• 제목/요약/키워드: Point of inflection

검색결과 213건 처리시간 0.028초

잡종견 급성폐손상 모델에서 Prone position 시행시 PEEP 수준에 따른 호흡 및 혈류역학적 효과 (The Respiratory and Hemodynamic Effects of Prone Position According to the Level of PEEP in a Dog Acute Lung Injury Model)

  • 임채만;진재용;고윤석;심태선;이상도;김우성;김동순;김원동
    • Tuberculosis and Respiratory Diseases
    • /
    • 제45권1호
    • /
    • pp.140-152
    • /
    • 1998
  • 배 경: 호흡부전의 치료에 있어 환자 체위를 prone position으로 하는 시도는 20년 전부터 보고되어 왔으며 폐산소화 및 심박출량 향상에 효과가 있다는 것이 알려져 있다. Prone position시 폐산소화의 호전은 임상 및 동물 실험에서 단락 감소에 의한 것으로 알려져 있으며 그 중요 기전은 supine position에 비해 prone position때 중력 의존부 폐의 늑막압이 더 작아 폐포 개방압이 줄어들기 때문인 바 저자 등은 prone position이 폐산소화에 미치는 효과는 supine position에서 사용한 PEEP의 폐포 고비 개방압과의 관계에 따라 달라질 것으로 추정하였다. Prone position에서의 심박출량 증가에 대하여는 양압환기시 발생하는 cardiac fossa lifting 현상이 prone position에 의해 완화될 수 있다는 주장이 제기된 바 있어 prone position이 또한 supine position에서 PEEP에 의해 초래된 심박출량 저하를 완화시킬 수 있는지를 잡종견 급성 폐손상 모델을 통해 알아보고자 하였다. 방 법 : 잡종견 7 마리 ($20.0{\pm}3.9$ kg)를 정맥 마취 후 기관내관을 삽관하고 인공호흡기를 Vt 15 ml/kg, f 20/min, I : E=1 : 3, pause 10%, PEEP 0 cm $H_2O$, $F_1O_2$ 1.0으로 설정하였다. 혈압, 분당맥박수, 폐동맥쐐기압, 심박출량 등의 측정과 동맥혈가스분석을 위해 서혜동맥과 폐동맥 천자술을 시행하였다. 대조기에 supine position 및 prone position 30분에 각각 호흡 지표 ($PaO_2/F_1O_2$[P/F], 총호흡기계탄성 [Cst]와 supine position, prone position 5분 및 prone position 30분에 혈류역학적 지표(평균동맥압, 분당 맥박수, 심박출량, 박출용적)을 측정하고 섭씨 38도의 생리식염수 (30~50 ml/kg)를 기관내관을 통하여 주입하여 급성 폐손상을 유도한 뒤 constant flow 법에 의해 inflection point(Pflex)를 측정하였다. 급성 폐손상에서의 supine position과 prone position실험은 Pflex보다 2 cm $H_2O$ 낮은 PEEP(Low PEEP)과 2 cm $H_2O$ 높은 PEEP (Optimal PEEP)에서 순차적으로 시행하고 각각 통일 시간대에 상기 지표들을 측정하였으며 Optimal PEEP 실험 마지막에 다시 supin position으로 체위를 바꾸고 5분 뒤 혈류역학적 지표들을 측정하였다. 결 과: 1. Prone position 시행시 Low PEEP 및 Optimal PEEP에서의 호흡 효과의 차이 Low PEEP하에서 P/F 비는 supine position에서 $195{\pm}112$ mm Hg, prone position 30분에서 $400{\pm}33$ mm Hg였고 (p<0.001) Optimal PEEP하에서 P/F 비는 supine position에서 $466{\pm}63$ mm Hg, prone position 30분에서 $499{\pm}63$ mm Hg였다 (p=0.016). Prone position에 의한 P/F 비 싱승량은 Low PEEP하에서 $205{\pm}90$ mm Hg로 Optimal PEEP($33{\pm}33$ mm Hg) 하에서 보다 유의하게 높았다(각각 p<0.05). 2. Prone position의 혈류역학적 효과 Low PEEP하에서 심박출량은 supine position($3.0{\pm}0.7$ L/min) 과 비교하여 prone position 5분 $3.3{\pm}0.7$ L/min(p=0.0180)로 증가하였고 prone position 30분 $3.7{\pm}0.8$ L/min(p=0.0630)로 차이가 없었다. 분당맥박수는 각각 $141{\pm}22\;min^{-1}$, $141{\pm}22\;min^{-1}$(p=0.8658) 및 $176{\pm}28\;min^{-1}$(p=0.0280)이었고 폐동맥쐐기압은 차이가 없었다. Optimal PEEP하에서 평균동맥압은 각각 $87{\pm}19$ mm Hg, $107{\pm}18$ mm Hg(p=0.0180) 및 $108{\pm}16$ mm Hg(p=0.0180), 심박출량은 각각 $2.4{\pm}0.5$ L/min, $3.3{\pm}0.6$ L/min(p=0.0180) 및 $3.6{\pm}0.7$ L/min(p=0.0180), 그리고 박출용적은 각각 $14{\pm}2$ml, $20{\pm}2$ ml(p=0.0180) 및 $21{\pm}2$ ml(p=0.0180)였다. 분당맥박수는 체위 변경에 따른 차이가 없었고 폐동맥쐐기압은 각각 $10.1{\pm}2.4$ mm Hg, $9.1{\pm}2.7$ mm Hg(p=0.0180) 및 $9.0{\pm}3.1$ mm Hg(p=0.0679) 이었다. Optimal PEEP하 prone position에서 다시 supine position으로 체위를 바꾸고 5분 후 평균동맥압은 $92{\pm}23$ mm Hg, 심박출량은 $2.4{\pm}0.5$ L/min, 그리고 박출용적은 $14{\pm}1$ ml로 모두 감소하였다(모두 p<0.05). 결 론 : 잡종견 급성폐손상 모델에서 prone position은 비교적 낮은 수준 PEEP의 폐산소화 호전 효과를 중대시켰고, 비교적 놓은 수준 PEEP에 의한 심박출량 저하를 완화시켰다. 이러한 결과들은 심박출량을 유지하면서 폐산소화를 호전시키고자 하는 ARDS 환자에서의 기계환기의 목표를 달성하는데 있어 prone position이 supine position보다 유리하다는 것을 시사한다.

  • PDF

한국 조경수목 근원직경 측정의 합리적 위치 설정에 대한 연구 (A Study on the Reasonable Measurement Point of Root Collar Diameter of Landscape Trees in Korea)

  • 한용희;김화정;김도균
    • 한국조경학회지
    • /
    • 제49권5호
    • /
    • pp.59-70
    • /
    • 2021
  • 본 연구는 한국 조경수목의 근원직경 측정의 모호성으로 생산자와 시공자 간의 검측 기준이 달라서 발생되는 분쟁을 줄일 수 있는 합리적인 근원직경 측정 위치 설정 방안에 대하여 실증 조사·분석하였다. 조경수목의 근원직경 측정 부위별 차이는 지하부 -6cm에서 표토부인 0cm까지는 3.59cm이었고, 지상부의 표토 0cm에서부터 6cm까지는 1.35cm로 근원직경의 측정위치별 차이는 지상부보다는 지하부에서 더 크게 나타났다. 조경수목 근원직경의 표준편차의 크기는 지하부 -6cm에서 표토부인 0cm까지는 0.64이었고, 지상부의 표토 0cm에서부터 6cm까지의 표준편차 차이는 0.16으로 근원직경의 측정위치별 차이는 지상부보다는 지하부에서 더 크게 나타났다. 조경수목 근원직경의 합리적 측정 위치 설정은 근원직경 측정 위치별 규격의 크기 변화 추세선에서 수간직경의 표준편차가 가장 적어지는 변곡점으로 설정하는 것이 제안되었다. 수종별 합리적인 측정 위치는 산딸나무 지상 18cm, 이팝나무 지상 12cm·느티나무 지상 12cm·팽나무 지상 12cm, 때죽나무 지상 10cm·산수유 지상 10cm, 단풍나무 지상 6cm·먼나무 지상 6cm, 가시나무 지상 4cm, 배롱나무 지상 2cm 이상으로 나타났다. 조경수목 근원직경 측정 부위별 차이가 공시수종 전체에서 표준편차가 작고, 편차의 기울기가 안정적인 합리적인 평균 측정위치는 지상부 평균 12cm 이상으로 나타났다. 조경수목 근원직경의 합리적인 측정위치 설정은 지상부 평균 12cm 이상에서부터라고 할 수 있으나 전통적인 관행상으로 익숙한 1자(尺) 30cm 인식이 빠르며, 측정자의 측정 위치의 편리성, 외국의 조경수목 측정기준에 대한 통일성 등 조경수목 근원직경의 합리적인 측정위치는 지표면 30cm 높이에서 측정하는 것이 좋을 것으로 추천되었다.

Bay 수와 가새재 설치가 시스템 비계 극한거동에 미치는 영향 (Effects of Number of bays and Bracing Member on the Ultimate Behavior of System Scaffolds)

  • 이선우;장남권;원정훈;정성춘
    • 한국안전학회지
    • /
    • 제35권3호
    • /
    • pp.6-15
    • /
    • 2020
  • This study examined the structural behaviors and ultimate loads of assembled system scaffolds by load tests. Considering the number of bay and bracing installation, four specimens were tested. The bays were divided into 1 bay and 2 bays, with and without the bracing member installed. Failure modes and horizontal displacements show that the whole column buckled without showing no point of inflection in the column, regardless of whether or not braces were installed. Thus, the current design method of selecting the vertical spacing between the horizontal members of the system scaffold as the effective buckling length underestimates the effective buckling length. In case of 1 bay specimens, the ultimate loads between specimens with and with bracing members are similar. However, in case of 2 bay specimens, the specimen with bracing members shows the increased ultimate load of 36% compared with that without bracing members. In addition, as the number of bays in the system scaffold increases, the ultimate load of the unit vertical column increases in case of the specimen with bracing installation. However, in the specimen without bracing members, the ultimate load of the unit column reduces with the increment of the number of bays due to the torsional buckling. Therefore, it is essential to install bracing members to increase the whole strength of system scaffolds and the ultimate load of the unit column.

The Investigation on Thermal Aging Characteristics of Oil-Paper Insulation in Bushing

  • Liao, Rui-jin;Hu, En-de;Yang, Li-jun;Xu, Zuo-ming
    • Journal of Electrical Engineering and Technology
    • /
    • 제10권3호
    • /
    • pp.1114-1123
    • /
    • 2015
  • Bushing is the key link to connect outer and inner insulating systems and also the essential electric accessory in electric power system, especially in the high voltage engineering (AC 1000kV, DC 800kV). This paper presented the experimental research of thermal aging characteristic of oil-paper insulation used in bushing. A thermally accelerated aging experiment at 90℃ was performed. The bushing models containing five layers of paper were sealed into the aging vessels and further aged for 250 days. Then several important parameters associated with the aging were observed and evaluated. The results showed that the degree of polymerization (DP) of papers gradually decreased. The DP values of outermost layer and middle layer fit well into the second-order kinematic model and first-order kinematic model, respectively. Less deterioration speed of the inter-layer paper than outer layer was confirmed by the variation of DP. Hydrolysis was considered as the main cause to this phenomenon. In addition, the logarithm of the furfural concentrations in insulation oil was found to have good linear relationship with DP of papers. Interestingly, when the aging time is about 250 days and DP is 419, the aging process reaches an inflection point at which the DP approaches the leveling off degree of polymerization (LODP) value. Both tanδ and acid number of oils increased, while surface and volume resistivity of papers decreased. The obtained results demonstrated that thermal aging and moisture absorbed in papers brought great influence to the degradation of insulating paper, leading to rapid decrease of DP and increase of the tanδ. Thus, the bushing should be avoided from damp and real-time monitoring to the variation of tanδ and DP values of paper is an effective way to evaluate the insulation status of bushing.

Effects of age on intestinal phosphate transport and biochemical values of broiler chickens

  • Li, Jianhui;Yuan, Jianmin;Miao, Zhiqiang;Guo, Yuming
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제30권2호
    • /
    • pp.221-228
    • /
    • 2017
  • Objective: The objective of this experiment was to characterize the mRNA expression profile of type IIb sodium-inorganic phosphate cotransporter (NaPi-IIb) and the biochemical values of serum alkaline phosphatase (AKP), calcium, inorganic phosphorus, tibial ash and minerals of broiler chickens with aging. Methods: A total of 56 one-day-old Arbor Acres male broiler chickens were used. Broiler chickens were weighed and samples were collected weekly from day 1. Results: The result showed that before the growth inflection point, ash, calcium, and phosphorus content in the tibia of broiler chickens increased with growth (before 3 weeks of age), although there were no significant differences in chicks at different ages in the later period of the experiment and weight gain rate was relatively slow at this stage (4 to 6 weeks). NaPi-IIb gene expression in the small intestine in the early growth stage was higher than that in the later growth stage. Expression of calbindin and the vitamin D receptor protein in the intestinal mucosa increased with age in the duodenum and jejunum. Serum AKP activity first increased and subsequently decreased after peaking at 1 week of age, but there was no significant difference after 3 weeks of age. Conclusion: These results show that compared with the early growth stage, the weight-gain rate of broiler chickens in the late growth stage gradually decreased with gradual tibia maturation, along with weaker positive transport of phosphorus in the intestine and reinforced re-absorption of phosphorus in the kidney, which might be the reason that phosphorus requirement in the late growth stage was decreased.

Statistically estimated storage potential of organic carbon by its association with clay content for Korean upland subsoil

  • Han, Kyung-Hwa;Zhang, Yong-Seon;Jung, Kang-Ho;Cho, Hee-Rae;Seo, Mi-Jin;Sonn, Yeon-Kyu
    • 농업과학연구
    • /
    • 제43권3호
    • /
    • pp.353-359
    • /
    • 2016
  • Soil organic carbon (SOC) retention has gradually gotten attention due to the need for mitigation of increased atmospheric carbon dioxide and the simultaneous increase in crop productivity. We estimated the statistical maximum value of soil organic carbon (SOC) fixed by clay content using the Korean detailed soil map database. Clay content is a major factor determining SOC of subsoil because it influences the vertical mobility and adsorption capacity of dissolved organic matter. We selected 1,912 soil data of B and C horizons from 13 soil series, Sangju, Jigog, Jungdong, Bonryang, Anryong, Banho, Baegsan, Daegog, Yeongog, Bugog, Weongog, Gopyeong, and Bancheon, mainly distributed in Korean upland. The ranges of SOC and clay content were $0-40g\;kg^{-1}$ and 0 - 60%, respectively. Soils having more than 25% clay content had much lower SOC in subsoil than topsoil, probably due to low vertical mobility of dissolved organic carbon. The statistical analysis of SOC storage potential of upland subsoil, performed using 90%, 95%, and 99% maximum values in cumulative SOC frequency distribution in a range of clay content, revealed that these results could be applicable to soils with 1% - 25% of clay content. The 90% SOC maximum values, closest to the inflection point, at 5%, 10%, 15%, and 25% of clay contents were $7g\;kg^{-1}$, $10g\;kg^{-1}$, $12g\;kg^{-1}$, and $13g\;kg^{-1}$, respectively. We expect that the statistical analysis of SOC maximum values for different clay contents could contribute to quantifying the soil carbon sink capacity of Korean upland soils.

Exploring the Formation of Galaxies through Metallicities of Globular Clusters

  • Kim, Sooyoung
    • 천문학회보
    • /
    • 제38권2호
    • /
    • pp.36-36
    • /
    • 2013
  • Globular clusters (GCs) are among the oldest stellar objects in the universe and provide valuable constraints on many aspects of galaxy evolution. GC systems typically exhibit bimodal color distributions the phenomenon of which has been a major topic in the area of GC research. GC color bimodality established a paradigm where scenarios to explain its origin require two GC groups with different formation origins. The GC division, asserted mainly by photometric color bimodality so far, has been viewed as the presence of two distinct metallicity subgroups within individual galaxies. In this study, we make use of spectroscopy of GC systems associated with two giant galaxies, M31 (the Andromeda) and M87 (NGC 4486), to investigate the GC bimodality and the underlying metallicity distributions. Recent spectroscopy on the globular cluster (GC) system of M31 with unprecedented precision witnessed a clear bimodality in absorption-line index distributions of old GCs. Given that spectroscopy is a more detailed probe into stellar population than photometry; the discovery of index bimodality may point to the very existence of dual GC populations. However, here we show that the observed spectroscopic dichotomy of M31 GCs emerges due to the nonlinear nature of metallicity-to-index conversion and thus one does not necessarily have to invoke two separate GC subsystems. We present spectra of 130 old globular clusters (GCs) associated with the Virgo giant elliptical galaxy M87, obtained using the Multi-Object Spectrography (MOS) mode of Faint Object Camera and Spectrograph (FOCAS) on the Subaru telescope. M87 GCs with reliable metallicity measurements exhibit significant inflection along the color-metallicity relations, through which observed color bimodality is reproduced from a broad, unimodal metallicity distribution. Our findings lend further support to this new interpretation of the GC color bimodality, which could change much of the current thought on the formation of GC systems and their host galaxies.

  • PDF

Merging and Splitting of Coronal Holes through a Solar Cycle

  • Jang, Min-Hwan;Choe, G.S.;Hong, Sun-Hak;Woods, Tom
    • 천문학회보
    • /
    • 제36권2호
    • /
    • pp.99-99
    • /
    • 2011
  • A statistical study of coronal hole merging and splitting has been performed through Solar Cycle 23. The NOAA/SESC solar synoptic maps are examined to identify inarguably clear events of coronal hole merging and splitting. The numbers of merging events and splitting events are more or less comparable regardless of the phase in the solar cycle. The number of both events, however, definitely shows the phase dependence in the solar cycle. It apparently has a minimum at the solar minimum whereas its maximum is located in the declining phase of the sunspot activity, about a year after the second peak in Solar Cycle 23. There are more events of merging and splitting in the descending phase than in the ascending phase. Interestingly, no event is found at the local minimum between the two peaks of the sunspot activity. This trend can be compared with the variation of the average magnetic field strength and the radial field component in the solar wind through the solar cycle. In Ulysses observations, both of these quantities have a minimum at the solar minimum while their maximum is located in the descending phase, a while after the second peak of the sunspot activity. At the local minimum between the two peaks in the solar cycle, the field strength and the radial component both have a shallow local minimum or an inflection point. At the moment, the physical reason for these resembling tendencies is difficult to understand with existing theories. Seeing that merging and splitting of coronal holes are possible by passage of opposite polarity magnetic structures, we may suggest that the energizing activities in the solar surface such as motions of flux tubes are not exactly in phase with sunspot generation, but are more active some time after the sunspot maximum.

  • PDF

간선도로 기능별 교통사고모형 개발 - 청주시를 사례로 - (Developing the Traffic Accident Models by the Function of Arterial Link Sections in the Case of Cheongju)

  • 김진선;김태영;김경환;박병호
    • 한국도로학회논문집
    • /
    • 제13권1호
    • /
    • pp.49-57
    • /
    • 2011
  • 이 연구는 청주시의 가로구간 교통사고를 다루고 있다. 연구의 목적은 가로구간의 기능별 사고모형을 개발하는 데 있다. 이를 위해서 이 연구는 전체 472개의 세부구간으로 분리된 주간선도로와 보조간선도로의 사고 자료를 이용하여 적합한 모형을 개발하는데 중점을 두고 있다. 연구의 주요 결과는 다음과 같다. 첫째, 주간선과 보조간선도로의 사고특성에 대한 t 검정은 두 도로의 사고건수와 EPDO에 차이가 있는 것으로 나타나 기능별 사고모형 개발이 적절한 것으로 분석된다. 둘째, 주간선도로의 EPDO와 사고건수는 모두 ZINB모형이 적합한 것으로 분석된다. 셋째, 보조간선도로 EPDO는 ZINB모형, 그리고 사고건수는 ZIP모형이 최적인 것으로 분석된다. 마지막으로 주간선도로 사고모형(ZINB)의 공통변수는 교통량과 굴곡점수, 보조간선도로의 EPDO모형(ZINB)과 사고건수모형(ZIP) 공통변수는 평균종단경사인 것으로 평가된다.

한국 남해에서 채집된 사량넙치 Psettina tosana 자어의 분자 동정 및 형태 발달 (Molecular Identification and Morphological Development of Larvae of Psettina tosana Collected from Southern Sea of Korea)

  • 지재민;유효재;황강석;박정호;이정훈;김진구
    • 한국어류학회지
    • /
    • 제29권4호
    • /
    • pp.244-251
    • /
    • 2017
  • 본 연구는 2016년에 한국 남해에서 채집된 둥글넙치과 자어를 분자방법으로 동정하였으며, 자어의 크기별 외부 형태를 상세히 기술하였다. 채집된 자어 15개체 (3.53~19.49 mm 체장)의 mitochondrial DNA (mtDNA) cytochrome c oxidase subunit I gene (COI) 434 bp의 염기서열을 비교한 결과, 모두 사량넙치로 확인되었다. 사량넙치의 자어는 2개의 길게 연장된 등지느러미 기조를 가지며, 등지느러미와 뒷지느러미 기저에 흑색소포가 일렬로 나 있는 반면 체측에는 흑색소포가 없었다. 성장하면서 체장에 대한 두장 및 두고의 비율이 증가 추세에서 감소 추세로 바뀌는 변곡점이 체장 9.93 mm~10.73mm에서 확인되었다. 사량넙치 자어는 형태적으로 가장 유사한 동백가자미(Psettina iijimae)와 달리 등지느러미와 뒷지느러미의 기저 근처에 흑색소포군을 가지지 않는 점에서 잘 구분된다.