• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.9
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• pp.4053-4064
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• 2012

The purpose of this study was to examine the effects of aroma foot reflexology and foot reflexology on blood pressure, pulse rate and blood lipid level of elderly essential hypertensive patients in a rural area. The research method was a non-equivalent control group pretest-posttest quasi-experimental design and the participants were consisted of 71 elderly patients with essential hypertension who were being registered at C health Clinic(G gun, Chungnam province). Here, we compared experimental group I(aroma foot reflexology) 24 persons, experimental group II(foot reflexology) 27 persons and control group(conventional treatment) 20 persons to measure the effect. The data were analyzed with SPSS/WIN 12.0. The systolic blood pressure(p<.05), the diastolic blood pressure(p<.05), and the pulse rates(p<.01) of experimental group I and II after intervening respectively with aroma foot reflexology, and foot reflexology for 6 weeks were significantly decreased than the control group, but the blood lipid level was no significant difference among 3 groups(p>.05). In conclusion, both of aroma foot reflexology and foot reflexology had positive effects to decrease the blood pressure and pulse rates of the elderly essential hypertensive patients in a rural area and would be utilized as a nursing intervention for them.

• The Journal of Korean Medicine
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• v.26 no.4
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• pp.122-129
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• 2005

Objectives: Graves' disease is the most common cause of hyperthyroidism, and its pathogenesis includes thyroid specific autoimmunity. Anti-thyroid drugs are widely used for regulating the thyroid function. However, in spite of long-term therapy with anti-thyroid drugs, about 40$\sim$$70\%$ of the treated patients have a relapse, and some suffer adverse effects. In this study, to evaluate the clinical efficacy of Ahnjeonbaekho-tang(AJBHT) on Graves' disease patients, we performed the clinical study prospectively. Methods: Through the thyroid function test(TFT) of 54 patients diagnosed as Graves' disease in other hospitals, 21 patients were assigned into the study. After the withdrawal of anti-thyroid drugs, AJBHT was administerd to patients for 2 months. At the same time, TFT, TSH binding inhibiting immunoglobulin(TEII) level and visual analogue scales (VAS) about fatigue and palpitation were measured before and after administration. Thirteen patients have completed the entire follow-up of this study over two months. Results: Serum levels of T3 and FT4 were significantly improved by AJBHT(T3: 298.85$\pm$79.60 ng/dl 181.15$\pm$33.92 ng/dl p<0.0001, FT4: 2.78$\pm$1.06 ng/dl$\rightarrow$1.78$\pm$0.83 ng/dl p<0.05). However, there were no significant changes in TSH and TBII values. And the VAS scores of fatigue and palpitation also were significantly improved(5.80$\pm$3.01$\rightarrow$3.60$\pm$2.63, p<0.05; 6.19$\pm$2.09$\rightarrow$3.60$\pm$2.46, p<0.01). Patients' age was related to the post-treatment FT4 values(p<0.05). Conclusions: From these results, we suggest that AJBHT is effective on the TFT and the symptoms of Graves' disease, and is a safe alternative drug for Graves' disease patients.

• Clinical and Experimental Pediatrics
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• v.56 no.7
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• pp.286-290
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• 2013

Purpose: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. Methods: We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3-11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses ($IgG_1$, $IgG_2$, $IgG_3$, and $IgG_4$) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers ${\geq}0.35{\mu}g/mL$ or with a ${\geq}4$-fold increase were considered as positive responses. Results: The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. $IgG_1$ deficiency was observed in 1 patient and $IgG_3$ deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types. Conclusion: Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment.

• Korean Security Journal
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• no.25
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• pp.89-107
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• 2010

The purpose of this study was to evaluate the effects of using cervical spinal stabilization exercise for the improvement of pain intensity, cervical range of motion, neck disability index, reposition sense, muscle tenderness with chronic neck pain in private security. For 21 patients diagnosed with chronic cervical pain and divided into cervical spinal stabilization exercise group and postural correction exercise group. Each exercise was conducted for 8 weeks. Pain and neck disability index were measured before and after exercise using the visual analogue scale(VAS) and the neck disability index(NDI). Range of motion were measured electronic goniometer, muscle tenderness of upper trapezius ad sternocleidomatoid were measured algometer, reposition sense were measured reposition panel before and after exercise. After 8 weeks of exercise, the cervical stabilization exercise group pain and neck disability were significantly decreased(p<0.05). Also there was significant difference in both group(p<0.05). In addition, range of motion, muscle tenderness reduce rate, reposition sense were significantly increase as compared to the pre-post exercise in cervical stabilization exercise group(p<0.05). But there was no significantly difference in postural correction group before and after exercise(p>0.05). And there was significantly increase more cervical stabilization exercise group than postural correction exercise group in range of motion, muscle tenderness reduce, reposition sense. In summary, cervical spinal stabilization exercise is more effective in improving cervical range of motion, muscle pain, reposition sense in private security on chronic cervical pain patients, in reducing patients' pain and disability. It is an effective treatment to aid rehabilitation in these cases.

• Biomolecules & Therapeutics
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• v.11 no.1
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• pp.58-64
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• 2003

Ondansetron is a potent, highly selective 5-hydroxytryptamin $e_3$(5-H $T_3$) receptor-antagonist, for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiography, and the treatment of post-operative nausea and vomiting. The purpose of the present study was to evaluate the bioequivalence of two ondansetron tablets, Zofran (Glaxo Smithcline Korea Ltd.) and Onfran (Korea United Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 24.39$\pm$1.69 year in age and 69.00$\pm$6.74kg in body weight, were divided into two groups and a randomized 2${\times}$2 cross-over study was employed. After one tablet containing 8mg of ondansetron was orally administered, blood was taken at predetermined time intervals and the concentrations of ondansetron in plasma were determined using HPLC with UV detector. Pharmacokinetic parameters such as AVC, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC, $C_{max}$ and T max between two tablets were 5.83％, 5.75％ and －5.71％, respectively when calculated against the Zofran, tablet. The powers (1-$\beta$) for AUC, $C_{max}$ and $T_{max}$ were above 90％, above 90％ and below 60％, respectively. Minimum detectable differences($\Delta$) at alpha=0.1 and 1-$\beta$=0.8 were less than 20％ (e.g., 12.74％ and 11.78％ for AUC and $C_{max}$ respectively). But minimum detectable differences($\Delta$) at alpha=0.1 and 1-$\beta$=0.8 for $T_{max}$ were more than 20％ (e.g., 34.22％). The 90％ confidence intervals were within $\pm$20％ (e.g., -2.73∼14.39 and -2.16∼13.67 for AUC and $C_{max}$ respectively). But 90％ confidence intervals for $T_{max}$ were not within $\pm$20％ (e.g., -28.71∼17.28). Another ANOVA test was conducted for logarithmically transformed AUC and $C_{max}$. These results showed that there are no significant difference in AUC and $C_{max}$ between the two formulations: The differences between the formulations in these log transformed parameters were all for less than 20％ (e.g., 5.83％ and 5.75％ for AUC and $C_{max}$ respectively). The 90％ confidence intervals for the log transformed data were the acceptance range of log 0.8 to log 1.25 (e.g., log 0.99∼log 1.15 and log 0.98∼log 1.15 for AUC and $C_{max}$ respectively). The major parameters, AUC and $C_{max}$, met the criteria of KFDA for bioequivalence although $T_{max}$ did not meet the criteria of KFDA for bioequivalence, indicating that Onfran tablet is bioequivalent to Zofrm1 tablet.t is bioequivalent to Zofrm1 tablet.m1 tablet.m1 tablet.m1 tablet.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.545-552
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• 2017

Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in $C_{max}$, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in $C_{max}$ and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.

• The Journal of Internal Korean Medicine
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• v.26 no.2
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• pp.353-359
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• 2005

Objectives: Dysphagia is a common in stroke patients. Dysphagia often affects the rehabilitation of stroke patients by increasing the risk of nutritional deficits and aspiration pneumonia. Despite the proliferation of physical therapies including swallowing training, much controversy remains regarding the application and benefit of them. Therefore, in this study, the clinical effect of moxibustion at Chonjung(CV17, Shanzhong) on post-stroke dysphagia were assessed using Swallowing Provocation Test(SPT). Methods: Dysphagia subjects were selected by Dysphagia Screening Test. Swallowing function was tested by Swallowing Provocation Test(sec). Direct moxibustion was applied to the acupoint, Chonjung, five times and Swallowing Provocation Test was performed before and after 30 minute. The Latency Time of Swallowing Reflex (LTSR) was checked by SPT. To find factors related with improving swallowing function, Cold-Heat and Excess-Deficiency Diagnosis were considered. Results: A total of 42 patient were included, but two of them were excluded due to severe coughing. Overall, the swallowing reflex improved significantly. In subgroup analysis on brain lesion, non-brain stem lesion patients significantly improved. Moxibustion was more effective in the cold group than in the heat group, but there were no differences between the Excess and the Deficiency groups. Conclusions: The result of this clinical study suggest that moxibustion at Chonjung(CV17, Shanzhong) is an effective treatment for the dysphagia patients after stroke, especially in non-brain stem lesion and the cold diagnosed patients.

• Journal of Science Education
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• v.37 no.1
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• pp.68-78
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• 2013

Until now, research to integrate art activities and science education have been making steady progress in the field of primary education and early childhood education that are directly involved in the art education of students. However, some science educators were interested in visualizing the artifacts by using design principles and experimental results through STEAM education. So, when conducting lessons for integrating science education with art activities, research is needed on the changing of the students' ability. Therefore, the purpose of this study is to investigate the effect of science experiments in collaboration with art activities for students' self-directed learning skills and creative personality in elementary school. This study was applied to 30 students(16 male, 14 female) of 4th grade in Changwon C elementary school. The teaching materials of this study was extracted some of the experiments from the 2007 revised national curriculum in elementary science textbook and 'Teachers for Exciting Science'. Experimental treatment was performed over a total of 10 class 5 subjects and a pre-post test was conducted through G-TAGAS. As a result, science experiments in collaboration with art activities have improved significantly students' self-directed learning skills and creative personality.

• Journal of Korean society of Dental Hygiene
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• v.12 no.2
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• pp.399-407
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• 2012

Objectives : Purpose of this research is to determined the general knowledge on oral health and the usage of oral hygiene products in the orthodontic patients and try to provide an appropriate oral hygiene products for the patients. Methods : Orthodontic patients who visited a dental clinic in Daejeon were selected and data from 352 patients were collected. Questionnaire based on survey was conducted from 1st of March to 30th in 2011 and all the data was analysed by using SPSS statistical program (VER 15.0). Frequency analysis, $x^2$ test, T-test and the amount of diurnal variance analysis (one-way ANOVA) were also used. After that, scheffe's post-test method was conducted. Results : According to the general characteristics of oral health care knowledge score was $2.87{\pm}0.60$, the attitude score was $2.96{\pm}0.57$. toothbrush replacement cycle were less than 3 months (p=0.007, p=0.000) and frequency of brushing one day more than three times higher in patients with knowledge to help attitude. according to the sex, age, and duration of orthodontic treatment with oral hygiene devices of usage was higher in the calibration toothbrush usage, awareness was higher in the interdental toothbrushes. according to the type of orthodontic devices from the oral hygiene devices usage, removable group was the orthodontic toothbrush and electric toothbrush group were highest in the 'unknown', the fixed group was orthodontic toothbrush(67.3%) and electric toothbrushes(40.8%) was higher in the usage. Patients who used oral hygiene devices such as orthodontic tooth brush, interdental brush, electric toothbrush, water pik and fern solution showed wider knowledge on oral health care and oral hygiene devices compared to patients who answered as does not aware of oral hygiene devices and never used these products before. Conclusions : Orthodontic patient's oral health attitudes, knowledge, and oral hygiene devices usage are the general characteristics of the highest in the orthodontic toothbrush usage, awareness was higher in the interdental brush. Water pik and fern solution, rubber and gingival interdental stimulator turned massage does not use or low. Based on results from research, overall orthodontic patients who visited a dental clinic had low awareness and usage of oral hygiene devices. Therefore, it is required to educate general publics and the orthodontic patients and also promote the importance of usage of oral hygiene devices.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.54-65
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• 2020

This randomized pre-post-controlled experimental study determined the effect on patients' anxiety, stress, systolic blood pressure, heart rate and Bis index when the Healing Beats program is applied after epidural blockage. The subjects were selected from the patients who visited the Department of Anesthesiology and Pain for the treatment of epidural blockage and volunteered through the recruitment announcement. A total of 74 sets of data were collected and analyzed with 25 subjects in the experimental group, 24 in the placebo group, and 25 in the control group. The data was analyzed using descriptive statistics, x2-tests, F-tests and repeated measures of ANOVA. As a result of the study, the general characteristics and variables of the experimental group, placebo group, and control group were all the same, and anxiety was measured twice before and after the study. There were significant differences between groups (F=27.175, p<.001), and stress (F=4.78, p<.001), heart rate (F=4.22, p<.001) and the Bis index (F=7.96, p<.001) were analyzed by variance according to population and time. There was a significant difference. However, there was no significant difference in systolic blood pressure (F=1.23, p=.298). In conclusion, the Healing Beats program can be used as an effective and effective intervention for sedation in clinical situations or stressful situations.