• 한국식품조리과학회지
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• 제27권4호
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• pp.35-46
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• 2011

검정콩 탁주를 발효원으로 한 증편에 기능성 재료로 경북 특산물인 하수오를 0, 2, 4, 6, 8%로 첨가하여 품질특성을 살펴본 결과, 하수오 분말을 첨가할수록 pH는 높게 나타났으며 증편의 팽화율은 대조군에 비해 하수오 2%, 4% 첨가군이 높게 나타났다. 하수오 분말 첨가량이 증가할수록 증편의 항산화성이 증가하였으며 색도에서 $L^*$값은 감소하였으며 $a^*$, $b^*$값은 증가하였다. 경도는 하수오 첨가량이 많을수록 증가하였으며 응집성은 감소하였다. 전체적인 관능검사에서는 하수오 첨가량 4%증편이 가장 높게 평가되었으며 기계적 검사와 관능검사의 상관관계 결과 색도에서 L값을 제외한 모든 항목에서 부의 상관관계를 나타냈으며 경도와 부서짐성이 전체적인 관능항목과 유의적으로 높은 상관관계를 나타냈다. 하수오 증편의 내부구조를 살펴 본 결과 6%이상 첨가 시 기공이 커지고 불규칙한 것을 관찰할 수 있었다. 위의 결과로 약리적인 기능과 항산화성을 가진 하수오를 증편에 첨가함으로써 증편의 기능성을 증진시킬 수 있을 것이다. 하수오의 첨가 농도가 높을수록 대조군에 비해 조직감이나 증편 모양에 좋지 않은 영향을 미치지만 하수오 4% 첨가 증편은 대조군과 비슷한 수준을 유지함과 동시에 관능평가에서도 가장 기호도가 높은 것으로 사료된다.

• 대한예방한의학회지
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• 제9권1호
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• pp.105-118
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• 2005

Objectives : The purpose of this study is to investigate the effects of Polygonum multiflorum THUNB(何首烏) on decresing concentration of serum lipid which are triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol. Thiobarbituric Acid Reactive(TBARS) in high cholesterol diet induced hyperlipidemia rats. Methods : Sprague-Dawley rats were divided into 3 groups, Normal group (supplied enough water and feeds only, Normal Group), high fat diet administered group(AIN-76 high fat diet #100496 used beef tallow for 4 weeks, Control Group) and Polygonum multiflorum THUNB(何首烏). administered group(AIN-76 high fat diet #100496 used beef tallow and Polygonum multiflorum THUNB(何首烏) extracts 85.0mg/200g 1time/day for 4 weeks, HSO Group). Rats were sacrificed and concentration of triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, TBARS were measured in rat's serum lipid. Results : There was no significant difference in the level of weigh between Control and HSO Group.(by Duncan test) Concentration of Total lipid has no significant difference in each group. (F=0.702, p=0.511, ANOVA test) Concentration of triglyceride has no significant difference in each group. (F=0.727, p=0.500, ANOVA test) Concentration of LDL-cholesterol was significantly different in each group.(F=.9.894. p=0.002, ANOVA test) It was significantly increased in the Control group compared with the Normal group and it significantly decreased in the HSO group compared with the Control group. Concentration of HDL-cholesterol has no significant difference in each group. (F=1.079, p=0.365, ANOVA test) TBARS values(Thiobarbituric Acid Reactive Substances) were significantly different in each group.(F=15.580, p=0.0001, ANOVA test) It was significantly increased in the Control group compared with the Normal group and significantly decreased in HSO group compared with the Control group. Conclusions : According to the above results, it is considered that Polygonum multiflorum THUNB(何首烏) is effective in decreasing concentration of serum lipid in high cholesterol diet induced hyperlipidemia rats.

• Natural Product Sciences
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• 제17권3호
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• pp.256-260
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• 2011

Polygoni multiflori Ramulus, the stem of Polygonum multiflorum Thunb., has been widely used as a traditional medicine for the treatment of many diseases. Presently, antinociceptive tests of the butanolic fraction of P. multiflorum (SPB) were performed using several thermal and chemical pain models. SPB had strong and dosedependent antinociceptive activities, both thermal and chemical, compared to the reference drugs Tramadol and Indomethacin. In combination with naloxone, the analgesic activity of SPB was unchanged indicating that the antinociceptive activity of SPB was not due to action as an opioid receptor agonist. The present results indicate the potential of SPB as an analgesic agent for pain control.

• Journal of Applied Biological Chemistry
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• 제62권3호
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• pp.275-280
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• 2019

약용식물 67종의 생리활성 부위를 대상으로 열수 추출물이 in vitro에서 xanthine oxidase의 활성에 미치는 효과를 확인하였다. 약용식물 중에서 황금, 지각, 하수오, 갈근, 청피, 복분자, 녹차 및 지실 추출물은 xanthine oxidase의 활성을 강력하게 저해하여 항통풍 천연소재로서의 활용 가능성이 높게 나타났다. 하수오 뿌리 추출물은 열과 pH에 대한 안정성이 우수하였고, 농도에 비례하여 xanthine oxidase의 활성을 저해하였다. 하수오 추출물은 2.0 mg/0.1 mL의 농도에서 xanthine oxidase에 대해 73.8%의 저해 효과를 나타내었다.

• Archives of Pharmacal Research
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• 제29권11호
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• pp.946-951
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• 2006

One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.

• 대한한방내과학회지
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• 제38권3호
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• pp.327-335
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• 2017

Objective: The goal of this preclinical study was to compare the dyslipidemic effect of pravastatin with that of herbal medicine in rats. Methods: In total, 40 rats were divided into 4 groups: Normal (10 rats), Control (10 rats), Statin alone (10 rats), and the MO-PM-S group (10 rats), which was given the powder of the cortex of Magnolia officinalis Rehd. et Wils., the root of Polygonum multiflorum Thunb, and pravastatin. The Control group, the Statin alone group, and the MO-PM-S group were all given a high-fat (45%) diet that made them obese. After 2 weeks of drug administration, the dyslipidemic effect of pravastatin was compared with that of herbal medicine in rats by analyzing the lipid profiles, measuring the body weights, and taking biopsies (liver, aorta). Results: The herbal medicine and the statin complex group got a much lower TG level and a slightly higher HDL-cholesterol level than the other groups. However, it got a higher total cholesterol and LDL-cholesterol level than the other groups. In biopsies, 30% of the Statin alone group and 10% of the MO-PM-S group showed mild histopathologic findings in the liver. Conclusion: The cortex of the Magnolia officinalis Rehd. et Wils. and the root of Polygonum multiflorum Thunb have dyslipidemic effects from the perspective of a TG level and HDL-cholesterol. However, the herbal mixture has a raising effect on both the LDL-cholesterol and the total cholesterol levels. Therefore, we cannot conclude that the herbal mixture helps to prevent dyslipidemia. In liver biopsies, the group administered with both the herbal mixture and the statin showed less histopathologic findings than the group administered with statin alone. This means that the herbal mixture helps to prevent fatty degeneration of the liver.

• 생약학회지
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• 제31권3호
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• pp.335-339
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• 2000

Polygoni Multiflori Radix, the root of Polygonum multiflorum Thunb., has been used as a tonic, and in the inflammation and constipation in Korea. In order to evaluate the quality of Polygoni Multiflori Radix, the method of isolation and quantitative determination of emodin as a reference standard compound has been developed. Different specimens of Polygoni Multiflori Radix were collected from twenty Korean markets and were analyzed with HPLC using the mobile phase of MeOH-water (64:36). The average content of emodin from Polygoni Multiflori Radix in Korean markets was 0.021%.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2007년도 춘계학술발표회
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• pp.91-92
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• 2007

• Natural Product Sciences
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• 제15권2호
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• pp.83-89
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• 2009

Polygoni multiflori Ramulus (PM), the stem of Polygonum multiflorum Thunb. has been widely used as a traditional medicine for the treatment of lots of diseases. In macrophages, nitric oxide is released as an inflammatory mediator and has been proposed to be an important modulator of many pathophysiological conditions in inflammation. In the present study, it was investigated that the inhibitory effects on NO and proinflammatory cytokines such as tumor necrosis factor alpha (TNF-${\alpha}$), interleukin-6 (IL-6) and the mechanism of down-regulation of immune response by 85% methanol extracts of PM in mouse (C57BL/6) peritoneal macrophages. Extracts of PM (0.1, 1 mg/ml) suppressed NO production and showed inhibition of proinflammatory cytokines like TNF-${\alpha}$, IL-6 and it attenuated iNOS and COX-2 expression via down-regulation of NF-${\kappa}$B activation. The present results indicate that the 85% methanol extracts of PM has an inhibitory effect on the production of NO through down-regulation of iNOS expression in LPS stimulated mouse peritoneal macrophages and therefore may be beneficial in diseases which related to macrophage-mediated inflammatory disorders.

• 한국식품저장유통학회지
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• 제23권3호
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• pp.432-437
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• 2016

본 논문은 국내 적하수오 및 백하수오 추출물의 항산화능 및 항균활성을 구명하기 위한 목적으로 진행하였다. 각 하수오의 열수, 에탄올, 부탄올 추출물에 대하여, 일반성분을 분석한 후, 항산화능에 대해서는 총 페놀함량 및 DPPH 라디칼 소거능을 측정하였으며, 항균활성에 대해서는 Staphylococcus aureus 및 Propionibacterium acne에 대한 최소생육저해농도(minimum inhibitory concentration, MIC) 및 생육저해환을 통하여 평가하였다. 적하수오 및 백하수오 부탄올 추출물의 총 페놀함량은 각각 1,212.6 및 1,454.5 mg/g GAE로 다른 유기용매 추출물에 비해 유의적으로 높은 함량을 보였다. 이에 비해 DPPH 라디칼 소거능은 열수추출물에 비해 에탄올 추출물(89.0%), 부탄올 추출물(88.9%)이 유의적으로 높은 값을 나타내었다. MIC 측정 결과, 적 백하수오 에탄올 추출물만이 0.8 mg/mL로 S. aureus와 P. acne에 대해서 항균효과를 나타냈다. 디스크 확산법 측정 결과, 모든 유기용매 추출물이 5 mg/disc 농도부터 생육저해환을 형성하였으며, 농도가 증가함에 따라 생육저해환의 크기도 증가하였다. 적하수오 및 백하수오 에탄올 추출물의 조사균주에 대한 생육저해완의 직경은 10 mg/mL 농도에서 각각 8.9 및 9.2 mm를 나타내, 추출물 중 가장 우수한 항균활성을 나타냈다. 본 연구는 하수오 추출물이 항산화 효과 뿐만 아니라 피부 건강과 관련된 세균에 대해 항균활성을 보여줌으로써, 하수오 추출물이 피부 건강을 위한 천연 유래의 기능성 화장품 소재로도 활용될 수 있는 잠재적 가능성을 제시하였다.