• Current Optics and Photonics
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• v.4 no.4
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• pp.368-372
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• 2020

We report the terahertz time-domain spectroscopy (THz-TDS) of transdermal drug delivery in human skin. The time evolution of transdermal nicotine delivery in nicotine patches was assessed by detecting the transmission coefficient of sub-picosecond THz pulses and using a semi-analytic model based on the single-layer effective medium approximation. Using commercial nicotine patches (Nicoderm CQ^®, 7 mg/24 h), THz transmission coefficients were measured to quantitatively analyze the cumulative amounts of nicotine released from the patches in the absence of their detailed specifications, including multilayer structures and optical properties at THz frequencies. The results agreed well with measurements by conventional in vitro and in vivo methods, using a diffusion cell with high-performance liquid chromatography and blood sampling respectively. Our study revealed the ability of the THz-TDS method to be an effective alternative to existing methods for noninvasive and label-free assessments of transdermal drug delivery, showing its high promise for biomedical, pharmaceutical, and cosmetic applications.

• Macromolecular Research
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• v.16 no.8
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• pp.686-694
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• 2008

We studied the molecular shapes and structural characteristics of a 33-armed, star polystyrene (PS-33A) and two $3^{rd}$-generation, dendrimer-like, star-branched poly(methyl methacrylate)s with different architectures (pMMA-G3a and PMMA-3Gb) and 32 end-branches under good solvent and theta ($\Theta$) solvent conditions by using synchrotron small angle X-ray scattering (SAXS). The SAXS analyses were used to determine the structural details of the star PS and dendrimer-like, star-branched PMMA polymers. PS-33A had a fuzzy-spherical shape, whereas PMMA-G3a and PMMA-G3b had fuzzy-ellipsoidal shapes of similar size, despite their different chemical architectures. The star PS polymer's arms were more extended than those of linear polystyrene. Furthermore, the branches of the dendrimer-like, star-branched polymers were more extended than those of the star PS polymer, despite having almost the same number of branches as PS-33A. The differences between the internal chain structures of these materials was attributed to their different chemical architectures.

• Proceedings of the Zoological Society Korea Conference
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• 1999.04a
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• pp.35-35
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• 1999

No Abstract, See Full Text

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.388-391
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• 2005

The characteristics of the total ozone variations measured by the ground-based Brewer Ozone Spectrophotometer and the Total Ozone Mapping Spectrometer (TOMS) over Pohang are statistically examined from January 1994 to December 2004. First of all, in the correlation analysis of the total ozone measured from the Brewer Ozone Spectrophotometer and the TOMS, the correlation coefficient was 0.88 and the used data were 2190. The annual mean value of the total ozone is 311 DU with the standard deviation of 13 DU. The maximum and the minimum value were found in March (343 DU) and in September (282 DU), respectively. It was also revealed that the longest seasonal variation is in Spring (341 DU) and the smallest is in Autumn (283 DU). The time series data of the total ozone indicates that the annual variation is significant and the variations for three months and six months are relatively weak. Finally, the annual mean total ozones in Pohang (Brewer), Seoul (Brewer) and Busan (TOMS) are 312 DU, 324 DU and 304 DU, respectively.

• Proceedings of the Optical Society of Korea Conference
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• 2005.02a
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• pp.14-15
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• 2005

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2002.05a
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• pp.101-101
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• 2002

• Proceedings of the Optical Society of Korea Conference
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• 2007.02a
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• pp.5-6
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• 2007

• Proceedings of the Optical Society of Korea Conference
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• 1996.09a
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• pp.38-38
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• 1996

• Proceedings of the Materials Research Society of Korea Conference
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• 1998.08a
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• pp.46.4-46
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• 1998

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3866-3873
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• 2023

In 4th^-generation storage rings, whether to operate the beam as round or flat is a critical question. A round beam has equal horizontal and vertical emittances, and is an efficient solution to reduce strong intra-beam scattering effects and lengthen the Touschek lifetimes, but a flat beam produces a brighter photon beam than a round beam. To provide both beams concurrently rather than bifurcating the beam time, this paper presents the exploitation of beam dynamics and the cutting-edge fast pulser that supports concurrent operation of round beam and flat beam.