• Acta Via Serica
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• v.4 no.1
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• pp.125-146
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• 2019

This paper deals with the question of the origin of polo. Although it is a sport that has been mainly active in the West since the nineteenthcentury, it is well known that British troops in the northern part of Pakistan learned about the sport from the local people there. Most agree that the origin of polo is Iran. However, in this paper, rather than specifying a specific area as the birthplace of polo, it is argued that polo was a cultural phenomenon commonly found on the Silk Road. This is based on the fact that polo has been known for centuries in China, the Korean Peninsula, and Japan, as well as throughout Iran, northern India, Tibet, Central Asia, and the Uighur Autonomous Region. Yet, the transmission of polo cannot be traced chronologically according to the supposed propagation route. This cultural phenomenon has changed over a long period of time according to the local environment, and the change was caused by mutual exchanges, not by one party. Therefore, there are limitations to interpreting cultural phenomena linearly. Thus, the origin of polo could also be identified with another area, namely Baltistan in modern day Pakistan, instead of Iran. These results support the argument that to understand Silk Road civilization, a process-centric approach based on 'exchanges', not a method of exploring archetypes to find 'the place of origin', should be utilized. Polo is undoubtedly an important cultural artifact with which to read the Silk Road as a cultural belt complex, as well as an example of the common culture created by the whole Silk Road.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.2
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• pp.152-157
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• 2019

Polo-like kinase 1 (Plk1) is crucial regulator of cell cycle progression during mitosis. It is known to highly overexpress in many different tumor types, and has been implicated as a potential antimitotic cancer target. The phosphopeptide, Pro-Leu-His-Ser-p-Thr (PLHSpT), was shown a high level of affinity and specificity for the polo-box domain (PBD) of Plk1. However, the peptide has the limitation of cell permeability. We designed the derivatives to enhance the limitation of PLHSpT using drug delivery system. In addition, we synthesized and evaluated its radiotracer for tumor diagnosis. This review discusses the derivative and radiotracer that are suitable for tumor treatment and diagnosis for PBD of Plk1.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.2
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• pp.139-145
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• 2020

Polo-like kinase 1 (Plk1) is a key protein in mitosis and has been validated as a target for tumor therapy. It is well known to highly overexpress in many kinds of tumor, which has been implicated as a potential biomarker for tumor treatment and diagnosis. Plk1 consists of two domains, the N-terminus kinase domain and the C-terminus polo-box domain (PBD). The inhibitors have been developed for PBD of Plk1, which were shown a high level of affinity and selectivity for Plk1 that led to mitotic arrest and apoptotic cell death. This review discusses the inhibitors for PBD of Plk1 that are suitable for in vivo tumor treatment. They can be further extended for developing in vivo imaging probes for early diagnosis of tumor.

• Journal of the Korea Fashion and Costume Design Association
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• v.5 no.3
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• pp.63-77
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• 2003

This study was to analyze the trademarks of The Polo Lauren Company in fashion products and its analogous trademarks that have been applied or registered in the Korean Patent Office. The data was collected from the Korean Patent Office and KIPRIS search system was used. Total 468 trademarks applied by the date of September 10, 2003 including 317 registered trademarks of the Polo Lauren Company and 151 its analogous trademarks applied for fashion products, were used for the analysis. The results were follows. (1) Total 73 different types of trademarks of the Polo Lauren Company were registered for 26 product classification. Trademarks were composed of all possible combination of letter, sign and sketch to prevent the registration of its analogous trademark. Also even the same trademarks were registered for each different product classification. Since the early 1990s the extended trademarks for each segments reflecting diverse lifestyles were frequently registered. (2) Total 134 trademarks that had applied for registration were rejected due to its analogousness to the Polo Lauren. Most of them were seem to purposely analogous to mislead and to confuse consumers. The major type was to add one or two words as brand extention to the genuine Polo brand. Next type was minor modification of genuine trademark. The last type was almost same brand names in different product categories. (3) Total 3 trademarks were not permit to register by the objection of the Polo Lauren Company. Total 19 trademarks were permit to register. Those showed low degree of analogousness. However most of these trademarks were cancelled by the lawsuit of the Polo Lauren company.

• Computers and Concrete
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• v.6 no.6
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• pp.505-521
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• 2009

The analysis of prismatic members made of reinforced concrete under inclined bending, especially the computation of ultimate loads, is a pronounced non-linear problem which is frequently solved by discretizing the stress distribution in the cross-section using interpolation functions. In the approach described in the present contribution the exact analytical stress distribution is used instead. The obtained expressions are integrated by means of a symbolic manipulation package and automatically converted to optimized Fortran code. The direct problem-computation of ultimate internal forces given the position of the neutral axis-is first described. Subsequently, two kinds of inverse problem are treated: the computation of rupture envelops and the dimensioning of reinforcement, given design internal forces. An iterative Newton-Raphson procedure is used. Examples are presented.

• BMB Reports
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• v.39 no.6
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• pp.709-716
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• 2006

Mammalian polo-like kinase 1 (Plk1) acts at various stages in early and late mitosis. Plk1 localizes at the centrosome and maintains this position through mitosis. Thereafter Plk1 moves to the kinetochore and midbody region, important sites during chromosome separation and cytokinesis. The catalytic domain of Plk1 is in the N-terminus region, whereas the non-catalytic region in the C-terminus of Plk1 has a conserved motif, named the Polobox. This motif is critical for Plk localization. EGFP proteins fused with the N-terminus and C-terminus of Plk1 localize in the nucleus and centrosomes, respectively. The core sequences of the polo-box (50 amino acids) also localize in Plk1 target organelles. To screen for domain-specific target proteins of Plk1, we constructed an N-terminal domain and a tandem repeat polo-box motif, and used them as templates in a yeast two-hybrid screen. The HeLa cell cDNA library indicated several proteins including the centrosome/kinetochore components or regulators, to be characterized as positive clones. Through in vitro protein binding analyses, we confirmed an interaction between these proteins and Plk1. The data reported from this study indicate that the N- and C- termini of Plk1 may function through recruitment and/or activation of domain-specific target proteins in dividing cells. Additionally, tandem repeats of the conserved core motif of the polo-box are sufficient for targeting and may be useful as a centrosome/kinetochore-specific targeting peptide.

• Journal of Bio-Environment Control
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• v.10 no.2
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• pp.75-79
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• 2001

Stem firmness and flowering response of cut lily as influenced by medium composition (Control; Upland soil, Pt; Peatmoss, Pe; Perilite, Ve; Vermiculite, Rrh; Rotted rice-hull, RPt: Russian Peatmoss) were studied. For 'Casa Blanca', plant height and length of flower stalk increased when bulbs were planted in Pt:Rrh:Ve (1:1:1, v.v$^{-1}$ ), and dried leaves of lower part plants decreased in RPt:Pe:Rrh (1:1:1, v.v$^{-1}$ ). In case of 'Marco Polo', plant height and length of lower stalk increased in Pt:Rrh (1:1, v.v$^{-1}$ ) as compared to other treatment, number of leaves and dried leaves increased when bulbs were planted in RPt:Pe:Rrh (1:1:1, v.v$^{-1}$ ) as compared to the control. Flowering of 'Casa Blanca' increased in RPt:Pe:Rrh (1:1:1, v.v$^{-1}$ ) as compared to the control and that o 'Marco Polo' increased when bulbs planted in Pt:Rrh(1:1, v.v$^{-1}$ ). Flower-bud blasting of both cultivars increased with Pt as compared. Stem firmness of 'Casa Blanca' increased in Pt:Pe:Ve (1:1:1, v.v$^{-1}$ ), and especially stem firmness of upper part plant of 'Marco Polo' increased in Pt:Rrh (1:1, v.v$^{-1}$ ) as compared to the control. Generally, stem firmness of 'Casa Blanca' was not influenced by the culture medium.

• Development and Reproduction
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• v.18 no.1
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• pp.65-71
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• 2014

Cell cycle process is regulated by a number of protein kinases and among them, serine/threonine kinases carry phosphate group from ATP to substrates. The most important three kinase families are Cyclin-dependent kinase (Cdk), Polo-like kinase (Plk), and Aurora kinase. Polo-like kinase family consists of 5 members (Plk1-Plk5) and they are involved in multiple functions in eukaryotic cell division. It regulates a variety of aspects such as, centrosome maturation, checkpoint recovery, spindle assembly, cytokinesis, apoptosis and many other features. Recently, it has been reported that Plks are related to tumor development and over-expressed in many kinds of tumor cells. When injected the anti-Plk antibody into human cells, the cells show aneuploidy, and if inhibit Plks, most of the mitotic cell division does not proceed properly. For that reasons, many inhibitors of Plk have been recently emerged as new target for remedy of the cancer therapeutic research. In this paper, we reviewed briefly the characteristics of Plk families and how Plks work in regulating cell cycles and cancer formation, and the possibilities of Plks as target for cancer therapy.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.3
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• pp.134-141
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• 2019

PURPOSE: This study conducted aA forward-looking study of elite water polo athletes, who trained at National Training Center, was conducted to determine the correlation between the incidence of sports injuries and the bone density among national water polo players. METHODS: Data on the general characteristics of all study subjects were analyszed usingin descriptive statistics. The incidence of sports injuries was calculated from the incidence of sports injuries per 1,000 hours and the incidence of sports injuries resulting from exposure to 1,000 training sessions. The incidence of all sports injuries was calculated with a 95% confidence interval. Furthermore, Pearson's correlation was calculated conducted to determine the correlation between sports injuries and bone density, bone mass and body composition. RESULTS: Water polo athletes suffered a total of 127 sports injuries in the three-year period, while the athletes suffered 3.5 sports injuries each year. The Ooverall injury rate of 3.2(95% CI 2.68-3.81) per 1,000h, 18.0(15% CI 14.89-21.16) of sports injuries per 1,000AE. For all athletes, 50.4% of the injuries were classified as mild, followed by moderate (26.8%) and severe (22.8%). The lower the bone density in all areas of sports injuries, the higher the incidence of sports injuries. In addition, and the lower the bone mass in all areas except for light injuries, the higher the incidence of sports injuries. CONCLUSION: In tThe correlation between sports injuries and bone density and bone composition of water polo athletes, revealed a significant correlation between the bone density and bone mass were statistically significant, and the lower the bone density and bone mass, the higher the incidence of sports injuries.

• Computers and Concrete
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• v.12 no.4
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• pp.393-411
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• 2013

In the analysis and design of reinforced concrete frames beam-column joints are sometimes assumed as rigid. This simplifying assumption can be unsafe because it is likely to affect the distributions of internal forces and moments, reduce drift and increase the overall load-carrying capacity of the frame. This study is concerned with the relevance of shear deformation of beam-column joints, in particular of exterior ones, on the quasi-static behavior of regular reinforced concrete sway frames. The included parametric studies of a simple sub-frame model reveal that the quasi-static monotonic behavior of unbraced regular reinforced concrete frames is prone to be significantly affected by the deformation of beam-column joints.