• 대한화학회지
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• 제38권2호
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• pp.136-145
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• 1994

Poly(4-vinylpyridine-co-styrene)[PVPS]리간드에 monomer착물인 M(Ⅱ)(SND) 및 M(Ⅱ)(SOPD)[M: Co(Ⅱ), Ni(Ⅱ) 및 Cu(Ⅱ)]들을 반응시켜 새로운 polymer다섯자리 Schiff base착물인 M(Ⅱ)(PVPS)(SND), M(Ⅱ)(PVPS)(SOPD)들을 합성하였다. 이들 착물들의 원소분석, IR-spectra, UV-visible spectra 및 T.G.A.측정결과에 의하여 Co(Ⅱ), Ni(Ⅱ) 및 Cu(Ⅱ) 착물들은 polymer 5배위 착물로 주어짐을 알았다. 또한 0.1M TEAP-DMF용액에서 순환 전압-전류법과 시차펄스 포라로그래피에 의한 이들의 전기화학적 성질은 Co(Ⅱ)(PVPS)(SND) 및 Co(Ⅱ)(PVPS)(SOPD)는 Co(Ⅲ)/Co(Ⅱ) 와 Co(Ⅱ)/Co(Ⅰ)의 두단계의 환원과정이 비가역적으로 일어나고, Ni(Ⅱ)(PVPS)(SND) 와 Ni(Ⅱ)(PVPS)(SOPD)는 Ni(Ⅱ)/Ni(Ⅰ)의 비가역적인 일단계 환원과정으로, 그리고 Cu(Ⅱ)(PVPS)(SND)와 Cu(Ⅱ)(PVPS)(SOPD)는 Cu(Ⅱ)/Cu(Ⅰ)의 비가역적인 일단계 환원과정으로 일어남을 알았다.

• 대한미생물학회지
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• 제21권4호
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• pp.423-434
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• 1986

The role of macrophages in the resistance of ICR mice to Candida albicans and Salmonella typhimurium was assessed using silica, agent which selectively inactivates macrophages or poly-2-vinylpyridine-N-oxide(PVNO), a lysosomal stabilizing agent. In addition, effect of silica on humoral and cellular immune responses to sheep red blood cells(SRBC) or polyvinylpyroridone(PVP) was examind. Colonyforming units(CFU) of C. albicans or S. typhimurium in the spleen, livers and kidneys of silica-treated or diluent-treated mice were enumerated at various times after infection. Silica was given i. v. to mice at 4 days or 1 day before infection. Although there was no apparent differences in the number of CFU of C. albicans cultured from the spleens or livers of silica-treated and control mice at every assay period, significant differences in the number of CFU of C. albicans in the kidneys of silica-treated and control mice. Namely, silica given to mice 1 day before infection significantly increased the number of CFU of C. albicans in the kidneys at 2, 4 and 6 days after infection, but did not change the number of CFU at 8 days after infection. Silica given to mice at 4 days before infection significantly increased the number CFU in the kidneys at 2 and 4 days after infection, but rather decreased the number of CFU at 8 days after infection. The number of CFU of C. albians cultured from the kidneys of splenectomized which were experimentally infected mice was similar to the number recovered from sham-operated mice at 4 and 8 days postinfection irrespective of time of infection relative to operation. The pretreatment of mice with PVNO appeared to abrogate the silica-induced susceptibility of mice to C. albicans. PVNO alone showed somewhat protective effect against challenge with C. albicans. In contrast, silica treatment did not alter the number of CFU of S. typhimurium recovered from the spleens and kidneys of mice. The administration of silica to mice at 4 days or 1 day before SRBC immunization significantly suppressed delayed-type hypersensitivity(DTH) reactions to SRBC and antibody production to SRBC, a thymus-dependent antigen and PVP, a thymus-independent antigen. These results provide evidence that macrophages play an important role in susceptibility to Candida infection and strongly demonstrated that macrophages play an essential role in the induction of immune responses in mice.