• 공업화학
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• 제19권5호
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• pp.457-465
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• 2008

인간의 질병을 치료하기 위한 여러 가지 의료 시스템의 개발이 생명공학의 발전과 함께 많은 연구가 이루어지고 있다. 또한 약물이나 유전자와 같은 생리활성물질을 체내에 안전하게 전달할 수 있는 시스템의 개발과 함께 이루어지고 있다. 이러한 시스템에 있어서 가장 중요한 것은 생체적합성 및 생체분해성 그리고 무독성의 특성을 가진 생체의료용 고분자를 개발하는 것이다. 천연고분자물질인 키토산은 좋은 생체적합성과 생체활성의 특성을 가지고 있어서 생체의료용 재료로 심도 있게 고려되어지고 있다. 키토산의 물성은 키틴의 결정성 구조에 따라 다르게 설명되므로 키틴의 구조적 분석에 대한 연구가 생체재료로써의 응용을 위해서 선행되어야 한다. 이러한 관점에서 본 총설에서는 키틴의 결정성 구조 분석, 키토산의 일반적인 물성 그리고 생체의료용 재료로써 저분자량 수용성 키토산의 가능성을 소개하였다. 또한 다양한 기능성기를 이용한 저분자량 수용성 키토산의 화학적인 개질을 약물전달체로써의 가능성을 강조하고 생체이용율의 향상을 위해 수행하였다.

• Journal of Biosystems Engineering
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• 제4권2호
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• pp.46-52
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• 1979

The water delivery hose for agricultural pump is getting popular in rural areas in korea. Friction head loss, discharge, and power requirements were measured in various discharge for different material and diameter of hose to get basic data for economical use in agricultural pump. The results attained in this study were as follows ; 1. Friction head loss increased significantly as the velocity increased, and the difference of velocity between the different diameter of hose was bigger than that between materials, which was resulted in the increase of the friction head loss. 2. Friction head loss in the case of that the velocity with 2m/sec was constant was about 3.53 to 4.01 m/100m in the diameter 3" and about 2.30 to 3.10 m/100m in the diameter 4". Material A of diameter 3" showed the maximum value 8.4m/100m in Reynolds number $2.0\times10^5$, 4" got the minimum value 2.24m/100m, the difference between these values was bigger than 6m per 100 meters in the friction head loss. 3. Darcy-Weisbach formular with friction coefficient [f] calculated by Nikurades formular in the smooth pipe or with friction coefficient [f] calculated on the base of C value 125 in Hazen-Williams formular was available in friction head loss of the water discharger hose in rural areas. 4. Total head increased as friction head loss increased , meanwhile total discharge decreased, and 20 percents of energy was more saved in Material C 4″pipe than Material A 3″pipe in the view point from the discharge per unit power requirement, this phenomenon suggested that long distance pipe would be advantage in larger diameter pipe for save of energy. for save of energy.

• 한국포장학회지
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• 제27권3호
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• pp.175-180
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• 2021

Although it has recently been regulated for use as an eco-friendly policy in Korea, the use of EPS (Expanded Polystyrene) cooling boxes, which are used as cold chain delivery insulation boxes for fresh agricultural and livestock products, is also increasing rapidly as e-commerce logistics such as delivery have increased rapidly due to COVID-19. Studies were conducted to optimize the EPS cooling container through internal air heat flow of CFD (Computational Fluid Dynamics) analysis and FEM (Finite Element Method) random vibration analysis using domestic PSD (Power Spectral Density) profile of the EPS cooling box to which the refrigerant is applied in this study. In the analysis of the internal air heat flow by the refrigerant in the EPS cooling box, the application of vertical protrusions inside was excellent in volume heat flow and internal air temperature distribution. In addition, as a result of random vibration analysis, the internal vertical protrusion gives the rigid effect of the cooling box, so that displacement and stress generation due to vibration during transport are smaller than that of a general cooling container without protrusion. By utilizing the resonance point (frequency) of the EPS cooling box derived by the Model analysis of ANSYS Software, it can be applied to the insulation and cushion packaging design of the EPS product line, which is widely used as insulation and cushion materials.

• Journal of Radiation Protection and Research
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• 제44권1호
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• pp.32-42
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• 2019

Background: There have been much efforts to develop the proper and realistic machine Quality Assurance (QA) reflecting on real Volumetric Modulated Arc Therapy (VMAT) plan. In this work we propose and test a special VMAT plan of plan-class specific (pcsr) QA, as a machine QA so that it might be a good solution to supplement weak point of present machine QA to make it more realistic for VMAT treatment. Materials and Methods: We divided human body into 5 treatment sites: brain, head and neck, chest, abdomen, and pelvis. One plan for each treatment site was selected from real VMAT cases and contours were mapped into the computational human phantom where the same plan as real VMAT plan was created and called plan-class specific reference (pcsr) QA plan. We delivered this pcsr QA plan on a daily basis over the full research period and tracked how much MLC movement and dosimetric error occurred in regular delivery. Several real patients under treatments were also tracked to test the usefulness of pcsr QA through comparisons between them. We used dynalog file viewer (DFV) and Dynalog file to analyze position and speed of individual MLC leaf. The gamma pass rate from portal dosimetry for different gamma criteria was analyzed to evaluate analyze dosimetric accuracy. Results and Discussion: The maxRMS of MLC position error for all plans were all within the tolerance limit of < 0.35 cm and the positional variation of maxPEs for both pcsr and real plans were observed very stable over the research session. Daily variations of maxRMS of MLC speed error and gamma pass rate for real VMAT plans were observed very comparable to those in their pcsr plans in good acceptable fluctuation. Conclusion: We believe that the newly proposed pcsr QA would be useful and helpful to predict the mid-term quality of real VMAT treatment delivery.

• 한국의학물리학회지:의학물리
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• 제28권2호
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• pp.39-44
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• 2017

This study aims to analyze dose distribution and treatment time of endobronchial brachytherapy (EBBT) by changing the position step size of the dwell position. A solid water phantom and an intraluminal catheter were used in the treatment plan. The treatment plans were generated for 3, 5, 7, and 10 cm treatment lengths, respectively. For each treatment length, the source position step sizes were set as 2.5, 5, and 10 mm. Three reference points were set 1 cm away from the central axis of the catheter, along the axis, for uniform dose distribution. Volumetric dose distribution was calculated to evaluate the dosimetric effect. The total radiation delivery time and total dwell time were estimated for treatment efficiency, which were increased with position step sizes. At half-life time, the differences between the position step sizes in the total radiation delivery time were 18.1, 15.4, 18.0, and 24.0 s for 3, 5, 7, and 10 cm treatment lengths, respectively. The dose distributions were more homogenous by increasing the position step sizes. The dose difference of the reference point was less than 10%. In brachytherapy, this difference can be negligible. For EBBT, the treatment time is the key factor while considering the patient status. To reduce the total treatment time, EBBT can be performed with 2.5 mm position step size.

• 대한방사선기술학회지:방사선기술과학
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• 제43권2호
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• pp.105-114
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• 2020

This study aimed to assess of beam-matching accuracy for an 8 MV beam between the same model linear accelerators(Linac) commissioned over two years. Two models were got the customer acceptance procedure(CAP) criteria. For commissioning data for beam-matched linacs, the percentage depth doses(PDDs), beam profiles, output factors, multi-leaf collimator(MLC) leaf transmission factors, and the dosimetric leaf gap(DLG) were compared. In addition, the accuracy of beam matching was verified at phantom and patient levels. At phantom level, the point doses specified in TG-53 and TG-119 were compared to evaluate the accuracy of beam modelling. At patient level, the dose volume histogram(DVH) parameters and the delivery accuracy are evaluated on volumetric modulated arc therapy(VMAT) plan for 40 patients that included 20 lung and 20 brain cases. Ionization depth curve and dose profiles obtained in CAP showed a good level for beam matching between both Linacs. The variations in commissioning beam data, such as PDDs, beam profiles, output factors, TF, and DLG were all less than 1%. For the treatment plans of brain tumor and lung cancer, the average and maximum differences in evaluated DVH parameters for the planning target volume(PTV) and the organs at risk(OARs) were within 0.30% and 1.30%. Furthermore, all gamma passing rates for both beam-matched Linacs were higher than 98% for the 2%/2 mm criteria and 99% for the 2%/3 mm criteria. The overall variations in the beam data, as well as tests at phantom and patient levels remains all within the tolerance (1% difference) of clinical acceptability between beam-matched Linacs. Thus, we found an excellent dosimetric agreement to 8 MV beam characteristics for the same model Linacs.

• 여성건강간호학회지
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• 제21권4호
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• pp.332-341
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• 2015

Purpose: Advanced aged pregnancy may be related with health problems so that more aggressive health care is necessary for these women. This study aimed to provide the basic data for developing nursing intervention programs to enhance the health of pregnant women and their new-born babies and by identifying the advanced aged women's need for pregnancy and childbirth. Methods: It is the cross-sectional descriptive study to identify the advanced aged women's need on pregnancy and childbirth. Subjects were pregnant women 35 years or older and postpartum women. Total number of subjects was 95. Measurement tool is self-reporting survey that consisted of 67 items with four-point Likert scale, which was completed during October to November 2014. Results: Average score was 3.44 out of maximum 4 on the care need on pregnancy and childbirth. Average scores according to category were as follows: baby rearing and parental role, 3.55; preconception care, 3.49; delivery care, 3.47; postpartum care 3.42; and prenatal pregnancy, 3.39. The degree of needs on pregnancy and childbirth was different according to delivery experience (t=-2.49, p=.014). Conclusion: Prenatal and postpartum nursing interventions were completed regardless of pregnant women's age until now; however, new nursing intervention programs are necessary to prevent the risk of advanced aged pregnancy, to provide the preconception care, and to increase the infant care and family support.

• 한국물환경학회지
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• 제33권6호
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• pp.744-753
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• 2017

The sediment delivery ratio (SDR) is widely used to estimate sediment loads by multiplying soil loss through the Revised Universal Equation (RUSLE). In this study, the SDR equation was developed for the Lake Imha watershed using soil loss calculated by RUSLE and sediment loads by the calibrated Hydrological Simulation. Program Fortran (HSPF). The ratio of watershed relief and channel length ($R_f/L_{ch}$), the ratio of watershed relief and watershed length ($R_f/L_b$), curve number (CN), area (A), and channel slope ($SLP_{ch}$) demonstrated strong correlations with SDR. SDR equations were developed by a combination of subwatershed parameters by referring to the correlation analysis. The area based power functional SDR developed in this study showed significant errors at the point right after entering major tributaries, because SDR was unrealistically reduced when the watershed area increased significantly. The $SLP_{ch}$-based power functional SDR also showed extraordinary values when the channel slope was gradual. The SDR equation that showed the highest value of the coefficient of determination also presented unrealistic changes in the sediment loads within a relatively short river distance. The SDR equation $SDR=0.0003A^{0.198}R_f/L{_w}^{1.167}$ was recommended for application to the Lake Imha watershed. Using this equation, sediment loads at the outlet of the Lake Imha watershed were calculated, and the HSPF parameters related to sediment in the uncalibrated subwatersheds were determined by referring to the sediment loads calculated with the SDR equation.

• 한국전자거래학회지
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• 제26권1호
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• pp.67-78
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• 2021

국내 전자상거래는 거래액을 기준으로 최근 5년간 연평균 20% 이상의 성장률을 지속적으로 기록하고 있다. 전자상거래의 급증으로 인해 소비자를 직접 만나기 어려운 유통기업들은 고객과의 유일한 접점이 되는 라스트마일 서비스 경쟁이 치열한데, 특히 최근 가장 경쟁이 뜨거운 배송영역은 서비스 차별화를 위해 풀필먼트 센터의 역할이 매우 중요하다. 소비자가 주문한 제품을 서비스 수준에 맞춰 신속하게 준비 할 수 있는 역량을 반드시 갖추고 있어야 한다. 본 연구는 전자상거래 시장에서 기업이 경쟁력을 갖추기 위한 방안으로써 풀필먼트 센터에서의 신속한 주문처리를 위해 오더피킹 시스템을 대상으로 연구를 진행하였다. 오더피킹 설비에서의 재고 보충 최적화를 위한 수리 모형 알고리즘을 구현하고, 실제 운영 프로세스와 데이터를 활용한 시뮬레이션을 통해 과학적이고 객관적인 방법으로 효과를 검증하였다.

• 대한암한의학회지
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• 제20권1호
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• pp.31-44
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• 2015

Background : The purpose of this study is to investigate the efficacy and safety of the circadian delivery schedule of fluorouracil or capecitabine based chemotherapy for advanced colorectal cancer. Patients and methods : A meta-analysis was performed using individual data from eight international randomized clinical trials, especially phase II or III trials, comparing 5-fluorouracil, or capeticabine in chronomodulated or conventional schedule. The data from 8 studies was composed of 692 patients receiving chronomodulated chemotheray and 684 patients receiving conventional chemotherapy. The main end point was response rate. Results : Response rate was insignificantly different from each group (RR 1.14, 95%CI 0.74-1.74, p=0.55). Overall survival and progresseion-free survival were not significant either. Chemotherapy induced anemia, diarrhea, and nausea/vomiting were worse in the chronotherapy group, with statistic significance respectively. On the other hand, chemotherapy induced thrombocytopenia, stomatitis, peripheral neuropathy, and dermatotoxicity were better but they were not statistically significant results. Conclusions : Patients lived longer but not significantly on chronomodulated chemotherapy rather than on conventional chemotherapy. Patients on chronomodulated chemotherapy experienced adverse events more. The chronomodulated chemotherapy schedule needs adjustment of its delivery schedule and further research is required.