• Title/Summary/Keyword: Platform-based analysis

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Genome-wide Survey of Copy Number Variants Associated with Blood Pressure and Body Mass Index in a Korean Population

  • Moon, Sang-Hoon;Kim, Young-Jin;Kim, Yun-Kyoung;Kim, Dong-Joon;Lee, Ji-Young;Go, Min-Jin;Shin, Young-Ah;Hong, Chang-Bum;Kim, Bong-Jo
    • Genomics & Informatics
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    • v.9 no.4
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    • pp.152-160
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    • 2011
  • Hypertension is the major factor of most death and high blood pressure (BP) can lead to stroke, myocardial infarction and cardiac failure. Moreover, hypertension is strongly correlated with body mass index (BMI). Although the exact causes of hypertension are still unclear, some of genetic loci were discovered from genome-wide association study (GWAS). Therefore, it is essential to study genetic variation for finding more genetic factor affecting hypertension. The purpose of our study is to conduct a CNV association study for hypertension-related traits, BP and BMI, in Korean individuals. We identified 2,206 CNV regions from 3,274 community-based Korean participants using the Affymetrix Genome-Wide Human SNP Array 6.0 platform and performed a logistic regression analysis of CNVs with two hypertension-related traits, BP and BMI. Moreover, the 4,692 participants in an independent cohort were selected for respective replication analyses. GWAS of CNV identified two loci encompassing previously known hypertension-related genes: LPA (lipoprotein) on 6q26, and JAK2 (Janus kinase 2) on 9p24, with suggestive p-values (0.0334 for LPA and 0.0305 for JAK2 ). These two positive findings, however, were not evaluated in the replication stage. Our result confirmed the conclusion of CNV study from the WTCCC suggesting weak association with common diseases. This is the first study of CNV association study with BP and BMI in Korean population and it provides a state of CNV association study with common human diseases using SNP array.

The development of parallel computation method for the fire-driven-flow in the subway station (도시철도역사에서 화재유동에 대한 병렬계산방법연구)

  • Jang, Yong-Jun;Lee, Chang-Hyun;Kim, Hag-Beom;Park, Won-Hee
    • Proceedings of the KSR Conference
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    • 2008.06a
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    • pp.1809-1815
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    • 2008
  • This experiment simulated the fire driven flow of an underground station through parallel processing method. Fire analysis program FDS(Fire Dynamics Simulation), using LES(Large Eddy Simulation), has been used and a 6-node parallel cluster, each node with 3.0Ghz_2set installed, has been used for parallel computation. Simulation model was based on the Kwangju-geumnan subway station. Underground station, and the total time for simulation was set at 600s. First, the whole underground passage was divided to 1-Mesh and 8-Mesh in order to compare the parallel computation of a single CPU and Multi-CPU. With matrix numbers($15{\times}10^6$) more than what a single CPU can handle, fire driven flow from the center of the platform and the subway itself was analyzed. As a result, there seemed to be almost no difference between the single CPU's result and the Multi-CPU's ones. $3{\times}10^6$ grid point one employed to test the computing time with 2CPU and 7CPU computation were computable two times and fire times faster than 1CPU respectively. In this study it was confirmed that CPU could be overcome by using parallel computation.

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Design and Implementation of Wireless Power Transfer System for a Personal Rapid Transit (PRT) Vehicle (PRT 차량의 무선급전 시스템 설계 및 구현)

  • Kang, Seok-Won;Jeong, Rag-Gyo;Byun, Yeun-Sub;Um, Ju-Hwan;Kim, Baek-Hyun
    • Journal of Digital Convergence
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    • v.12 no.11
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    • pp.289-298
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    • 2014
  • Recently, the traditional paradigm in railroad technology is changing as more efficient and cost-effective electric vehicle (EV) technologies have emerged. The original concept of PRT (Personal Rapid Transit) proposed in the past has come to be regarded as unrealistic, but its feasibility is improving through the utilization of an EV platform. In particular, battery-powered vehicles pose difficult technical challenges in attempts to achieve reliable and efficient operation. However, based on the inductive power transfer (IPT) technology, the fast charging of supercapacitors with high energy density can contribute to overcoming this technical challenge and promote the transition to electric-powered ground transportation by improving the appearance of cities. This study discusses the development process of a power supply system for PRT, including concept design, numerical analysis, and device manufacturing, along with performance predictions and evaluations. In terms of results, the system was found to meet the performance requirements for power supply modules on a test-bed.

A Study on the Impact of the Epidemic Disease on the Number of Books Checked Out of the Public Libraries: Based on the Middle East Respiratory Syndrome Coronavirus (유행성 질병이 공공도서관의 대출책수에 미치는 영향: 메르스 사태를 중심으로)

  • Kim, Wan-Jong
    • Journal of the Korean Society for information Management
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    • v.32 no.4
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    • pp.273-287
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    • 2015
  • This study aimed to investigate the impact of the epidemic disease including Middle East Respiratory Syndrome Coronavirus (MERS) on the usage of public libraries. Such disease yields anxiety throughout the nation and discourages social activities in general. 18,711,453 records from 303 public libraries were examined with "big data retrieval & analysis platform for public libraries" located in Sejong National Library. The results are as follows. First, in 2015, when MERS was prevalent, the daily mean of books checked out was 64,645.05, showing decrease of 6,300 per day compared to that of 2014. Second, in 2014, the daily mean of books checked out from July 5th to August 19th was greater than that of from April 4th to May 19th and that of from May 20th to July 4th, implying the impact of summer vacation on the increase in books checked out in public libraries. Third, in 2015, the daily mean of books checked out from July 5th was greater than during MERS outbreak(from May 20th to July 4th), while it did not show statistically significant difference with that of before the outbreak. Fourth, the daily mean of books checked out did not show statistically significant difference between 2014 and 2015 before and during the outbreak, while it showed statistically significant difference between 2014 and 2015 after the epidemic period. The results indicate that MERS and the anxiety it brought nationwide had an impact on the daily mean of books checked out in public libraries after the epidemic period rather than during the outbreak.

The Effects of Belongingness and Loneliness on Self-Disclosure in MIM: The Moderating Role of System Quality (모바일 인스턴트 메신저 상황에서 소속감, 외로움이 자기노출 행동에 미치는 영향: 시스템 품질의 조절효과를 중심으로)

  • Jung, Bo-Hee;Kim, Han-Ku
    • Journal of Distribution Science
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    • v.14 no.9
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    • pp.85-94
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    • 2016
  • Purpose - Recently, Mobile technologies and devices including smart phones and tablets have increased the possibility of communicating with other people and sharing personal information without time and space restriction. In order to realize the market potential related to mobile technologies, a large number of internet services have been incorporated into mobile platforms. Especially, The number of MIM(Mobile Instant Messenger) users has been increasing dramatically and services using MIM platform also have diversified. In spite of drastic growth in markets related to MIM, there is little empirical research on MIM and users' behaviors. This study designed to examine the structural relationships among belongingness, loneliness, self-disclosure intention, system quality, and self-disclosure behavior in context of MIM. Research design, data, and methodology - Three hypotheses were about the relationship among belongingness, loneliness and self-disclosure intention. The other two hypotheses were about the moderating effect of system quality in the causal relationship between self-disclosure intention and self-disclosure behavior. The data was analyzed by structural equation modeling. Research data were obtained from 330 undergraduate students who were KakaoTalk users and total 314 valid questionnaires were used in the final analysis. Results - The results from this study are as follow. First, the belongingness and the loneliness had a significant impact on self-disclosure intention in MIM. Second, the self-disclosure intention in MIM also had a positive impact on the self-disclosure behavior. Lastly, there is a moderating effect of the system quality in the relationship between the self-disclosure intention and self-disclosure behavior in MIM. Specifically, the higher system quality level was perceived, the positive effect of the self-disclosure intention in MIM on the self-disclosure behavior was greater. Conclusions - Based on the results from this study, academic and practical implications can be drawn. First, the study extends the scope of research about SNS through focusing on MIM to be classified by closed type SNS and identifies the relationship between emotion, behavioral intention and behaviors in MIM. Second, this study provides strategic guidelines to increase the efficiency for promotion activity. Limitations for the study also should be discussed.

A Study on Development of Curriculum for Convergence Education School for the Gifted (융합형 영재교육기관의 교육과정 개발에 관한 연구)

  • Lee, Jae-Ho
    • Journal of The Korean Association of Information Education
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    • v.16 no.1
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    • pp.123-130
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    • 2012
  • As a sequel of "special improvement act for gifted student education" legislated on January 2000, "regulation act for gifted student education" was published on April 2002 which is the time Korea has settled down its education for the gifted. Announced in the December 2007 "general plan for development of gifted student education" provided a platform for the gifted student education in Korea of growth in quantity, in which a plan of providing gifted student education up to 1 percent of the elementary and middle school level students (approximately 70 thousands) has been established while the education currently provides to 0.59 percent (40 thousands) of all students. Until recently, however, education for gifted students has been performed based on the way of concentrating on academic domains. and it has put more weights on mathematics and english domains. In order to overcome this drawbacks, there have been various attempts for growth in quality of education for gifted students, one of them is the our proposal of convergence of science and art education for cultivating 21 century creative humans through establishment of new type of institution. In this paper, education curriculum and management strategies appliable to the proposed convergence education institutions for gifted students. For this purpose we derived the implication points through analysis on education processes used in korea science school for the gifted students, a representative institution for the gifted students in Korea, and we suggested educational process curriculums for the science and art institute for gifted students along with the detailed contents of convergence subject which is an essential subject to the institute.

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A Research on Streaming Protocol for User-Created Contents in Digital Cable Broadcasting environment (디지털 케이블 방송 환경에서 개인 미디어를 위한 스트리밍 프로토콜 연구)

  • Kim, Seong-Won;Kim, Jung-Hwan;Si, Jang-Hyun;Jung, Moon-Ryul
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.44 no.1
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    • pp.54-61
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    • 2007
  • In this paper, on-demand service streaming protocol for user-created contents in digital cable broadcasting environment is considered. In order to provide variety media contents service like UCC in digital cable broadcasting environment, the same service model as RVOD(Real Video on Demand) is required and the different interface for each broadcasting platform is needed in a current OCAP environment. Using return path based RTP, we separate existing VOD stream band into broadcasting and VOD stream band. In order to broaden On-demand service, consistent expansion of the infrastructure same as live broadcasting system is inefficient in the digital cable broadcasting environment. Using existing network protocol, the service which is insensitive to the infrastructure for VOD service becomes possible. Therefore we considered the analysis of the class of download available structure in the Set-Top-Box for RTP(Real-time Transport Protocol) and designing the decoding available streaming server for UCC transcoding and transmission in the receiver. Designing a efficient VOD service and system under the broadcasting environment gives a expansion of On-Demand service and more chance to upload and utilization of contents.

Beacon-based Internet of Things(IoT) analysis of the Case Study (비콘 기반의 사물인터넷(IoT) 활용 사례 분석)

  • Hwang, Hyun-seo;Park, Jin-tae;Yun, Jun-soo;Phyo, Gyung-soo;Moon, Il-young;Lee, Jong-sung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.977-980
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    • 2015
  • Beacons have been noted in the core of the recent things Internet. It is also the technology is spreading most rapidly among the things Internet-related communication technologies. Beacon is a data communications technology that provides information that is customized to know the user's location. Using the BLE technology, to grasp the position of such people and goods. In addition to the non-contact method, since it is possible to communicate within the maximum 70m, it has attracted the interest than the NFC. Beacon, guidance for the current coupon, you can use as an advertising platform, such as the provision of product information, it has also been used in the indoor positioning service. Therefore, in this paper, we introduce about whether Case Study beacon is utilized how in the Internet of Things, were analyzed. Beacon exit the smart phone, the date to be used in conjunction with a wearable device, such as Google glasses and smart watch was not far away. Future it is expected or beacons are used everywhere to be expanded.

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Exploratory Study of Characterizing Scholarly Communication Patterns in Humanities for Facilitating Consilience in Cyberscholarship Environment: Based on Historians' Research Activities (사이버스칼러쉽 환경에서의 융복합 연구 촉진을 위한 인문학 분야 학술 커뮤니케이션 특성 파악에 관한 연구 - 역사학 분야를 중심으로 -)

  • Yu, So-Young
    • Journal of the Korean Society for Library and Information Science
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    • v.50 no.1
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    • pp.331-351
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    • 2016
  • Digitalized data and literature in scholarly community has developed the concept of digital humanities and cyberscholarship which indicate the characteristics of a new aspect and approach in scholarly activities with digitalized resources or new media. This study was performed in order to identify the changes in national research activities of art and humanities by using a multi-modal approach. The combined methodology of in-depth interview and content analysis on publishing and citing behaviors in literature was executed. The steps of research process is identified as a non-linear combination of 3 parts: developing research idea, developing the research idea to write, and submitting manuscript to publish. Prominent implementations of cyberscholarship were found in the 2nd step for accessing and using research data and literatures. Understanding the characteristics of scholar communication using cyberscholarhip factors in humanities for interdisciplinarity, sophisticating the environment of cyberscholarhip for data sharing, investing and developing archivist and archives, and providing a various platform for accelerating scholarly communication were derived by the panel discussion for developing interdisciplinary research for humanities.

Implementation of a Photo-Input Game Interface Using Image Search (이미지 검색을 이용한 사진입력 게임 인터페이스 구현)

  • Lee, Taeho;Han, Jaesun;Park, Heemin
    • KIISE Transactions on Computing Practices
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    • v.21 no.10
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    • pp.658-669
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    • 2015
  • The paradigm of game development changes with technological trends. If the system can analyze and determine undefined inputs, users' input choices are not restricted. Therefore, game scenarios can have multifarious flows depending upon the user's input data. In this paper, we propose a method of including an output plan in the game system that is based on the user's input but is not restricted to predefined choices. We have implemented an experimental game on the Android platform by combining network communication and APIs. The game interface works as follows: first, the user's input data is transmitted to the server using HTTP protocol; then, the server carries out an analysis on the input data; and finally, the server returns the decision result to the game device. The game can provide users a scenario that corresponds to the decision results. In this paper, we used an image file for the user's input data format. The server calculates similarities between the user's image file and reference images obtained from the Naver Image Search API and then returns determination results. We have confirmed the value of integrating the game development framework with other computing technologies demonstrating the potential of the proposed methods for application to various future game interfaces.