• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권6호
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• pp.421-425
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• 2012

Purpose: The aim of this study is to compare the soft tissue changes of the midfacial area at the repose position and the natural smiling position for the improvement of evaluation and planning in the orthognathic surgery. Methods: The total of 30 subjects, 15 male and 15 female, were included in this study. The metal point landmarks were placed at the cheek, orbital rim, subpupil, and nasal base. The movements of the landmarks were evaluated at the repose position and smiling position in the lateral and posteroanterior cephalograms. Paired t test and correlation analysis were used for the evaluation of the soft tissue changes statistically. Results: In the lateral cephalograms, the cheek point (4.49 mm in female, 4.87 mm in male) showed the most distant movement. All points presented significant movements, except the orbital rim and nasal base point in male. Cheek point presented significant positive correlation between the horizontal and vertical change in male. Subpupil point presented significant positive correlation between horizontal and vertical change in both male and female. In the posteroanterior cephalograms, the nasal base point (5.41 mm in female, 6.30 mm in male) showed the most distant movement. Subpupil point and nasal base point presented significant movements in both female and male. Nasal base point presented significant negative correlation between the horizontal and vertical change in both male and female. In the lateral and posteroanterior cephalograms, the positional changes of all points presented significant positive correlation with each other in both female and male. Conclusion: The cheek point in the sagittal view and the nasal base point in the frontal view showed the most distant movement on smile. In the sagittal view, the subpupil point and cheek point moved anteriorsuperiorly on smile. In the frontal view, the nasal base points moved laterosuperiorly on smile. In both the sagittal and frontal view, the positional changes of all point were highly correlated to each other. These results may be used in the soft tissue references for the treatment planning of the dentofacial deformity patients.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.13.1-13.8
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• 2018

Background: We evaluated change in the mandibular condyle after orthognathic surgery using cone-beam computed tomography (CBCT) in patients with facial asymmetry. Methods: Thirty patients with skeletal class III malocclusion and mandibular prognathism or facial asymmetry were classified into two groups according to the amount of menton deviation (MD) from the facial midline on anteroposterior (AP) cephalogram: group A (asymmetry, MD ≥ 4 mm; n = 15) and group B (symmetry, MD < 4 mm; n = 15). Position and angle of condylar heads on the axial, sagittal, and coronal views were measured within 1 month preoperatively (T0) and postoperatively (T1) and 6 months (T2) postoperatively. Results: On axial view, both groups showed inward rotation of condylar heads at T1, but at T2, the change was gradually removed and the condylar head returned to its original position. At T1, both groups showed no AP condylar head changes on sagittal view, although downward movement of the condylar heads occurred. Then, at T2, the condylar heads tended to return to their original position. The change in distance between the two condylar heads showed that they had moved outward in both groups, causing an increase in the width between the two heads postoperatively. Analysis of all three-dimensional changes of the condylar head positions demonstrated statistically significant changes in the three different CBCT views in group B and no statistically significant changes in group A. Conclusions: There was no significant difference between the two groups in condylar head position. Because sagittal split ramus osteotomy can be performed without significant change in symmetrical and asymmetrical cases, it can be regarded as an effective method to stabilize the condylar head position in patients with skeletal class III malocclusion and mandibular prognathism or facial asymmetry.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권5호
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• pp.413-419
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• 2011

Purpose: Reposition of the maxilla is a common technique for correction of midfacial deformities. To achieve the goal of the surgery, the maxilla should be repositioned based on the precisely planned position during surgery. The internal reference points (IRPs) and the external reference points (ERPs) are usually used to determine vertical dimension of maxilla, which is an important factor for confirming maxillary position. However, the IRPs are known to be inaccurate in determining the vertical dimension. In this study, we investigated the correlation of positional change of the modified IRPs with repositioned maxilla. Methods: The study group consisted of 26 patients with dentofacial deformities. For the simulation of the surgery, patient maxillary CT data and 3-D virtual surgery programs (V-$Works^{(R)}$ and V-$Surgery^{(R)}$) were used. IRPs of this study were set on both the lateral wall of piriform aperture, inferior margin of both infraorbital foramen, and the labial surfaces of the canine and first molar. The distance from the point on lateral wall of the piriform aperture to the point on the buccal surface of the canine was defined as IRP-C, and the distance from the point on the inferior margin of the infraorbital foramen to the point on the buccal surface of the $1^{st}$ molar was defined as IRP-M. After the virtual simulation of Le Fort I osteotomy, the changes in IRP-C and IRP-M were compared with the maxillary movement. All measures were analyzed statistically. Results: With respect to vertical movements, the IRP-C (approximately 98%) and the IRP-M (approximately 96%) represented the movement of the canine and the $1^{st}$ molar. Regarding rotating movement, the IRPs changed according to the movement of the canine and the $1^{st}$ molar. In particular, the IRP-C was changed in accordance with the canine. Conclusion: IRPs could be good indicators for predicting vertical movements of the maxilla during surgery.

• 대한치과교정학회지
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• 제24권1호
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• pp.63-86
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• 1994

III급 부정교합자의 치료후 예후를 예측하려는 연구의 일환으로서 경북대병원 치과교정과에 반대교합을 주소로 내원한 초기 영구치열을 가진 환자 5명을 교정적 치료를 시행하여 좋은 결과를 얻은 2증례와 동적 치료종료시에는 좋은 결과를 얻었으나 그 이후 관찰기간동안 치열 및 악골에서 재발을 보인 3증례에서 연속적으로 채득한 측모 두부방사선 사진, 사진, 석고모형, 치료기록을 자료로 분석한 결과 아래와 같이 요약할 수 있다. 1. 관찰 증례중 동적 치료시 하악골이 후하방 이동한 swing back type의 경우 관찰기간 동안 악골의 전후적 관계가 양호하게 유지되었으며 교합도 안정된 상태로 유지되었다. 2. 동적 치료시 Y-axis type의 하악골 위치 변화를 보인 증례중 상하악골의 성장이 조화를 이룬 증례는 교합이 안정되게 나타났고, 그렇지 못한 증례는 교합이 불안정하게 되었다. 3. 동적 치료시 swing back type의 하악골 위치 변화를 보인 증례는 관찰기간동안 swing back type가 유지되었으며, Y-axis type를 보인 증례는 관찰기간동안 Y-axis type가 유지되는 증례와 forward type로 변화한 증례가 있었다. 4. 반대교합 개선시 하안면 고경은 모든 증례에서 증가되었으며 관찰기간동안 교합이 안정되게 나타난 증례에서는 하안면 고경이 계속 증가되었으나, 하안면 고경이 감소한 증례에서는 교합이 불안정하게 되었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제37권
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• pp.36.1-36.7
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• 2015

Background: This study was performed to evaluate three-dimensional positional change of the condyle using three-dimensional computed tomography (3D-CT) following unilateral sagittal split ramus osteotomy (USSRO) in patients with mandibular prognathism. Methods: This study examined two patients exhibiting skeletal class III malocclusion with facial asymmetry who underwent USSRO for a mandibular setback. 3D-CT was performed before surgery, immediately after surgery, and 6 months postoperatively. After creating 3D-CT images by using the In-vivo $5^{TM}$ program, the axial plane, coronal plane, and sagittal plane were configured. Three-dimensional positional changes from each plane to the condyle, axial condylar head axis angle (AHA), axial condylar head position (AHP), frontal condylar head axis angle (FHA), frontal condylar head position (FHP), sagittal condylar head axis angle (SHA), and sagittal condylar head position (SHP) of the two patients were measured before surgery, immediately after surgery, and 6 months postoperatively. Results: In the first patient, medial rotation of the operated condyle in AHA and anterior rotation in SHA were observed. There were no significant changes after surgery in AHP, FHP, and SHP after surgery. In the second patient, medial rotation of the operated condyle in AHA and lateral rotation of the operated condyle in FHA were observed. There were no significant changes in AHP, FHP, and SHP postoperatively. This indicates that in USSRO, postoperative movement of the condylar head is insignificant; however, medial rotation of the condylar head is possible. Although three-dimensional changes were observed, these were not clinically significant. Conclusions: The results of this study suggest that although three-dimensional changes in condylar head position are observed in patients post SSRO, there are no significant changes that would clinically affect the patient.

• 한국식물학회:학술대회논문집
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• 한국식물학회 2002년도 춘계학술발표대회:발표눈문요지록
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• pp.62-72
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• 2002

This study has investigated the biosynthesis and function of the heavy metal binding peptides, the phytochelatins, in plants. PCs are synthesised enzymatically from glutathione by the enzyme PC synthase in the presence of heavy metal ions. Using Arabidopsis thaliana as a model organism cadmium-sensitive, phytochelatin-deficient mutants have been isolated and characterised in previous studies. The cadl mutants have wildtype levels of glutathione, are PC deficient and lack PC synthase activity. Thus, the CADl gene has been proposed to encode PC synthase. The CADl gene was isolated by a positional cloning strategy The gene was mapped and a candidate identified. Each of four cadl mutants had a single base pair change in the candidate gene and the cadmium-sensitive, cadl phenotype was complemented by the candidate gene. This demonstrated the CADl gene had been cloned. A homologous gene in the fission yeast, Schizosaccharomyces pombe was identified through database searches. A targeted-deletion mutation of this gene was constructed and the mutant, like cadl mutants of Arabidopsis, was cadmium-sensitive and PC-deficient. A comparison of the redicted amino acid sequences reveals a highly conserved N-terminal region Presumed to be the catalytic domain and a variable C-terminal region containing multiple Cys residues proposed to be involved in activation of the enzyme by metal ions. Similar genes were also identified in animal species. The Arabidopsis CADl/AtPCSl and S. pombe SpbPCS genes were expressed in E. coli and were shown to be sufficient for glutathione-dependent, heavy metal activate PC synthesis in vitro, thus demonstrating these genes encode PC synthase enzymes. Using RT-PCR, AtPCSl expression appeared to be independent of Cd exposure. However, at higher levels of Cd exposure a AtPCSl-CUS reporter gene construct appeared to be more highly expressed. Using the reporter gene construct, AtPCSl was expressed most tissues. Expression appeared to be greater in younger tissues and same higher levels of expression was observed in some regions, including carpels and the base of siliques. AtPCS2 was a functional gene encoding an active PC synthase. However, its Pattern of expression and the phenotype of a mutant (or antisense line) have not been determined. Assuming the gene is functional then it has clearly been maintained through evolution and must provide some selective advantage. This implies that, at least in some cells or tissue, it is likely to be the dominant PC synthase expressed. This remains to be determined

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권2호
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• pp.100-105
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• 2012

Purpose: In general, the surgical treatment for mandibular retrognathism is represented by two methods, distraction osteogenesis (DO) and mandibular osteotomy surgery. The DO is mostly preferred when the degree of advancement of mandible is large. However, the postoperative stability of mandibular advancement using DO have not been actively investigated. Therefore, in the present study we have compared the postoperative stability between DO and bilateral sagittal split ramus osteotomy (BSSRO) in mandibular retrognathism. Methods: Seven patients who had been treated by DO and thirteen patients with BSSRO were included in this study. Serial lateral cephalograms were analyzed by manual tracing and the amount of the mandibular elongation was measured. To evaluate the postoperative stability, positional changes of the condylar position and B point were analyzed. Results: Mean amount of mandibular advancement was $6.51{\pm}3.57mm$ for BSSRO group and $12.43{\pm}4.35mm$ for DO group, respectively. There was no significant difference in age between the two groups (P>0.05). Mean follow up periods were 10.77 months for BSSRO group and 11.28 months for DO group, respectively. After mandibular advancement, mean positional changes in the condyle were $0.56{\pm}1.43mm$ horizontally and $0.72{\pm}1.61mm$ vertically for BSSRO group and $0.53{\pm}1.56mm$ horizontally and $0.56{\pm}1.75mm$ vertically for DO group, respectively. Mean change of distance from B point to Y-axis was $-1.76{\pm}0.83mm$ for BSSRO group and $-2.14{\pm}1.82mm$ for DO group, respectively. According to the condylar position and B point, there were no significant differences in postoperative stability between the two groups (P>0.05). Conclusion: There was no significant difference in postoperative stability between DO and BSSRO group according to condylar position and B point. Based on the results of the present study, it is hypothesized that DO would be a good treatment choice for severe mandibular retrognathism because DO could achieve more mandibular advancement and concurrent soft tissue elongation.

• 한국측량학회지
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• 제19권2호
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• pp.173-181
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• 2001

수치지도 일반화 과정을 통해 생성된 수치지도의 공간데이터에 관한 품질을 평가하는 것은 매우 중요하다. 본 연구에서는, 공간데이터 품질유지 측면에서, 변환된 수치지도 데이터가 해당 축척의 수치지도 규정 및 정확도에 위배되지 않도록 하기 위해 이론적 기대정확도의 허용범위를 살펴보고 공간데이터의 품질 평가 기준을 정립하였다. 그리고, 대축척 수치지도를 소축척 수치지도로 변환할 때, 단순화, 완만화, 정리 등과 같은 처리과정을 통해 복잡성을 감소시키게 되면 공간적인 위치변화는 항상 발생하게 될 것이다. 따라서, 각 지점의 변환된 위치에 관한 공간정확도를 분석하는 것은 매우 힘든 일이기 때문에 평가방법으로서 버퍼링기법을 이용하였다. 비록 축척 1/1,000 및 l/5,000에 대한 일반적인 위치오차의 허용범위는 관련법규를 기준으로 결정되었다 하더라도, 각 처리요소에 적용된 알고리즘들은 서로 다른 특성을 가지고 있기 때문에, 알고리즘에 따라 적절한 매개변수와 허용오차를 결정하지 않는다면, 일반화 처리후의 허용범위를 만족할 수 없을 것이다. 허용범위에 근거를 둔 각 알고리즘의 변수에 관한 본 연구에서의 실험결과는 단순화 및 위치오차의 매개변수가 각각 0.2617 m, 0.4617 m를 나타내고 있었다.

• Restorative Dentistry and Endodontics
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• 제31권1호
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• pp.30-35
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• 2006

만곡근관에서 근관형성방법에 따른 근관작업장 변화를 평가하기 위하여 발거된 대구치의 협측 또는 근심 근관 40개에서 스테인레스-스틸 수동 파일 ($MANI^{(R)}$, 일본), 니켈-티타늄 수동 파일 (Naviflex $NT^{TM}$, 미국), ProFile, 또는 $ProTaper^{TM}$ (Dentsply-Maillefor, 스위스)를 사용하여 crown-down 방법으로 30번 크기까지 근관을 형성하고 근관형성 전후의 근관작업장 및 만곡도의 변화를 관찰하였다. 근단공에 대한 10-K파일 끝의 위치변화를 AutoCAD2000 (Autodesk 사, 미국)으로 측정하고 일원변량분석법 및 Tukey's studentized range test로 통계 분석하였다. 모든 군에서 근관형성후 근관장 및 만곡도가 유의하게 감소하였으며, 치관부 근관형성시 Gates Glidden bur를 사용한 수동파일 군이 ProFile 군보다 유의하게 많은 근관장 감소를 초래하였고, 치관부 및 근단부 전체 근관형성후에는 스테인레스 스틸 수동파일 군이 ProFile 군에서보다 유의하게 많은 근관장 감소를 나타내었다 (p<0.05).

• 대한소아치과학회지
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• 제39권3호
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• pp.306-313
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• 2012

III급 부정 교합과 전치부 반대 교합은 동양인에게서 더 빈번히 관찰되며 이 문제는 치과 의사뿐 아니라 부모도 쉽게 인지할 수 있다. 유치열기 반대 교합의 경우, 피개량이 깊어질수록 하악의 기능성 전방 변위가 현저해지는데 이를 방치하면 골격성 반대 교합으로 이행될 우려가 있다. 따라서 치료가 필요한 유치열기 반대 교합의 경우 조기에 정확히 진단하는 것이 중요하고 조기교정 치료를 통해 개입할 필요가 있다. 본 증례에서는 유치열기에 전치부 반대 교합을 주소로 내원하여 기능성 반대 교합으로 진단된 만 4세 어린이들에게 구강내 장치를 이용한 치료를 시행하여 정상적 상하악 치열 관계로 개선시켰다. 또한 본과에서 유치열기 반대 교합 치료를 받은 7명의 어린이들의 치료 기간과 사용된 장치를 고찰하고, 측방 두부 규격 방사선 사진 분석을 통해 치료 전후의 상하악의 위치적 관계의 변화, 악골 크기의 변화량 등을 분석하였다. 그 결과 구내 장치와 III급 고무줄을 이용한 치료에서 대부분의 어린이들은 1년 이내에 반대 교합의 개선을 보였고, 그 치료 결과는 전하안면 고경의 수직적 성장을 통한 하악의 후하방 회전에 의한 것으로 나타났다.