 정상인 남자가 20.6${\pm}$6.34초, 여자가 17.2${\pm}$4.20초였고, 성대용종 환자에서 남자가 13.1${\pm}$4.26초, 여자가 11.6${\pm}$4.43초였다. 평균호기류율은 정상인 남자가 170.0${\pm}$67.00ml/sec, 여자가 131.1${\pm}$49.03ml/sec였고, 성대용종 환자에서 남자가 255.7${\pm}$216.52ml/sec, 여자가 183.24${\pm}$107.16ml/sec였다. 발성기류량은 정상인 남자가 3179.0${\pm}$648.94ml. 여자가 2144.1${\pm}$650.81ml였고, 성대용종 환자에서 남자가 2905.8${\pm}$1295.35ml, 여자가 1904.4${\pm}$1068.59ml였다 성문하압은 정상인 남자가 4.0${\pm}$1.88cm$H_2O$, 여자가 3.5${\pm}$4.20cm$H_2O$였고, 성대용종 환자에서 남자가 4.2$\pm$1.48cm$H_2O$, 여자가 3.9${\pm}$1.12cm$H_2O$였다. 성대용종 환자에서 통계학적으로 유의성있게 최대발성지속시간은 감소하고, 평균호기류율은 증가하였으며, 발성기류량과 성문하압은 여자환자에서만 의미 있게 각각 감소하거나 증가하였다. 이상의 결과는 정상인과 성대용종 환자에 있어서 객관적인 공기역학적 검사결과를 보여주며 이는 성대용종 환자의 음성이상에 대한 상태판정이나 치료 후 효과 판정에 기본자료로 이용할 수 있을 것으로 생각된다.

• Clinics in Shoulder and Elbow
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• 제15권1호
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• pp.37-42
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• 2012

목적: 총상에 의한 상완골 골절 증례를 통해 치료의 원칙에 대하여 고찰한다. 대상 및 방법: 28세 남자가 좌측 상완부의 총상으로 수상 후 5일에 응급실로 내원하였다. 상지의 신경 및 혈관 손상의 징후 및 타장기의 손상은 없었으며, 생체징후는 안정적이었다. 수상 당시 타 병원에서 총상에 대한 변연 절제술 및 세척술 후에 일차적 봉합술을 시행받았으며, 상완부의 전외측에 5 cm 가량의 오염된 상처가 있었다. 본원에서 변연절제술 및 탄환 파편의 제거술을 시행하고 외고정을 통하여 해부학적 정렬을 유지하였다. 술 후 8일까지 상처에 대한 무균적 소독을 시행하였으며, 정맥 항생제를 유지하였다. 술 후 9일째에 광범위 변연 절제술 및 항생제를 섞은 시멘트 구슬 삽입술을 시행하였다. 감염이 호전되는 소견을 보여, 시멘트 구슬 삽입 2주째에 외고정 장치를 제거하고 외고정 핀 삽입부의 피부 봉합술을 시행하였다. 1주 후에, 금속판을 이용하여 내고정을 하였다. 결과: 유합술 후 3 개월째, 만족스러운 상완골의 정렬과 골 유합을 얻었다.