• 제목/요약/키워드: Poisoning Effect

검색결과 273건 처리시간 0.023초

음이온 교환막의 정확한 OH-전도도 및 CO2 피독 효과 분석을 위한 전기화학적 측정법 (Electrochemical Method for Measurement of Hydroxide Ion Conductivity and CO2 Poisoning Behavior of Anion Exchange Membrane)

  • 김수연;권후근;이혜진;정남기;배병찬;신동원
    • 전기화학회지
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    • 제25권2호
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    • pp.88-94
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    • 2022
  • 알칼리막 연료전지에 사용되는 음이온 교환막은 OH-을 전달하는 역할을 하며 연료전지의 성능에 많은 영향을 미친다. 따라서 음이온 교환막의 정확한 OH- 전도도를 측정하는 것은 매우 중요하다. 그러나 OH-은 대기 중의 CO2에 의해 중탄산염 형태로 쉽게 피독되어 전해질막의 정확한 OH- 전도도를 측정하는 것은 매우 어렵다. 본 연구에서는 음이온 교환막의 정확한 OH- 전도도를 측정하기 위하여 전기화학적 이온교환 처리법을 검증하였다. 또한 CO2에 노출된 전해질막의 거동을 OH- 전도도 변화를 통하여 확인하였다. 상용 음이온 교환 막인 Fumatech사의 FAA-3-50과 Orion Polymer사의 Orion TM1와 함께 본 연구 그룹에서 개발한 QPP-6F를 사용하여 정확한 OH- 전도도 측정 및 CO2 피독 효과에 대해서 분석하였다.

온도, pH 및 빛에 대한 Domoic Acid의 안정성 (Stability of Domoic Acid at Different Temperature, pH and Light)

  • 목종수;이태식;오은경;손광태;황혜진;김지회
    • 한국수산과학회지
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    • 제42권1호
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    • pp.8-14
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    • 2009
  • To prevent the food poisoning originated by consumption of shellfish contaminated with domoic acid, the quantitative analysis of domoic acid is to be very important. The stability of domoic acid at different temperature, pH and light was investigated using high performance liquid chromatography (HPLC). The mean recoveries of domoic acid in the methanol extracts from oyster (Crassostrea gigas), blue mussel (Mytilus edulis), short neck clam (Ruditapes philippinarum) and ark shell (Scapharca broughtonii) were 85.4-104.5%, 94.8-101.2%, 91.0-104.6%, and 95.7-109.6%, respectively. The working solutions of domoic acid standard were very stable for one month at $-18^{\circ}C$, $4^{\circ}C$, and room temperature. And domoic acid in the methanol extract from oyster was stable for a day at $4^{\circ}C$ and room temperature, and for a week at $-18^{\circ}C$. Therefore, this implies that quantitative analysis for domoic acid must consider the storage conditions of the standard solutions and the methanol extracts from shellfish. The standard solutions adjusted to pH 3-9 were also stable after heating at $121^{\circ}C$ for 30 min. The effect of light exposure on domoic acid was tested by exposing the methanol extracts to light. Domoic acid degraded slowly when the samples were kept in the dark (brown vial). However, following the light exposure the photodegradation became more rapid; no detectable domoic acid remained in $1.0{\mu}g/mL$ of methanol extract after 5 hours.

일부 식용식물이 랫트의 카드뮴 중독에 미치는 防禦效果와 酵素反應 (Protective Effect and Enzyme Activity of Field Horsetail, Mugwort and Champignon on the Cadmium Poisoning of Rat)

  • 기노석;염정호;김남송;황인담
    • 한국환경보건학회지
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    • 제23권1호
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    • pp.81-94
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    • 1997
  • The concentrations of cadmium, metallothionein(MT), superoxide dismutase(SOD), and lactate dehydrogenase(LDH) were investigated in liver and kidney of rats which were fed the water containing 50 or 100ppm cadmium chloride with basal diet(group A), 5% horsetail diet(group, B), 5% mugwort diet(group C) and 5% champignon diet(group D) for weeks. Cadmium in liver decreased for the first 12 weeks of treatment, but thereafter increased, and was lower in experimental group B,C,D than in control group A. Cadmium in kidney increased linearly during the 16 weeks of treatment, and was lower in group B than in group A. MT in liver decreased for the first 12 weeks of treatment in group A, but increased linearly during the 16 weeks in group B,C,D, higher in group B than in group A. There were significantly higher accumulation of cadmium and MT in liver than in kidney in the beginning of cadmium treatment, but reversed in the ending of treatment. The SOD and LDH activities were not affected during the 16 weeks treatment, and there was no significant difference between groups. Histologic examination revealed moderate to severe hepatic and renal injury in group A compared to horsetail diet group B. These results indicate that the kidney is a major target organ of chronic cadmium poisoning, and suggest that Cd-induced hepatic injury, via release of Cd-MT, may play an important role in the nephrotoxicity. In addition, higher MT concentrations in liver and kidney in the group B constitute a plausible explanation of the protective effects of horsetail diet against the cadmium toxicity in relation to histologic findings.

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Korean Red Ginseng Protects Oxidative Injury Caused by Lead Poisoning

  • Park, Myoung-Soo;Cho, Eun-Jung;Lee, Sang-Ki;Lee, Eun-Ji;Lee, Dae-Sik;Lee, Kwon-Ho;Jeon, Byeong-Hwa
    • Journal of Ginseng Research
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    • 제34권2호
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    • pp.132-137
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    • 2010
  • Lead (Pb) is a metal that is generally considered to be toxic to the cardiovascular system. Pb-exposed animals display the evidence of increased oxidative stress and hypertension. The current study was designed to examine whether Korean red ginseng (KRG) has protective effects against Pb-induced hypertension and oxidative stress in Pb-exposed rats. Male Sprague-Dawley rats were randomly assigned to Pb exposure or control groups. KRG was administered in drinking water at a concentration of 100 mg/kg/day; the control group received plain drinking water. Animals in the Pb-exposed groups were provided with drinking water containing 100 ppm Pb acetate for 12 weeks. Blood pressure, plasma glutathione, blood Pb concentration, and hematologic data, such as red blood cell quantity, were determined. Pb poisoning was assessed by measuring the blood Pb concentration. Pb exposure (100 ppm) for 12 weeks resulted in a marked rise in systolic blood pressure and blood Pb concentration, as well as a significant reduction in plasma glutathione levels and red blood cell quantity. Other measurements, such as heart rate, body weight, and white blood cell quantity, were unchanged. Treatment with KRG significantly lowered blood pressure, raised plasma glutathione and increased red blood cell numbers in Pb-exposed animals; it also had no effect on heart rate, body weight, or white blood cell quantity. However, the elevated blood Pb concentration was not reduced by treatment with KRG (100 mg/kg). Taken together, these data indicate that treatment with KRG in Pb-exposed animals can reduce oxidative stress and lower blood pressure, suggesting that KRG might be protective against Pb-exposed hypertension and oxidative stress.

새롭게 출현한 Arcobacter butzleri의 유기산과 trisodium phosphate 처리에 의한 생육저해효과 (Growth Inhibition of Newly Emerging Arcobacter butzlrei by Organic Acids and Trisodium Phosphate)

  • 장정순;이영덕;박종현
    • 한국식품과학회지
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    • 제35권6호
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    • pp.1169-1173
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    • 2003
  • 새롭게 출현한 식중독 세균으로 국내 유통 계육 등에 많이 오염이 되어 있는 Arcobacter butzleri를 제어하기 위해 여러 위생제 처리에 따른 생육영향을 평가하였다. 이들 균체에 1%농도의 유기산과 trisodium phosphate를 5, 10분간 처리한 결과 대부분이 10분 이내에 사멸한 것을 확인할 수 있었으며, 젖산의 경우는 5분 이내에 모든 균주가 사멸하였다. 배양할 때의 유기산의 농도별 생육영향은 1%의 농도로는 1시간 이내에, 0.1%의 농도에서 72시간 이내에 A. butzleri가 사멸한 것을 볼 수 있었으며, trisodium phosphate의 경우 2% 농도에서는 1 시간이내에 사멸하였다. 유기산 중에는 젖산의 생육저해효과가 가장 우수하게 나타났으며 hydrogen peroxide, sodium hypochlorite와 ethanol에 대한 사멸효과를 보았으나, 이 처리제는 효과가 나쁘거나 풍미에 영향을 주어 좋은 처리제라 할 수 없었다. 그리고 마늘과 양파즙에 대한 항미생물 작용에서 마늘에만 생육저해작용을 확인할 수 있었으며, 젖산균이 생산하는 유기산에 의한 낮은 pH에 의한 저해효과를 확인할 수 있었다. 따라서 계육 등의 육가공 및 취급 시에 유기산 및 TSP 등을 이용하여 주요 Arcobacter에 의한 식중독저해가 가능할 것으로 사료되었다.

베라파밀 중독의 쥐 모델에서 지방에멀젼 정맥주사의 효과 (The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity)

  • 하대명;김동훈;김태윤;이수훈;정진희;이상봉;임대성;강창우
    • 대한임상독성학회지
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    • 제16권1호
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    • pp.9-14
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    • 2018
  • Purpose: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated the hemodynamic changes and survival in a rat model of verapamil intoxication. Methods: Fourteen male Sprague-Dawley rats were sedated and treated with ILE or normal saline (control), followed by continuous intravenous infusion of verapamil (20 mg/kg/h). Mean arterial pressure and heart rate of rats were monitored during the infusion. In addition, the total dose of infused verapamil and the duration of survival were measured. Results: Survival was prolonged in the ILE group ($32.43{\pm}5.8min$) relative to the control group ($24.14{\pm}4.3min$) (p=0.01). The cumulative mean lethal dose of verapamil was higher in the ILE group ($4.3{\pm}0.7mg/kg$) than in the control group ($3.2{\pm}0.5mg/kg$; p=0.017). Conclusion: ILE pretreatment prolonged survival and increased the lethal dose in a rat model of verapamil poisoning.

해수의 대장균군과 분변계대장균의 검출률 비교 분석 (Comparative Analysis of Total and Fecal Coliforms in Sea Water)

  • 김영만;김경희;박혜정
    • 한국수산과학회지
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    • 제40권5호
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    • pp.288-292
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    • 2007
  • Seafood, if eaten raw, carries the risk of food poisoning. Seafood poisoning is often caused by pathogenic microorganisms originating from fecal contamination, such as Salmonella sp. and norovirus. Fecal coliforms are an important indicator of fecal contamination. Therefore, data on fecal coliforms are very important for evaluating the safety of fisheries in coastal areas. In this study, 2,226 sea water samples were collected from the southeast coast of Korea, and total and fecal coliforms were compared and analyzed. Total coliforms were detected in 76.5% of the samples and 71.4% of the total coliforms were fecal coliforms. At sea water temperatures above $20.0^{\circ}C$, total coliforms were found in 78.8% of the samples and fecal coliforms constituted 72.0% of the total coliforms. In sea water below $19.9^{\circ}C$, the respective values were 74.6% and 70.9%. These results suggest that temperature does not have a significant effect on the detection of fecal coliforms. When the salinity exceeded 30.0%o, total coliforms were found in 72.1% of the samples and fecal coliforms constituted 66.0% of these. At salinities below 29.9%o, the respective values for total and fecal coliforms were 90.4% and 85.2%. These results strongly suggest that the detection of fecal coliforms is proportional to the amount of precipitation.

피부 찰과상을 통한 파라쿼트 중독에 의한 사망 1례 (The Fatal Paraquat Poisoning Through Skin Abrasion -Case Report-)

  • 김성은;조준휘;천승환;이승용;최기훈;배지훈;서정열;안희철;안무업;옥택근;박찬우
    • 대한임상독성학회지
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    • 제3권2호
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    • pp.122-125
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    • 2005
  • Paraquat, is a widely used for its great effect as a herbicide. But the mortality rate by paraquat intoxication is known to be very high. It is thought to act by changing form to superoxide and peroxide free radical. Almost paraquat intoxication is through ingestion. A few intoxication of paraquat is through skin absorption. But there was no known death case through skin absorption. We experienced a case of a expired patient by paraquat intoxication through skin abrasion and scratching wound. A 75-year-old man was visited emergency room after motorcycle accident during transporting paraquat. He has multiple abrasion and scratching wound on extremities, and pelvic bone fracture. There was no evidence of ingestion of paraquat. But serum/urine gramoxone level was all positive. In spite of wound irrigation and hemoperfusion, his condition was been gone form bed to worse. 2 days after, multiple organ failure and the respiratory arrest were developed and he was expired. Paraquat intoxication through skin wound is extremely dangerous and death by that could possibly happen

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이진쑥 추출물의 병원성 세균에 대한 시험관내 항균효과 (Antimicrobial Effects of Artemisia capillaris Extracts on the Pathogenic Bacteria In Vitro)

  • 김홍태;김주완;임미경;여상건;장광호;오태호;이근우
    • 한국임상수의학회지
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    • 제24권2호
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    • pp.130-136
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    • 2007
  • Artemisia capillaris THUNB is a perennial herb that belongs to the family Compositae spp and the most common plant among the various herbal folk remedies used in treatment of abdominal pain, hepatitis, chronic liver disease, jaundice and coughing in Korea. In this study, antimicrobial effects of Artemisia capillaris extracts on the food poisoning bacteria were investigated for further clinical application, which is an alternative for the use of antibiotics and their unexpected resistance. Artemisia capillaris extract using ethyl acetate showed the highest antimicrobial effects on S. enteritidis, E. coli O157 : H7, L. monocytogenes and S. aureus. The chloroform extract showed strong effects on all kinds of bacteria; whereas ethanol and methanol extracts showed weaker effects. Finally, ether and water extracts showed the weakest effects under the same conditions. The minimum inhibitory concentration (MIC) of ethyl acetate extract was 1 mg/mL for E. coli O157 : H7 and L. monocytogenes, and 2 mg/mL for S. enteritidis and S. aureus. The inhibitory effects on all the bacteria continued for 12 hours after incubation using 20 mg/mL and 30 mg/mL of ethyl acetate extract. The inhibitory effects continued maximally for 72 hours. The results of these studies indicate Artemisia capillaris extract exhibited excellent antimicrobial and inhibitory effects on the food poisoning pathogenic bacteria; S. enteritidis, E. coli O157 : H7, L. monocytogenes and S. aureus.

일산화탄소중독 이후 발생한 지연성 신경정신과학적 후유증에 대한 한방치료 증례보고 1례 (A Case Report on Korean Medical Treatment for Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning)

  • 정솔;진효원;황지현;박정림;전혜수;문병순;윤종민
    • 대한한방내과학회지
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    • 제43권2호
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    • pp.159-165
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    • 2022
  • Objective: This clinical study describes the effect of Korean medicine on a patient with Delayed Neuropsychiatric Sequelae after Carbon Monoxide Poisoning. Case presentation: A patient with the delayed neuropsychiatric effects of carbon monoxide exposure was treated with herbal medicine, acupuncture, moxibustion, and cupping. Clinical symptoms were measured with the Korean Mini Mental State Examination (K-MMSE), Functional Independence Measure (FIM), and the Modified Barthel Index (MBI). After 32 days of treatment, the patient's K-MMSE score increased from 11 to 21 points, the FIM score from 52 to 94 points, and the MBI score from 46 to 84 points. There were no side effects. Conclusion: According to this case study, Korean medicine may be considered an effective treatment for delayed neuropsychiatric sequelae, although more studies are needed to confirm its validity.